The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246 · see citing works

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471 · see citing works

Sex Steroids and the Construction and Conservation of the Adult Skeleton

Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846 · see citing works

Genetics and biology of vitamin D receptor polymorphisms

Uitterlinden, A. G., Fang, Y., van Meurs, J. B. J., Pols, H. A. P., & van Leeuwen, J. P. T. M. (2004) · Gene · doi:10.1016/j.gene.2004.05.014 · Cited by 1,542 · see citing works

Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens

Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416 · see citing works

Effect of testosterone and estradiol in a man with aromatase deficiency

Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151 · see citing works

Glucocorticoid-induced osteoporosis: pathophysiology and therapy

CANALIS, E. M., Mazziotti, G., Giustina, A., & Bilezikian, J. P. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0394-0 · Cited by 1,118 · see citing works

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

Nelson, D. R., Zeldin, D. C., Hoffman, S. M. G., Maltais, L. J., Wain, H., & Nebert, D. W. (2003) · Pharmacogenetics · doi:10.1097/00008571-200401000-00001 · Cited by 1,023 · see citing works

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

Stein, B., & Yang, M. X. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4971 · Cited by 697 · see citing works

The runx genes: gain or loss of function in cancer

Blyth, K., Cameron, E. R., & Neil, J. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1607 · Cited by 453 · see citing works

Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

Banerjee, C., McCabe, L. R., Choi, J., Hiebert, S. W., Stein, J. L., Stein, G. S., & Lian, J. B. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19970701)66:1 · Cited by 430 · see citing works

Paracrine and Autocrine Regulation of Epidermal Growth Factor-Like Factors in Cumulus Oocyte Complexes and Granulosa Cells: Key Roles for Prostaglandin Synthase 2 and Progesterone Receptor

Shimada, M., Hernández, I., González, I., & Richards, J. S. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0504 · Cited by 420 · see citing works

Regulation of Osteoclast Function

Suda, T., Nakamura, I., Jimi, E., & Takahashi, N. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.6.869 · Cited by 404 · see citing works

Mechanisms of sex steroid effects on bone

Syed, F., & Khosla, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.097 · Cited by 380 · see citing works

Suppressive function of androgen receptor in bone resorption

Kawano, H., Sato, T., Yamada, T., Μatsumoto, T., Sekine, K., Watanabe, T., Nakamura, T., Fukuda, T., Yoshimura, K., Yoshizawa, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533500100 · Cited by 318 · see citing works

Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.

Pratap, J., Galindo, M. A., Zaidi, S. K., Vradii, D., Bhat, B. M., Robinson, J. A., Choi, J. Y., Komori, T., Stein, J. L., Lian, J. B., et al. (2003) · PubMed · Cited by 301 · see citing works

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

Ray, A., Prefontaine, K. E., & Ray, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99966-7 · Cited by 298 · see citing works

Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain Proteins to Chromatin of the Osteocalcin Gene

Hassan, M. Q., Javed, A., Morasso, M. I., Karlin, J., Montecino, M. A., van Wijnen, A. J., Stein, G. S., Stein, J. L., & Lian, J. B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9248-9261.2004 · Cited by 285 · see citing works

The Tissue-Specific Nuclear Matrix Protein, NMP-2, Is a Member of the AML/PEBP2/Runt Domain Transcription Factor Family: Interactions with the Osteocalcin Gene Promoter

Merriman, H. L., van Wijnen, A. J., Hiebert, S. W., Bidwell, J. P., Fey, E. G., Lian, J. B., Stein, J. L., & Stein, G. S. (1995) · Biochemistry · doi:10.1021/bi00040a025 · Cited by 247 · see citing works

The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts

Galindo, M. A., Pratap, J., Young, D. W., Hovhannisyan, H., Im, H., Choi, J., Lian, J. B., Stein, J. L., Stein, G. S., & van Wijnen, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413665200 · Cited by 240 · see citing works

Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2

Young, D. W., Hassan, M. Q., Pratap, J., Galindo, M. A., Zaidi, S. K., Lee, S.-H., Yang, X., Xie, R., Javed, A., Underwood, J. M., et al. (2007) · Nature · doi:10.1038/nature05473 · Cited by 220 · see citing works

