Fatigue in MS is related to sympathetic vasomotor dysfunction
Abstract
The authors studied standard autonomic function tests and measures of heart rate variability in 60 patients with multiple sclerosis (MS) and correlated results with the Fatigue Severity Scale and the Modified Fatigue Impact Scale. The authors found that autonomic responses correlated with fatigue resembling a hypoadrenergic orthostatic response, possibly due to a sympathetic vasomotor lesion with intact vagal heart control. Treatments to control sympathetic dysfunction for MS-associated fatigue deserve further study.
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In MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels.
“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Flachenecker et al., 2003
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Assessment of autonomic function in humans by heart rate spectral analysis
Pomeranz, B., Macaulay, R. J., Caudill, M. A., Kutz, I., Adam, D., Gordon, D., Kilborn, K. M., Barger, A. C., Shannon, D. C., Cohen, R. J., et al. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.1.h151 · Cited by 2,876 · see citing works
Flachenecker, P., Kümpfel, T., Kallmann, B. A., Gottschalk, M., Grauer, O. M., Rieckmann, P., Trenkwalder, C., & Toyka, K. V. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms839oa · Cited by 635 · see citing works
Self-citationFatigue in multiple sclerosis: current understanding and future directions.
Schwid, S. R., Covington, M., Segal, B. M., & Goodman, A. D. (2002) · PubMed · Cited by 225 · see citing works
Mathias, C. J., Mallipeddi, R., & Bleasdale-Barr, K. (1999) · Journal of Neurology · doi:10.1007/s004150050479 · Cited by 178 · see citing works
Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance
Flachenecker, P., Wolf, A., Krauser, M., Hartung, H., & Reiners, K. (1999) · Journal of Neurology · doi:10.1007/s004150050407 · Cited by 110 · see citing works
Self-citationCardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach, S., Dillmann, U., Kölmel, C., Holz, J., & Müller, M. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700508 · Cited by 63 · see citing works
Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?
Keselbrener, L., AKSELROD, S., Ahiron, A., Eldar, M., Barak, Y., & Rotstein, Z. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291352 · Cited by 58 · see citing works
Egg, R., Högl, B., Glatzl, S., Beer, R., & Berger, T. (2002) · Multiple Sclerosis Journal · doi:10.1191/1352458502ms793oa · Cited by 27 · see citing works
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Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression
Stephan, K. E., Manjaly, Z. M., Mathys, C. D., Weber, L. A. E., Paliwal, S., Gard, T., Tittgemeyer, M., Fleming, S. M., Haker, H., Seth, A. K., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00550 · Cited by 437 · see citing works
“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
BackgroundPathophysiological and cognitive mechanisms of fatigue in multiple sclerosis
Manjaly, Z., Harrison, N. A., Critchley, H., Tri, C., Stefanics, G., Wenderoth, N., Lutterotti, A., Müller, A. E., & Stephan, K. E. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-320050 · Cited by 329 · see citing works
Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity
Mizuno, K., Tanaka, M., Yamaguti, K., Kajimoto, O., Kuratsune, H., & Watanabe, Y. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-17 · Cited by 276 · see citing works
Multiple sclerosis-associated fatigue
Krupp, L., Serafin, D., & Christodoulou, C. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.99 · Cited by 231 · see citing works
Symptoms of autonomic dysfunction in chronic fatigue syndrome
Newton, J. L., Okonkwo, O., Sutcliffe, K., Seth, A., Shin, J. Y., & Jones, D. E. (2007) · QJM · doi:10.1093/qjmed/hcm057 · Cited by 180 · see citing works
Cytokine mRNA expression in patients with multiple sclerosis and fatigue
Flachenecker, P., Bihler, I., Weber, F., Gottschalk, M., Toyka, K. V., & Rieckmann, P. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms991oa · Cited by 169 · see citing works
Self-citationFatigue in multiple sclerosis – Insights into evaluation and management
