Peroxisomes, myelination, and axonal integrity in the CNS

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 39,119 · see citing works

A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood

Guindon, S., & Gascuel, O. (2003) · Systematic Biology · doi:10.1080/10635150390235520 · Cited by 16,698 · see citing works

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment

Kumar, S. (2004) · Briefings in Bioinformatics · doi:10.1093/bib/5.2.150 · Cited by 11,642 · see citing works

A simple method for organotypic cultures of nervous tissue

Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism

Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,079 · see citing works

ProtTest: selection of best-fit models of protein evolution

Abascal, F., Zardoya, R., & Posada, D. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti263 · Cited by 3,063 · see citing works

Direct transesterification of all classes of lipids in a one-step reaction.

Lepage, G., & ROY, C. C. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38861-1 · Cited by 2,385 · see citing works

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724 · see citing works

Metabolism and functions of glutathione in brain

Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702 · see citing works

Peroxisomes (microbodies and related particles).

De Duve, C., & Baudhuin, P. (1966) · Physiological Reviews · doi:10.1152/physrev.1966.46.2.323 · Cited by 1,666 · see citing works

The PredictProtein server

Rost, B., Yachdav, G., & Liu, J. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh377 · Cited by 1,462 · see citing works

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillée, S., Rule, M., McMahon, A. P., Doucette, W. T., Siwek, D. F., Ferrante, R. J., et al. (2003) · Science · doi:10.1126/science.1086071 · Cited by 1,101 · see citing works

The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina

Lauritzen, L. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00017-5 · Cited by 1,066 · see citing works

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036 · see citing works

Biochemistry of mammalian peroxisomes revisited

Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995 · see citing works

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889 · see citing works

Metabolism of highly unsaturated n-3 and n-6 fatty acids

Sprecher, H. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00077-9 · Cited by 869 · see citing works

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease

Brenner, M., Johnson, T., Boespflug‐Tanguy, O., Rodriguez, D., Goldman, J. E., & Messing, A. (2001) · Nature Genetics · doi:10.1038/83679 · Cited by 689 · see citing works

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study

Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686 · see citing works

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669 · see citing works

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637 · see citing works

Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 1: micronutrients.

Bourre, J. M. (2006) · PubMed · Cited by 609 · see citing works

Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy

Rost, B., Fariselli, P., & Casadio, R. (1996) · Protein Science · doi:10.1002/pro.5560050824 · Cited by 606 · see citing works

Role of omega-3 fatty acids in brain development and function: Potential implications for the pathogenesis and prevention of psychopathology

McNamara, R. K., & Carlson, S. E. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.010 · Cited by 546 · see citing works

Peroxisome biogenesis disorders

Steinberg, S. J., Dodt, G., Raymond, G. V., Braverman, N. E., Moser, A. B., & Moser, H. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.010 · Cited by 522 · see citing works

Fatty Acid Regulation of Hepatic Gene Transcription

Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Christian, B., & Demeure, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2503 · Cited by 477 · see citing works

Contribution of the Endoplasmic Reticulum to Peroxisome Formation

Hoepfner, D., Schildknegt, D., Braakman, I., Philippsen, P., & Tabak, H. F. (2005) · Cell · doi:10.1016/j.cell.2005.04.025 · Cited by 463 · see citing works

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

Lepore, A. C., Rauck, B., Dejea, C., Pardo, A. C., Rao, M. S., Rothstein, J. D., & Maragakis, N. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2210 · Cited by 441 · see citing works

Antioxidant defense of the brain: a role for astrocytes

Wilson, J. X. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-146 · Cited by 430 · see citing works

Polyunsaturated Fatty Acid Regulation of Gene Expression

Sessler, A. M., & Ntambi, J. M. (1998) · Journal of Nutrition · doi:10.1093/jn/128.6.923 · Cited by 426 · see citing works

Functions and biosynthesis of plasmalogens in health and disease

Brites, P., Waterham, H. R., & Wanders, R. J. A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.12.010 · Cited by 415 · see citing works

The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.

Kamijo, K., Taketani, S., Yokota, S., Osumi, T., & Hashimoto, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39595-x · Cited by 391 · see citing works

Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress

Thorburne, S. K., & Juurlink, B. H. J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031014.x · Cited by 390 · see citing works

Reversal of Early Neurologic and Neuroradiologic Manifestations of X-Linked Adrenoleukodystrophy by Bone Marrow Transplantation

Aubourg, P., Blanche, S., Jambaqué, I., Rocchiccioli, F., Kalifa, G., Naud-Saudreau, C., Rolland, M.-O., Debré, M., Chaussain, J.-L., Griscelli, C., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006283222607 · Cited by 366 · see citing works

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357 · see citing works

Long-term effect of bone-marrow transplantation for childhood-onset cerebral X-linked adrenoleukodystrophy

Shapiro, E., Krivit, W., Lockman, L., Jambaqué, I., Peters, C., Cowan, M., Harris, R., Blanche, S., Bordigoni, P., Loes, D., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02629-5 · Cited by 329 · see citing works

The ABC transporter proteins Pat1 and Pat2 are required for import of long‐chain fatty acids into peroxisomes of Saccharomyces cerevisiae.

