The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753

Principles of Bone Biology

(2019) · Elsevier eBooks · doi:10.1016/c2015-1-01622-2 · Cited by 1,690

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B. F., Broxmeyer, H. E., & Manolagas, S. C. (1992) · Science · doi:10.1126/science.1621100 · Cited by 1,440

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development · doi:10.1242/dev.127.19.4277 · Cited by 1,064

Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.025 · Cited by 1,013

A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

Lee, N. K., Choi, Y. G., Baik, J. Y., Han, S.-Y., Jeong, D.-W., Bae, Y. S., Kim, N., & Lee, S. Y. (2005) · Blood · doi:10.1182/blood-2004-09-3662 · Cited by 969

Aging and bone

Almeida, M., & Manolagas, S. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00012-9 · Cited by 4

Gonadal Steroids

Manolagas, S. C., Almeida, M., & Jilka, R. L. (2013) · Wiley eBooks · doi:10.1002/9781118453926.ch25 · Cited by 4

Elucidating the mechanism of triphenyl phosphate interference in bone metabolism via network toxicology and molecular docking methodologies

Xu, M., Wu, Y., Meng, J., Chen, M., & Ding, C. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1606877 · Cited by 3

Increased BMD in SLD Patients Without Advanced Hepatic Fibrosis: Evidence From the NHANES 2017–2020 Database

Wu, T., Li, L., Mei, Y., Lv, P., Cui, J., Liu, L., Nan, Y., & Li, A. (2025) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/cjgh/6969761 · Cited by 3

The detection of Gper1 as an important gene promoting jawbone regeneration in the context of estrogen deficiency

Feng, Y., Wang, H., Xu, S., Huang, J., Pei, Q., & Wang, Z. (2023) · Bone · doi:10.1016/j.bone.2023.116990 · Cited by 3

Lysine specific demethylase 1 conditional myeloid cell knockout mice have decreased osteoclast differentiation due to increased IFN- β gene expression

Astleford, K., Abrahante, J. E., Bradley, E. W., & Mansky, K. C. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae142 · Cited by 6

Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis

Xu, T., Jin, H., & Tong, P. (2018) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-018-2930-x · Cited by 3

Effects of Dietary Protein Source and Quantity on Bone Morphology and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model for Postmenopausal Obesity

Wright, C. S., Hill, E. R., Fernandez, P. C. R., Thompson, W. R., Gallant, M. A., Campbell, W. W., & Main, R. P. (2022) · Nutrients · doi:10.3390/nu14112262 · Cited by 3

Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Landwehr, V. C., Fretwurst, T., Heinen, J., Vach, K., Nelson, K., Nahles, S., & Iglhaut, G. (2022) · International Journal of Implant Dentistry · doi:10.1186/s40729-022-00447-x · Cited by 3

Sex and the single nucleotide polymorphism: Exploring the genetic causes of skeletal sex differences

Nielson, C. M., Klein, R. F., & ORWOLL, E. S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1723 · Cited by 3

Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model

Wang, Y., Liu, Z., Wang, Q., Feng, Q., & Chen, W. (2017) · BioMed Research International · doi:10.1155/2017/9654056 · Cited by 3

Role of Estrogens and Androgens in Osteoporosis

Laurent, M. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65814-2 · Cited by 3

Ovariectomy-induced bone loss through inappropriate inflammatory response: an osteoimmunological perspective on postmenopausal osteoporosis

Higuchi, L., Ouchi, N., Negishi, Y., Naruo, M., Kusano, M., Suzuki, S., Okuda, T., & Morita, R. (2025) · Immunological Medicine · doi:10.1080/25785826.2025.2506870 · Cited by 2

Mechanistic Roles of Androgen and Estrogen in Aging and Age-Related Diseases

Takayama, K.-I. (2026) · Journal of Ageing and Longevity · doi:10.3390/jal6010019 · Cited by 2

Modest Effects of Osteoclast‐Specific ERα Deletion after Skeletal Maturity

Doolittle, M. L., Eckhardt, B. A., Vos, S. J., Grain, S., Rowsey, J. L., Ruan, M. M., Saul, D., Farr, J. N., Weivoda, M. M., Khosla, S., et al. (2023) · JBMR Plus · doi:10.1002/jbm4.10797 · Cited by 2

