Regulation of Energy Balance via BDNF Expressed in Nonparaventricular Hypothalamic Neurons
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Brain-derived neurotrophic factor (BDNF) expressed in the paraventricular hypothalamus (PVH) has been shown to play a key role in regulating energy intake and energy expenditure. BDNF is also expressed in other hypothalamic nuclei; however, the role in the control of energy balance for BDNF produced in these structures remains largely unknown. We found that deleting the Bdnf gene in the ventromedial hypothalamus (VMH) during embryogenesis using the Sf1-Cre transgene had no effect on body weight in mice. In contrast, deleting the Bdnf gene in the adult VMH using Cre-expressing virus led to significant hyperphagia and obesity. These observations indicate that the lack of a hyperphagia phenotype in the Sf1-Cre/Bdnf mutant mice is likely due to developmental compensation. To investigate the role of BDNF expressed in other hypothalamic areas, we employed the hypothalamus-specific Nkx2.1-Cre transgene to delete the Bdnf gene. We found that the Nkx2.1-Cre transgene could abolish BDNF expression in many hypothalamic nuclei, but not in the PVH, and that the resulting mutant mice developed modest obesity due to reduced energy expenditure. Thus, BDNF produced in the VMH plays a role in regulating energy intake. Furthermore, BDNF expressed in hypothalamic areas other than PVH and VMH is also involved in the control of energy expenditure.
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Deletion of the BDNF gene in the VMH resulted in hyperphagia and obesity.
“Deletion of the BDNF gene in the VMH resulted in hyperphagia and obesity [48].”
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- Authors
- Yang, H., An, J. J., Sun, C., & Xu, B.
- Affiliations
- Scripps Research Institute (US)
- Northwest A&F University (CN)
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2016-05-01
- Volume
- 30
- Issue
- 5
- Pages
- 494-503
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC4853567
- OpenAlex
- W2303691587
- Cited by
- 37
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2 · 2016: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089237, R01DK103335)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brain-derived neurotrophic factor, energy balance, ventromedial hypothalamus, paraventricular hypothalamus, hyperphagia, obesity, energy expenditure, energy intake, hypothalamic nuclei, developmental compensation
- MeSH terms
- RNA Splicing Factors, Thyroid Nuclear Factor 1, Animals, Body Weight, Energy Intake, Energy Metabolism, Hyperphagia, Hypothalamus, Mice, Inbred C57BL, Neurons, Obesity, Paraventricular Hypothalamic Nucleus, Ventromedial Hypothalamic Nucleus, Transgenes, Brain-Derived Neurotrophic Factor, Mice
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