Hettema, E. H., van Roermund, C. W., Distel, B., van den Berg, M., Vilela, C., Rodrigues‐Pousada, C., Wanders, R. J., & Tabak, H. F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00755.x · Cited by 323 · see citing works

DOCOSAHEXAENOIC ACID: MEMBRANE FUNCTION AND METABOLISM

Salem, N., Kim, H., & Yergey, J. A. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-644360-8.50019-4 · Cited by 317 · see citing works

Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP

Footitt, S., Slocombe, S. P., Larner, V. S., Kurup, S., Wu, Y., Larson, T. R., Graham, I. A., Baker, A., & Holdsworth, M. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf300 · Cited by 316 · see citing works

A mouse model for X-linked adrenoleukodystrophy

Lu, J.-F., Lawler, A. M., Watkins, P. A., Powers, J. M., Moser, A. B., Moser, H. W., & Smith, K. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9366 · Cited by 293 · see citing works

Peroxisomal disorders: The single peroxisomal enzyme deficiencies

Wanders, R. J. A., & Waterham, H. R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.010 · Cited by 279 · see citing works

Membrane reconstitution of ABC transporters and assays of translocator function

Geertsma, E. R., Mahmood, N. A. B. N., Schuurman‐Wolters, G. K., & Poolman, B. (2008) · Nature Protocols · doi:10.1038/nprot.2007.519 · Cited by 267 · see citing works

Real-Time Reverse Transcription-PCR Expression Profiling of the Complete Human ATP-Binding Cassette Transporter Superfamily in Various Tissues

Langmann, T., Mauerer, R., Zahn, A., Moehle, C., Probst, M., Stremmel, W., & Schmitz, G. (2003) · Clinical Chemistry · doi:10.1373/49.2.230 · Cited by 259 · see citing works

F ATTY A CID T RANSPORT A CROSS M EMBRANES : Relevance to Nutrition and Metabolic Pathology

Hajri, T., & Abumrad, N. A. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.020402.130846 · Cited by 247 · see citing works

Peroxisomal fatty acid α- and β-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases

Wanders, R. J. A., Vreken, P., Ferdinandusse, S., Jansen, G. A., Waterham, H. R., van Roermund, C. W. T., & van Grunsven, E. G. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290250 · Cited by 246 · see citing works

Serotoninergic neurotransmission is affected by n‐3 polyunsaturated fatty acids in the rat

Kodas, E., Galineau, L., Bodard, S., Vancassel, S., Guilloteau, D., Besnard, J., & Chalon, S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02401.x · Cited by 244 · see citing works

The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl–CoA esters

van Roermund, C. W. T., Visser, W. F., IJlst, L., van Cruchten, A., Boek, M., Kulik, W., Waterham, H. R., & Wanders, R. J. A. (2008) · The FASEB Journal · doi:10.1096/fj.08-110866 · Cited by 233 · see citing works

The ether lipid-deficient mouse: Tracking down plasmalogen functions

Gorgas, K., Teigler, A., Komljenovic, D., & Just, W. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.038 · Cited by 231 · see citing works

Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice

Rodemer, C., Thai, T.-P., Brügger, B., Kaercher, T., Werner, H. B., Nave, K., Wieland, F., Gorgas, K., & Just, W. W. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg191 · Cited by 225 · see citing works

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.

Lombard-Platet, G., Savary, S., Sarde, C. O., Mandel, J. L., & Chimini, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1265 · Cited by 222 · see citing works

Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders

Wanders, R. J. A., & Waterham, H. R. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00329.x · Cited by 220 · see citing works

Transcriptional regulatory networks in lipid metabolism control ABCA1 expression

Schmitz, G., & Langmann, T. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.04.004 · Cited by 220 · see citing works

Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy

Pujol, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.499 · Cited by 214 · see citing works

Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy

Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214 · see citing works

Peroxisomal Disorders: Genotype, Phenotype, Major Neuropathologic Lesions, and Pathogenesis

Powers, J. M., & Moser, H. W. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00139.x · Cited by 208 · see citing works

Adrenomyeloneuropathy: A Neuropathologic Review Featuring Its Noninflammatory Myelopathy

Powers, J. M., DeCiero, D. P., Ito, M., Moser, A. B., & Moser, H. W. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.2.89 · Cited by 204 · see citing works

Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy

Pujol, A., Ferrer, I., Camps, C., Metzger, E., Hindelang, C., Callizot, N., Ruiz, M., Pàmpols, T., Giròs, M., & Mandel, J. L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh323 · Cited by 201 · see citing works

X-linked adrenoleukodystrophy: Clinical, biochemical and pathogenetic aspects

Berger, J., & Gärtner, J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.010 · Cited by 199 · see citing works

Clinical and biochemical spectrum of D‐bifunctional protein deficiency

Ferdinandusse, S., Denis, S. W., Mooyer, P. A. W., Dekker, C., Durán, M., Soorani‐Lunsing, R. J., Boltshauser, E., Macaya, A., Gärtner, J., Majoie, C. B. L. M., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20702 · Cited by 198 · see citing works

Abnormal profiles of polyunsaturated fatty acids in the brain, liver, kidney and retina of patients with peroxisomal disorders

Martínez, M. (1992) · Brain Research · doi:10.1016/s0006-8993(10)80021-6 · Cited by 190 · see citing works

Bioactive lipids in metabolic syndrome

Nagao, K., & Yanagita, T. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.002 · Cited by 187 · see citing works

Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

Eichler, F. S., Ren, J., Cossoy, M., Rietsch, A. M., Nagpal, S., Moser, A. B., Frosch, M. P., & Ransohoff, R. M. (2008) · Annals of Neurology · doi:10.1002/ana.21391 · Cited by 178 · see citing works

Mammalian peroxisomes and reactive oxygen species

Schrader, M., & Fahimi, H. D. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0673-1 · Cited by 177 · see citing works

Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration

Zöller, I., Meixner, M., Hartmann, D., Büssow, H., Meyer, R., Gieselmann, V., & Eckhardt, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0458-08.2008 · Cited by 174 · see citing works

From bone marrow to microglia: barriers and avenues

Davoust, N., Vuaillat, C., Androdias, G., & Nataf, S. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.01.010 · Cited by 173 · see citing works

Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid

Moore, S. A., Hurt, E., Yoder, E. J., Sprecher, H. W., & Spector, A. A. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39724-8 · Cited by 171 · see citing works

Metabolite transport across the peroxisomal membrane

Visser, W. F., van Roermund, C. W. T., IJlst, L., Waterham, H. R., & Wanders, R. J. A. (2006) · Biochemical Journal · doi:10.1042/bj20061352 · Cited by 169 · see citing works

The Evolutionary Origin of Peroxisomes: An ER-Peroxisome Connection

Schlüter, A., Fourcade, S., Ripp, R., Mandel, J., Poch, O., & Pujol, A. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msj103 · Cited by 166 · see citing works

A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters.

Shani, N., & Valle, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11901 · Cited by 157 · see citing works

PAL: an object-oriented programming library for molecular evolution and phylogenetics

Drummond, A. J., & Strimmer, K. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.7.662 · Cited by 157 · see citing works

Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

Louet, J., Chatelain, F., Decaux, J., Park, E. A., Kohl, C., Pineau, T., Girard, J. R., & Pégorier, J. P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540189 · Cited by 154 · see citing works

Adrenoleukodystrophy-Related Protein Can Compensate Functionally for Adrenoleukodystrophy Protein Deficiency (X-ALD): Implications for Therapy

Netik, A., Forss-Petter, S., Holzinger, A., Molzer, B., Unterrainer, G., & Berger, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.907 · Cited by 148 · see citing works

Role of ALDP (ABCD1) and Mitochondria in X-Linked Adrenoleukodystrophy

McGuinness, M. C., Lu, J.-F., Zhang, H.-P., Dong, G.-X., Heinzer, A. K., Watkins, P. A., Powers, J., & Smith, K. D. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.744-753.2003 · Cited by 147 · see citing works

Potential Environmental and Host Participants in the Early White Matter Lesion of Adreno-Leukodystrophy: Morphologic Evidence for CD8 Cytotoxic T Cells, Cytolysis of Oligodendrocytes, and CD1-Mediated Lipid Antigen Presentation

Ito, M., Blumberg, B. M., Mock, D. J., Goodman, A. D., Moser, A. B., Moser, H. W., Smith, K. D., & Powers, J. M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.1004 · Cited by 125 · see citing works

Identification of a Fourth Half ABC Transporter in the Human Peroxisomal Membrane

Shani, N., Jiménez‐Sánchez, G., Steel, G., Dean, M. C., & Valle, D. L. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1925 · Cited by 124 · see citing works

The neurobiology of X-linked adrenoleukodystrophy, a demyelinating peroxisomal disorder

Dubois-Dalcq, M., Feigenbaum, V., & Aubourg, P. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01319-8 · Cited by 121 · see citing works

Transport of Activated Fatty Acids by the Peroxisomal ATP‐binding‐cassette Transporter Pxa2 in a Semi‐Intact Yeast Cell System

Verleur, N., Hettema, E. H., Van Roermund, C. W. T., Tabak, H. F., & Wanders, R. J. A. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00657.x · Cited by 117 · see citing works

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata

Brites, P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg236 · Cited by 116 · see citing works

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4968-07.2008 · Cited by 115 · see citing works

Expression of the adrenoleukodystrophy protein in the human and mouse central nervous system

Fouquet, F., Zhou, J. M., Ralston, E., Murray, K., Troalen, F., Magal, E., Robain, O., Dubois-Dalcq, M., & Aubourg, P. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0127 · Cited by 115 · see citing works

Ataxia with loss of Purkinje cells in a mouse model for Refsum disease

Ferdinandusse, S., Zomer, A. W. M., Komen, J. C., Brink, C. E. V. D., Thanos, M., Hamers, F. P. T., Wanders, R. J. A., van der Saag, P. T., Poll‐The, B. T., & Brites, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806066105 · Cited by 109 · see citing works

Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage

Ferrer, I., Kapfhammer, J. P., Hindelang, C., Kemp, S., Troffer-Charlier, N., Broccoli, V., Callyzot, N., Mooyer, P., Selhorst, J., Vreken, P., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi384 · Cited by 106 · see citing works

A key role for the peroxisomal<i>ABCD2</i>transporter in fatty acid homeostasis

Fourcade, S., Ruiz, M., Camps, C., Schlüter, A., Houten, S. M., Mooyer, P. A. W., Pàmpols, T., Dacremont, G., Wanders, R. J. A., Giròs, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90736.2008 · Cited by 104 · see citing works

MR of Zellweger syndrome.