Ayache, S. S., & Chalah, M. A. (2017) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2017.02.004 · Cited by 163 · see citing works
Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort
Jones, D. E. J., Bhala, N., Burt, J., Goldblatt, J., Prince, M., & Newton, J. L. (2006) · Gut · doi:10.1136/gut.2005.080317 · Cited by 136 · see citing works
The psychology of fatigue in patients with multiple sclerosis: A review
Bol, Y., Duits, A., Hupperts, R., Vlaeyen, J. W. S., & Verhey, F. R. J. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.05.003 · Cited by 131 · see citing works
Distinguishing between Fatigue and Fatigability in Multiple Sclerosis
Enoka, R. M., Almuklass, A. M., Alenazy, M. S., Álvarez, E., & Duchateau, J. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211046257 · Cited by 136 · see citing works
Autonomic dysfunction in multiple sclerosis
Haensch, C., & Jörg, J. (2006) · Journal of Neurology · doi:10.1007/s00415-006-1102-2 · Cited by 131 · see citing works
Central nervous system fatigue alters autonomic nerve activity
Tanaka, M., Mizuno, K., Tajima, S., Sasabe, T., & Watanabe, Y. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.12.004 · Cited by 120 · see citing works
The Relationship Between Spectral Changes in Heart Rate Variability and Fatigue
Tran, Y., Wijesuriya, N. S., Tarvainen, M. P., Karjalainen, P. A., & Craig, A. R. (2009) · Journal of Psychophysiology · doi:10.1027/0269-8803.23.3.143 · Cited by 111 · see citing works
Exercise and rehabilitation for individuals with multiple sclerosis.
Brown, T., & Kraft, G. (2005) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2005.01.005 · Cited by 122 · see citing works
Fatigue and psychiatric illness in a large community sample of persons with multiple sclerosis
Chwastiak, L., Gibbons, L. E., Ehde, D. M., Sullivan, M. D., Bowen, J. D., Bombardier, C. H., & Kraft, G. H. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2005.06.001 · Cited by 109 · see citing works
Langeskov‐Christensen, M., Bisson, E. J., Finlayson, M. L., & Dalgas, U. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.01.002 · Cited by 99 · see citing works
Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice
de, J., Airas, L. M., Bartholome, E. J., Grigoriadis, N., Mattle, H. P., Oreja‐Guevara, C., O’Riordan, J. I., Sellebjerg, F. T., Stankoff, B., Vass, K., et al. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611403646 · Cited by 93 · see citing works
Fatigue in neuromuscular disorders: focus on Guillain–Barré syndrome and Pompe disease
de Vries, J. M., Hagemans, M. L. C., Bussmann, J. B. J., van der Ploeg, A. T., & van Doorn, P. A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0184-2 · Cited by 95 · see citing works
Moller, F., Poettgen, J., Broemel, F., Neuhaus, A. A., Däumer, M., & Heesen, C. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511402410 · Cited by 92 · see citing works
Systemic Symptoms in Non-Alcoholic Fatty Liver Disease
Newton, J. L. (2010) · Digestive Diseases · doi:10.1159/000282089 · Cited by 92 · see citing works
Autonomic nervous alterations associated with daily level of fatigue
Tanaka, M., Mizuno, K., Yamaguti, K., Kuratsune, H., Fujii, A., Baba, H., Matsuda, K., Nishimae, A., Takesaka, T., & Watanabe, Y. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-46 · Cited by 89 · see citing works
Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity
Newton, J. L., Davidson, A. W., Kerr, S. R. J., Bhala, N., Pairman, J., Burt, J., & Jones, D. E. J. (2007) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000252629.96043.67 · Cited by 84 · see citing works
Autonomic dysfunction in Guillain-Barré syndrome and multiple sclerosis
Flachenecker, P. (2007) · Journal of Neurology · doi:10.1007/s00415-007-2024-3 · Cited by 81 · see citing works
Self-citationFatigue and autonomic dysfunction in non-alcoholic fatty liver disease
Newton, J. L., Pairman, J., Wilton, K., Jones, D. E. J., & Day, C. P. (2009) · Clinical Autonomic Research · doi:10.1007/s10286-009-0031-4 · Cited by 77 · see citing works
Does cardiovascular autonomic dysfunction contribute to fatigue in Parkinson's disease?