Very low serum IGF-1 levels are associated with vertebral fractures in adult males with beta-thalassemia major

Costanzo, G., Naselli, A., Arpi, M. L., Piticchio, T., Moli, R. L., Belfiore, A., & Frasca, F. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02270-6 · Cited by 2

Cardenolides; calotropin and gomphogenin from Calotropis procera (Aiton) mitigate bone turnover in ovariectomized osteoporotic rats: Targeting RANKL/OPG axis and estrogen receptor-alpha

Mettwally, W. S. A., Hussein, R. A., Jaleel, G. A. A., Hassan, A. H. M., Saleh, D. O., & El‐Beih, A. A. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106226 · Cited by 2

Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

Ikedo, A., Yamashita, M., Hoshino, M., Okuno, Y., Koike, M., Uga, M., Tanifuji, K., Segawa, H., Fukumoto, S., & Imai, Y. (2025) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjaf129 · Cited by 2

Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats

Spalding, M., Amschilnger, P. F., Prado, M. D. A., Balducci, I., & Carvalho, Y. R. (2012) · Brazilian Dental Science · doi:10.14295/bds.2012.v15i3.844 · Cited by 2

Nuclear Receptor Regulation of Osteoclast and Bone Remodeling

Jin, Z., Li, X., & Wan, Y. (2015) · Cited by 2

Exophytic giant-cell tumor of the tibial tubercle

Schetter, E. C., Chew, F. S., & Hoch, B. L. (2011) · Radiology Case Reports · doi:10.2484/rcr.v6i1.466 · Cited by 2

Estrogen-associated regulation of the bone tissue remodeling

Поворознюк, В. В., Резниченко, Н. А., & Майлян, Э. А. (2014) · Reproductive Endocrinology · doi:10.18370/2309-4117.2014.15.14-18 · Cited by 2

Osteoimmunology: immunological mechanisms in pathogenesis of postmenopausal

Поворознюк, В. В., Резниченко, Н. А., & Майлян, Э. А. (2013) · Reproductive Endocrinology · doi:10.18370/2309-4117.2013.14.17-22 · Cited by 1

The Role of Sex Steroids in the Effects of Immune System on Bone

Grčević, D., Kovačić, N., & Lee, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800571-2.00012-8 · Cited by 2

Regulation of Bone Cell Function by Estrogens

Wardell, S. E., McDonnell, D. P., & Nelson, E. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00014-5 · Cited by 2

Employment of selective pharmacologically active natural compounds in treatment and management of osteoporosis

Upmanyu, V., Sapra, L., & Srivastava, R. K. (2022) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91250-1.00005-7 · Cited by 2

Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling

Kim, S., Moon, S. J., & Seo, J. T. (2019) · International Journal of Oral Biology · doi:10.11620/ijob.2019.44.1.1 · Cited by 2

Osteoporosis in men: what is similar and what is different?

Laurent, M. R., Gielen, E., ORWOLL, E. S., & Vanderschueren, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813073-5.00025-3 · Cited by 2

Mechanisms of Osteoprotective Actions of Estrogens

Kato, S., Sawatsubashi, S., Yokoyama, A., Nakamura, T., & Kouzmenko, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11273-5 · Cited by 2

Effect of estrogen depression on alveolar bone microarchitecture and periodontal ligament cells during orthodontic movement

Ruivo, A. K., Calsa, B., Cancellara, M. G., Lima, J. P. N., Rovaris, K., Esquisatto, M. A. M., & Santamaria, M. (2024) · European Journal Of Oral Sciences · doi:10.1111/eos.13014 · Cited by 1

Female Mice Lacking LSD1 in Myeloid Cells Are Resistant to Inflammatory Bone Loss

Astleford, K., Saavedra, F. M., Bittner‐Eddy, P. D., Stein, C., Auger, J. L., Clark, R., Abrahante, J. E., Binstadt, B. A., Thumbigere‐Math, V., & Mansky, K. C. (2025) · Cells · doi:10.3390/cells14141111 · Cited by 1

