Cited by 190Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis ResearchHistorical and Modern Theater Studies

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Activities of daily living in frontotemporal dementia and Alzheimer disease

Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., Hodges, J. R.·2007·Neurology

DOI 10.1212/01.wnl.0000264897.13722.53

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Abstract

OBJECTIVE: To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction. METHODS: Fifty-nine patients and caregivers participated in this cross-sectional study: behavioral variant frontotemporal dementia (bv-FTD, n = 15), progressive nonfluent aphasia (PNFA, n = 10), semantic dementia (n = 15), and Alzheimer disease (AD, n = 19). Caregivers were interviewed with the Disability Assessment for Dementia (DAD) to provide two outcome measures about ADLs: basic and instrumental ADLs (BADLs, IADL). In addition, patients were rated on the Clinical Dementia Rating Scale (CDR), and performance on cognitive measures (Addenbrooke's Cognitive Examination Revised [ACE-R]) was assessed. RESULTS: On the DAD, the bv-FTD group was most affected (56% of normal), whereas PNFA and semantic dementia patients were least impaired (83% and 85%); AD was intermediate (76%). The opposite pattern was seen on the ACE-R, where PNFA and semantic dementia groups were most affected, and bv-FTD showed least impairment; AD was again intermediate. Scores on the DAD did not correlate with cognitive measures, CDR, or disease duration. We further analyzed which aspect of ADLs was most affected, and a unique pattern of deficits emerged for the bv-FTD group (initiation affected > planning > execution for BADLs). CONCLUSION: Frontotemporal dementia has a devastating effect on activities of daily living, which is of considerable importance to caregivers and not captured by bedside cognitive tests.

