Autonomic symptom burden is associated with MS-related fatigue and quality of life
Abstract
Background Nonspecific symptoms such as fatigue and dizziness are common in multiple sclerosis (MS), even in patients with normal exams. Little is known about the relationship of autonomic dysfunction with these symptoms and quality of life.Objective Assess the association of autonomic symptom burden with fatigue, clinical status and quality of life.Methods Subjects completed an autonomic symptom (COMPASS-31), quality of life (MSQOL-54) and fatigue (FSS) questionnaire at their routine MS clinic follow-up. Demographic and clinical data were collected from the medical record. Pearson correlations were assessed between autonomic symptoms and fatigue, quality of life, disability and disease duration.Results One-hundred subjects completed the study (mean age 48 years; 78% female; 84% relapsing-remitting), mean disease duration was 14.7 years and mean EDSS 2.5. MSQOL-54 composite scores were 58 physical and 65 mental. COMPASS-31 correlated with MSQOL-54 (Physical R= -0.60; Mental -0.54; p<0.001) and FSS (R=0.51; p<0.001). There was no relationship between COMPASS-31 and EDSS (R=0, p=0.97) or disease duration (R= -0.02, p=0.84).Conclusions Autonomic symptom burden is correlated with decreased quality of life and increased fatigue. Autonomic symptoms are present early in the disease and at low disability and may reflect aspects of disease burden that are not well-captured by current disability measures.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels.
“Specifically, in MS patients, various measures of autonomic dysfunction correlate strongly with individual fatigue levels (Flachenecker et al., 2003; Cortez et al., 2015).”
From Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression (2016) · cites this paper as Cortez et al., 2015
Cites
Krupp, L. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520460115022 · Cited by 6,172 · see citing works
A health-related quality of life measure for multiple sclerosis
Vickrey, B. G., Hays, R. D., Harooni, R., Myers, L. W., & Ellison, G. W. (1995) · Quality of Life Research · doi:10.1007/bf02260859 · Cited by 1,132 · see citing works
COMPASS 31: a refined and abbreviated composite autonomic symptom score
Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J., & Singer, W. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.10.013 · Cited by 741 · see citing works
Low, P. A., & Benarroch, E. E. (2009) · Cited by 345 · see citing works
Suárez, G. A., Opfer-Gehrking, T. L., Offord, K. P., Atkinson, E. J., O’Brien, P. C., & Low, P. A. (1999) · Neurology · doi:10.1212/wnl.52.3.523 · Cited by 315 · see citing works
Urinary symptoms and the neurological features of bladder dysfunction in multiple sclerosis.
Betts, C. D., D'Mellow, M. T., & Fowler, C. J. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.3.245 · Cited by 274 · see citing works
Prevalence of bowel dysfunction in multiple sclerosis
Hinds, J. P., Eidelman, B. H., & Wald, A. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91087-m · Cited by 226 · see citing works
Application to Patients With Multiple Sclerosis and Systemic Lupus Erythematosus
Krupp, L., LaRocca, N. G., Muir-Nash, J., & Steinberg, A. D. (2016) · Cited by 151 · see citing works
Flachenecker, P., Reiners, K., Krauser, M., Wolf, A., & Toyka, K. V. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700509 · Cited by 147 · see citing works
Fatigue in MS is related to sympathetic vasomotor dysfunction
Flachenecker, P., Rufer, A., Bihler, I., Hippel, C., Reiners, K., Toyka, K. V., & Kesselring, J. (2003) · Neurology · doi:10.1212/01.wnl.0000080365.95436.b8 · Cited by 125 · see citing works
