The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging
Open accessAbstract
Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.
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Exercise leads to cognitive improvement in normal aging and Alzheimer's disease.
“It is well established that exercise leads to cognitive improvement in normal aging and Alzheimer’s disease 62–64.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [64]
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- [58]Bohnen NI, Koeppe RA, Minoshima S, et al. Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study. J Nucl Med. 2011;52:848–855. doi: 10.2967/jnumed.111.089946. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
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Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
- Authors
- Ray, N. J., & Strafella, A. P.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Strafella, Antonio P.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2012-10
- Volume
- 27
- Issue
- 12
- Pages
- 1484-1492
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC4452226
- OpenAlex
- W2034665418
- Cited by
- 35
- References
- 61
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 3
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-110 962, 110962_1)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, cognitive impairment, Parkinson's disease dementia, dopamine replacement therapy, neural correlates of cognition, functional neuroimaging, cognitive heterogeneity, dopaminergic neuron loss
- MeSH terms
- Animals, Brain, Cognition Disorders, Humans, Nerve Net, Neurobiology, Parkinson Disease, Neuroimaging
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