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“It is generally assessed with self-report, informant-based questionnaires evaluating basic (e.g., eating ) and instrumental ADL (e.g., meal preparation ; Mioshi et al., 2007), and simulated activities of daily living (S-ADL; e.g., Schwartz et al., 2002).”
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Deconstructing the performance of everyday activities: a case in dementia
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Regional cerebral blood flow in behavioral variant of FTD: hypoperfusion patterns and clinical associations
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“In fact, compared to Alzheimer’s Disease (AD) [7, 8], or other FTD subtypes [9], the behavioral variant of FTD (bvFTD) is characterized by faster rate of functional decline and more profound deficits.”
Better Living with Non-memory-led Dementia: study protocol for a randomised controlled trial of a web-based caregiver educational programme (BELIDE trial)
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Multimodal Correlates of Longitudinal Functional Decline in Behavioral Variant Frontotemporal Dementia (bvFTD)
Chatzidimitriou, E., Ntritsos, G., Poptsi, E., Tsardoulias, E., Symeonidis, A. L., Tsolaki, M., Charalambous, P., Sioka, C., Aretouli, E., Iakovou, I. P., et al. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16080415 · Cited by 1
“Importantly, bvFTD is often associated with a relatively rapid clinical course [5,9].”
Influential
Are clients' performances on the Rowland Universal Dementia Assessment Scale associated with their functional performance? A preliminary investigation
Jolliffe, L. J., Brown, T., & Fielding, L. (2015) · British Journal of Occupational Therapy · doi:10.1177/0308022614561236 · Cited by 1
“Mioshi et al. (2007) completed a study of patients with fronto-temporal dementia and found that some patients who obtained low scores on the Addenbrooke’s Cognitive Examination – Revised (ACE-R) also had scores that categorized them as having normal ADL abilities when evaluated by two…”
Assessment with Non-cognitive Screening Instruments and Combinations of Scales
Larner, A. J. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6371-8_5 · Cited by 1
Assessment with Non-Cognitive Screening Instruments
Larner, A. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-75259-4_5 · Cited by 1
Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease
Archer, T., & Johansson, B. E. A. (2013) · Springer eBooks · doi:10.1007/978-81-322-1184-6_15 · Cited by 1
Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis
Barker, M. S., Shneider, N. A., Manoochehri, M., Huey, E. D., & Lindenberger, E. C. (2025) · Psychiatry Research Case Reports · doi:10.1016/j.psycr.2025.100247 · Cited by 1
“The cognitive, behavioral and emotional symptoms of ALS are associated with greater caregiver burden than the motor symptoms (Hsieh et al., 2016; Mioshi et al., 2007), and a better understanding of the non-motor symptoms of ALS will thus help us to better address the clinical needs of ALS patients…”
Clinical aspects of dementia
Golden, E. C., & Josephs, K. A. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107588660.002 · Cited by 1
Reproductive aging and executive functions in healthy women
Martino, P., Cervigni, M., Pulopulos, M. M., Audisio, E. O., Bonet, J. L., de Bortoli, M. Á., & Politis, D. G. (2020) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2020.1859083 · Cited by 1
“…been systematically investigated is crucial for the scientific literature given that they are especially involved in daily life activities, and they are commonly affected in neurodegenerative diseases such as Alzheimer’s Disease or Frontotemporal dementia (Law et al., 2001; Mioshi et al., 2007).”
BackgroundInfluential
Disability Assessment for Dementia
Fish, J. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_1800 · Cited by 1
A Comparison of Caregiver Report and Performance-Based Measures of Functional Ability in Dementia: An Examination of Moderating Variables
Snyder, C. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/f49c-ad92
Avaliação fonoaudiológica da deglutição na demência frontotemporal
Marin, S. D. M. C. (2014) · doi:10.11606/t.5.2014.tde-26082014-111637
MALATTIA DI ALZHEIMER E DEGENERAZIONE LOBARE FRONTOTEMPORALE: RICERCA DI MUTAZIONI AUTOSOMICHE DOMINANTI E ANALISI GENETICA E FUNZIONALE DI GENI CANDIDATI
Serpente, M. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/serpente-maria_phd2013-02-12
Empirically Based Interventions for Error Monitoring Deficits in Dementia
Bettcher, B. M. (2009) · PsycEXTRA Dataset · doi:10.1037/e633012009-001
Treatment
Dickerson, B. C. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.019
The multidisciplinary evaluation of the atypical dementia patient
Geschwind, M. D., & Belkoura, C. R. (2016) · doi:10.1002/9781118797662.ch2
Agir sur le monde qui nous entoure : réflexions sur les relations entre la mémoire sémantique, les actions routinières et la résolution de problèmes Interacting with the world around us: reflections on the relationship between semantic memory, everyday actions and problem solving
Bier, N., Macoir, J., Hudon, C., Bottari, C. L., & Joubert, S. (2017)
Validação da escala de estadiamento e progressão da demência frontotemporal (FTD-FRS)
da Silva, T. B. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-09052018-111153
Damasio, Antonio R. (1944–)
Ryan, J. P., & King, T. Z. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_612-2
Behavioral and everyday functioning changes in frontotemporal dementia and their relationship with neuropsychological performances
Χατζηδημητρίου, Η. Ά. (2021) · Aristotle University of Thessaloniki · doi:10.26262/heal.auth.ir.326417
Differences in Multimodal EEG and Clinical Correlations Between Alzheimer’s Disease and Frontotemporal DementiaPreprint
Lin, N., Gao, J., Mao, C., Sun, H., Lü, Q., & Cui, L. (2021) · Research Square · doi:10.21203/rs.3.rs-149165/v1
“Previous study reported that FTD was associated with greater impairments in ADLs than AD [32].”
Current awareness in geriatric psychiatry
(2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1924
Disability Assessment for Dementia
Fish, J. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_1800-2
Decline in activities of daily living in the rarer dementias
Taylor, B., Mohamud, S., Brotherhood, E., Harding, E., Waddington, C., Camic, P. M., Alexander, D. C., Crutch, S. J., Stott, J. C. H., Hardy, C. J. D., et al. (2025) · General Psychiatry · doi:10.1136/gpsych-2024-101905 · Cited by 2
“Demographics were clearly and appropriately reported by all studies, statistical analyses were uniformly appropriate and the conclusions of all studies were clearly supported by the data.”
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Illán‐Gala, I., & Miller, B. L. (2025) · Cambridge University Press eBooks · doi:10.1017/9781108985055.011
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Calibrating limitation features and dependence levels in basic activities of daily living among individuals with dementia: an item response theory-based analysis
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“Despite being physically capable, individuals with dementia often experience difficulties in executing BADL; their cognitive deficits can interfere with their ability to do so [3].”
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“…Assessment for Dementia demonstrated that bv-FTLD is associated with greater functional impairment — particularly in basic activities of daily living (BADLs) — compared to AD and other FTLD subtypes, with limited correlation with cognitive measures or global staging scales such as the CDR [23].”
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dos Santos, J. G., de Andrade, L. P., Cassemiliano, G., Santos, V. R. D. S., Farche, A. C. S., Carnavale, B. F., Pedroso, R. V., & Takahashi, A. C. D. M. (2026) · Geriatric Nursing · doi:10.1016/j.gerinurse.2026.104315
External validation of an integrative model of functional impairment in early-stage behavioral variant frontotemporal dementia (bvFTD)
Chatzidimitriou, E., Moraitou, D., Ioannidis, P., Aretouli, E., Chen, Y., Rosen, H. J., Gorno‐Tempini, M., Seeley, W. W., Miller, B. L., & Rankin, K. P. (2026) · Journal of Neurology · doi:10.1007/s00415-026-14182-5
“As a result, functional impairment constitutes one of the most clinically meaningful outcomes in bvFTD, closely linked to caregiver burden, supervision needs, institutionalization risk, and reduced quality of life [6].”
Influential

Authors: Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R.
Affiliations: MRC Cognition and Brain Sciences Unit (GB)
ORCID: Mioshi, E.
Kipps, C. M.
Dawson, K.
Hodges, J. R.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-06-12
Volume: 68
Issue: 24
Pages: 2077-2084
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000264897.13722.53
OpenAlex: W2079397002
Cited by: 188
References: 52
Citations by year: 2026: 6 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 15 · 2013: 13 · 2012: 7
FWCI: 8.46
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders: Wellcome Trust (073580)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: activities of daily living, frontotemporal dementia, Alzheimer's disease, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, instrumental activities of daily living, basic activities of daily living, cognitive impairment, caregiver burden, Disability Assessment for Dementia, Clinical Dementia Rating, Addenbrooke's Cognitive Examination-Revised
MeSH terms: Activities of Daily Living, Aged, Alzheimer Disease, Cognition Disorders, Cross-Sectional Studies, Dementia, Disability Evaluation, Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Age Distribution, Sex Distribution

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Activities of daily living in frontotemporal dementia and Alzheimer disease

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