Neuroimaging of peroxisome biogenesis disorders (Zellweger spectrum) with prolonged survival
Abstract
OBJECTIVE: To define neuroimaging characteristics of peroxisome biogenesis disorders (PBD) with prolonged survival belonging to the Zellweger spectrum (ZeS). METHODS: The authors studied MR images of 25 patients surviving the first year. Neuroimages were compared to neurologic profiles, PBD-ZeS specific compound developmental scores, and two common PEX1 mutations. RESULTS: Three groups are defined based on normal findings, developmental anomalies, and regressive changes. Regressive changes consisting of leukoencephalopathy were identified in patients who had either stable clinical course or progressive deterioration. Concomitant neocortical atrophy was encountered in a minority. Leukoencephalopathy with stable clinical course represents the largest subgroup (48%). The authors found the central cerebellar white matter a focus for early changes in both asymptomatic and symptomatic leukoencephalopathy. A relationship between white matter involvement in clinically stable leukoencephalopathy and degree of developmental failure could not be established. The common homozygous PEX1 G843D mutation is represented in the three main outcome groups. This result points to variable phenotypic expression of the most common PEX1 mutation. CONCLUSIONS: MR findings in ZeS patients surviving the first year differ from Zellweger syndrome in predominance of regressive over developmental changes. Distribution pattern suggests identical pathomechanisms for symptomatic and asymptomatic leukoencephalopathy.
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Neurological manifestations in PBD vary from primarily neurodevelopmental alterations in the most severe phenotypes to mainly degenerative abnormalities in the milder cases.
“In accordance, also the neurological manifestations vary from primarily neurodevelopmental alterations in the most severe phenotypes to mainly degenerative abnormalities in the milder cases [48].”
From Peroxisomes in brain development and function (2016) · cites this paper as [48]
Cites
Peroxisomal and Mitochondrial Defects in the Cerebro-Hepato-Renal Syndrome
Goldfischer, S. L., Moore, C. L., Johnson, T., Spiro, A. J., Valsamis, M. P., Wisniewski, H. K., Ritch, R. H., Norton, W. T., Rapin, I., & Gartner, L. M. (1973) · Science · doi:10.1126/science.182.4107.62 · Cited by 791 · see citing works
Phenotype of patients with peroxisomal disorders subdivided into sixteen complementation groups
Moser, A. B., Rasmussen, M., Naidu, S., Watkins, P. A., McGuinness, M. C., Hajra, A. K., Chen, G. L., Raymond, G. V., Liu, A., Gordon, D., et al. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70250-4 · Cited by 244 · see citing works
Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders
Reuber, B. E., Germain‐Lee, E. L., Collins, C. S., Morrell, J. C., Ameritunga, R., Moser, H. W., Valle, D. L., & Gould, S. J. (1997) · Nature Genetics · doi:10.1038/ng1297-445 · Cited by 234 · see citing works
Kelley, R. I., Datta, N. S., Dobyns, W. B., Hajra, A. K., Moser, A. B., Noetzel, M. J., Zackai, E. H., Moser, H. W., Opitz, J. M., & Reynolds, J. F. (1986) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320230404 · Cited by 219 · see citing works
Evrard, P., Caviness, V. S., Prats-Vinas, J., & Lyon, G. (1978) · Acta Neuropathologica · doi:10.1007/bf00689761 · Cited by 175 · see citing works
Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders
Portsteffen, H., Beyer, A., Becker, E., Epplen, C., Pawlak, A., Kunau, W., & Dodt, G. (1997) · Nature Genetics · doi:10.1038/ng1297-449 · Cited by 148 · see citing works
