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Cited by 277Amyotrophic Lateral Sclerosis ResearchOccupational Health and PerformanceAmyloidosis: Diagnosis, Treatment, Outcomes

The DOI matches its Crossref record.

Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

Horner, R.D., Kamins, K.G., Feussner, J.R., Grambow, S.C., Hoff-Lindquist, J., Harati, Y., Mitsumoto, H., Pascuzzi, R., Spencer, P.S., Tim, R., Howard, D., Smith, T.C., Ryan, M.A.K., Coffman, C.J., Kasarskis, E.J.·2003·Neurology
DOI 10.1212/01.wnl.0000069922.32557.ca
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Abstract

Background In response to Gulf War veterans' concerns of high rates of ALS, this investigation sought to determine if Gulf War veterans have an elevated rate of ALS. Methods A nationwide epidemiologic case ascertainment study design was used to ascertain all occurrences of ALS for the 10-year period since August 1990 among active duty military and mobilized Reserves, including National Guard, who served during the Gulf War (August 2, 1990, through July 31, 1991). The diagnosis of ALS was confirmed by medical record review. Risk was assessed by the age-adjusted, average, annual 10-year cumulative incidence rate. Results Among approximately 2.5 million eligible military personnel, 107 confirmed cases of ALS were identified for an overall occurrence of 0.43 per 100,000 persons per year. A significant elevated risk of ALS occurred among all deployed personnel (RR = 1.92; 95% CL = 1.29, 2.84), deployed active duty military (RR = 2.15, 95% CL = 1.38, 3.36), deployed Air Force (RR = 2.68, 95% CL = 1.24, 5.78), and deployed Army (RR = 2.04; 95% CL = 1.10, 3.77) personnel. Elevated, but nonsignificant, risks were observed for deployed Reserves and National Guard (RR = 2.50; 95% CL = 0.88, 7.07), deployed Navy (RR = 1.48, 95% CL = 0.62, 3.57), and deployed Marine Corps (RR = 1.13; 95% CL = 0.27, 4.79) personnel. Overall, the attributable risk associated with deployment was 18% (95% CL = 4.9%, 29.4%). Conclusions Military personnel who were deployed to the Gulf Region during the Gulf Wa…

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  • There are reports of a potentially increased risk of ALS in US veterans.

    “Following reports of a potentially increased risk of ALS in US veterans (23–25), we are currently conducting a case-control study called GENEVA”

    From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [23]

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Metadata

Authors
Horner, R. D., Kamins, K. G., Feussner, J. R., Grambow, S. C., Hoff-Lindquist, J., Harati, Y., Mitsumoto, H., Pascuzzi, R., Spencer, P. S., Tim, R., Howard, D., Smith, T. C., Ryan, M. A. K., Coffman, C. J., & Kasarskis, E. J.
Affiliations
  • National Institutes of Health (US)
  • Medical University of South Carolina (US)
  • From the National Institute of Neurological Disorders and Stroke (Dr. Horner), Bethesda, MD; National Institute for Environmental Health Sciences (Dr. Kamins), Research Triangle, NC; Department of Medicine (Dr. Feussner), Medical University of South Carolina, Charleston, SC; VA Epidemiologic Research & Information Center (Dr. Grambow and D. Howard) and VA Center for Health Service Research in Primary Care (Drs. Grambow and Coffman, and J. Hoff-Lindquist), Durham, NC; Department of Biostatistics...
  • Naval Medical Center San Diego (US)
  • University of Kentucky (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-09-23
Volume
61
Issue
6
Pages
742-749
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000069922.32557.ca
OpenAlex
W2130248130
Cited by
277
References
0
Citations by year
2026: 6 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 16 · 2018: 5 · 2017: 14 · 2016: 19 · 2015: 17 · 2014: 15 · 2013: 8 · 2012: 13
FWCI
9.45
Type
journal article
Language
en
Update notices
correction (2003-11-11)
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational Health and Performance
  • Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
Keywords
amyotrophic lateral sclerosis, Gulf War veterans, military deployment, Gulf War, ALS incidence, risk factors, military personnel, National Guard, military mobilization
MeSH terms
Adult, Amyotrophic Lateral Sclerosis, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk, Veterans, Warfare, Cohort Studies, Incidence, Age of Onset, Persian Gulf Syndrome, Indian Ocean

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