Perspective: Quantifying Osteoblast and Osteocyte Apoptosis: Challenges and Rewards

Jilka, R. L., Weinstein, R. S., PARFITT, A. M., & Manolagas, S. C. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070518 · Cited by 211 · see citing works

Upstream and downstream targets of RUNX proteins

Otto, F., Lübbert, M., & Stock, M. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10491 · Cited by 201 · see citing works

Regulation of the Bone-Specific Osteocalcin Gene by p300 Requires Runx2/Cbfa1 and the Vitamin D3 Receptor but Not p300 Intrinsic Histone Acetyltransferase Activity

Sierra, J., Villagra, A., Paredes, R., Cruzat, F., Gutierrez, S. E., Javed, A., Arriagada, G., Olate, J., Imschenetzky, M., van Wijnen, A. J., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3339-3351.2003 · Cited by 196 · see citing works

Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts

Prince, M., Banerjee, C., Javed, A., Green, J., Lian, J. B., Stein, G. S., Bodine, P. V. N., & Komm, B. S. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010301)80:3 · Cited by 182 · see citing works

Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin‐D3, dexamethasone, and local growth factors in primary human osteoblasts

Viereck, V., Siggelkow, H., Tauber, S. C., Raddatz, D., Schütze, N., & Hüfner, M. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10220 · Cited by 174 · see citing works

1,25-(OH)2-Vitamin D3 Suppresses the Bone-Related Runx2/Cbfa1 Gene Promoter

Drissi, H. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5474 · Cited by 173 · see citing works

The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin

Shen, Q., & Christakos, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504166200 · Cited by 173 · see citing works

Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2

Young, D. W., Hassan, M. Q., Yang, X., Galindo, M. A., Javed, A., Zaidi, S. K., Furcinitti, P. S., Lapointe, D. S., Montecino, M. A., Lian, J. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611419104 · Cited by 162 · see citing works

The direct role of vitamin D on bone homeostasis

St‐Arnaud, R. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.038 · Cited by 158 · see citing works

Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1

Hu, M.-C., Hsu, N.-C., El Hadj, N. B., Pai, C.-I., Chu, H.-P., Wang, C.-K. L., & Chung, B.-C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0055 · Cited by 153 · see citing works

Cytochrome P450s and cholesterol homeostasis

Pikuleva, I. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.014 · Cited by 153 · see citing works

Osteoblast Differentiation and Control by Vitamin D and Vitamin D Metabolites

Van, M., Pols, H. A. P., & van Leeuwen, J. P. T. M. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043383818 · Cited by 151 · see citing works

Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands

Jurutka, P. W., Bartik, L., Whitfield, G. K., Mathern, D. R., Barthel, T. K., Gurevich, M., Hsieh, J., Kaczmarska, M. J., Haussler, C. A., & Haussler, M. R. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.07s216 · Cited by 148 · see citing works

Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter

Kitazawa, S., Kajimoto, K., Kondo, T., & Kitazawa, R. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10567 · Cited by 145 · see citing works

Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation

Phillips‐Cremins, J. E., Gersbach, C. A., Wojtowicz, A. M., & Garcı́a, A. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.02758 · Cited by 141 · see citing works

Bone-Specific Transcription Factor Runx2 Interacts with the 1α,25-Dihydroxyvitamin D3 Receptor To Up-Regulate Rat Osteocalcin Gene Expression in Osteoblastic Cells

Paredes, R., Arriagada, G., Cruzat, F., Villagra, A., Olate, J., Zaidi, K., van Wijnen, A. J., Lian, J. B., Stein, G. S., Stein, J. L., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8847-8861.2004 · Cited by 135 · see citing works

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors

Teplyuk, N. M., Galindo, M. A., Teplyuk, V. I., Pratap, J., Young, D. W., Lapointe, D. S., Javed, A., Stein, J. L., Lian, J. B., Stein, G. S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802453200 · Cited by 128 · see citing works