An in vivo assay for osteoclast activity using mouse calvaria

Grieg, C., Culbertson, M. D., & O’Connor, J. P. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70112 · Cited by 1

Potential modulation of ED-71 in regulating H3K18 histone lactylation to suppress osteoclast differentiation and alleviate postmenopausal osteoporosis

Ji, Y., Cao, T., Rong, X., Li, S., Liu, H., Hasegawa, T., & Li, M. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118088 · Cited by 1

Relationship between impaired forearm endothelial function and osteoporosis in Tunisian postmenopausal women: Serum lipids or others factors?

Baccouche, K., Fraj, H. B., Debbabi, H., Belghali, S., Elamri, N., Zeglaoui, H., & Bouajina, E. (2017) · Journal of Indian College of Cardiology · doi:10.1016/j.jicc.2017.12.003 · Cited by 1

Skeletal Tissue and Ovarian Function: Puberty and Menopause

Colao, A., Somma, C. D., & Zhukouskaya, V. V. (2018) · Springer eBooks · doi:10.1007/978-3-319-75110-8_8 · Cited by 1

Multiple causes of osteoporosis and their molecular mechanisms

東, 浩. (2019) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.56.116 · Cited by 1

Can mango reverse bone loss in ovariectomized mice

Vitale, E. (2011) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · Cited by 1

Bone Remodeling and Homeostasis

Zhen, G., & Cao, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11180-8 · Cited by 1

Gonadal Steroids

Manolagas, S. C., & Almeida, M. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch26 · Cited by 1

The regulatory role of osteoblasts in castration-resistant growth of prostate cancer

Thulin, M. H. (2015)

Estrogen receptors in health and disease

Gurjar, A. A., Khan, K., Yadav, M., Kumar, H., Chattopadhyay, N., & Sanyal, S. (2013) · Journal of Endocrinology & Reproduction · doi:10.18519/jer/2013/v17/75682

Is Bone Mineral Density Associated with Estrogen Receptor a in Chinese Men? A Pilot Study

Lin, Y., Zhang, Y., Huang, Y., Wang, W., Feng, E., & Lin, Y. (2016) · Journal of Hard Tissue Biology · doi:10.2485/jhtb.25.288

Parathyroid Hormone in the Pathophysiology of Osteoporosis

Khosla, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397166-1.00058-8

Estrogens and interleukin-17 in arthritis and associated osteoporosis

Andersson, A. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Association between ER-a polymorphisms and bone mineral density in patients with Turner syndrome subjected to estroprogestagen treatment—a pilot study

CheøstowskiGra, K. (2011)

Estrogen represses Tgfbr1 and Bmpr1a expression via estrogen receptor beta in MC3T3-E1 cellsPreprint

He, H., Wang, C., Tang, Q., Yang, F., & Xu, Y. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/170084

El estado metabólico y su asociación con la actividad ósea en la mujer posmenopáusica

Pérez, N. C., Acevedo, M. L., García, R. P. S., Luna, A. K. R., Cruz, E. R., Arregoitia-Sarabia, C. K., Valencia, M. H., García, B. C. S., & Maldonado, E. R. (2017) · Clínica e Investigación en Ginecología y Obstetricia · doi:10.1016/j.gine.2017.10.001

Sex Steroid Hormones and Osteosarcopenia

Girgis, C. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-25890-0_8

Estrogens and Male Osteoporosis

Rochira, V., & Madeo, B. (2020) · Trends in andrology and sexual medicine · doi:10.1007/978-3-319-96376-1_6

Intestinal Microbiota and Osteoporosis

Xu, X., Jia, X., Mo, L., Liu, C., Zheng, L., Yuan, Q., & Zhou, X. (2020) · Springer eBooks · doi:10.1007/978-981-15-7899-1_10

Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in micePreprint

Ponte, F., Kim, H., Warren, A. D., Iyer, S. V., Li, H., Mannen, E. M., Gómez-Acevedo, H., Nookaew, I., Almeida, M., & Manolagas, S. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.15.452452

