Cited by 283Autism Spectrum Disorder ResearchFace Recognition and PerceptionVisual perception and processing mechanisms

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Functional imbalance of visual pathways indicates alternative face processing strategies in autism

Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., Dierks, T.·2003·Neurology

DOI 10.1212/01.wnl.0000091862.22033.1a

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Abstract

OBJECTIVE: To investigate whether autistic subjects show a different pattern of neural activity than healthy individuals during processing of faces and complex patterns. METHODS: Blood oxygen level-dependent (BOLD) signal changes accompanying visual processing of faces and complex patterns were analyzed in an autistic group (n = 7; 25.3 [6.9] years) and a control group (n = 7; 27.7 [7.8] years). RESULTS: Compared with unaffected subjects, autistic subjects demonstrated lower BOLD signals in the fusiform gyrus, most prominently during face processing, and higher signals in the more object-related medial occipital gyrus. Further signal increases in autistic subjects vs controls were found in regions highly important for visual search: the superior parietal lobule and the medial frontal gyrus, where the frontal eye fields are located. CONCLUSIONS: The cortical activation pattern during face processing indicates deficits in the face-specific regions, with higher activations in regions involved in visual search. These findings reflect different strategies for visual processing, supporting models that propose a predisposition to local rather than global modes of information processing in autism.

