The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Functional imbalance of visual pathways indicates alternative face processing strategies in autism
Abstract
OBJECTIVE: To investigate whether autistic subjects show a different pattern of neural activity than healthy individuals during processing of faces and complex patterns. METHODS: Blood oxygen level-dependent (BOLD) signal changes accompanying visual processing of faces and complex patterns were analyzed in an autistic group (n = 7; 25.3 [6.9] years) and a control group (n = 7; 27.7 [7.8] years). RESULTS: Compared with unaffected subjects, autistic subjects demonstrated lower BOLD signals in the fusiform gyrus, most prominently during face processing, and higher signals in the more object-related medial occipital gyrus. Further signal increases in autistic subjects vs controls were found in regions highly important for visual search: the superior parietal lobule and the medial frontal gyrus, where the frontal eye fields are located. CONCLUSIONS: The cortical activation pattern during face processing indicates deficits in the face-specific regions, with higher activations in regions involved in visual search. These findings reflect different strategies for visual processing, supporting models that propose a predisposition to local rather than global modes of information processing in autism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“numerous imaging studies have shown reduced activation in the fusiform face area (FFA) in individuals with ASD (Corbett et al., 2009; Hubl et al., 2003; Pierce et al., 2001)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Hubl et al., 2003
Citations
Cites
The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Linguistic complexity: locality of syntactic dependencies
Gibson, E. (1998) · Cognition · doi:10.1016/s0010-0277(98)00034-1 · Cited by 2,537
Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex.
Malach, R., Reppas, J. B., Benson, R. R., Kwong, K. K., Jiang, H., Kennedy, W. A., Ledden, P. J., Brady, T. J., Rosen, B. R., & Tootell, R. B. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8135 · Cited by 1,761
Expertise for cars and birds recruits brain areas involved in face recognition
Gauthier, I., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Nature Neuroscience · doi:10.1038/72140 · Cited by 1,418
Schultz, R. T., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A. W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D. J., & Gore, J. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.331 · Cited by 1,000
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898
The fusiform “face area” is part of a network that processes faces at the individual level
Gauthier, I., Tarr, M. J., Moylan, J., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562165 · Cited by 859
Research works printed but not linked: 3
- Bölte S, Poustka F. The factor structure of the Autism Diagnostic Interview–Revised (ADI-R): a study on the dimensional versus categorical classification of autistic disorders. Z Kinder Jug Psych . 2001; 29: 221–229.
- Doepfner M, Berner W, Leventhal BL. Reliability and factorial validity of the Youth Self-Report of the Child Behavior Checklist in a clinical sample. Diagnostica . 1995; 41: 221–244.
- Ekman P Friesen WV. Pictures of facial affects. San Francisco: Consulting Psychologist Press 1979.
Cited by
Sorted by citations
Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception
Mottron, L., Dawson, M., Soulières, I., Hubert, B., & Burack, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0040-7 · Cited by 1,957
Blair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071
Harms, M. B., Martin, A., & Wallace, G. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9138-6 · Cited by 1,028
Vision in autism spectrum disorders
Simmons, D. R., Robertson, A. E., McKay, L. S., Toal, E., McAleer, P., & Pollick, F. E. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.005 · Cited by 827
Metadata
- Authors
- Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T.
- Affiliations
- From the Department of Psychiatric Neurophysiology (Drs. Hubl, Federspiel, Strik, and Dierks), University Hospital of Clinical Psychiatry, Bern, Switzerland; and Department of Child and Adolescent Psychiatry (Drs. Bölte and Pousstka, S. Feineis–Matthews) and Institute of Neuroradiology (Dr. Lanfermann), Department of Radiology, University of Frankfurt, Germany.
- Venue
- Neurology
- Published
- 2003-11-11
- Volume
- 61
- Issue
- 9
- Pages
- 1232-1237
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2007787462
- Cited by
- 283
- References
- 43
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 19 · 2012: 15
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- autism spectrum disorder, face processing, visual pathway, fusiform gyrus, visual search, frontal eye field, superior parietal lobule, cortical activation
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Autistic Disorder, Behavior, Brain, Brain Mapping, Emotions, Face, Humans, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Photic Stimulation, Visual Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