Stefano, N. D., Dotti, M. T., Mortilla, M., & Federico, A. (2001) · Brain · doi:10.1093/brain/124.1.121 · Cited by 133 · see citing works
Infantile Refsum disease: an inherited peroxisomal disorder
Poll‐The, B. T., Saudubray, J., de Baulny, H. O., Odi�vre, M., Scotto, J. M., Monnens, L. A. H., Govaerts, L. C. P., Roels, F., Cornelis, A., Schutgens, R. B. H., et al. (1987) · European Journal of Pediatrics · doi:10.1007/bf00441598 · Cited by 132 · see citing works
Barkovich, A. J., & Peck, W. W. (1997) · PubMed Central · Cited by 97 · see citing works
Proton NMR Spectroscopy of Cerebral Metabolic Alterations in Infantile Peroxisomal Disorders
Bruhn, H., Kruse, B., Korenke, G. C., Hanefeld, F. A., Hänicke, W., Merboldt, K. D., & Frahm, J. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199205000-00001 · Cited by 95 · see citing works
Aubourg, P., Scotto, J., Rocchiccioli, F., Feldmann-Pautrat, D., & Robain, O. (1986) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.1.77 · Cited by 77 · see citing works
Preuss, N., Brosius, U., Biermanns, M., Muntau, A. C., Conzelmann, E., & Gärtner, J. (2002) · Pediatric Research · doi:10.1203/00006450-200206000-00008 · Cited by 69 · see citing works
Brain MRI and electrophysiologic abnormalities in preclinical and clinical adrenomyeloneuropathy
Aubourg, P. R., Adamsbaum, C., Lavallard-Rousseau, M. C., Lemaitre, A., Boureau, F., Mayer, M., & Kalifa, G. (1992) · Neurology · doi:10.1212/wnl.42.1.85 · Cited by 63 · see citing works
Sharp, P. C., Johnson, D., & Poulos, A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02558.x · Cited by 58 · see citing works
Aubourg, P. R., Robain, O., Rocchiccioli, F., Dancea, S., & Scotto, J. M. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90003-6 · Cited by 51 · see citing works
Late onset white matter disease in peroxisome biogenesis disorder
Barth, P. G., Gootjes, J., Bode, H., Vreken, P., Majoie, C. B. L. M., & Wanders, R. J. A. (2001) · Neurology · doi:10.1212/wnl.57.11.1949 · Cited by 48 · see citing works
A milder variant of Zellweger syndrome
Barth, P. G., Schutgens, R. B. H., Bakkeren, J. A. J. M., Dingemans, K. P., Heymans, H. S. A., Douwes, A. C., & Moorsel, J. M. V. D. K. (1985) · European Journal of Pediatrics · doi:10.1007/bf00441774 · Cited by 41 · see citing works
Barth, P. G., Wanders, R. J. A., Schutgens, R. B. H., Bleeker‐Wagemakers, E. M., & van Heemstra, D. (1990) · European Journal of Pediatrics · doi:10.1007/bf01959531 · Cited by 28 · see citing works
Groenendaal, F., Bianchi, M. C., Battini, R., Tosetti, M., Boldrini, A., de Vries, L. S., & Cioni, G. (2001) · Neuropediatrics · doi:10.1055/s-2001-12218 · Cited by 25 · see citing works
Ataxia and peripheral neuropathy: A benign variant of peroxisome dysgenesis
MacCollin, M., Vivo, D. C. D., Moser, A. B., & Beard, M. E. (1990) · Annals of Neurology · doi:10.1002/ana.410280617 · Cited by 20 · see citing works
Diagnosis and Follow-Up of a Case of Peroxisomal Disorder With Peroxisomal Mosaicism
Pineda, M., Girós, M., Roels, F., Espeel, M., Ruíz, M., Moser, A. B., Moser, H. W., Wanders, R. J. A., Pavía, C., Conill, J., et al. (1999) · Journal of Child Neurology · doi:10.1177/088307389901400705 · Cited by 19 · see citing works
Long Survival in a Case of Peroxisomal Biogenesis Disorder with Peroxisome Mosaicism in the Liver
Girós, M., Roels, F., Prats, J. M., Ruíz, M., Ribes, A., Espeel, M., Wanders, R. J. A., Schutgens, R. B. H., & Pàmpols, T. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb18689.x · Cited by 16 · see citing works
Wanders, R. J. A., Mooijer, P. A. W., Dekker, C., Suzuki, Y., & Shimozawa, N. (1999) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1005504104541 · Cited by 14 · see citing works
