CoChat
Sign Up
Cited by 440Dementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Inflammatory markers and the risk of Alzheimer disease: The Framingham Study

Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., Seshadri, S.·2007·Neurology
DOI 10.1212/01.wnl.0000263217.36439.da
Open this paper in CoChat — free account

Abstract

OBJECTIVE: To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD). METHODS: We followed 691 cognitively intact community-dwelling participants (mean age 79 years, 62% women) and related PBMC cytokine production (tertiles of spontaneous production of interleukin 1 [IL-1], IL-1 receptor antagonist, and tumor necrosis factor alpha [TNF-alpha]) and serum C-reactive protein and interleukin 6 (IL-6) to the risk of incident AD. RESULTS: Adjusting for clinical covariates, individuals in the top two tertiles (T2 and T3) of PBMC production of IL-1 or the top tertile (T3) of PBMC production of TNF-alpha were at increased risk of developing AD (multivariable-adjusted hazard ratio [HR] for IL-1 T2 = 2.84, 95% CI 1.09 to 7.43; p = 0.03 and T3 = 2.61, 95% CI 0.96 to 7.07; p = 0.06; for TNF-alpha, adjusted HR for T2 = 1.30, 95% CI 0.53 to 3.17; p = 0.57 and T3 = 2.59, 95% CI 1.09 to 6.12; p = 0.031]) compared with those in the lowest tertile (T1). INTERPRETATION: Higher spontaneous production of interleukin 1 or tumor necrosis factor alpha by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals. These data strengthen the evidence for a pathophysiologic role of inflammation in the development of clinical AD.

Overview

Integrity signals

Registry

Crossref · 10.1212/01.wnl.0000263217.36439.da

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 43 references

Research works printed but not linked: 3

  1. 10.1161/hs1101.098151 · DOI
  2. Tarkowski E, Wallin A, Blennow K, Tarkowski A. Local production of TNF-a, a potent neuroprotective agent, in Alzheimer's disease and vascular dementia. J Clin Immunol 1999;19:223–230.
  3. Paolisso G, Rizzo MR, Mazziotti G, et al. Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. Am J Physiol Endocrinol Metab 1998;38:E294–E299.

Cited by

Sorted by citations

Items 401–440 of 440

Related

See all

Metadata

Authors
Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., & Seshadri, S.
Affiliations
Boston University (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-05-29
Volume
68
Issue
22
Pages
1902-1908
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000263217.36439.da
OpenAlex
W2106118263
Cited by
440
References
43
Citations by year
2026: 6 · 2025: 10 · 2024: 21 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 22 · 2019: 20 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 22 · 2014: 34 · 2013: 28 · 2012: 35
FWCI
15.90
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01hc25195-41-0-1)
  • National Institute on Aging (5R01 AG 16495, R01AG016495, 5-R01-AG-08122, P30AG013846, R01AG008122, P30-AG13846))
  • National Heart, Lung, and Blood Institute (N01‐HC25195)
  • National Institute of Neurological Disorders and Stroke (5-R01-NS-17950, R01NS017950)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, inflammatory markers, serum cytokines, peripheral blood mononuclear cells, interleukin-1, TNF-α, interleukin-1 receptor antagonist, C-reactive protein, interleukin-6, inflammation, dementia risk, older adults
MeSH terms
Aged, Alzheimer Disease, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Interleukin-1, Leukocytes, Mononuclear, Male, Neuropsychological Tests, Risk Factors, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Immunoprecipitation, Interleukin 1 Receptor Antagonist Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review