Cited by 125Multiple Sclerosis Research StudiesHeart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic Disorders

Fatigue in MS is related to sympathetic vasomotor dysfunction

Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K.V., Kesselring, J.·2003·Neurology

Abstract

The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.

Integrity signals

Registry

Crossref · 10.1212/01.wnl.0000080365.95436.b8

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels.

    “Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J.
Affiliations
University of Würzburg (DE)
Venue
Neurology
Published
2003-09-23
Volume
61
Issue
6
Pages
851-853
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W1970120310
Cited by
125
References
8
Citations by year
2025: 1 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
FWCI
2.40
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords
multiple sclerosis, fatigue, autonomic dysfunction, sympathetic nervous system, vasomotor dysfunction, heart rate variability, orthostatic response, Fatigue Severity Scale, Modified Fatigue Impact Scale
MeSH terms
Adult, Aged, Blood Pressure, Electrocardiography, Fatigue, Female, Fourier Analysis, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Multiple Sclerosis, Posture, Surveys and Questionnaires, Severity of Illness Index, Sympathetic Nervous System, Vagus Nerve, Valsalva Maneuver, Vasomotor System, Hand Strength

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review