Cited by 440Dementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Inflammatory markers and the risk of Alzheimer disease: The Framingham Study

Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., Seshadri, S.·2007·Neurology

DOI 10.1212/01.wnl.0000263217.36439.da

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Abstract

OBJECTIVE: To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD). METHODS: We followed 691 cognitively intact community-dwelling participants (mean age 79 years, 62% women) and related PBMC cytokine production (tertiles of spontaneous production of interleukin 1 [IL-1], IL-1 receptor antagonist, and tumor necrosis factor alpha [TNF-alpha]) and serum C-reactive protein and interleukin 6 (IL-6) to the risk of incident AD. RESULTS: Adjusting for clinical covariates, individuals in the top two tertiles (T2 and T3) of PBMC production of IL-1 or the top tertile (T3) of PBMC production of TNF-alpha were at increased risk of developing AD (multivariable-adjusted hazard ratio [HR] for IL-1 T2 = 2.84, 95% CI 1.09 to 7.43; p = 0.03 and T3 = 2.61, 95% CI 0.96 to 7.07; p = 0.06; for TNF-alpha, adjusted HR for T2 = 1.30, 95% CI 0.53 to 3.17; p = 0.57 and T3 = 2.59, 95% CI 1.09 to 6.12; p = 0.031]) compared with those in the lowest tertile (T1). INTERPRETATION: Higher spontaneous production of interleukin 1 or tumor necrosis factor alpha by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals. These data strengthen the evidence for a pathophysiologic role of inflammation in the development of clinical AD.

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Authors: Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., & Seshadri, S.
Affiliations: Boston University (US)
ORCID: Tan, Z. S.
Beiser, A. S.
Vasan, R. S.
Roubenoff, R.
Dinarello, C. A.
Harris, T. B.
Benjamin, E. J.
Au, R.
Kiel, D. P.
Wolf, P. A.
Seshadri, S.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-05-29
Volume: 68
Issue: 22
Pages: 1902-1908
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000263217.36439.da
OpenAlex: W2106118263
Cited by: 440
References: 43
Citations by year: 2026: 6 · 2025: 10 · 2024: 21 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 22 · 2019: 20 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 22 · 2014: 34 · 2013: 28 · 2012: 35
FWCI: 15.90
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc25195-41-0-1)
National Institute on Aging (5R01 AG 16495, R01AG016495, 5-R01-AG-08122, P30AG013846, R01AG008122, P30-AG13846))
National Heart, Lung, and Blood Institute (N01‐HC25195)
National Institute of Neurological Disorders and Stroke (5-R01-NS-17950, R01NS017950)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, inflammatory markers, serum cytokines, peripheral blood mononuclear cells, interleukin-1, TNF-α, interleukin-1 receptor antagonist, C-reactive protein, interleukin-6, inflammation, dementia risk, older adults
MeSH terms: Aged, Alzheimer Disease, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Interleukin-1, Leukocytes, Mononuclear, Male, Neuropsychological Tests, Risk Factors, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Cytokines, Immunoprecipitation, Interleukin 1 Receptor Antagonist Protein

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Inflammatory markers and the risk of Alzheimer disease: The Framingham Study

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