Beits, C. D., JONES, S. J., Fowler, C., & Fowler, C. J. (1994) · Brain · doi:10.1093/brain/117.6.1303 · Cited by 122 · see citing works
Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance
Flachenecker, P., Wolf, A., Krauser, M., Hartung, H., & Reiners, K. (1999) · Journal of Neurology · doi:10.1007/s004150050407 · Cited by 110 · see citing works
Erectile dysfunction in multiple sclerosis
Kirkeby, H. J., Poulsen, E. U., Petersen, T., & Dørup, J. G. (1988) · Neurology · doi:10.1212/wnl.38.9.1366 · Cited by 109 · see citing works
Cardiovascular dysfunction inmultiple sclerosis
Acevedo, A., Nava, C., Arriada, N., Violante, A., & Corona, T. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.101002085.x · Cited by 107 · see citing works
Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions
Vita, G., Fazio, M. C., Milone, S., Blandino, A., Salvi, L., & Messina, C. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90029-x · Cited by 103 · see citing works
Autonomic nervous system function in multiple sclerosis
McDougall, A., & McLeod, J. G. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00205-3 · Cited by 96 · see citing works
Cardiovascular autonomic function in multiple sclerosis
Anema, J. R., Heijenbrok, M. W., Faes, T. J. C., Heimans, J. J., Lanting, P., & Polman, C. H. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90301-m · Cited by 78 · see citing works
Thomaides, T., Zoukos, Y., Chaudhuri, К. R., & Mathias, C. J. (1993) · Journal of Neurology · doi:10.1007/bf00857517 · Cited by 73 · see citing works
Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS
Saari, A., Tolonen, U., Pääkkö, E. L., Suominen, K., Pyhtinen, J., Sotaniemi, K. A., & Myllylä, V. V. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.012 · Cited by 72 · see citing works
Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates
Seze, J. D., Stojkovic, T., Gauvrit, J., Devos, D., Ayachi, M., Cassim, F., Michel, T. S., Pruvo, J., Guieu, J., & Vermersch, P. (2001) · Journal of Neurology · doi:10.1007/s004150170204 · Cited by 72 · see citing works
Kanjwal, K., Karabin, B. L., Kanjwal, Y., & Grubb, B. P. (2010) · International Journal of Medical Sciences · doi:10.7150/ijms.7.62 · Cited by 66 · see citing works
Cardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach, S., Dillmann, U., Kölmel, C., Holz, J., & Müller, M. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700508 · Cited by 63 · see citing works
Disseminated abnormalities of cardiovascular autonomic functions in multiple sclerosis
Sterman, A., Coyle, P. K., Panasci, D. J., & GRIMSON, R. C. (1985) · Neurology · doi:10.1212/wnl.35.11.1665 · Cited by 63 · see citing works
Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?
Keselbrener, L., AKSELROD, S., Ahiron, A., Eldar, M., Barak, Y., & Rotstein, Z. (2000) · Clinical Autonomic Research · doi:10.1007/bf02291352 · Cited by 58 · see citing works
Hypothermia in multiple sclerosis.
White, K. D., Scoones, D., & Newman, P. K. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.4.369 · Cited by 49 · see citing works
Multiple sclerosis and the autonomic nervous system
Merkelbach, S., Haensch, C., Hemmer, B., Koehler, J., König, N. H., & Ziemssen, T. (2006) · Journal of Neurology · doi:10.1007/s00415-006-1105-z · Cited by 49 · see citing works
Progressive Impairment of Autonomic Control of Heart Rate in Patients with Multiple Sclerosis
Mahović, D., & Lakušić, N. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.11.009 · Cited by 46 · see citing works
Multiple Sclerosis as a Cause of Atrial Fibrillation and Electrocardiographic Changes
Schroth, W., Tenner, S. M., Rappaport, B. A., & Mani, R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530280116034 · Cited by 36 · see citing works