Nakamura, T., Hirayama, M., Hara, T., Hama, T., Watanabe, H., & Sobue, G. (2011) · Movement Disorders · doi:10.1002/mds.23744 · Cited by 75 · see citing works
Meyer‐Heim, A., Rothmaier, M., Weder, M., Kool, J., Schenk, P., & Kesselring, J. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506070648 · Cited by 68 · see citing works
Self-citationKanjwal, K., Karabin, B. L., Kanjwal, Y., & Grubb, B. P. (2010) · International Journal of Medical Sciences · doi:10.7150/ijms.7.62 · Cited by 66 · see citing works
Findling, O., Hauer, L., Pezawas, T., Rommer, P. S., Struhal, W., & Sellner, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020335 · Cited by 65 · see citing works
Autonomic dysfunction in multiple sclerosis
Racosta, J. M., Kimpinski, K., Morrow, S. A., & Kremenchutzky, M. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.06.001 · Cited by 65 · see citing works
Autonomic symptom burden is associated with MS-related fatigue and quality of life
Cortez, M. M., Nagi Reddy, S. K., Goodman, B., Carter, J. L., & Wingerchuk, D. M. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.03.007 · Cited by 59 · see citing works
Is Metabolic Flexibility Altered in Multiple Sclerosis Patients?
Mähler, A., Steiniger, J., Bock, M., Brandt, A. U., Haas, V. K., Boschmann, M., & Paul, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043675 · Cited by 55 · see citing works
Autonomic Dysregulation in Multiple Sclerosis
Pintér, A., Cseh, D., Sárközi, A., Illigens, B. M. W., & Siepmann, T. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160816920 · Cited by 50 · see citing works
Association of a deficit of arousal with fatigue in multiple sclerosis: Effect of modafinil
Niepel, G., Bibani, R. H., Vilisaar, J., Langley, R. W., Bradshaw, C. M., Szabadi, E., & Constantinescu, C. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.036 · Cited by 42 · see citing works
Autonomic dysfunction in multiple sclerosis: Implications for exercise
Huang, M. R., Jay, O., & Davis, S. L. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.10.017 · Cited by 43 · see citing works
Altered cytokine responses to cognitive stress in multiple sclerosis patients with fatigue
Heesen, C., Koehler, G., Gross, R., Tessmer, W., Schulz, K., & Gold, S. M. (2005) · Multiple Sclerosis Journal · doi:10.1191/1352458505ms1129oa · Cited by 43 · see citing works
Perceived fatigue is comparable between different disease groups
Jones, D. E. J., Gray, J. C., & Newton, J. L. (2009) · QJM · doi:10.1093/qjmed/hcp091 · Cited by 41 · see citing works
Postural Orthostatic Tachycardia Syndrome (POTS) and Vitamin B12 Deficiency in Adolescents
Öner, T., Güven, B., Tavlı, V., Meşe, T., Yılmazer, M. M., & Demirpençe, S. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3427 · Cited by 40 · see citing works
Autonomic Disorders in Multiple Sclerosis
Lensch, E., & Jost, W. H. (2011) · Autoimmune Diseases · doi:10.4061/2011/803841 · Cited by 40 · see citing works
Zimek, D., Miklusova, M., & Mareš, J. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s429862 · Cited by 38 · see citing works
Understanding and Treating Fatigue in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
Jopson, L., Dyson, J. K., & Jones, D. E. J. (2015) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.08.007 · Cited by 38 · see citing works
Cao, Y., Wittert, G., Taylor, A. W., Adams, R., & Shi, Z. (2016) · Nutrients · doi:10.3390/nu8040207 · Cited by 37 · see citing works
Fatigue and cognition: Pupillary responses to problem‐solving in early multiple sclerosis patients
Benavent, S. A. D. R., Nygaard, G. O., Harbo, H. F., Tønnesen, S., Sowa, P., Landrø, N. I., Wendel‐Haga, M., Etholm, L., Nilsen, K. B., Drolsum, L., et al. (2017) · Brain and Behavior · doi:10.1002/brb3.717 · Cited by 38 · see citing works
Fatigue in Primary Biliary Cirrhosis
Newton, J. L. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.010 · Cited by 37 · see citing works
Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients
Sander, C., Hildebrandt, H., Schlake, H.-P., Eling, P., & Hanken, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00475 · Cited by 34 · see citing works
Validation of the Neurological Fatigue Index for stroke (NFI-Stroke)
Mills, R. J., Pallant, J., Koufali, M., Sharma, A. K., Day, S., Tennant, A., & Young, C. A. (2012) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-10-51 · Cited by 34 · see citing works
Barbi, C., Pizzini, F. B., Tamburin, S., Martini, A., Pedrinolla, A., Laginestra, F. G., Giuriato, G., Martignon, C., Schena, F. F., & Venturelli, M. (2022) · Neurology International · doi:10.3390/neurolint14020042 · Cited by 30 · see citing works
Sander, C., Modes, F., Schlake, H.-P., Eling, P., & Hildebrandt, H. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.04.013 · Cited by 30 · see citing works
Sternberg, Z. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.04.004 · Cited by 30 · see citing works
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue
Skorić, M. K., Crnošija, L., Adamec, I., Barun, B., Gabelić, T., Smoljo, T., Stanić, I., Pavičić, T., Pavlović, I., Drulovic, J. S., et al. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0563-6 · Cited by 29 · see citing works
Payne, B., Hateley, C. A., Ong, E. L. C., Premchand, N., Schmid, M., Schwab, U., Newton, J. L., & Price, D. (2012) · HIV Medicine · doi:10.1111/j.1468-1293.2012.01050.x · Cited by 29 · see citing works
The Potential Role of Neurophysiology in the Management of Multiple Sclerosis-Related Fatigue
Capone, F., Motolese, F., Falato, E., Rossi, M., & Lazzaro, V. D. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00251 · Cited by 28 · see citing works
Autonomic dysfunction in clinically isolated syndrome suggestive of multiple sclerosis
Crnošija, L., Adamec, I., Lovrić, M., Junaković, A., Skorić, M. K., Lušić, I., & Habek, M. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.06.010 · Cited by 26 · see citing works
Bazar, K. A., Yun, A. J., & Lee, P. Y. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.04.015 · Cited by 26 · see citing works
Biosensing in multiple sclerosis
Yousef, A., Jonzzon, S., Suleiman, L., Arjona, J. K., & Graves, J. S. (2017) · Expert Review of Medical Devices · doi:10.1080/17434440.2017.1388162 · Cited by 25 · see citing works
Pilipović, I., Stojić-Vukanić, Z., Prijić, I., Jasnic, N. I., & Leposavić, G. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104665 · Cited by 25 · see citing works
Postural orthostatic tachycardia syndrome associated with multiple sclerosis
Adamec, I., Lovrić, M., Žaper, D., Barušić, A. K., Bach, I., Junaković, A., Mišmaš, A., & Habek, M. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.11.009 · Cited by 24 · see citing works
Biological outcome measurements for behavioral interventions in multiple sclerosis
Fischer, A., Heesen, C., & Gold, S. M. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611405252 · Cited by 22 · see citing works
Sternberg, Z. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.04.012 · Cited by 22 · see citing works
Sternberg, Z. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8481-2 · Cited by 20 · see citing works
Perfectionism and fatigue in multiple sclerosis
Beshārat, M. A., Pourhosein, R., Rostami, R., & Bazzāziān, S. (2010) · Psychology and Health · doi:10.1080/08870440903464228 · Cited by 20 · see citing works
Rudroff, T. (2024) · Experimental Brain Research · doi:10.1007/s00221-024-06882-z · Cited by 18 · see citing works
Rzepiński, Ł., Zawadka‐Kunikowska, M., Newton, J. L., Zalewski, P., & Słomko, J. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06099-4 · Cited by 17 · see citing works
Autonomic nervous system disorders in multiple sclerosis
Koutsouraki, E., Koukoulidis, T., Eleni, G., Marianna, K., Areti, N., Ariadni, K., & Michmizos, D. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11725-y · Cited by 17 · see citing works