Nomenclature for Runt-related (RUNX) proteins

van Wijnen, A. J., Stein, G. S., Gergen, J. P., Groner, Y., Hiebert, S. W., Ito, Y., Liu, P., Neil, J. C., Ohki, M., & Speck, N. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207758 · Cited by 122 · see citing works

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

Tuckey, R. C., Li, W., Zjawiony, J. K., Zmijewski, M. A., Nguyen, M. N., Sweatman, T., Miller, D., & Slominski, A. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06406.x · Cited by 118 · see citing works

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

Zbytek, B., Janjetovic, Z., Tuckey, R. C., Zmijewski, M. A., Sweatman, T. W., Jones, E., Nguyen, M. N., & Slominski, A. T. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.62 · Cited by 118 · see citing works

Runx2 Integrates Estrogen Activity in Osteoblasts

McCarthy, T. L., Chang, W., & Liu, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306531200 · Cited by 115 · see citing works

Mitochondrial specificity of the early steps in steroidogenesis

Miller, W. L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00212-x · Cited by 111 · see citing works

Elucidation of estrogen receptor function in bone with the use of mouse models

Windahl, S. H., Andersson, G. N., & Gustafsson, J.-Å. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00594-5 · Cited by 102 · see citing works

Runx2 and MYC Collaborate in Lymphoma Development by Suppressing Apoptotic and Growth Arrest Pathways In vivo

Blyth, K., Vaillant, F., Hanlon, L., Mackay, N. A., Bell, M., Jenkins, A., Neil, J. C., & Cameron, E. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3558 · Cited by 101 · see citing works

An alternative pathway of vitamin D₂ metabolism: Cytochrome P450scc (CYP11A1)‐mediated conversion to 20‐hydroxyvitamin D₂ and 17,20‐dihydroxyvitamin D₂

Slominski, A., Semak, I., Wortsman, J., Zjawiony, J., Li, W., Zbytek, B., & Tuckey, R. C. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05302.x · Cited by 98 · see citing works

Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential

Zaidi, S. K., Pande, S., Pratap, J., Gaur, T., Grigoriu, S., Ali, S. A., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709650104 · Cited by 82 · see citing works

Expression of Runx2 transcription factor in non‐skeletal tissues, sperm and brain

Jeong, J., Jin, J.-S., Kim, H., Kang, S., Liu, J. C., Lengner, C. J., Otto, F., Mundlos, S., Stein, J. L., van Wijnen, A. J., et al. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21524 · Cited by 81 · see citing works

Reconstitution of Runx2/Cbfa1‐null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation

Bae, J., Gutierrez, S. E., Narla, R. R., Pratap, J., Devados, R., van Wijnen, A. J., Stein, J. L., Stein, G. S., Lian, J. B., & Javed, A. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21039 · Cited by 78 · see citing works

The relationship between bone mineral density and fracture risk

McClung, M. R. (2005) · Current Osteoporosis Reports · doi:10.1007/s11914-005-0005-y · Cited by 77 · see citing works

17β-Estradiol Potently Suppresses cAMP-induced Insulin-like Growth Factor-I Gene Activation in Primary Rat Osteoblast Cultures

McCarthy, T. L., Ji, C., Shu, H., Casinghino, S. R., Crothers, K. A., & Rotwein, P. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18132 · Cited by 77 · see citing works

In vivo function of VDR in gene expression-VDR knock-out mice

Kato, S., Takeyama, K.-I., Kitanaka, S., Murayama, A., Sekine, K., & Yoshizawa, T. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00042-4 · Cited by 76 · see citing works

Luteinizing Hormone-Induced RUNX1 Regulates the Expression of Genes in Granulosa Cells of Rat Periovulatory Follicles

Jo, M., & Curry, T. E. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0512 · Cited by 75 · see citing works

Androgens and bone

Vanderschueren, D., Gaytant, J., Boonen, S., & Venken, K. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282fe6ca9 · Cited by 67 · see citing works

Aromatase in bone: roles of Vitamin D3 and androgens

Yanase, T., Suzuki, S., Goto, K., Nomura, M., Okabe, T., Takayanagi, R., & Nawata, H. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00349-2 · Cited by 65 · see citing works

Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival

Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P., Cameron, E. R., & Neil, J. C. (2008) · Oncogene · doi:10.1038/onc.2008.195 · Cited by 60 · see citing works

Regulation of proteins in the cholesterol side-chain cleavage system in JEG-3 and Y-1 cells

Black, S. M., Szklarz, G. D., Harikrishna, J. A., Lin, D., Wolf, C. R., & Miller, W. L. (1993) · Endocrinology · doi:10.1210/endo.132.2.8425475 · Cited by 58 · see citing works

Intricate gene regulatory networks of helix‐loop‐helix (HLH) proteins support regulation of bone‐tissue related genes during osteoblast differentiation

Zhang, Y., Hassan, M. Q., Li, Z., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21844 · Cited by 55 · see citing works

Runx2 Disruption Promotes Immortalization and Confers Resistance to Oncogene-Induced Senescence in Primary Murine Fibroblasts

Kilbey, A., Blyth, K., Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E. R., & Neil, J. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3016 · Cited by 51 · see citing works

Identification of Novel Target Genes of the Bone-Specific Transcription Factor Runx2

Stock, M., Schäfer, H. S., Fliegauf, M., & Otto, F. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2004.19.6.959 · Cited by 47 · see citing works

Cytochrome P-450scc: Enzymology, and the Regulation of Intramitochondrial Cholesterol Delivery to the Enzyme

Lambeth, J. D., & Stevens, V. L. (1984) · Endocrine Research · doi:10.1080/07435808409036502 · Cited by 41 · see citing works

Estren (4-Estren-3α,17β-diol) Is a Prohormone that Regulates Both Androgenic and Estrogenic Transcriptional Effects through the Androgen Receptor

McCarthy, T. L., Chang, W., Labaree, D. C., & Hochberg, R. B. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0491 · Cited by 38 · see citing works

Glucocorticoid-induced osteoporosis: an osteoblastic disease.

Migliaccio, S., Brama, M., Fornari, R., Greco, E. A., Spera, G., & Malavolta, N. (2007) · PubMed · Cited by 35 · see citing works

The Cellular and Clinical Parameters of Anabolic Therapy for Osteoporosis

Rosen, C. J. (2003) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.v13.i1.30 · Cited by 32 · see citing works

Cell cycle related modulations in Runx2 protein levels are independent of lymphocyte enhancer-binding factor 1 (Lef1) in proliferating osteoblasts

Galindo, M. A., Kahler, R. A., Teplyuk, N. M., Stein, J. L., Lian, J. B., Stein, G. S., Westendorf, J. J., & van Wijnen, A. J. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9143-0 · Cited by 29 · see citing works

Role of the cholesterol biosynthetic pathway in osteoblastic differentiation.

Viccica, G., Vignali, E., & Marcocci, C. (2007) · PubMed · Cited by 29 · see citing works

Biochemical markers in preclinical models of osteoporosis

Sørensen, M. G., Henriksen, K., Schaller, S., & Karsdal, M. A. (2007) · Biomarkers · doi:10.1080/13547500601070842 · Cited by 27 · see citing works

Maintenance of Open Chromatin and Selective Genomic Occupancy at the Cell Cycle-Regulated Histone H4 Promoter during Differentiation of HL-60 Promyelocytic Leukemia Cells

Hovhannisyan, H., Cho, B. C., Mitra, P., Montecino, M. A., Stein, G. S., van Wijnen, A. J., & Stein, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1460-1469.2003 · Cited by 27 · see citing works

Steroid Hormone Action in Musculoskeletal Cells Involves Membrane Receptor and Nuclear Receptor Mechanisms

Boyan, B. D., Dean, D. D., Sylvia, V. L., & Schwartz, Z. (2003) · Connective Tissue Research · doi:10.1080/03008200390152214 · Cited by 26 · see citing works

Identification of Target Cells for the Genomic Effects of Estrogens in Bone

Windahl, S. H., Lagerquist, M. K., Andersson, N., Jochéms, C., Kallkopf, A., Håkansson, C. H., Inzunza, J., Gustafsson, J.-Α., van der Saag, P. T., Carlsten, H., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0508 · Cited by 26 · see citing works

