Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers
Abstract
Accurate diagnosis of vascular dementia is important for the recognition of underlying pathophysiology and the institution of appropriate therapy. It is also important for the determination of the incidence and prevalence of not only vascular dementia but also Alzheimer's disease (AD), since differentiating between these two entities is often problematic. The State of California Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC) herein propose criteria for the diagnosis of ischemic vascular dementia (IVD). These criteria broaden the conceptualization of vascular dementia, include the results of neuroimaging studies, emphasize the importance of neuropathologic confirmation, refine nosology, and identify areas that require further research. Parallel use of the proposed definitions of "possible" and "mixed" categories in the diagnosis of both AD and IVD would ensure compatibility between the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) criteria for AD and the ADDTC criteria for IVD. Uniform classification of subtypes of IVD will improve the generalizability of individual studies and aid in multicenter collaborations.
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Vascular cognitive disorders are a heterogeneous group with varied pathologies and clinical presentations.
“Cognitive disorders of vascular etiology are a heterogeneous group of disorders with diverse pathologies and clinical manifestations, discussed broadly under the rubric of vascular cognitive disorders (VCD).”
From Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement (2014) · cites this paper as [5]
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- Authors
- Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R.
- Affiliations
- University of Southern California (US)
- ORCID
- Chui, H. C.
- Venue
- Neurology
- Published
- 1992-03
- Volume
- 42
- Issue
- 3
- Pages
- 473-473
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1989294823
- Cited by
- 1,201
- References
- 0
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 20 · 2023: 13 · 2022: 17 · 2021: 25 · 2020: 21 · 2019: 20 · 2018: 15 · 2017: 34 · 2016: 21 · 2015: 25 · 2014: 24 · 2013: 43 · 2012: 51
- FWCI
- 21.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag007624-05)
- National Institute on Aging (1P50-AG-05142, R01 AG07624, P50AG005142)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- diagnostic criteria, Alzheimer's disease, differential diagnosis, neuroimaging, disease classification, mixed dementia
- MeSH terms
- Brain Ischemia, Cerebrovascular Disorders, Cognition Disorders, Humans, Dementia, Vascular
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