Longitudinal follow-up of cardiovascular reflex tests in multiple sclerosis
Nasseri, K., TenVoorde, B. J., Adèr, H. J., Uitdehaag, B. M. J., & Polman, C. H. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00273-6 · Cited by 33 · see citing works
Gastrointestinal dysfunction in multiple sclerosis
Sullivan, S., & Ebers, G. C. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90414-6 · Cited by 32 · see citing works
Adamec, I., Bach, I., Barušić, A. K., Mišmaš, A., & Habek, M. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.10.006 · Cited by 27 · see citing works
Autonomie Dysreflexia in a Man With Multiple Sclerosis
Külcü, D. G., Akbaş, N. B., Çitçi, B., & Cihangiroğlu, M. (2009) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2009.11760772 · Cited by 26 · see citing works
Postural orthostatic tachycardia syndrome associated with multiple sclerosis
Adamec, I., Lovrić, M., Žaper, D., Barušić, A. K., Bach, I., Junaković, A., Mišmaš, A., & Habek, M. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.11.009 · Cited by 24 · see citing works
Gastrointestinal Dysfunction in Multiple Sclerosis
Fowler, C., & Henry, M. M. (1996) · Seminars in Neurology · doi:10.1055/s-2008-1040985 · Cited by 15 · see citing works
COMPASS 31 – A Refined and Abbreviated Composite Autonomic Symptom Score (P03.019)
Sletten, D. M., Mandrekar, J. N., Low, P., & Singer, W. (2013) · Neurology · doi:10.1212/wnl.80.7_supplement.p03.019 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Allostatic Self-efficacy: A Metacognitive Theory of Dyshomeostasis-Induced Fatigue and Depression
Stephan, K. E., Manjaly, Z. M., Mathys, C. D., Weber, L. A. E., Paliwal, S., Gard, T., Tittgemeyer, M., Fleming, S. M., Haker, H., Seth, A. K., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00550 · Cited by 437 · see citing works
Greco, C., Gennaro, F. D., D’Amato, C., Morganti, R., Corradini, D., Sun, A., Longo, S., Lauro, D., Pierangeli, G., Cortelli, P., et al. (2016) · Diabetic Medicine · doi:10.1111/dme.13310 · Cited by 93 · see citing works
Cardiovascular Dysfunction in Multiple Sclerosis
Kaplan, T., Berkowitz, A. L., & Samuels, M. A. (2015) · The Neurologist · doi:10.1097/nrl.0000000000000064 · Cited by 87 · see citing works
Immune and autonomic nervous system interactions in multiple sclerosis: clinical implications
Habek, M. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00605-z · Cited by 84 · see citing works
Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire
Adler, B. L., Russell, J. W., Hummers, L. K., & McMahan, Z. H. (2018) · The Journal of Rheumatology · doi:10.3899/jrheum.170868 · Cited by 69 · see citing works
Drulovic, J. S., Gavrilović, A., Crnošija, L., Kisić-Tepavčević, D., Skorić, M. K., Ivanović, J., Adamec, I., Dujmović, I., Junaković, A., Maric, G. D., et al. (2017) · Croatian Medical Journal · doi:10.3325/cmj.2017.58 · Cited by 44 · see citing works
Singh, R., Arbaz, M., Rai, N. K., & Joshi, R. P. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s214085 · Cited by 48 · see citing works
The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism
Kim, Y., Seok, J. M., Park, J., Kim, K.-H., Min, J., Cho, J. W., Park, S., Kim, H., Kim, B. J., & Youn, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180744 · Cited by 43 · see citing works
Bossola, M., Stasio, E. D., Marzetti, E., Lorenzis, K. D., Pepe, G., & Vulpio, C. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1875-0 · Cited by 42 · see citing works
Nakane, S., Mukaino, A., Higuchi, O., Maeda, Y., Takamatsu, K., Yamakawa, M., Watari, M., Tawara, N., Nakahara, K., Kawakami, A., et al. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102403 · Cited by 41 · see citing works
Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients
Sander, C., Hildebrandt, H., Schlake, H.-P., Eling, P., & Hanken, K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00475 · Cited by 34 · see citing works
Anti-ganglionic AChR antibodies in Japanese patients with motility disorders
Mukaino, A., Minami, H., Isomoto, H., Hamamoto, H., Ihara, E., Maeda, Y., Higuchi, O., Okanishi, T., Kokudo, Y., Deguchi, K., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1477-8 · Cited by 34 · see citing works
Barbi, C., Pizzini, F. B., Tamburin, S., Martini, A., Pedrinolla, A., Laginestra, F. G., Giuriato, G., Martignon, C., Schena, F. F., & Venturelli, M. (2022) · Neurology International · doi:10.3390/neurolint14020042 · Cited by 30 · see citing works
Garis, G., Haupts, M. R., Duning, T., & Hildebrandt, H. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06385-1 · Cited by 34 · see citing works
Sander, C., Modes, F., Schlake, H.-P., Eling, P., & Hildebrandt, H. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.04.013 · Cited by 30 · see citing works
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue
Skorić, M. K., Crnošija, L., Adamec, I., Barun, B., Gabelić, T., Smoljo, T., Stanić, I., Pavičić, T., Pavlović, I., Drulovic, J. S., et al. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0563-6 · Cited by 29 · see citing works
Ruška, B., Pavičić, T., Pavlović, I., Junaković, A., Adamec, I., Crnošija, L., Krbot Skorić, M., & Habek, M. (2018) · Neurological Sciences · doi:10.1007/s10072-018-3542-8 · Cited by 28 · see citing works
Association between autonomic dysfunction and fatigue in Parkinson disease
Chou, K. L., Gilman, S., & Bohnen, N. I. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.04.023 · Cited by 28 · see citing works
Foschi, M., Giannini, G., Merli, E., Mancinelli, L., Zenesini, C., Viti, B., Guaraldi, P., Cortelli, P., & Lugaresi, A. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04620-1 · Cited by 23 · see citing works
Autonomic dysfunction in patients with COVID‑19
Erdal, Y., Atalar, A. Ç., Güneş, T., Okluoglu, T., Yavuz, N., & Emre, U. (2022) · Acta Neurologica Belgica · doi:10.1007/s13760-022-01899-z · Cited by 17 · see citing works
Hilty, M., Oldrati, P., Barrios, L., Müller, T., Blumer, C., Foege, M., Holz, C., & Lutterotti, A. (2022) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173221103436 · Cited by 15 · see citing works
Autonomic Symptoms in Gulf War Veterans Evaluated at the War Related Illness and Injury Study Center
Fox, A., Helmer, D. A., Tseng, C., McCarron, K. K., Satcher, S., & Osinubi, O. (2018) · Military Medicine · doi:10.1093/milmed/usy227 · Cited by 15 · see citing works
Chen, W. C., Chang, Y., Chen, S. F., Lin, W. C., Su, Y., & Luo, S. D. (2018) · Rhinology Journal · doi:10.4193/rhin18.005 · Cited by 14 · see citing works
Clinical and Immunologic Effects of Paraprobiotics in Long-COVID Patients
Docampo, M. J., Batruch, M., Oldrati, P., Berenjeno‐Correa, E., Hilty, M., Leventhal, G. E., Lutterotti, A., Martinꝉ, R., & Sospedra, M. (2024) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200296 · Cited by 14 · see citing works
Allostatic load index in patients with multiple sclerosis: A case-control study
Waliszewska‐Prosół, M., Nowakowska-Kotas, M. M., Misiak, B., Chojdak-Łukasiewicz, J., Budrewicz, S. P., & Pokryszko‐Dragan, A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105788 · Cited by 13 · see citing works
Trinh, D.-T. T., Le, H.-L. T., Bui, M.-M. P., & Thai, K. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1116154 · Cited by 12 · see citing works
Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
Renno, S., Hildesheim, H., van Uem, J. M. T., Suenkel, U., Röeben, B., Brockmann, K., Mychajliw, C., Eschweiler, G. W., Berg, D., & Maetzler, W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.757748 · Cited by 12 · see citing works