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The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738
The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Pictures of Facial Affect
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Linguistic complexity: locality of syntactic dependencies
Gibson, E. (1998) · Cognition · doi:10.1016/s0010-0277(98)00034-1 · Cited by 2,537
Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex.
Malach, R., Reppas, J. B., Benson, R. R., Kwong, K. K., Jiang, H., Kennedy, W. A., Ledden, P. J., Brady, T. J., Rosen, B. R., & Tootell, R. B. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8135 · Cited by 1,761
Expertise for cars and birds recruits brain areas involved in face recognition
Gauthier, I., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Nature Neuroscience · doi:10.1038/72140 · Cited by 1,418
Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome
Schultz, R. T., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A. W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D. J., & Gore, J. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.331 · Cited by 1,000
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898
The fusiform “face area” is part of a network that processes faces at the individual level
Gauthier, I., Tarr, M. J., Moylan, J., Skudlarski, P., Gore, J. C., & Anderson, A. W. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562165 · Cited by 859
The functional neuroanatomy of social behaviour
Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., et al. (2000) · Brain · doi:10.1093/brain/123.11.2203 · Cited by 816
Location and function of the human frontal eye-field: A selective review
Paus, T. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00134-4 · Cited by 762
Activation of Heschl’s Gyrus during Auditory Hallucinations
Dierks, T., Linden, D. E. J., Jandl, M., Formisano, E., Goebel, R., Lanfermann, H., & Singer, W. (1999) · Neuron · doi:10.1016/s0896-6273(00)80715-1 · Cited by 752
Self-citation
The Effect of Face Inversion on Activity in Human Neural Systems for Face and Object Perception
Haxby, J. V., Ungerleider, L. G., Clark, V. P., Schouten, J. L., Hoffman, E. A., & Martin, A. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80690-x · Cited by 657
FFA: a flexible fusiform area for subordinate-level visual processing automatized by expertise
Tarr, M. J., & Gauthier, L. (2000) · Nature Neuroscience · doi:10.1038/77666 · Cited by 645
Superior visual search in autism.
O'riordan, M., Plaisted, K., Driver, J., & Baron-Cohen, S. (2001) · Journal of Experimental Psychology: Human Perception and Performance · doi:10.1037/0096-1523.27.3.719 · Cited by 624
Distributed Neural Systems for the Generation of Visual Images
Ishai, A., Ungerleider, L. G., & Haxby, J. V. (2000) · Neuron · doi:10.1016/s0896-6273(00)00168-9 · Cited by 579
Superior visual search in autism.
O’Riordan, M., Plaisted, K. C., Driver, J., & Baron‐Cohen, S. (2001) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.27.3.719 · Cited by 557
The Generality of Parietal Involvement in Visual Attention
Wojciulik, E., & Kanwisher, N. (1999) · Neuron · doi:10.1016/s0896-6273(01)80033-7 · Cited by 548
Face encoding and recognition in the human brain.
Haxby, J. V., Ungerleider, L. G., Horwitz, B., Maisog, J. M., Rapoport, S. I., & Grady, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.922 · Cited by 508
What's in a face? The case of autism
Hobson, R. P., Ouston, J., & Lee, A. L. (1988) · British Journal of Psychology · doi:10.1111/j.2044-8295.1988.tb02745.x · Cited by 452
The effect of face inversion on the human fusiform face area
Kanwisher, N., Tong, F., & Nakayama, K. (1998) · Cognition · doi:10.1016/s0010-0277(98)00035-3 · Cited by 434
Unraveling mechanisms for expert object recognition: Bridging brain activity and behavior.
Gauthier, L., & Tarr, M. J. (2002) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.28.2.431 · Cited by 424
Random Effects Analysis
Penny, W. D., & Holmes, A. J. (2007) · Elsevier eBooks · doi:10.1016/b978-012372560-8/50012-7 · Cited by 406
Unfamiliar Face Recognition in Relatively Able Autistic Children
Boucher, J., & LEWIS, V. A. (1992) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1992.tb01960.x · Cited by 363
Image-based object recognition in man, monkey and machine
Tarr, M. J., & Bülthoff, H. (1998) · Cognition · doi:10.1016/s0010-0277(98)00026-2 · Cited by 326
Cerebral correlates of preserved cognitive skills in autism
RING, H. A., Baron‐Cohen, S., Wheelwright, S. J., Williams, S., Brammer, M. J., Andrew, C., & Bullmore, E. T. (1999) · Brain · doi:10.1093/brain/122.7.1305 · Cited by 325
Explicit and Incidental Facial Expression Processing: An fMRI Study
Gorno‐Tempini, M. L., Pradelli, S., Serafini, M., Pagnoni, G., Baraldi, P., Porro, C. A., Nicoletti, R., Umità, C., & Nichelli, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0811 · Cited by 313
Unraveling mechanisms for expert object recognition: Bridging brain activity and behavior.
Gauthier, L., & Tarr, M. J. (2002) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.28.2.431 · Cited by 302
Graded Functional Activation in the Visuospatial System with the Amount of Task Demand
Carpenter, P. A., Just, M. A., Keller, T. A., Eddy, W., & Thulborn, K. R. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563210 · Cited by 299
Enhanced discrimination in autism
O’Riordan, M., & Plaisted, K. C. (2001) · The Quarterly Journal of Experimental Psychology Section A · doi:10.1080/713756000 · Cited by 231
Do children with autism recognise surprise? A research note
Baron‐Cohen, S., Spitz, A., & Cross, P. (1993) · Cognition & Emotion · doi:10.1080/02699939308409202 · Cited by 222
Functional Imaging of Visuospatial Processing in Alzheimer's Disease
Prvulovic, D., Hubl, D., Sack, A. T., Melillo, L., Maurer, K., Frölich, L., Lanfermann, H., Zanella, F., Goebel, R., Linden, D. E. J., et al. (2002) · NeuroImage · doi:10.1006/nimg.2002.1271 · Cited by 204
Self-citation
Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism
Samochowiec, J., Lesch, K., Rottmann, M., Smolka, M. N., Syagailo, Y. V., Okladnova, O., Rommelspacher, H., Winterer, G., Schmidt, L. G., & Sander, T. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00020-7 · Cited by 190
Functional Anatomy of Visual Search: Regional Segregations within the Frontal Eye Fields and Effective Connectivity of the Superior Colliculus
Gitelman, D. R., Parrish, T. B., Friston, K. J., & Mesulam, M. M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1006 · Cited by 139
An Investigation of Attention and Affect in Children with Autism and Down Syndrome
Joseph, R. M., & Tager-Flusberg, H. B. (1997) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025853321118 · Cited by 129
Direct comparison of the neural substrates of recognition memory for words and faces
Kim, J., Andreasen, N. C., OʼLeary, D. S., Wiser, A. K., Ponto, L. L. B., Watkins, G. L., & Hichwa, R. D. (1999) · Brain · doi:10.1093/brain/122.6.1069 · Cited by 117
Differential activation in parahippocampal and prefrontal cortex during word and face encoding tasks
Leube, D., Erb, M., Grodd, W., Bartels, M., & Kircher, T. T. J. (2001) · Neuroreport · doi:10.1097/00001756-200108280-00035 · Cited by 70
The Standardized Diagnosis of Autism, Autism Diagnostic Interview-Revised: Interrater Reliability of the German Form of the Interview
Poustka, F., Lisch, S., Rühl, D., Sacher, A., Schmötzer, G., & Werner, K. (2010) · Psychopathology · doi:10.1159/000284984 · Cited by 70
Self-citation
Real-Time Monitoring of Eye Movements Using Infrared Video-oculography during Functional Magnetic Resonance Imaging of the Frontal Eye Fields
Gitelman, D. R., Parrish, T. B., LaBar, K. S., & Mesulam, M. M. (2000) · NeuroImage · doi:10.1006/nimg.1999.0517 · Cited by 65
Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: a case study of parietal lobe function in a patient with Huntington's disease
Dierks, T., Linden, D. E. J., Hertel, A., Günther, T., Lanfermann, H., Niesen, A., Frölich, L., Zanella, F. E., Hör, G., Goebel, R., et al. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00040-7 · Cited by 45
Self-citation
Magnetic Resonance Imaging of Human Brain Function
Bandettini, P. A., & Wong, E. C. (1997) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30309-7 · Cited by 44
Die Faktorenstruktur des Autismus Diagnostischen Interviews-Revision (ADI-R): Eine Untersuchung zur dimensionalen versus kategorialen Klassifikation autistischer Störungen
Bölte, S., & Poustka, F. (2001) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024//1422-4917.29.3.221 · Cited by 39
Self-citation
Activation of Broca's area by syntactic processing under conditions of concurrent articulation
Caplan, D., Alpert, N., Waters, G., & Olivieri, A. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200002)9:2

