The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Acute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome
Abstract
OBJECTIVE: To determine whether early seizures that occur frequently after intracerebral hemorrhage (ICH) lead to increased brain edema as manifested by increased midline shift. METHODS: A total of 109 patients with ischemic stroke (n = 46) and intraparenchymal hemorrhage (n = 63) prospectively underwent continuous EEG monitoring after admission. The incidence, timing, and factors associated with seizures were defined. Serial CT brain imaging was conducted at admission, 24 hours, and 48 to 72 hours after hemorrhage and assessed for hemorrhage volume and midline shift. Outcome at time of discharge was assessed using the Glasgow Outcome Scale score. RESULTS: Electrographic seizures occurred in 18 of 63 (28%) patients with ICH, compared with 3 of 46 (6%) patients with ischemic stroke (OR = 5.7, 95% CI 1.4 to 26.5, p < 0.004) during the initial 72 hours after admission. Seizures were most often focal with secondary generalization. Seizures were more common in lobar hemorrhages but occurred in 21% of subcortical hemorrhages. Posthemorrhagic seizures were associated with neurologic worsening on the NIH Stroke Scale (14.8 vs 18.6, p < 0.05) and with an increase in midline shift (+ 2.7 mm vs -2.4 mm, p < 0.03). There was a trend toward increased poor outcome (p < 0.06) in patients with posthemorrhagic seizures. On multivariate analysis, age and initial NIH Stroke Scale score were independent predictors of outcome. CONCLUSION: Seizures occur commonly after ICH and may be nonconvulsive. Seizures are independently associated with increased midline shift after intraparenchymal hemorrhage.
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Cites
Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality.
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Spontaneous intracerebral hemorrhage
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Seizures After Stroke: A Prospective Multicenter Study
Bladin, C. F. (2000) · Archives of Neurology · doi:10.1001/archneur.57.11.1617 · Cited by 812
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Vespa, P. M., Nuwer, M. R., Nenov, V., Ronne-Engstrom, E., Hovda, D. A., Bergsneider, M., Kelly, D. F., Martin, N. A., & Becker, D. P. (1999) · Journal of Neurosurgery · doi:10.3171/jns.1999.91.5.0750 · Cited by 599
Self-citationTuhrim, S., Horowitz, D. R., Sacher, M., & Godbold, J. H. (1999) · Critical Care Medicine · doi:10.1097/00003246-199903000-00045 · Cited by 430
Progression of Mass Effect After Intracerebral Hemorrhage
Zazulia, A. R., Diringer, M. N., Derdeyn, C. P., & Powers, W. J. (1999) · Stroke · doi:10.1161/01.str.30.6.1167 · Cited by 395
Hypoperfusion without Ischemia Surrounding Acute Intracerebral Hemorrhage
Zazulia, A. R., Diringer, M. N., Videen, T. O., Adams, R. E., Yundt, K., Aiyagari, V., Grubb, R. L., & Powers, W. J. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200107000-00005 · Cited by 367
Cited by
Greenberg, S. M., Ziai, W. C., Cordonnier, C., Dowlatshahi, D., Francis, B., Goldstein, J. N., Hemphill, J. C., Johnson, R., Keigher, K. M., Mack, W. J., et al. (2022) · Stroke · doi:10.1161/str.0000000000000407 · Cited by 1,639
Qureshi, A. I., Mendelow, A. D., & Hanley, D. F. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60371-8 · Cited by 1,526
Broderick, J., Connolly, S., Feldmann, E., Hanley, D., Kase, C., Krieger, D., Mayberg, M., Morgenstern, L., Ogilvy, C. S., Vespa, P., et al. (2007) · Stroke · doi:10.1161/strokeaha.107.183689 · Cited by 1,125
Self-citationVespa, P. M., Miller, C., McArthur, D., Eliseo, M., Etchepare, M., Hirt, D., Glenn, T. C., Martin, N., & Hovda, D. (2007) · Critical Care Medicine · doi:10.1097/00003246-200712000-00023 · Cited by 451
Self-citationComplications of intracerebral haemorrhage
Balami, J. S., & Buchan, A. M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70264-2 · Cited by 444
Metadata
- Authors
- Vespa, P. M., O’Phelan, K., Shah, M., Mirabelli, J., Starkman, S., Kidwell, C., Saver, J., Nuwer, M. R., Frazee, J. G., McArthur, D. A., & Martin, N. A.
- Venue
- Neurology
- Published
- 2003-05-13
- Volume
- 60
- Issue
- 9
- Pages
- 1441-1446
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2082863795
- Cited by
- 561
- References
- 29
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vespa, P. M., O’Phelan, K., Shah, M., Mirabelli, J., Starkman, S., Kidwell, C., Saver, J., Nuwer, M. R., Frazee, J. G., McArthur, D. A., & Martin, N. A. (2003). Acute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome. Neurology. https://doi.org/10.1212/01.wnl.0000063316.47591.b4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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