Barkovich, A. J., & Peck, W. W. (1997) · PubMed Central · Cited by 97 · see citing works

MRI of the brain and cervical spinal cord in rhizomelic chondrodysplasia punctata

Bams-Mengerink, A. M., Majoie, C. B. L. M., Duran, M., Wanders, R. J. A., Van Hove, J., Scheurer, C. D., Barth, P. G., & Poll-The, B. T. (2006) · Neurology · doi:10.1212/01.wnl.0000205594.34647.d0 · Cited by 97 · see citing works

Elongation of very long-chain fatty acids is enhanced in X-linked adrenoleukodystrophy

Kemp, S., Valianpour, F., Denis, S., Ofman, R., Sanders, R.-J., Mooyer, P., Barth, P. G., & Wanders, R. J. A. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.09.015 · Cited by 97 · see citing works

Measurement of peroxisomal fatty acid β‐oxidation in cultured human skin fibroblasts

Wanders, R. J. A., Denis, S. W., Ruiter, J. P. N., Schutgens, R. B. H., van Roermund, C. W. T., & Jacobs, B. S. (1995) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00711434 · Cited by 95 · see citing works

Peroxisomal multifunctional protein-2: The enzyme, the patients and the knockout mouse model.

Huyghe, S., Mannaerts, G. P., Baes, M., & Van Veldhoven, P. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.006 · Cited by 91 · see citing works

Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver

Krysko, O., Hulshagen, L., Janssen, A., Schütz, G., Klein, R., De Bruycker, M., Espeel, M., Gressens, P., & Baes, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21097 · Cited by 90 · see citing works

Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute Coronary Syndrome Patients

Harris, W. S., Reid, K. J., Sands, S. A., & Spertus, J. A. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.08.013 · Cited by 89 · see citing works

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy

Heinzer, A. K. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg126 · Cited by 87 · see citing works

Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin

Khan, M., Singh, J., & Singh, I. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05513.x · Cited by 86 · see citing works

Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy

Asheuer, M., Bieche, I., Laurendeau, I., Moser, A., Hainque, B., Vidaud, M., & Aubourg, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi140 · Cited by 86 · see citing works

Mirror expression of adrenoleukodystrophy and adrenoleukodystrophy related genes in mouse tissues and human cell lines

Troffer-Charlier, N., Doerflinger, N., Metzger, E., Fouquet, F., Mandel, J.-L., & Aubourg, P. (1998) · European Journal of Cell Biology · doi:10.1016/s0171-9335(98)80121-0 · Cited by 85 · see citing works

Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders.

Mayatepek, E., Lehmann, W. D., Fauler, J., Tsikas, D., Frölich, J. C., Schutgens, R. B. H., Wanders, R. J. A., & KEPPLER, D. O. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116309 · Cited by 84 · see citing works

Murine model of Alexander disease: Analysis of GFAP aggregate formation and its pathological significance

Tanaka, K. F., Takebayashi, H., Yamazaki, Y., Ono, K., Naruse, M., Iwasato, T., Itohara, S., Kato, H., & Ikenaka, K. (2007) · Glia · doi:10.1002/glia.20486 · Cited by 79 · see citing works

Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects

Duarri, A., Teijido, Ó., López-Hernández, T., Scheper, G. C., Barrière, H., Boor, I., Aguado, F., Zorzano, A., Palacı́n, M., Martı́nez, A., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn269 · Cited by 76 · see citing works

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

Singh, J., Khan, M., & Singh, I. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800321-jlr200 · Cited by 75 · see citing works

Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Δ5 and Δ6 desaturases, SREBP-1, PPARα, and PGC-1

Rodríguez‐Cruz, M., Tovar, A. R., Palacios, B., Prado, M. D., & Torres, N. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500407-jlr200 · Cited by 74 · see citing works

PeroxisomeDB: a database for the peroxisomal proteome, functional genomics and disease

Schlüter, A., Fourcade, S., Domènech‐Estévez, E., Gabaldón, T., Huerta‐Cepas, J., Berthommier, G., Ripp, R., Wanders, R. J. A., Poch, O., & Pujol, A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl935 · Cited by 74 · see citing works

The effect of clofibrate-feeding on hepatic fatty acid metabolism

Christiansen, R. Z. (1978) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(78)90151-0 · Cited by 74 · see citing works

Evidence that Plasmalogen is Protective Against Oxidative Stress in the Rat Brain

Kuczynski, B., & Reo, N. V. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9061-7 · Cited by 72 · see citing works

The pathology of peroxisomal disorders with pathogenetic considerations.