Skeletal hormones and the C/EBP and Runx transcription factors: interactions that integrate and redefine gene expression

Christakos, S., & McCarthy, T. L. (2004) · Gene · doi:10.1016/j.gene.2004.06.036 · Cited by 25 · see citing works

Cytochrome P450 side-chain cleavage: Insights gained from homology modeling

Storbeck, K., Swart, P., & Swart, A. C. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.005 · Cited by 24 · see citing works

Mutual transactivational repression of Runx2 and the androgen receptor by an impairment of their normal compartmentalization

Kawate, H., Wu, Y., Ohnaka, K., & Takayanagi, R. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.11.020 · Cited by 24 · see citing works

Dexamethasone promotes DMP1 mRNA expression by inhibiting negative regulation of Runx2 in multipotential mesenchymal progenitor, ROB‐C26

Mikami, Y., Takahashi, T., Kato, S., & Takagi, M. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.08.033 · Cited by 21 · see citing works

High-dose estrogen-induced osteogenesis is decreased in aged RUNX2+/− mice

Jüttner, K. V., & Perry, M. J. (2007) · Bone · doi:10.1016/j.bone.2007.03.012 · Cited by 18 · see citing works

Human estrogen receptor α gene is a target of Runx2 transcription factor in osteoblasts

Lambertini, E., Penolazzi, L., Tavanti, E., Schincaglia, G. P., Zennaro, M., Gambari, R., & Piva, R. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.02.002 · Cited by 18 · see citing works

Identification of tooth-specific downstream targets of Runx2

Gaikwad, J., Cavender, A. C., & D’Souza, R. N. (2001) · Gene · doi:10.1016/s0378-1119(01)00759-4 · Cited by 17 · see citing works

3-Ketosteroid Reductase Activity and Expression by Fetal Rat Osteoblasts

McCarthy, T. L., Hochberg, R. B., & Labaree, D. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m707502200 · Cited by 17 · see citing works

Expression of an estrogen receptor agonist in differentiating osteoblast cultures

McCarthy, T. L., Clough, M. E., & Gundberg, C. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800085105 · Cited by 12 · see citing works

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Slominski, A. T., Kim, T.-K., Li, W., Yi, A.-K., Postlethwaite, A., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.012 · Cited by 170 · see citing works

Bone As An Endocrine Organ

Guntur, A. R., & Rosen, C. J. (2012) · Endocrine Practice · doi:10.4158/ep12141.ra · Cited by 150 · see citing works

The cancer‐related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines

Lucero, C. M. J., Vega, O. A., Osorio, M., Tapia, J. C., Antonelli, M., Stein, G. S., van Wijnen, A. J., & Galindo, M. A. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24218 · Cited by 120 · see citing works

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

Chalmel, F., Lardenois, A., Evrard, B., Mathiéu, R., Feig, C., Demougin, P., Gattiker, A., Schulze, W., Jégou, B., Kirchhoff, C., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des301 · Cited by 101 · see citing works

The significance of CYP11A1 expression in skin physiology and pathology

Slominski, R. M., Raman, C., Elmets, C. A., Jetten, A. M., Slominski, A. T., & Tuckey, R. C. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111238 · Cited by 97 · see citing works

Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility

van der Deen, M., Akech, J., Lapointe, D. S., Gupta, S. V., Young, D. W., Montecino, M. A., Galindo, M. A., Lian, J. B., Stein, J. L., Stein, G. S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287771 · Cited by 94 · see citing works

TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages

Huang, J., Pan, H., Sun, J., Wu, J., Xuan, Q., Wang, J., Ke, S., Lu, S., Li, Z., Feng, Z., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02865-0 · Cited by 92 · see citing works

Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways

Slominski, A. T., Zmijewski, M. A., Semak, I. V., Zbytek, B., Pisarchik, A. V., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990308 · Cited by 91 · see citing works

