Bone As An Endocrine Organ
Open accessAbstract
Objective To review the recent evidence that has emerged supporting the role of bone as an endocrine organ.Methods This review will detail how bone has emerged as a bona fide endocrine "gland," and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue by detailing the evidence in the literature supporting this view.Results The recent advances point to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of the bone-specific protein osteocalcin.Conclusions Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism.
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Bone has endocrine functions that affect other organs.
“Additionally, recent studies have focused on the bone endocrine functions which are able to affect other organs [202].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [202]
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
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Nicolini, C., Michalski, B., Toepp, S. L., Turco, C. V., D'Hoine, T., Harasym, D., Gibala, M. J., Fahnestock, M., & Nelson, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.042 · Cited by 69 · see citing works
- Authors
- Guntur, A. R., & Rosen, C. J.
- Affiliations
- Maine Medical Center Research Institute (US)
- Corresponding author
- Rosen, Clifford J.
- Venue
- Endocrine Practice
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 18
- Issue
- 5
- Pages
- 758-762
- ISSN
- 1530-891X (ISSN-L)
- PMC
- PMC3571654
- OpenAlex
- W2313316194
- Cited by
- 150
- References
- 26
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 8 · 2017: 6 · 2016: 13 · 2015: 8 · 2014: 3 · 2013: 6
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrine Practice (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR045433, R01AR045433)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- bone as endocrine organ, osteocalcin, glucose tolerance, testosterone production, bone metabolism, metabolic regulation
- MeSH terms
- Bone and Bones, Endocrine Glands, Humans, Models, Biological
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