Powers, J. M. (1995) · PubMed · Cited by 72 · see citing works

The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects

Bremer, J. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00004-2 · Cited by 72 · see citing works

Distribution and cellular localization of adrenoleukodystrophy protein in human tissues: implications for X-linked adrenoleukodystrophy

Höftberger, R., Kunze, M., Weinhofer, I., Aboul-Enein, F., Voigtländer, T., Oezen, I., Amann, G., Bernheimer, H., Budka, H., & Berger, J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.007 · Cited by 69 · see citing works

Differential expression of peroxisomal matrix and membrane proteins during postnatal development of mouse brain

Ahlemeyer, B., Neubert, I., Kovacs, W. J., & Baumgart‐Vogt, E. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21448 · Cited by 68 · see citing works

Childhood ataxia with CNS hypomyelination/vanishing white matter disease—A common leukodystrophy caused by abnormal control of protein synthesis

Schiffmann, R., & Elroy‐Stein, O. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.10.019 · Cited by 67 · see citing works

PRESIDENTIAL ADDRESS: The Pathology of Peroxisomal Disorders with Pathogenetic Considerations

Powers, J. M. (1995) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199509000-00014 · Cited by 67 · see citing works

Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation

Kan, I., Melamed, E., Offen, D., & Green, P. (2006) · Journal of Lipid Research · doi:10.1194/jlr.c600022-jlr200 · Cited by 64 · see citing works

Stimulation of microperoxisomal β-oxidation in rat heart by high-fat diets

Norseth, J., & Thomassen, M. S. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90289-8 · Cited by 63 · see citing works

20-Hydroxyeicosatetraenoic Acid (20-HETE) Metabolism in Coronary Endothelial Cells

Kaduce, T. L., Fang, X., Harmon, S. D., Oltman, C. L., Dellsperger, K. C., Teesch, L. M., Gopal, V. R., Falck, J. R., Campbell, W. B., Weintraub, N. L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306849200 · Cited by 60 · see citing works

Cerebral MRI as a valuable diagnostic tool in Zellweger spectrum patients

Weller, S., Rosewich, H., & Gärtner, J. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-0856-3 · Cited by 58 · see citing works

Docosahexaenoic Acid Deficit Is Not a Major Pathogenic Factor in Peroxisome-Deficient Mice

Janssen, A., Baes, M. I., Gressèns, P., Mannaerts, G. P., Declercq, P. E., & Veldhoven, P. P. V. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780005 · Cited by 53 · see citing works

The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

Lu, J., Barron‐Casella, E. A., Brose, R. D., Heinzer, A. K., Moser, A. B., Bentley, K. L. D. M., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., et al. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700512 · Cited by 48 · see citing works

The Neuronal Migration Defect in Mice with Zellweger Syndrome (Pex5Knockout) is not Caused by the Inactivity of Peroxisomal β-Oxidation

Baes, M. I., Gressèns, P., Huyghe, S., Nys, K. D., Qi, C., Jia, Y., Mannaerts, G. P., Evrard, P., Veldhoven, P. P. V., Declercq, P. E., et al. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.4.368 · Cited by 47 · see citing works

Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans.

Diczfalusy, U., Kase, B. F., Alexson, S. E. H., & Björkhem, I. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115401 · Cited by 47 · see citing works

20-Carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors α and γ

Fang, X., Dillon, J. S., Hu, S., Harmon, S. D., Yao, J., Anjaiah, S., Falck, J. R., & Spector, A. A. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.002 · Cited by 46 · see citing works

Peroxisomal Multifunctional Protein-2 Deficiency Causes Motor Deficits and Glial Lesions in the Adult Central Nervous System

Huyghe, S., Schmalbruch, H., Hulshagen, L., Veldhoven, P. P. V., Baes, M. I., & Hartmann, D. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.041220 · Cited by 45 · see citing works

Generalised and conditional inactivation of Pex genes in mice

Baes, M. I., & Veldhoven, P. P. V. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.018 · Cited by 45 · see citing works

Glycosyl Phosphatidylinositol-Linked Glycoconjugates:Structure, Biosynthesis and function

Hwa, K. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1267-7_15 · Cited by 43 · see citing works

Neuroimaging of peroxisome biogenesis disorders (Zellweger spectrum) with prolonged survival

Barth, P. G., Majoie, C. B. L. M., Gootjes, J., Wanders, R. J. A., Waterham, H. R., van der Knaap, M. S., de Klerk, J. B. C., Smeitink, J., & Poll-The, B. T. (2004) · Neurology · doi:10.1212/01.wnl.0000106943.40848.03 · Cited by 43 · see citing works

Identification of the peroxisomal β-oxidation enzymes involved in the degradation of leukotrienes

Ferdinandusse, S., Meißner, T., Wanders, R. J. A., & Mayatepek, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00214-0 · Cited by 38 · see citing works

Accumulation of very long-chain fatty acids does not affect mitochondrial function in adrenoleukodystrophy protein deficiency

Oezen, I., Rossmanith, W., Forss‐Petter, S., Kemp, S., Voigtländer, T., Moser-Thier, K., Wanders, R. J. A., Bittner, R. E., & Berger, J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi125 · Cited by 37 · see citing works

Studies on the metabolic fate of n-3 polyunsaturated fatty acids

Ferdinandusse, S., Denis, S. W., Dacremont, G., & Wanders, R. J. A. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300223-jlr200 · Cited by 36 · see citing works

Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process

Nguyen, S. D., Baes, M. I., & Veldhoven, P. P. V. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.004 · Cited by 33 · see citing works

Clinical variation in X-linked adrenoleukodystrophy: Fatty acid and lipid metabolism in cultured fibroblasts

Boles, D. J., Craft, D. A., Padgett, D. A., Loria, R. M., & Rizzo, W. B. (1991) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(91)90010-i · Cited by 32 · see citing works

Omega‐6 and omega‐3 fatty acids predict accelerated decline of peripheral nerve function in older persons