Hem1 promotes osteoclast fusion and bone resorption in micePreprint

Wang, X., Shao, L., Warren, A. D., Krager, K. J., Aykin‐Burns, N., Hromas, R., Zhou, D., Almeida, M., & Kim, H. (2021) · Research Square · doi:10.21203/rs.3.rs-763477/v1

Biology and Clinical Aspects of Estrogen Action on Bone

Monroe, D. G., & Khosla, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11272-3

Ovarian function and menopause

Martínez‐Massa, A., Marín‐Montes, A., Abril‐Pérez, J., & Cano, A. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch84

Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiencyPreprint

Ponte, F., Kim, H., Warren, A. D., Iyer, S. V., Han, L., Mannen, E. M., Gómez-Acevedo, H., Nookaew, I., Almeida, M., & Manolagas, S. C. (2022) · Research Square · doi:10.21203/rs.3.rs-1431477/v1

TUTORIAL DE MONTAGEM DO SIMULADOR MECÂNICO PARA TREINAMENTO DE TÉCNICAS ENDOSCÓPICAS

Gregorio, J. M., Ide, E., Martins, B. D. C., Sakai, P., Junior, C. K. F., Kotinda, A. P. S. T., Rocha, F. C. F., MATUGUMA, S. E., Barros, L. G. C., & Figueiredo, L. Z. (2022) · doi:10.22533/at.ed.40722280420

TRATAMENTO DE ÁGUA PARA CONSUMO HUMANO NA REGIÃO DO AMAZONAS, ATRAVÉS DO USO DE SEMENTES DE MORINGA OLEÍFERA

dos Santos, M. F., Caetano, B. D. M. M., & Marcolan, L. G. (2022) · doi:10.22533/at.ed.40722280419

Osteoporosis

Imai, Y. (2015) · Springer eBooks · doi:10.1007/978-3-319-20777-3_33

Ovarian Hormones and Bone

Colaianni, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11228-0

Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]

Dirkes, R. K. (2020) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/81560

Estrogens and progestins

Monroe, D. G., & Khosla, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00035-x

Orchestration of the Synthesis of Sex Hormones and their Roles in Establishing Sex Differences in Mammals

Baba, T. (2022) · Springer eBooks · doi:10.1007/978-981-19-5359-0_9

Role of estrogens and androgens in osteoporosis

Laurent, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00041-8

HSD17B7 counters bone loss in estrogen deficiency via estrogen receptor stabilization and mediates the effect of raloxifenePreprint

Moon, Y. J., Zhang, J., Song, Y., Koo, J.-H., Chen, S., Jang, K. Y., Yoon, S., & Kim, J. R. (2025) · Research Square · doi:10.21203/rs.3.rs-6158228/v1

Estrogens protect bone mass by inhibiting NAD + metabolism in osteoclastsPreprint

Marques-Carvalho, A., Adam, G. O., Chalke, A., Resende-Coelho, A., Reyes‐Castro, O., Warren, A., Grilo, L. F., Chini, C. C. S., Stronach, B., Alturkmani, F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664289

The osteogenic properties of novel bioactive and nanostructured biomaterials for mesenchymal stromal cell differentiation

Illsley, M. J. (2011) · University of Brighton Repository (University of Brighton)

Additional file 2 of Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway

Park, J. H., Son, Y. J., Lee, C. H., Nho, C. W., & Yoo, G. (2020) · Figshare · doi:10.6084/m9.figshare.12178134

Additional file 1 of Development and validation of a risk prediction model for osteoporosis in elderly patients with type 2 diabetes mellitus: a retrospective and multicenter study

Tan, J., Zhang, Z., He, Y., Xu, X., Yang, Y., Xu, Q., Yuan, Y., Wu, X., Niu, J., Tang, S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24452420

Additional file 1 of Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway

Park, J. H., Son, Y. J., Lee, C. H., Nho, C. W., & Yoo, G. (2020) · Figshare · doi:10.6084/m9.figshare.12178125

Additional file 1 of Association of sex steroid hormones and new bone formation rate after iliac onlay grafting: a prospective clinical pilot study