Research works printed but not linked: 3

Bölte S, Poustka F. The factor structure of the Autism Diagnostic Interview–Revised (ADI-R): a study on the dimensional versus categorical classification of autistic disorders. Z Kinder Jug Psych . 2001; 29: 221–229.
Doepfner M, Berner W, Leventhal BL. Reliability and factorial validity of the Youth Self-Report of the Child Behavior Checklist in a clinical sample. Diagnostica . 1995; 41: 221–244.
Ekman P Friesen WV. Pictures of facial affects. San Francisco: Consulting Psychologist Press 1979.

Sorted by citations

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Mottron, L., Dawson, M., Soulières, I., Hubert, B., & Burack, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-005-0040-7 · Cited by 1,957
Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations
Blair, R. J. R. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2005.06.004 · Cited by 1,365
Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071
Facial emotion recognition in autism spectrum disorders: a review of behavioral and neuroimaging studies
Harms, M. B., Martin, A., & Wallace, G. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9138-6 · Cited by 1,028
Vision in autism spectrum disorders
Simmons, D. R., Robertson, A. E., McKay, L. S., Toal, E., McAleer, P., & Pollick, F. E. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.005 · Cited by 827

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Authors: Hubl, D., Bölte, S., Feineis–Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T.
Affiliations: From the Department of Psychiatric Neurophysiology (Drs. Hubl, Federspiel, Strik, and Dierks), University Hospital of Clinical Psychiatry, Bern, Switzerland; and Department of Child and Adolescent Psychiatry (Drs. Bölte and Pousstka, S. Feineis–Matthews) and Institute of Neuroradiology (Dr. Lanfermann), Department of Radiology, University of Frankfurt, Germany.
ORCID: Hubl, D.
Lanfermann, H.
Federspiel, A.
Strik, W.
Dierks, T.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-11-11
Volume: 61
Issue: 9
Pages: 1232-1237
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000091862.22033.1a
OpenAlex: W2007787462
Cited by: 283
References: 43
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 14 · 2019: 9 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 19 · 2012: 15
FWCI: 7.78
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
BORIS (University Library Bern) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords: autism spectrum disorder, face processing, visual pathway, fusiform gyrus, visual search, frontal eye field, superior parietal lobule, cortical activation
MeSH terms: Adolescent, Adult, Analysis of Variance, Autistic Disorder, Behavior, Brain, Brain Mapping, Emotions, Face, Humans, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Photic Stimulation, Visual Pathways

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Functional imbalance of visual pathways indicates alternative face processing strategies in autism

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