Lauretani, F., Bandinelli, S., Benedetta, B., Cherubini, A., Iorio, A. D., Blè, A., Giacomini, V., Corsi, A., Guralnik, J. M., & Ferrucci, L. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01860.x · Cited by 30 · see citing works

The Zellweger syndrome: deficient chain-shortening of erucic acid (22:1 (n−9)) and adrenic acid (22:4 (n−6)) in cultured skin fibroblasts

Christensen, E., Hagve, T., & Christophersen, B. O. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90019-7 · Cited by 29 · see citing works

Axons need glial peroxisomes

Aubourg, P. R. (2007) · Nature Genetics · doi:10.1038/ng0807-936 · Cited by 18 · see citing works

Increased urinary excretion of LTB4 and ω-carboxy-LTB4 in patients with Zellweger syndrome

Mayatepek, E., & Flock, B. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00015-7 · Cited by 10 · see citing works

Untitled work

Forss-Petter, S. (1997) · doi:10.1002/(sici)1097-4547(19971201)50:5

Myelination and support of axonal integrity by glia

Nave, K.-A. (2010) · Nature · doi:10.1038/nature09614 · Cited by 1,062 · see citing works

Role of peroxisomes in ros/rns-metabolism: Implications for human disease

Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644 · see citing works

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009761 · Cited by 314 · see citing works

Peroxisomes in brain development and function

Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works

Fission and proliferation of peroxisomes

Schrader, M., Bonekamp, N. A., & Islinger, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.014 · Cited by 189 · see citing works

Peroxisomal ABC transporters: Structure, function and role in disease

Morita, M., & Imanaka, T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.009 · Cited by 183 · see citing works

Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives

Braverman, N., D’Agostino, D., & MacLean, G. E. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1113 · Cited by 162 · see citing works

Pexophagy: The Selective Degradation of Peroxisomes

Till, A., Lakhani, R., Burnett, S. F., & Subramani, S. E. (2012) · International Journal of Cell Biology · doi:10.1155/2012/512721 · Cited by 156 · see citing works

Peroxisomes, lipid metabolism and lipotoxicity

Wanders, R. J. A., Ferdinandusse, S., Brites, P., & Kemp, S. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.01.001 · Cited by 169 · see citing works

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

Mannelli, L. D. C., D’Agostino, G., Pacini, A., Russo, R., Zanardelli, M., Ghelardini, C., & Calignano, A. (2013) · Mediators of Inflammation · doi:10.1155/2013/328797 · Cited by 132 · see citing works

Peroxisome biogenesis disorders

Argyriou, C., D’Agostino, D., & Braverman, N. (2016) · Translational Science of Rare Diseases · doi:10.3233/trd-160003 · Cited by 126 · see citing works

Evidence of oxidative stress in very long chain fatty acid – Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins

Baarine, M., Andreoletti, P., Athias, A., Nury, T., Zarrouk, A., Ragot, K., Véjux, A., Riedinger, J., Kattan, Z., Bessède, G., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.058 · Cited by 119 · see citing works

Be different—The diversity of peroxisomes in the animal kingdom

Islinger, M., Cardoso, M. J., & Schrader, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.03.013 · Cited by 115 · see citing works

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T. L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P., & Nasr-Esfahani, M. H. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8370-x · Cited by 101 · see citing works

Brain peroxisomes

Trompier, D., Véjux, A., Zarrouk, A., Gondcaille, C., Geillon, F., Nury, T., Savary, S., & Lizard, G. (2013) · Biochimie · doi:10.1016/j.biochi.2013.09.009 · Cited by 99 · see citing works

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

Debbabi, M., Nury, T., Zarrouk, A., Mekahli, N., Bezine, M., Sghaier, R., Gregoire, S., Martine, L., Durand, P., Prost-Camus, E., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121973 · Cited by 80 · see citing works

Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells

Cai, M., Sun, X., Wang, W., Lian, Z., Wu, P., Han, S., Chen, H., & Zhang, P. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.02.021 · Cited by 72 · see citing works

Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation

Cherkaoui‐Malki, M., Surapureddi, S., Hajj, H. I. E., Vamecq, J., & Andreoletti, P. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762765 · Cited by 69 · see citing works

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Bottelbergs, A., Verheijden, S., Van Veldhoven, P. P., Just, W., Devos, R., & Baes, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-61 · Cited by 66 · see citing works

Antioxidant cytoprotection by peroxisomal peroxiredoxin-5

Walbrecq, G., Wang, B., Becker, S., Hannotiau, A., Fransen, M., & Knoops, B. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.02.032 · Cited by 66 · see citing works

Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies

Baes, M. I., & Veldhoven, P. P. V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.03.003 · Cited by 66 · see citing works

LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

Lin, J.-P., Mironova, Y. A., Shrager, P., & Giger, R. J. (2017) · eLife · doi:10.7554/elife.30498 · Cited by 64 · see citing works

Conjugated Linoleic Acid and Brain Metabolism: A Possible Anti-Neuroinflammatory Role Mediated by PPARα Activation

Murru, E., Carta, G., Manca, C., Sogos, V., Pistis, M., Melis, M., & Banni, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587140 · Cited by 63 · see citing works

Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N

Badreddine, A., Zarrouk, A., Karym, E. M., Debbabi, M., Nury, T., Meddeb, W., Sghaier, R., Bezine, M., Véjux, A., Martine, L., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102220 · Cited by 62 · see citing works