Fatigue – concepts for physiotherapy management and measurement
O'Connell, C., & Stokes, E. (2007) · Physical Therapy Reviews · doi:10.1179/108331907x223100 · Cited by 17 · see citing works
Interoceptive and metacognitive facets of fatigue in multiple sclerosis
Rouault, M., Pereira, I., Galioulline, H., Fleming, S. M., Stephan, K. E., & Manjaly, Z. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16048 · Cited by 19 · see citing works
Orthostatic blood pressure regulation predicts classroom effort in children
Randle, S. C., Siedlarz, M., Jackson, S. L., & Perlmuter, L. C. (2008) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.01.004 · Cited by 16 · see citing works
Relação entre fadiga e distúrbios autonômicos na esclerose múltipla
Lebre, A., Mendes, M. F., Tilbery, C. P., Almeida, A. L. D. J., & Neto, A. S. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000400023 · Cited by 16 · see citing works
Wireless medical sensor measurements of fatigue in patients with multiple sclerosis
Fei, Y., Bilberg, A., & Stenager, E. (2010) · 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology · doi:10.1109/iembs.2010.5627530 · Cited by 18 · see citing works
Sternberg, Z. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9599-y · Cited by 16 · see citing works
Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis
Sevim, S., Kaleağası, H., & Taşdelen, B. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.05.010 · Cited by 15 · see citing works
Fatigue in Parkinson’s Disease Associates with Lower Ambulatory Diastolic Blood Pressure
Kotagal, V., Szpara, A., Albin, R. L., & Bohnen, N. I. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191579 · Cited by 14 · see citing works
Flachenecker, P., Meißner, H., Frey, R., & Guldin, W. O. (2017) · European Neurology · doi:10.1159/000481941 · Cited by 13 · see citing works
Self-citationYu, F., Bilberg, A., Dalgas, U., & Stenager, E. (2012) · Disability and Rehabilitation Assistive Technology · doi:10.3109/17483107.2012.680941 · Cited by 12 · see citing works
Blood pressure normalization post-jugular venous balloon angioplasty
Sternberg, Z., Grewal, P. K., Cen, S., DeBarge-Igoe, F., Yu, J., & Arata, M. A. (2013) · Phlebology The Journal of Venous Disease · doi:10.1177/0268355513512824 · Cited by 11 · see citing works
Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis.
Pilipović, I., Stojić-Vukanić, Z., & Leposavić, G. (2023) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2023.108358 · Cited by 12 · see citing works
Fatigue in multiple sclerosis: a diagnostic and therapeutic challenge
Paul, F., & Veauthier, C. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.667075 · Cited by 11 · see citing works
Fatigue in Neurologic Disorders
Bhat, S., & Chokroverty, S. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2013.02.006 · Cited by 11 · see citing works
Metaboreflex activity in multiple sclerosis patients
Marongiu, E., Olla, S., Magnani, S., Palazzolo, G., Sanna, I., Tocco, F., Marcelli, M., Loi, A., Corona, F., Mulliri, G., et al. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3271-0 · Cited by 11 · see citing works
Yang, L., Li, W., Xie, Y., Ma, S., Zhou, X., Huang, X., & Tan, S. (2023) · BMC Neurology · doi:10.1186/s12883-023-03162-1 · Cited by 10 · see citing works
Kindred, J. H., Ketelhut, N. B., & Rudroff, T. (2014) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2014.12.005 · Cited by 10 · see citing works
Clinical Neurophysiology of Multiple Sclerosis
Habek, M., Adamec, I., Barun, B., Crnošija, L., Gabelić, T., & Skorić, M. K. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-47861-6_8 · Cited by 10 · see citing works
Arata, M. A., & Sternberg, Z. (2014) · Journal of Endovascular Therapy · doi:10.1583/13-4605mr.1 · Cited by 8 · see citing works
Can biofeedback-based training alleviate fatigue and vigilance performance in fatigued MS patients?