Myelination and Retarded Myelination
van der Knaap, M. S., & Valk, J. (1995) · Springer eBooks · doi:10.1007/978-3-662-03078-3_4 · Cited by 14 · see citing works
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Clinical and biochemical spectrum of D‐bifunctional protein deficiency
Ferdinandusse, S., Denis, S. W., Mooyer, P. A. W., Dekker, C., Durán, M., Soorani‐Lunsing, R. J., Boltshauser, E., Macaya, A., Gärtner, J., Majoie, C. B. L. M., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20702 · Cited by 198 · see citing works
Peroxisomes in brain development and function
Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works
Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives
Braverman, N., D’Agostino, D., & MacLean, G. E. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1113 · Cited by 162 · see citing works
Peroxisome biogenesis disorders
Argyriou, C., D’Agostino, D., & Braverman, N. (2016) · Translational Science of Rare Diseases · doi:10.3233/trd-160003 · Cited by 126 · see citing works
Trompier, D., Véjux, A., Zarrouk, A., Gondcaille, C., Geillon, F., Nury, T., Savary, S., & Lizard, G. (2013) · Biochimie · doi:10.1016/j.biochi.2013.09.009 · Cited by 99 · see citing works
Zellweger spectrum disorders: clinical manifestations in patients surviving into adulthood
Berendse, K., Engelen, M., Ferdinandusse, S., Majoie, C. B. L. M., Waterham, H. R., Vaz, F. M., Koelman, J. H. T. M., Barth, P. G., Wanders, R. J. A., & Poll‐The, B. T. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9880-2 · Cited by 91 · see citing works
“Some data from patients 1, 3–6, 8, 13–14, 16–18 (Poll-The et al 2004) and patient 4 (Ebberink et al 2012) were reported previously.”
Clinical diagnosis, biochemical findings and MRI spectrum of peroxisomal disorders
Poll-The, B. T., & Gärtner, J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.03.011 · Cited by 85 · see citing works
Bottelbergs, A., Verheijden, S., Van Veldhoven, P. P., Just, W., Devos, R., & Baes, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-61 · Cited by 66 · see citing works
Peroxisomes, myelination, and axonal integrity in the CNS
Baes, M., & Aubourg, P. (2009) · The Neuroscientist · doi:10.1177/1073858409336297 · Cited by 65 · see citing works
Cerebral MRI as a valuable diagnostic tool in Zellweger spectrum patients
Weller, S., Rosewich, H., & Gärtner, J. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-0856-3 · Cited by 58 · see citing works
“These studies contributed 25 of the patients (Barth et al 2001, 2004).”
BackgroundResultInfluentialPeroxisomal acyl‐CoA‐oxidase deficiency: Two new cases
Carrozzo, R., Bellini, C., Lucioli, S., Deodato, F., Cassandrini, D., Cassanello, M., Caruso, U., Rizzo, C., Rizza, T., Napolitano, M. L., et al. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32298 · Cited by 40 · see citing works
“On the other hand, our second patient showed polymicrogyria that represents a frequent finding in Zellweger spectrum disorders [Barth et al., 2004] and D-bifunctional protein deficiency [Watkins et al.”
BackgroundPEX1mutations in the Zellweger spectrum of the peroxisome biogenesis disorders
Crane, D. I., Maxwell, M., & Paton, B. C. (2005) · Human Mutation · doi:10.1002/humu.20211 · Cited by 39 · see citing works
“The problem of phenotypic overlap is even apparent for some G843D homozygotes classified as having mild disease, with reports of renal cysts and optic atrophy [Preuss et al., 2002] and discordant neuroimaging findings [Barth et al., 2004] – features that are more typical of the ZS phenotype.”