Landwehr, V. C., Fretwurst, T., Heinen, J., Vach, K., Nelson, K., Nahles, S., & Iglhaut, G. (2022) · Figshare · doi:10.6084/m9.figshare.21557287

HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene

Zhang, J., Song, Y., Koo, J., Chen, S., Jang, K. Y., Yoon, S., Kim, J. R., & Moon, Y. J. (2026) · MedComm · doi:10.1002/mco2.70623

Fermentation time Determines Anti-inflammatory and Osteoprotective Activity of Green Tea Kombucha in a Rat Model of Experimental Periodontitis

da Silva, E. C., Beserra, M. M. N., Leitão, M. G. S., Maia, I. D. F. V. C., Alves, B. E. D. S., Gonçalves, P. G., Leite, D. C. D. A., Neves, B. G., Pereira, K. M. A., Rodrigues, L. K. A., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10937-8

Ectodysplasin-A (EDA) Signaling Cross-Talk in Skeletogenesis

Ahi, E. P., Moustakas-Verho, J. E., & Singh, P. (2026) · Calcified Tissue International · doi:10.1007/s00223-026-01502-0 · Cited by 1

Role of the bone microenvironment in systemic breast cancer growth and metastasis

Aslan, Y. (2020) · theses.fr (ABES) · doi:10.70675/a6793073zd42dz4dacz843azd9606734d152

Rôles respectifs des sous fonctions du ER alpha impliquées dans les effets bénéfiques des œstrogènes sur l'os : du squelette appendiculaire aux maxillaires

Vinel, A. (2015) · theses.fr (ABES) · doi:10.70675/01d5a665z7499z4ef9za360zc2f10dc7b7bf

Ubiquitin-proteasome system regulation of bone remodeling in postmenopausal osteoporosis

Chen, X., Zhao, T., 周海伦, Zeng, Q., Xu, H., Dai, Y., & Yan, M. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1788812

The Role of Osteocyte Estrogen Receptor β in Bone Mass Maintenance and Tibial Stiffness Following Sex Hormone Withdrawal in Male and Female MicePreprint

Xu, X., Hoge, M., Tai, J. A. C., & Main, R. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.31.729157

Sex differences in murine bone matrix maturation modulate osteoblast-endothelial interactions

Sharma, A., Emery, R., Pitsillides, A. A., & Clarkin, C. E. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00960-3

Human biomonitoring of phthalate exposure and serum estradiol levels in U.S. adult males

Rahman, H. H., Stokey, W. R., & Munson‐McGee, S. H. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109360

Short- and long-term effects of social isolation on adult murine bone are sex-dependent

Martel, W. A., King, S. B., Buchanan, E., Merrill, B. M., Stohn, J. P., Brooks, D. J., Barlow, D. J., Motyl, K. J., & Mountain, R. V. (2026) · Biology of Sex Differences · doi:10.1186/s13293-026-00995-6

Gut microbiota-immune-bone axis in osteoporosis: mechanisms and intervention strategies

Huang, M., Xie, B., & Liu, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1879472

Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts

Imai, Y., Youn, M., Kondoh, S., Nakamura, T., Kouzmenko, A., Μatsumoto, T., Takada, I., Takaoka, K., & Kato, S. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04954.x · Cited by 107

Minireview: Osteoprotective Action of Estrogens Is Mediated by Osteoclastic Estrogen Receptor-α

Imai, Y., Kondoh, S., Kouzmenko, A., & Kato, S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0238 · Cited by 75

Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.025 · Cited by 1,013

Estrogen directly down-regulates the bone-resorbing activity of mature osteoclasts through nuclear estrogen receptor α

Mano, H., Hakeda, Y., & Kumegawa, M. (2001) · Cytotechnology · doi:10.1023/a:1008188120766 · Cited by 7

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual

Almeida, M., Iyer, S. V., Martín-Millán, M., Bartell, S. M., Han, L., Ambrogini, E., Onal, M., Xiong, J., Weinstein, R. S., Jilka, R. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci65910 · Cited by 260