Gervasoni, E., Bove, M., Sinatra, M., Grosso, C., Rovaris, M., Cattaneo, D., & Merati, G. (2018) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2018.06.003 · Cited by 12 · see citing works
Sakakibara, R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102795 · Cited by 11 · see citing works
Advances in tissue engineering of peripheral nerve and tissue innervation – a systematic review
Sueters, J., van Heiningen, R., de Vries, R., Güler, Z., Huirne, J. A. F., & Smit, T. H. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251316918 · Cited by 10 · see citing works
Yang, L., Li, W., Xie, Y., Ma, S., Zhou, X., Huang, X., & Tan, S. (2023) · BMC Neurology · doi:10.1186/s12883-023-03162-1 · Cited by 10 · see citing works
Autonomic symptoms and associated factors in patients with chronic heart failure
Silva, H. D., Pardaens, S., Vanderheyden, M., SUTTER, J. D., Demeyer, H., Pauw, M. D., Demulier, L., Stautemas, J., & Calders, P. (2021) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2021.2010953 · Cited by 9 · see citing works
Hanken, K., Sander, C., Schlake, H.-P., Kastrup, A., Eling, P., & Hildebrandt, H. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101401 · Cited by 8 · see citing works
Can biofeedback-based training alleviate fatigue and vigilance performance in fatigued MS patients?
Sander, C., Braun, N., Modes, F., Schlake, H.-P., Eling, P., & Hildebrandt, H. (2020) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2020.1808023 · Cited by 8 · see citing works
Hayashi, T., Nakane, S., Mukaino, A., Higuchi, O., Yamakawa, M., Matsuo, H., & Kimura, K. (2022) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864221110048 · Cited by 8 · see citing works
Ahn, J. H., Seok, J. M., Park, J., Jeong, H., Kim, Y., Song, J., Choi, I., Cho, J. W., Min, J., Kim, B. J., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258897 · Cited by 7 · see citing works
Gastrointestinal Dysfunction in Multiple Sclerosis and Related Conditions
Sakakibara, R. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1771462 · Cited by 7 · see citing works
Dinoto, A., Baldini, S., Morelli, M. E., Pasquin, F., Bratina, A., Bosco, A., Sartori, A., & Manganotti, P. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05487-6 · Cited by 7 · see citing works
gAChR antibodies in children and adolescents with acquired autoimmune dysautonomia in Japan
Yamakawa, M., Watari, M., Torii, K.-I., Kuki, I., Miharu, M., Kawazu, M., Mukaino, A., Higuchi, O., Maeda, Y., Ikeda, T., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51317 · Cited by 5 · see citing works
Crnošija, L., Moštak, I., Višnjić, N., Junaković, A., Karić, A., Adamec, I., Skorić, M. K., & Habek, M. (2022) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2022.06.003 · Cited by 5 · see citing works
Andabaka, M., Pekmezovic, T. D., Crnošija, L., Veselinovic, N., Junaković, A., Tamaš, O., Budimkic, M. S., Jovičević, V., Momčilović, N., Roganović, M., et al. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.104953 · Cited by 4 · see citing works
Lizarraga, A., Rammohan, K. W., Weinstock‐Guttman, B., & Sharma, K. R. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103254 · Cited by 4 · see citing works
Association of Autonomic Symptom Burden with Sudden Sensorineural Hearing Loss
Yang, C., Lin, W., Chen, W., Luo, S., Yang, M., Hwang, C., & Chen, S. (2023) · Otolaryngology · doi:10.1002/ohn.560 · Cited by 4 · see citing works
Assessing the structural and functional changes in vagus nerve in multiple sclerosis
Abdelnaby, R., Meshref, M. M., Gaber, D. E., Mohamed, K. A., Madhav, N., & Elshabrawy, H. A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110863 · Cited by 3 · see citing works