Role of Metabolism in Bone Development and Homeostasis

Suzuki, A., Minamide, M., Iwaya, C., Ogata, K., & Iwata, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238992 · Cited by 90 · see citing works

Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients

Zhang, C.-L., Wang, H., Yan, C., Gao, X., & Ling, X.-J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.059 · Cited by 82 · see citing works

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals

Costa, B., Pini, S., Gabelloni, P., Da Pozzo, E., Abelli, M., Lari, L., Preve, M., Lucacchini, A., Cassano, G. B., & Martini, C. (2009) · Endocrinology · doi:10.1210/en.2009-0752 · Cited by 68 · see citing works

Impaired cell cycle regulation of the osteoblast‐related heterodimeric transcription factor Runx2‐Cbfβ in osteosarcoma cells

Martin, I. A. S., Varela, N., Gaete, M., Villegas, K., Osorio, M., Tapia, J. C., Antonelli, M., Mancilla, E. E., Pereira, B. P., Nathan, S. S., et al. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21894 · Cited by 63 · see citing works

Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility

Leong, D. T., Lim, J. C.-H., Goh, X., Pratap, J., Pereira, B. P., Kwok, H. S., Nathan, S. S., Dobson, J. R., Lian, J. B., Ito, Y., et al. (2010) · Breast Cancer Research · doi:10.1186/bcr2762 · Cited by 63 · see citing works

Role of RUNX2 in Breast Carcinogenesis

Wysokiński, D., Błasiak, J., & Pawłowska, E. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160920969 · Cited by 59 · see citing works

Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas

Lee, M., Marinoni, I., Irmler, M., Psaras, T., Honegger, J. B., Beschorner, R., Anastasov, N., Beckers, J., Theodoropoulou, M., Roncaroli, F., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1132-7 · Cited by 55 · see citing works

Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function

Mare, S. D., & Aqeilan, R. I. (2015) · Scientific Reports · doi:10.1038/srep12959 · Cited by 40 · see citing works

An essential role for the circadian‐regulated gene Nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis

Guntur, A. R., Kawai, M., Le, P. T., Bouxsein, M., Bornstein, S., Green, C. B., & Rosen, C. J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06213.x · Cited by 35 · see citing works

The Gene for Aromatase, a Rate-Limiting Enzyme for Local Estrogen Biosynthesis, Is a Downstream Target Gene of Runx2 in Skeletal Tissues

Jeong, J.-H., Jung, Y., Kim, H.-J., Jin, J.-S., Kim, H., Kang, S., Kim, S., van Wijnen, A. J., Stein, J. L., Lian, J. B., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00672-09 · Cited by 34 · see citing works

miRNA320a-3p/RUNX2 signal programming mediates the transgenerational inheritance of inhibited ovarian estrogen synthesis in female offspring rats induced by prenatal dexamethasone exposure

Gong, X., Zhang, J., Ge, C., Yi, Y., Dai, S., Fan, G., Li, C., Zhang, Y., Wang, H., & Xu, D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105435 · Cited by 29 · see citing works

Effects of In Utero and Lactational Exposure to New Generation Green Plasticizers on Adult Male Rats: A Comparative Study With Di(2-Ethylhexyl) Phthalate

Albert, O., Nardelli, T. C., Lalancette, C., Hales, B. F., & Robaire, B. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy072 · Cited by 29 · see citing works

CYP11A1 expression in bone is associated with aromatase inhibitor-related bone loss

Rodríguez-Sanz, M., García‐Giralt, N., Prieto‐Alhambra, D., Servitja, S., Balcells, S., Pecorelli, R., Díez‐Pérez, A., Grinberg, D., Tusquets, I., & Nogués, X. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0079 · Cited by 26 · see citing works

Tanshinone IIA promotes osteogenic differentiation of human periodontal ligament stem cells via ERK1/2-dependent Runx2 induction.

