Cited by 827Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

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Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

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Jack, C. R., Shiung, M. M., Gunter, J. L., O’Brien, P. C., Weigand, S. D., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Cha, R. H., Tangalos, E. G., Petersen, R. C.·2004·Neurology

DOI 10.1212/01.wnl.0000110315.26026.efPMC PMC2730165

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Abstract

OBJECTIVE: To correlate different methods of measuring rates of brain atrophy from serial MRI with corresponding clinical change in normal elderly subjects, patients with mild cognitive impairment (MCI), and patients with probable Alzheimer disease (AD). METHODS: One hundred sixty subjects were recruited from the Mayo Clinic Alzheimer's Disease Research Center and Alzheimer's Disease Patient Registry Studies. At baseline, 55 subjects were cognitively normal, 41 met criteria for MCI, and 64 met criteria for AD. Each subject underwent an MRI examination of the brain at the time of the baseline clinical assessment and then again at the time of a follow-up clinical assessment, 1 to 5 years later. The annualized changes in volume of four structures were measured from the serial MRI studies: hippocampus, entorhinal cortex, whole brain, and ventricle. Rates of change on several cognitive tests/rating scales were also assessed. Subjects who were classified as normal or MCI at baseline could either remain stable or convert to a lower-functioning group. AD subjects were dichotomized into slow vs fast progressors. RESULTS: All four atrophy rates were greater among normal subjects who converted to MCI or AD than among those who remained stable, greater among MCI subjects who converted to AD than among those who remained stable, and greater among fast than slow AD progressors. In general, atrophy on MRI was detected more consistently than decline on specific cognitive tests/rating scales. With one exception, no differences were found among the four MRI rate measures in the strength of the correlation with clinical deterioration at different stages of the disease. CONCLUSIONS: These data support the use of rates of change from serial MRI studies in addition to standard clinical/psychometric measures as surrogate markers of disease progression in AD. Estimated sample sizes required to power a therapeutic trial in MCI were an order of magnitude less for MRI than for change measures based on cognitive tests/rating scales.

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Method
Additional file 1 of Exploring morphological similarity and randomness in Alzheimer’s disease using adjacent grey matter voxel-based structural analysis
Chen, T.-Y., Zhu, J.-D., Tsai, S.-J., & Yang, A. C. (2024) · Figshare · doi:10.6084/m9.figshare.25678585
Additional file 1 of Characterization of Alzheimer’s tau biomarker discordance using plasma, CSF, and PET
Guo, Y., Huang, Y.-Y., Shen, X.-N., Chen, S.-D., Hu, H., Wang, Z.-T., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.14538932
Additional file 1 of White matter hyperintensities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer’s disease
Desmarais, P., Gao, A. F., Lanctôt, K. L., Rogaeva, E. A., Ramirez, J., Herrmann, N., Stuss, D. T., Black, S. E., Keith, J., & Masellis, M. (2021) · Figshare · doi:10.6084/m9.figshare.14978557
Additional file 1 of Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach
Wang, X., Ye, T., Zhou, W., & Zhang, J. (2023) · Figshare · doi:10.6084/m9.figshare.22619095
Additional file 1 of Genetic evidence for the causal relationships between migraine, dementia, and longitudinal brain atrophy
Zhao, L., Tang, Y., Tu, Y., & Cao, J. (2024) · Figshare · doi:10.6084/m9.figshare.26729974

Authors: Jack, C. R., Shiung, M. M., Gunter, J. L., O’Brien, P. C., Weigand, S. D., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Cha, R. H., Tangalos, E. G., & Petersen, R. C.
Affiliations: Mayo Clinic (US)
ORCID: Jack, C. R.
Gunter, J. L.
O’Brien, P. C.
Weigand, S. D.
Knopman, D. S.
Boeve, B. F.
Smith, G. E.
Petersen, R. C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-02-24
Volume: 62
Issue: 4
Pages: 591-600
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000110315.26026.ef
PMC: PMC2730165
OpenAlex: W2005133023
Cited by: 827
References: 41
Citations by year: 2026: 17 · 2025: 19 · 2024: 21 · 2023: 25 · 2022: 20 · 2021: 36 · 2020: 27 · 2019: 38 · 2018: 36 · 2017: 37 · 2016: 33 · 2015: 39 · 2014: 41 · 2013: 48 · 2012: 38
FWCI: 28.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, U19AG010483, R37AG011378, P50AG016574)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Alzheimer's disease, brain atrophy rate, serial MRI, hippocampal atrophy, entorhinal cortex atrophy, whole brain atrophy, ventriculomegaly, mild cognitive impairment, disease progression, surrogate markers, cognitive decline, trial size, MCI conversion
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Atrophy, Brain, Cognition Disorders, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Cohort Studies, Disease Progression, Entorhinal Cortex, Apolipoprotein E4

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Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

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