Multiple Sclerosis is Not a Disease of the Immune System

Corthals, A. (2011) · The Quarterly Review of Biology · doi:10.1086/662453 · Cited by 61 · see citing works

Oligodendrocytes: Functioning in a Delicate Balance Between High Metabolic Requirements and Oxidative Damage

Roth, A. D., & Núñez, M. T. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_8 · Cited by 58 · see citing works

The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure

Renz‐Polster, H., Tremblay, M., Bienzle, D., & Fischer, J. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.888232 · Cited by 53 · see citing works

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

Verheijden, S., Bottelbergs, A., Krysko, O., Krysko, D. V., Beckers, L., De Munter, S., Van Veldhoven, P. P., Wyns, S., Kulik, W., Nave, K.-A., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.006 · Cited by 54 · see citing works

Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol

Nury, T., Sghaier, R., Zarrouk, A., Ménétrier, F., Uzun, T., Leoni, V., Caccia, C., Meddeb, W., Namsi, A., Sassi, K., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.009 · Cited by 54 · see citing works

Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy

Moruno-Manchon, J. F., Uzor, N.-E., Kesler, S. R., Wefel, J. S., Townley, D. M., Nagaraja, A. S., Pradeep, S., Mangala, L. S., Sood, A. K., & Tsvetkov, A. S. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.11.014 · Cited by 52 · see citing works

A mixture of oleic, erucic and conjugated linoleic acids modulates cerebrospinal fluid inflammatory markers and improve somatosensorial evoked potential in X-linked adrenoleukodystrophy female carriers

Cappa, M., Bizzarri, C., Petroni, A., Carta, G., Cordeddu, L., Valeriani, M., Vollono, C., De Pasquale, L., Blasevich, M., & Banni, S. (2012) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-011-9432-3 · Cited by 49 · see citing works

Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-α on oligodendrocytes and astrocytes

Baarine, M., Ragot, K., Athias, A., Nury, T., Kattan, Z., Genin, E. C., Andreoletti, P., Ménétrier, F., Riedinger, J.-M., Bardou, M., et al. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.10.007 · Cited by 43 · see citing works

Peroxisome deficient invertebrate and vertebrate animal models

Veldhoven, P. P. V., & Baes, M. I. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00335 · Cited by 37 · see citing works

Myelin lesions associated with lysosomal and peroxisomal disorders

Faust, P. L., Kaye, E. M., & Powers, J. M. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.127 · Cited by 31 · see citing works

Peroxisome Dynamics: Molecular Players, Mechanisms, and (Dys)functions

Fransen, M. (2012) · ISRN Cell Biology · doi:10.5402/2012/714192 · Cited by 31 · see citing works

Impact of 7‐ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: Evaluation via LAURDAN and FAMIS spectral image analysis

Kahn, E., Baarine, M., Dauphin, A., Ragot, K., Tissot, N., Seguin, A., Ménétrier, F., Kattan, Z., Bachelet, C., Frouin, F., et al. (2011) · Cytometry Part A · doi:10.1002/cyto.a.21017 · Cited by 29 · see citing works

Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities

Wang, X. M., Yik, W. Y., Zhang, P., Lu, W., Huang, N., Kim, B. R., Shibata, D. K., Zitting, M., Chow, R. H.-P., Moser, A. B., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0149-3 · Cited by 22 · see citing works

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β‐oxidation deficiency

Geric, I., Tyurina, Y. Y., Krysko, O., Krysko, D. V., de Schryver, E., Kagan, V. E., Veldhoven, P. P. V., Baes, M. I., & Verheijden, S. (2017) · Immunology · doi:10.1111/imm.12844 · Cited by 22 · see citing works

Peroxisomal biogenesis in ischemic brain

Young, J. M., Nelson, J. W., Cheng, J., Zhang, W., Mader, S., Davis, C. M., Morrison, R. S., & Alkayed, N. J. (2015) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2014.5833 · Cited by 21 · see citing works

Very Long Chain Fatty Acid β-Oxidation in Astrocytes: Contribution of the ABCD1-Dependent and -Independent Pathways

Morita, M., Shinbo, S., 朝日彰子, & Imanaka, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00411 · Cited by 22 · see citing works

Peroxisome proliferator‐activated receptor gamma‐coactivator‐1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis

Camacho‐Morales, A., Huang, J. K., Delint‐Ramírez, I., Tan, C. Y., Fuller, M., Lelliott, C. J., Vidal‐Puig, A., & Franklin, R. J. M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12281 · Cited by 21 · see citing works

Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating Adipocyte Dysfunction via Oxidative Stress

Piao, L., Dorotea, D., Jiang, S., Koh, E. H., Oh, G. T., & Ha, H. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7614 · Cited by 20 · see citing works

Peroxisome deficient aP2–Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone

Martens, K., Bottelbergs, A., Peeters, A., Jacobs, F., Espeel, M., Carmeliet, P., Veldhoven, P. P. V., & Baes, M. I. (2012) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2012.10.015 · Cited by 20 · see citing works

Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders

Hanson, M. G., Hood, V. L., Vrana, J. D., Tucker, C. L., & Niswander, L. A. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.08.026 · Cited by 17 · see citing works