Sander, C., Braun, N., Modes, F., Schlake, H.-P., Eling, P., & Hildebrandt, H. (2020) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2020.1808023 · Cited by 8 · see citing works
A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis
Buenafe, A. C., Zwickey, H. L., Moes, N., Oken, B., & Jones, R. E. (2008) · Lab Animal · doi:10.1038/laban0808-361 · Cited by 8 · see citing works
Dinoto, A., Baldini, S., Morelli, M. E., Pasquin, F., Bratina, A., Bosco, A., Sartori, A., & Manganotti, P. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05487-6 · Cited by 7 · see citing works
Racosta, J. M. (2014) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000212 · Cited by 7 · see citing works
Greenberg, B. M., Fan, Y., Carriere, L. J., & Sullivan, A. B. (2016) · International Journal of MS Care · doi:10.7224/1537-2073.2016-012 · Cited by 7 · see citing works
Understanding fatigue in multiple sclerosis
Chatterton, H. J., & Spearing, R. (2006) · Physical Therapy Reviews · doi:10.1179/108331906x144154 · Cited by 7 · see citing works
Benavent, S. A. D. R., Nygaard, G. O., Nilsen, K. B., Etholm, L., Sowa, P., Wendel‐Haga, M., Harbo, H. F., Drolsum, L., Laeng, B., Kerty, E., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00507 · Cited by 6 · see citing works
Garis, G., Dettmers, C., Hildebrandt, A., Duning, T., & Hildebrandt, H. (2023) · Neurological Sciences · doi:10.1007/s10072-023-07042-x · Cited by 5 · see citing works
Zawadka‐Kunikowska, M., Rzepiński, Ł., Cieślicka, M., Klawe, J. J., & Tafil‐Klawe, M. (2023) · Brain Sciences · doi:10.3390/brainsci13091342 · Cited by 5 · see citing works
Current understanding of cardiovascular autonomic dysfunction in multiple sclerosis
Zahoor, I., Pan, G.-D., Cerghet, M., Elbayoumi, T. M., Mao-Draayer, Y., Giri, S., & Palaniyandi, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35753 · Cited by 6 · see citing works
Heart rate variability in people with multiple sclerosis: A systematic review and meta-analysis
Mirmosayyeb, O., Panah, M. Y., Alinejadfard, M., Oraee, S., Vaheb, S., & Shaygannejad, V. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-025-02829-5 · Cited by 4 · see citing works
A Simple Sensitive Method for Measuring Borderline Mental Fatigue
Aydin, L., Gündoğan, N. Ü., Kızıltan, E., Yazıcı, C., Öztürk, B. S. S., Kara, B., Yeşilova, Y., Erdemir, I., Bulbul, C., & Oner, E. (2016) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2016/25893 · Cited by 4 · see citing works
Sternberg, Z. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8375-5 · Cited by 4 · see citing works
Understanding fatigue in multiple sclerosis : from a psychological perspective
Bol, Y. (2010) · doi:10.26481/dis.20100305yb · Cited by 4 · see citing works
Galperin, I., Buzaglo, D., Gazit, E., Shimoni, N., Tamir, R., Regev, K., Karni, A., & Hausdorff, J. M. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12339-8 · Cited by 3 · see citing works
Multiple sclerosis-associated fatigue
Krupp Lauren, B., & Serafin Dana, J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9781139023986.059 · Cited by 3 · see citing works
Assessing the structural and functional changes in vagus nerve in multiple sclerosis
Abdelnaby, R., Meshref, M. M., Gaber, D. E., Mohamed, K. A., Madhav, N., & Elshabrawy, H. A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110863 · Cited by 3 · see citing works
Abnormal baroreflex responses in multiple sclerosis
Flachenecker, P., & Reiners, K. (2005) · Clinical Autonomic Research · doi:10.1007/s10286-005-0315-2 · Cited by 3 · see citing works
Self-citation
- Authors
- Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J.
- Affiliations
- University of Würzburg (DE)
- Venue
- Neurology
- Published
- 2003-09-23
- Volume
- 61
- Issue
- 6
- Pages
- 851-853
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1970120310
- Cited by
- 125
- References
- 8
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- multiple sclerosis, fatigue, autonomic dysfunction, sympathetic nervous system, vasomotor dysfunction, heart rate variability, orthostatic response, Fatigue Severity Scale, Modified Fatigue Impact Scale
- MeSH terms
- Adult, Aged, Blood Pressure, Electrocardiography, Fatigue, Female, Fourier Analysis, Heart Rate, Humans, Hypotension, Orthostatic, Male, Middle Aged, Multiple Sclerosis, Posture, Surveys and Questionnaires, Severity of Illness Index, Sympathetic Nervous System, Vagus Nerve, Valsalva Maneuver, Vasomotor System, Hand Strength
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