BackgroundResultZellweger Spectrum Disorder with Mild Phenotype Caused by PEX2 Gene Mutations
Mignarri, A., Vinciguerra, C., Giorgio, A., Ferdinandusse, S., Waterham, H. R., Wanders, R. J. A., Bertini, E., Dotti, M. T., & Federico, A. (2012) · JIMD Reports · doi:10.1007/8904_2011_102 · Cited by 37 · see citing works
Diagnosis of a mild peroxisomal phenotype with next-generation sequencing
Ventura, M. J., Wheaton, D. K., Xu, M., Birch, D. G., Bowne, S. J., Sullivan, L. S., Daiger, S. P., Whitney, A. E., Jones, R. O., Moser, A. B., et al. (2016) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2016.10.006 · Cited by 36 · see citing works
Leukodystrophies and other genetic metabolic leukoencephalopathies in children and adults
Kohlschütter, A., Bley, A. E., Brockmann, K., Gärtner, J., Krägeloh‐Mann, I., Rolfs, A., & Schöls, L. J. (2009) · Brain and Development · doi:10.1016/j.braindev.2009.03.014 · Cited by 29 · see citing works
Neurometabolic diseases of childhood
Patay, Z. J., Blasér, S., Poretti, A., & Huisman, T. A. G. M. (2015) · Pediatric Radiology · doi:10.1007/s00247-015-3279-y · Cited by 28 · see citing works
In Vivo NMR Studies of the Brain with Hereditary or Acquired Metabolic Disorders
Sherry, E. B., Lee, P., & Choi, I.-Y. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1772-1 · Cited by 18 · see citing works
Clinical and Neuroimaging Spectrum of Peroxisomal Disorders
Tan, A. P., Gonçalves, F. G., Almehdar, A., & Soares, B. P. (2018) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000172 · Cited by 16 · see citing works
Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration
Amin, S., & Taverna, E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600034 · Cited by 13 · see citing works
Barth, P. G. (2011) · Brain and Development · doi:10.1016/j.braindev.2011.02.008 · Cited by 9 · see citing works
“Better resolution is obtained when the signal of the surrounding white matter becomes altered, as in the case of white matter disorders such as L2-hydroxyglutaric aciduria and some peroxisomal disorders that involve peroxisomal beta oxidation [9,10].”
BackgroundBraverman, N., Argyriou, C., & Moser, A. B. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1788-0_4 · Cited by 7 · see citing works
“Brain MRI imaging can also be normal, but there is an unknown risk for the occurrence of demyelination over time, which can stabilize or progress (Barth et al. 2004).”
BackgroundGenetic and Metabolic Disorders of the White Matter
Vanderver, A. L., & Wolf, N. I. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0435-8.00071-8 · Cited by 6 · see citing works
Engelen, M. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-323-99209-1.00021-1 · Cited by 5 · see citing works
A founder mutation in PEX12 among Egyptian patients in peroxisomal biogenesis disorder
Zaki, M. S., Issa, M. Y., Thomas, M. M., Elbendary, H. M., Rafat, K., Menabawy, N. M. A., Selim, L., Ismail, S. I., Abdel‐Salam, G. M. H., & Gleeson, J. G. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04843-2 · Cited by 5 · see citing works
First Japanese case of Zellweger syndrome with a mutation in PEX14
Komatsuzaki, S., Ogawa, E., Shimozawa, N., Sakamoto, O., Haginoya, K., Uematsu, M., Hasegawa, Y., Matsubara, Y., & Ohura, T. (2015) · Pediatrics International · doi:10.1111/ped.12713 · Cited by 5 · see citing works
Neuroimaging in Children With Inherited Metabolic Epilepsies
Latzer, I. T., Yang, E., de Figueiredo, V. L. P., Huang, S. Y., Matsubara, T., & Pearl, P. L. (2025) · Neurology · doi:10.1212/wnl.0000000000213485 · Cited by 4 · see citing works
“Of interest, leukoencephalopathy has been described described to reverse in response to the ketogenic diet.”
