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Cited by 113Genetics and Neurodevelopmental DisordersVisual perception and processing mechanismsFace Recognition and Perception

Integrative cortical dysfunction and pervasive motion perception deficit in fragile X syndrome

Kogan, C. S., Bertone, A., Cornish, K., Boutet, I., Der Kaloustian, V. M., Andermann, E., Faubert, J., Chaudhuri, A.·2004·Neurology
DOI 10.1212/01.wnl.0000142987.44035.3b
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Abstract

BACKGROUND: Fragile X syndrome (FXS) is associated with neurologic deficits recently attributed to the magnocellular pathway of the lateral geniculate nucleus. OBJECTIVE: To test the hypotheses that FXS individuals 1) have a pervasive visual motion perception impairment affecting neocortical circuits in the parietal lobe and 2) have deficits in integrative neocortical mechanisms necessary for perception of complex stimuli. METHODS: Psychophysical tests of visual motion and form perception defined by either first-order (luminance) or second-order (texture) attributes were used to probe early and later occipito-temporal and occipito-parietal functioning. RESULTS: When compared to developmental- and age-matched controls, FXS individuals displayed severe impairments in first- and second-order motion perception. This deficit was accompanied by near normal perception for first-order form stimuli but not second-order form stimuli. CONCLUSIONS: Impaired visual motion processing for first- and second-order stimuli suggests that both early- and later-level neurologic function of the parietal lobe are affected in Fragile X syndrome (FXS). Furthermore, this deficit likely stems from abnormal input from the magnocellular compartment of the lateral geniculate nucleus. Impaired visual form and motion processing for complex visual stimuli with normal processing for simple (i.e., first-order) form stimuli suggests that FXS individuals have normal early form processing accompanied by a generalized impairment in neurologic mechanisms necessary for integrating all early visual input.

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Crossref · 10.1212/01.wnl.0000142987.44035.3b

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  • Kogan et al. (2004) found that modulation thresholds for local motion direction identification were impaired for both first- and second-order stimuli in Fragile-X Syndrome.

    “Kogan et al. (2004)found that modulation thresholds for local motion direction identification were impaired for both first-and second-order stimuli in this population”

    From Vision in autism spectrum disorders (2009) · cites this paper as Kogan et al. (2004)

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Authors
Kogan, C. S., Bertone, A., Cornish, K., Boutet, I., Der Kaloustian, V. M., Andermann, E., Faubert, J., & Chaudhuri, A.
Affiliations
  • Montreal Neurological Institute and Hospital (CA)
  • From the Departments of Educational Psychology and Neurology and Neurosurgery (Dr. Cornish), Psychology (Drs. Boutet and Chaudhuri, C.S. Kogan), and Pediatrics and Human Genetics (Dr. Der Kaloustian), McGill University; École d’Optométrie (A. Bertone and Dr. Faubert), Université de Montréal; and Departments of Neurology and Neurosurgery and Human Genetics (Dr. Andermann), McGill University and the Montreal Neurological Hospital and Institute, Canada.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-11-09
Volume
63
Issue
9
Pages
1634-1639
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000142987.44035.3b
OpenAlex
W2042756959
Cited by
113
References
33
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 4 · 2014: 6 · 2013: 10 · 2012: 6
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
fragile X syndrome, visual motion perception, second-order motion, first-order motion, parietal lobe, magnocellular pathway, lateral geniculate nucleus, cortical integration, visual processing deficits
MeSH terms
Adolescent, Adult, Fragile X Syndrome, Geniculate Bodies, Humans, Male, Motion Perception, Occipital Lobe, Parietal Lobe, Sensory Thresholds, Temporal Lobe, Visual Pathways, Visual Perception

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