PPAR-γImpairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures

Mannelli, L. D. C., Zanardelli, M., Micheli, L., & Ghelardini, C. (2014) · BioMed Research International · doi:10.1155/2014/546453 · Cited by 16 · see citing works

Evolution of adrenoleukodystrophy model systems

Ferrer, R. M., Heine, V. M., Kemp, S., & Engelen, M. (2020) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12357 · Cited by 15 · see citing works

Association Between Peroxisomal Biogenesis Factor 7 and Autism Spectrum Disorders in a Korean Population

Ro, M., Park, J., Nam, M., Bang, H. J., Yang, J.-W., Choi, K.-S., Kim, S. K., Chung, J., & Kwack, K. (2012) · Journal of Child Neurology · doi:10.1177/0883073811435507 · Cited by 14 · see citing works

Vesicular trafficking and cell-cell communication in neurodevelopment and neurodegeneration

Amin, S., & Taverna, E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600034 · Cited by 13 · see citing works

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains

Uzor, N.-E., Morales‐Scheihing, D., Kim, G. S., Moruno-Manchon, J. F., Zhu, L., Reynolds, C. R., Stephenson, J. M., Holmes, A., McCullough, L. D., & Tsvetkov, A. S. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103536 · Cited by 8 · see citing works

Formation and Maintenance of Myelin

Macklin, W. B., & Rasband, M. N. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374947-5.00031-6 · Cited by 7 · see citing works

Altered lipid metabolic homeostasis in the pathogenesis of Alzheimer’s disease

Marian, O. C., Tran, C. L., & Don, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00023-3 · Cited by 2 · see citing works

Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, Fatty Acids and Mitochondria

Bongarzone, E. R., Givogri, M. I., Vivo, D. C. D., & DiMauro, S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374947-5.00043-2 · Cited by 5 · see citing works

Specific suppression of microgliosis cannot circumvent the severe neuropathology in peroxisomal β-oxidation-deficient mice

Beckers, L., Stroobants, S., Verheijden, S., West, B. L., D’Hooge, R., & Baes, M. I. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.03.004 · Cited by 4 · see citing works

Lipidomics Analysis of Peroxisomal Disorders: Discovery of Deficits in Phosphatidyglycerol Levels in Rhizomelic Chondrodysplasia Type 1

Braverman, N. (2014) · Journal of Data Mining in Genomics & Proteomics · doi:10.4172/2153-0602.1000s1-001 · Cited by 3 · see citing works

Purifying selection of the lysosomal enzymes arylsulfatase A and beta-galactocerebrosidase and their evolutionary impact on myelin integrity

Luetzen, M. A., Chakraborty, R., Moreno-Ramos, O. A., Echeverri-Peña, O. Y., Satta, Y., & Montaño, A. M. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100769 · Cited by 3 · see citing works

Peroxisomes

Lazarow, P. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.20022-9 · Cited by 3 · see citing works

Peroxisomes as emerging clinical targets in neuroinflammatory diseases

Roczkowsky, A., Rachubinski, R. A., Hobman, T. C., & Power, C. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1642590 · Cited by 2 · see citing works

Tissue Distribution and Versatile Functions of PPARs

Youssef, J., & Badr, M. Z. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-420-3_5 · Cited by 2 · see citing works

Metabolic Symbiosis and Vulnerability in the CNS Axon-Myelin Unit

Miao, K., Meng, M., Liu, L., Li, M., Bai, Y., Guo, Y., Zhang, G., Kong, J., & Mu, J. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01729-3 · Cited by 1 · see citing works

Activités cytotoxiques et pro-oxydantes d'acides gras à très longue chaîne sur des oligodendrocytes murins sauvages et déficients en Abcd1 et Acox1 : application à la physiopathologie de l'X-ALD et de la P-NALD

Baarine, M. (2010) · theses.fr (ABES) · doi:10.70675/7ab2bcc8z16d2z420cz92f9zb3fd52371382 · Cited by 1 · see citing works

History of PPAR Discovery

Youssef, J., & Badr, M. Z. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-420-3_2

The role of Nrg1-ErbB signaling in promoting Schwann cell myelination

Syed, N. (2012) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t3n878ms

Literaturverzeichnis

(2015) · Elsevier eBooks · doi:10.1016/b978-3-437-31618-0.16001-8

Peroxisome Biogenesis Disorders

Demers, N. D., & Kim, P. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65924-x

Olfactory dysfunction and submicroscopic abnormalities: unveiling hidden pathologies

Bilińska, K., Pasińska, M., & de Castro, F. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1861373

Axons need glial peroxisomes

Aubourg, P. R. (2007) · Nature Genetics · doi:10.1038/ng0807-936 · Cited by 18 · see citing works

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity

Kassmann, C. M., Quintes, S., Rietdorf, J., Möbius, W., Sereda, M. W., Nientiedt, T., Saher, G., Baes, M., & Nave, K.-A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.032 · Cited by 52 · see citing works

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4968-07.2008 · Cited by 115 · see citing works

The role of peroxisomes in the formation and maintenance of myelinated axons.

Bottelbergs, A. (2012)

Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes

Bottelbergs, A., Verheijden, S., Hulshagen, L., Gutmann, D. H., Goebbels, S., Nave, K., Kassmann, C., & Baes, M. (2010) · Glia · doi:10.1002/glia.21027 · Cited by 78 · see citing works