Genetic and Metabolic Disorders of the White Matter
Vanderver, A. L., & Wolf, N. I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-37101-8.00099-0 · Cited by 4 · see citing works
Poll‐The, B. T., Aubourg, P. R., & Wanders, R. J. A. (2011) · Springer eBooks · doi:10.1007/978-3-642-15720-2_41 · Cited by 4 · see citing works
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Wanders, R. J. A. (2005) · Springer eBooks · doi:10.1007/3-540-27660-2_17 · Cited by 3 · see citing works
If at first you don't succeed, test again (for peroxisomal biogenesis disorders)
Vanderver, A. L. (2012) · Neurology · doi:10.1212/wnl.0b013e3182535d47 · Cited by 3 · see citing works
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Roczkowsky, A., Rachubinski, R. A., Hobman, T. C., & Power, C. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1642590 · Cited by 2 · see citing works
Wanders, R. J. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00110-5 · Cited by 2 · see citing works
Hellings, T. P., Lamzira-Arichi, N., Vreijling, J. P., Mei, H., Cats, D., Kuipers, T. B., Derks, R. J. E., Heijink, M., Blomberg, N., Сидоров, И. В., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101018 · Cited by 1 · see citing works
“In patients with ZSD and RCDP, defects of myelination are observed (56, 57).”
Zellweger Spectrum Disorders: Beyond the Peroxisome
Maheshwari, A., & Huisman, T. A. (2026) · Newborn · doi:10.5005/jp-journals-11002-0164 · Cited by 1 · see citing works
Selected Syndromes and Chromosomal Disorders
McAlister, W. H., Herman, T. E., & Kronemer, K. A. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04520-9.50174-x · Cited by 1 · see citing works
Malformations of Cortical Development
Geraldo, A. F., Rossi, A., & Severino, M. (2021) · Springer eBooks · doi:10.1007/978-3-662-46258-4_6-1 · Cited by 2 · see citing works
(2005) · Springer eBooks · doi:10.1007/3-540-27660-2_18 · Cited by 1 · see citing works
Inherited Metabolic and Neurodegenerative Brain Disorders
Cecil, K. M., & Faerber, E. N. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04520-9.50057-5
Poll‐The, B. T., Aubourg, P. R., & Wanders, R. J. A. (2006) · Springer eBooks · doi:10.1007/978-3-540-28785-8_40
Lachman, R. S. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-01931-6.50034-7
Raymond, G. V., Baranano, K. W., Wangler, M. F., & Fatemi, A. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-10944-7.00065-2
A brief history of the human liver peroxisome
Craemer, D. D., Branden, C. V. D., & Roels, F. (2026) · Histochemistry and Cell Biology · doi:10.1007/s00418-026-02495-5
“…Zellweger spectrum disorder concluded that “next to the PEX1 genotype other yet unknown factors determine the ultimate phenotype”; the presence of peroxisomal mosaics was not considered (Poll-The et al. 2004), although the authors were acquainted with two published mosaic cases (Barth et al. 2004).”
- Authors
- Barth, P. G., Majoie, C. B. L. M., Gootjes, J., Wanders, R. J. A., Waterham, H. R., van der Knaap, M. S., de Klerk, J. B. C., Smeitink, J., & Poll-The, B. T.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- From the Departments of Pediatric Neurology (Drs. Barth and Poll-The) and Pediatrics (Drs. Wanders and Waterham, J. Gootjes) and the Laboratory of Genetic Metabolic Disease (Drs. Wanders and Waterham, J. Gootjes), Emma Children’s Hospital, and the Department of Radiology (Dr. Majoie), Academic Medical Center, University of Amsterdam; the Department of Child Neurology (Dr. van der Knaap), Vrije Universiteit Medical Center, Amsterdam; the Department of Pediatrics, Sofia Children’s Hospital (Dr. de...
- Venue
- Neurology
- Published
- 2004-02-10
- Volume
- 62
- Issue
- 3
- Pages
- 439-444
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2143020603
- Cited by
- 43
- References
- 24
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 5
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- peroxisome biogenesis disorders, Zellweger syndrome, leukoencephalopathy, cerebellar white matter, development failure, phenotypic variability, MRI findings, long-term survival
- MeSH terms
- ATPases Associated with Diverse Cellular Activities, Adolescent, Adult, Atrophy, Cerebral Ventricles, Child, Child, Preschool, Female, Humans, Infant, Male, Membrane Proteins, Myelin Sheath, Phenotype, Zellweger Syndrome, Survival Analysis, Disease Progression, Neocortex, Amino Acid Substitution, Mutation, Missense
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