Liu, X., Niu, Y., Xie, W., Wei, D., & Du, Q. (2019) · Europe PMC (PubMed Central) · Cited by 26 · see citing works

Alternative pathways for vitamin D metabolism

Slominski, A. T., Tuckey, R. C., Jenkinson, C., Li, W., & Jetten, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00001-5 · Cited by 21 · see citing works

Interrelationship of Runx2 and estrogen pathway in skeletal tissues

Jeong, J.-H., & Choi, J. (2011) · BMB Reports · doi:10.5483/bmbrep.2011.44.10.613 · Cited by 19 · see citing works

Expression of the ectodomain‐releasing protease ADAM17 is directly regulated by the osteosarcoma and bone‐related transcription factor RUNX2

Araya, H., Sepúlveda, H., Lizama, C. O., Vega, O. A., Jerez, S., Briceño, P., Thaler, R., Riester, S. M., Antonelli, M., Salazar‐Onfray, F., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26832 · Cited by 17 · see citing works

Novel oxysterols activate the Hedgehog pathway and induce osteogenesis

Stappenbeck, F., Xiao, W., Epperson, M., Riley, M., Priest, A., Huang, D., Nguyen, K. T., Jung, M. E., Thies, R. S., & Farouz, F. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.07.073 · Cited by 16 · see citing works

Moderate and intensive mechanical loading differentially modulate the phenotype of tendon stem/progenitor cells in vivo

Zhang, J., Nie, D., Williamson, K. M., McDowell, A. R., Hogan, M. V., & Wang, J. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242640 · Cited by 16 · see citing works

Steroid hormone metabolizing enzymes in benign and malignant human bone tumors

Svoboda, M., Hamilton, G., & Thalhammer, T. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425251003592129 · Cited by 16 · see citing works

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Oo, Z. M., Illendula, A., Grembecka, J. E., Schmidt, C., Zhou, Y., Esain, V., Kwan, W., Frost, I. M., North, T. E., Rajewski, R. A., et al. (2017) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1410882 · Cited by 14 · see citing works

Association of CYP39A1, RUNX2 and Oxidized Alpha-1 Antitrypsin Expression in Relation to Cholangiocarcinoma Progression

Khenjanta, C., Thanan, R., Jusakul, A., Techasen, A., Jamnongkan, W., Namwat, N., Loilome, W., Pairojkul, C., & Yongvanit, P. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.23.10187 · Cited by 13 · see citing works

Effects of Bisphenols A, AF, and S on Endochondral Ossification and the Transcriptome of Murine Limb Buds

Iskandarani, L., McHattie, T., Robaire, B., & Hales, B. F. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab145 · Cited by 12 · see citing works

AP-002: A novel inhibitor of osteoclast differentiation and function without disruption of osteogenesis

Wang, Y., Mei, Y., Song, Y., Bachus, C., Sun, C., Sheshbaradaran, H., & Glogauer, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173613 · Cited by 12 · see citing works

Comparison of cytochrome P450 expression in four different human osteoblast models

Liu, L., Pathak, J. L., Zhu, Y., & Bureik, M. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0205 · Cited by 9 · see citing works

Epigenetic regulation of oxysterol formation

Meaney, S. (2012) · Biochimie · doi:10.1016/j.biochi.2012.08.020 · Cited by 9 · see citing works

Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment

Gerini, G., Traversa, A., Cece, F., Cassandri, M., Pontecorvi, P., Camero, S., Nannini, G., Romano, E., Marampon, F., Venneri, M. A., et al. (2025) · Cells · doi:10.3390/cells14020135 · Cited by 8 · see citing works

The roles of RUNX2 and osteoclasts in regulating expression of steroidogenic enzymes in castration-resistant prostate cancer cells

Huang, J., Thulin, M. H., Damber, J., & Welén, K. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111380 · Cited by 8 · see citing works

Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation

Emons, J. A. M., Dutilh, B. E., Decker, E., Pirzer, H., Sticht, C., Gretz, N., Rappold, G., Cameron, E. R., Neil, J. C., Stein, G. S., et al. (2011) · Journal of Endocrinology · doi:10.1530/joe-10-0219 · Cited by 7 · see citing works

SALL4 promotes osteoblast differentiation by deactivating NOTCH2 signaling

Yu, W., Jiang, D., Yu, S., Fu, J., Li, Z., Wu, Y., & Wang, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.144 · Cited by 7 · see citing works