Autonomic dysfunction in multiple sclerosis and neuromyelitis optica spectrum disorder
Kwon, S., & Min, J. (2023) · Annals of Clinical Neurophysiology · doi:10.14253/acn.2023.25.1.19 · Cited by 3 · see citing works
Palliative Care in Neurological Diseases
Nair, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-3390-3_20 · Cited by 3 · see citing works
DiCriscio, A. S., Beiler, D., Smith, J., Asdell, P. B., Dickey, S., DiStefano, M. T., & Troiani, V. (2023) · Research in Autism · doi:10.1016/j.rasd.2023.102234 · Cited by 2 · see citing works
Nakane, S., Mukaino, A., Okumura, Y., Hirosawa, H., Higuchi, O., Matsuo, H., Kainuma, M., & Nakatsuji, Y. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14050485 · Cited by 3 · see citing works
Goldman, M. D., Lobo, J. M., Min, S., Canissario, R., & Sohn, M. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104194 · Cited by 2 · see citing works
Chnitir, S., Souissi, A., Gharbi, A., Abida, Y., Atrous, A., Mrabet, S., Kacem, I., Gargouri, A., & Gouider, R. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106409 · Cited by 1 · see citing works
Gurau, A., Nizam, W., Khan, H., Seshadri, N., Kim, C. G., Yamauchi, S., Collaço, R. D. C., Ma, R., Ecoff, K., Cruyssen, J. V., et al. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01178-w · Cited by 1 · see citing works
Neurocardiology Update: The Brain–Heart Connection in Multiple Sclerosis—A Narrative Review
Gherghel, N., Pavăl, D., Stan, A. D., Orasan, O. H., Sitar-Tăut, A., & Cozma, A. (2025) · Health Science Reports · doi:10.1002/hsr2.70607 · Cited by 1 · see citing works
Cognition, disease activity and MRI changes in early multiple sclerosis
Nygaard, G. O. (2016) · NORA - Norwegian Open Research Archives
Liu, Y., Meng, L., Li, J., Wang, X., Zhang, X., Kong, X., & Zhang, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1698950
Yang, L., Li, W., Xie, Y., Ma, S., Zhou, X., Huang, X., & Tan, S. (2023) · Figshare · doi:10.6084/m9.figshare.22625642
Tekin, R. T., Aslan, H., & Vural, G. (2025) · Karya Journal of Health Science · doi:10.52831/kjhs.1711721
Bossola, M., Mariani, I., Piccinni, C. P., & Stasio, E. D. (2026) · Hemodialysis International · doi:10.1111/hdi.70059
Dysautonomia and joint hypermobility reflect a distinct subtype in eosinophilic esophagitis
Patel, R. H., Peraza, R., Keeley, K., Dehghani, Z., Singer, W., Fortunato, J. E., Osgood, P. T., Hoffmann, N. V., White, M. J. V., & Wechsler, J. B. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.05.027
Cortez, M. M., Cook, G., Miglis, M. G., Raj, S. R., Robbins, N. M., Singer, W., Sletten, D. M., Stino, A. M., & Vernino, S. A. (2026) · Clinical Autonomic Research · doi:10.1007/s10286-026-01238-9
- Authors
- Cortez, M. M., Nagi Reddy, S. K., Goodman, B., Carter, J. L., & Wingerchuk, D. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Cortez, M.M.
- Goodman, B.
- Carter, J.L.
- Wingerchuk, D.M.
- Venue
- Multiple Sclerosis and Related Disorders
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 4
- Issue
- 3
- Pages
- 258-263
- ISSN
- 2211-0348 (ISSN-L)
- OpenAlex
- W2092678919
- Cited by
- 59
- References
- 36
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 8 · 2022: 9 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis and Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- Mayo Foundation for Medical Education and Research
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- multiple sclerosis, autonomic dysfunction, fatigue, quality of life, dizziness, disability, disease duration, COMPASS-31, MSQOL-54, Fatigue Severity Scale
- MeSH terms
- Adult, Aged, Autonomic Nervous System Diseases, Disability Evaluation, Fatigue, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
