The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Two insulin-like growth factor I messenger RNAs are expressed in human liver.
Open accessAbstract
Through use of a synthetic oligonucleotide probe, human insulin-like growth factor I (IGF-I) cDNA clones were isolated from a liver library. Two types of cDNAs were defined by restriction enzyme analysis and DNA sequencing. Both encode IGF-I precursors of either 195 or 153 amino acids. The two predicted protein precursors are identical from their amino terminus to a lysine residue 16 codons beyond the IGF-I sequence, and then they diverge. Both cDNAs predict additional unique carboxyl-terminal extension peptides. Since there is only one IGF-I gene in the human genome, the finding of two different cDNAs suggests that alternative RNA processing plays a role in IGF-I gene expression. The functions of the different extension peptides remain to be elucidated.
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Cites
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Cited by
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Self-citationCellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus
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Metadata
- Authors
- Rotwein, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-01
- Volume
- 83
- Issue
- 1
- Pages
- 77-81
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977219363
- Cited by
- 258
- References
- 33
- FWCI
- 23.09
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