Exploring the impact of CYP11A1’s missense SNPs on the interaction between CYP11A1 and cholesterol: A comprehensive structural analysis and MD simulation study

Redouane, S., Harmak, H., Elkarhat, Z., Charoute, H., Malki, A., Barakat, A., & Rouba, H. (2023) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2023.107937 · Cited by 5 · see citing works

Metabolomics profiling of cleidocranial dysplasia

Zhang, Z., Li, K., Yan, M., Lin, Q., Lv, J., Zhu, P., & Xu, Y. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2496-9 · Cited by 5 · see citing works

Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

Cunha, J. B., Elenbaas, J. S., Maitra, D., Kuo, N., Azuero-Dajud, R., Ferguson, A. C., Griffin, M. S., Lentz, S. I., Shavit, J. A., & Omary, M. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-88668-9 · Cited by 5 · see citing works

RUNX2 Transcriptional Regulation in Development and Disease

Brusgard, J. L., & Passaniti, A. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_3 · Cited by 4 · see citing works

Precision RNA interference of Smad3 and Runx2 via dual targeting nanocarriers mitigates aortic valve disease

Voicu, G., Mocanu, C. A., Safciuc, F., Anghelache, M., Turtoi, M., Deleanu, M., Simionescu, M., Mânduțeanu, I., & Călin, M. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07686-1 · Cited by 3 · see citing works

The ENCODE mouse postnatal developmental time course identifies regulatory programs of cell types and cell statesPreprint

Rebboah, E., Rezaie, N., Williams, B. A., Weimer, A. K. K., Shi, M., Yang, X., Liang, H. Y., Dionne, L. A., Reese, F., Trout, D. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.12.598567 · Cited by 3 · see citing works

Assignment of functional impact on genetic data in two mouse models of affective disorders

Widner-Andrä, R. (2012) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.14380 · Cited by 2 · see citing works

The regulatory role of osteoblasts in castration-resistant growth of prostate cancer

Thulin, M. H. (2015)

Computational characterization of genome-wide DNA-binding profiles

Rödelsperger, C. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7616

Current World Literature

(2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328339f31e

Marine Bioceramic Generation for Bone Tissue Regeneration: Sea Urchin (Echinometra mathaei) Exoskeleton-Derived Calcium Carbonate as a Precursor for Hydroxyapatite Synthesis, Incorporated into Chitosan Based-Hydrogel and 3D-Printed PCL Scaffold for Osteogenic Differentiation

Jamshidizadeh, S., Biuki, N. A., & Zarei, M. (2026) · Marine Biotechnology · doi:10.1007/s10126-025-10555-5

BindingDB Entry 50042133: Novel oxysterols activate the Hedgehog pathway and induce osteogenesis.

BindingDB (2013) · UC San Diego · doi:10.7270/q2wh2r9r

RUNX2 & sex steroids: molecular mechanisms in regulating bone turnover

Martin, A. (. (2014) · University of Southern California Digital Library · doi:10.25549/usctheses-c3-484441

De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis

Sandor, L. F., Huh, J. B., Benko, P., Hiraga, T., Póliska, S., Dobó‐Nagy, C., Simpson, J. P., Homer, N. Z. M., Mahata, B., & Győri, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113936 · Cited by 18 · see citing works

Bone-specific master transcription factor Runx2 regulates signaling and metabolism related programs in osteoprogenitors

Teplyuk, N. M., & Teplyuk, V. I. (2010) · Biopolymers and Cell · doi:10.7124/bc.00015f · Cited by 1 · see citing works

DEC1 regulates osteoblast proliferation and differentiation via the RUNX2 signaling pathway

Qian, W., Mei, K., Zhu, L., Lv, J., & Yun, C. (2026) · Open Life Sciences · doi:10.1515/biol-2025-1217

The Runx2 transcription factor plays a key role in the 1α,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells

Paredes, R., Arriagada, G., Cruzat, F., Olate, J., van Wijnen, A. J., Lian, J. B., Stein, G., Stein, J. L., & Montecino, M. A. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.03.076 · Cited by 66 · see citing works