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White matter lesions impair frontal lobe function regardless of their location
Open accessAbstract
OBJECTIVE: To analyze the effect of white matter lesions in different brain regions on regional cortical glucose metabolism, regional cortical atrophy, and cognitive function in a sample with a broad range of cerebrovascular disease and cognitive function. METHODS: Subjects (n = 78) were recruited for a study of subcortical ischemic vascular disease (SIVD) and Alzheimer disease (AD) contributions to dementia. A new method was developed to define volumes of interest from high-resolution three-dimensional T1-weighted MR images. Volumetric measures of MRI segmented white matter signal hyperintensities (WMH) in five different brain regions were related to regional PET glucose metabolism (rCMRglc) in cerebral cortex, MRI measures of regional cortical atrophy, and neuropsychological assessment of executive and memory function. RESULTS: WMH was significantly higher in the prefrontal region compared to the other brain regions. In all subjects, higher frontal and parietal WMH were associated with reduced frontal rCMRglc, whereas occipitotemporal WMH was only marginally associated with frontal rCMRglc. These associations were stronger and more widely distributed in nondemented subjects where reduced frontal rCMRglc was correlated with WMH for all regions measured. In contrast, there was no relationship between WMH in any brain region and rCMRglc in either parietal or occipitotemporal regions. WMHs in all brain regions were associated with low executive scores in nondemented subjects. CONCLUSIONS: The frontal lobes are most severely affected by SIVD. WMHs are more abundant in the frontal region. Regardless of where in the brain these WMHs are located, they are associated with frontal hypometabolism and executive dysfunction.
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“Previous studies investigating the impact of regional distribution of WMHs on executive function (EF) found that WMHs in all cortical regions (frontal areas, occipital, parietal and temporal) are associated with deficits in EF scores [15,16,17]”
From Amyloid-PET and White Matter Hyperintensities Have Independent Effects on Baseline Cognitive Function and Synergistic Effects on Longitudinal Executive Function (2023) · cites this paper as [17]
Experimental — accuracy not yet measuredIn the citing paper
“The demonstration of abnormalities on neuroimaging is critical for increased certainty in the diagnosis, and the lack of neuroimaging data can result in significant diagnostic inaccuracy by overlooking silent brain infarction and WMLs.37”
From Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement (2014) · cites this paper as [37]
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Metadata
- Authors
- Tullberg, M., Fletcher, E., DeCarli, C., Mungas, D., Reed, B. R., Harvey, D. J., Weiner, M. W., Chui, H. C., & Jagust, W. J.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Venue
- Neurology
- Published
- 2004-07-27
- Volume
- 63
- Issue
- 2
- Pages
- 246-253
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC1893004
- OpenAlex
- W2077066095
- Cited by
- 530
- References
- 51
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 12 · 2023: 17 · 2022: 16 · 2021: 19 · 2020: 27 · 2019: 27 · 2018: 17 · 2017: 21 · 2016: 24 · 2015: 30 · 2014: 32 · 2013: 36 · 2012: 25
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG010129, AG 12435, AG-10129, P01AG012435, P50AG023501)
- National Institute of Neurological Disorders and Stroke (R01NS017950)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- white matter lesions, white matter hyperintensities, subcortical ischemic vascular disease, Alzheimer's disease, dementia, frontal lobe, regional cerebral glucose metabolism, frontal hypometabolism, cortical atrophy, executive function, memory, cerebrovascular disease, lesion localization
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition Disorders, Female, Frontal Lobe, Glucose, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Myelin Sheath, Neuropsychological Tests, Dementia, Vascular, Positron-Emission Tomography
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