Cited by 362Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Anatomic and Behavioral Aspects of Frontal‐Subcortical Circuitsa

CUMMINGS, JEFFREY L.·1995·Annals of the New York Academy of Sciences

Abstract

Frontal-subcortical circuits provide a comprehensive framework for understanding the anatomy, biochemistry, and pharmacology of behavior. The three principal behaviorally relevant circuits originate in the dorsolateral prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex, respectively. Circuit-specific marker behaviors associated with each circuit are executive dysfunction (dorsolateral prefrontal-subcortical circuit), disinhibition and OCD (orbitofrontal-subcortical circuit), and apathy (medial frontal-subcortical circuit). Environmental dependency is common to all prefrontal-subcortical syndromes and may reflect disruption of working memory. Depression, mania, and psychosis are mediated by structures involved in prefrontal-subcortical circuits and are circuit-related but not circuit-specific behaviors. The actions of PCP, LSD, serotonergic antidepressants, anxiolytics, sedative-hypnotics, antipsychotic agents, and ethanol may all be partially or primarily mediated through transmitter systems and receptor effects expressed through frontal-subcortical circuits.

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Crossref · 10.1111/j.1749-6632.1995.tb38127.x

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Authors
CUMMINGS, J. L.
Affiliations
University of California, Los Angeles (US)
Corresponding author
CUMMINGS, JEFFREY L.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1995-12
Volume
769
Issue
1
Pages
1-14
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2011582442
Cited by
362
References
24
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 12 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 17 · 2014: 22 · 2013: 23 · 2012: 12
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 10123, P30AG010123)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
frontal-subcortical circuits, dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, executive dysfunction, disinhibition, obsessive-compulsive disorder, apathy, working memory, depression, mania, psychosis, psychopharmacology, PCP, LSD, serotonergic antidepressants, anxiolytics, sedative-hypnotic drugs, antipsychotic drugs, ethanol, neurotransmitter systems
MeSH terms
Afferent Pathways, Behavior, Efferent Pathways, Electrophysiology, Frontal Lobe, gamma-Aminobutyric Acid, Humans, Glutamic Acid

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