The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Cloning and Functional Characterization of a Complementary DNA Encoding the Murine Fibroblast Bombesin/Gastrin-Releasing Peptide Receptor
Open accessAbstract
The amphibian tetradecapeptide bombesin and its mammalian homolog gastrin-releasing peptide are neurotransmitters and paracrine hormones, and are mitogenic for fibroblast and small cell lung carcinoma cell lines. cDNAs encoding the bombesin/gastrin-releasing peptide receptor (BR) expressed by murine Swiss 3T3 fibroblasts were isolated using electrophysiological and luminometric Xenopus oocyte expression assays. Oocytes microinjected with BR transcripts responded to concentrations of bombesin from 1 x 10(-10) to 1 x 10(-6) M. These responses showed homologous desensitization and could be specifically blocked by bombesin antagonists. Sequence analysis showed that the BR has seven membrane-spanning domains and five potential N-linked glycosylation sites. Data base analysis showed that the BR is most homologous to the tachykinin receptors. Although tyrosine kinase activity has been associated with BR function, no tyrosine kinase homologies occur within the BR sequence.
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Cites
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Cited by
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Sequence Alignment of the G-Protein Coupled Receptor Superfamily
PROBST, W. C., SNYDER, L. A., SCHUSTER, D. I., BROSIUS, J., & SEALFON, S. C. (1992) · DNA and Cell Biology · doi:10.1089/dna.1992.11.1 · Cited by 845
Metadata
- Authors
- Spindel, E. R., Giladi, E., Brehm, P., Goodman, R. H., & Segerson, T. P.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1990-12
- Volume
- 4
- Issue
- 12
- Pages
- 1956-1963
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2139996880
- Cited by
- 255
- References
- 35
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cloning and Functional Characterization of a Complementary DNA Encoding the Murine Fibroblast Bombesin/Gastrin-Releasing Peptide Receptor. https://app.cochat.ai/papers/10.1210/mend-4-12-1956
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- Spindel, E. R., Giladi, E., Brehm, P., Goodman, R. H., & Segerson, T. P. (1990). Cloning and Functional Characterization of a Complementary DNA Encoding the Murine Fibroblast Bombesin/Gastrin-Releasing Peptide Receptor. Molecular Endocrinology. https://doi.org/10.1210/mend-4-12-1956
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
