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Activities of daily living in frontotemporal dementia and Alzheimer disease
Abstract
OBJECTIVE: To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction. METHODS: Fifty-nine patients and caregivers participated in this cross-sectional study: behavioral variant frontotemporal dementia (bv-FTD, n = 15), progressive nonfluent aphasia (PNFA, n = 10), semantic dementia (n = 15), and Alzheimer disease (AD, n = 19). Caregivers were interviewed with the Disability Assessment for Dementia (DAD) to provide two outcome measures about ADLs: basic and instrumental ADLs (BADLs, IADL). In addition, patients were rated on the Clinical Dementia Rating Scale (CDR), and performance on cognitive measures (Addenbrooke's Cognitive Examination Revised [ACE-R]) was assessed. RESULTS: On the DAD, the bv-FTD group was most affected (56% of normal), whereas PNFA and semantic dementia patients were least impaired (83% and 85%); AD was intermediate (76%). The opposite pattern was seen on the ACE-R, where PNFA and semantic dementia groups were most affected, and bv-FTD showed least impairment; AD was again intermediate. Scores on the DAD did not correlate with cognitive measures, CDR, or disease duration. We further analyzed which aspect of ADLs was most affected, and a unique pattern of deficits emerged for the bv-FTD group (initiation affected > planning > execution for BADLs). CONCLUSION: Frontotemporal dementia has a devastating effect on activities of daily living, which is of considerable importance to caregivers and not captured by bedside cognitive tests.
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“Moreover, ADL deficits do not always show association with cognitive scores in various dementia subtypes (Mioshi et al., 2007; O'Connor, Clemson, Flanagan, et al., 2016; O'Connor, Clemson, Hornberger, et al., 2016), highlighting the importance of including ADL scores in studies investigating wellbeing of carers of people with dementia.”
From Exploring the impact of carer stressors and psychological inflexibility on depression and anxiety in family carers of people with dementia (2020) · cites this paper as Mioshi et al., 2007
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Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
“Patients with bvFTD typically present with moderate to severe disability, even at early stages of the disease (Rosen et al., 2004a; Rascovsky et al., 2005; Mioshi et al., 2007).”
BackgroundSemantic dementia: a unique clinicopathological syndrome
Hodges, J. R., & Patterson, K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70266-1 · Cited by 772
Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management
Piguet, O., Hornberger, M., Mioshi, E., & Hodges, J. R. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70299-4 · Cited by 496
Brief cognitive screening instruments: an update
Ismail, Z., Rajji, T. K., & Shulman, K. I. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2306 · Cited by 459
“One such limitation of the ACE-R is that its scores did not correlate with scores of basic and instrumental activities of daily living among patients with different types of dementias such as AD and FTD (Mioshi et al., 2007).”
BackgroundClinical staging and disease progression in frontotemporal dementia
Mioshi, E., Hsieh, S., Savage, S., Hornberger, M., & Hodges, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e04070 · Cited by 362
Self-citationDaily functioning and dementia
Cipriani, G., Danti, S., Picchi, L., Nuti, A., & Fiorino, M. D. (2020) · Dementia & Neuropsychologia · doi:10.1590/1980-57642020dn14-020001 · Cited by 325
Sikkes, S. A. M., Klerk, E. S. M. D. L., Pijnenburg, Y. A. L., Scheltens, P., & Uitdehaag, B. M. J. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.155838 · Cited by 267
Sajjadi, S. A., Patterson, K. E., Arnold, R. J., Watson, P., & Nestor, P. J. (2012) · Neurology · doi:10.1212/wnl.0b013e3182574f79 · Cited by 234
Activities of daily living and quality of life across different stages of dementia: a UK study
Giebel, C. M., Sutcliffe, C., & Challis, D. (2014) · Aging & Mental Health · doi:10.1080/13607863.2014.915920 · Cited by 202
“…(Lawton & Brody, 1969), and basic activities of daily living (ADLs), including bathing, continence, dressing, feeding, toileting and transfer (Katz, Ford, Moskowitz, Jackson, & Jaffe, 1963), the former are found to decline from the early and pre-diagnostic stages onwards (Mioshi et al., 2007).”
Adenzato, M., Cavallo, M., & Enrici, I. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.08.001 · Cited by 189
“Thus, it is not by chance that Mioshi et al. (2007) recently found that bv-FTD has a devastating effect, more than SD and PNFA, in everyday life social situations. Marked difficulties in appropriately performing ToM tasks emerged in all of the studies examined herein, a finding that strongly supports the proposal that…”
BackgroundNeuroanatomy of Apathy and Disinhibition in Frontotemporal Lobar Degeneration
Massimo, L., Powers, C., Moore, P., Vesely, L., Avants, B., Gee, J., Libon, D. J., & Grossman, M. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000194658 · Cited by 156
“While the precise basis for a social disorder continues to be an active area of investigation, its profound consequences on a wide variety of daily activities are clear [”
BackgroundFrontotemporal dementia and motor neurone disease: Overlapping clinic-pathological disorders
Lillo, P., & Hodges, J. R. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.03.005 · Cited by 161
“A fuller characterisation of the extent of cognitive and behavioural dysfunction in MND is not simply of academic interest but has important implications given that the burden and stress for carers of patients with FTD is very great.(81) It also has relevance to effective communication, legal issues and end-of-life de…”
BackgroundFrontotemporal Dementia: diagnosis, Deficits and Management
Bott, N. T., Radke, A., Stephens, M. L., & Kramer, J. H. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.34 · Cited by 164
Factors underlying caregiver stress in frontotemporal dementia and Alzheimer's disease
Mioshi, E., Bristow, M., Cook, R., & Hodges, J. R. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000193626 · Cited by 133
“These behavioural changes can include apathy, disinhibition, emotional blunting, stereotypic behaviour, and in conjunction with cognitive decline ultimately lead to severe disability in everyday life [”
BackgroundSelf-citationGiebel, C. M., Sutcliffe, C., Stolt, M., Karlsson, S., Guiteras, A. R., Soto, M. E., Verbeek, H., Zabalegui, A., & Challis, D. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214000775 · Cited by 134
“However, the majority of literature on ADL performance also employs indirect daily activity reports, particularly for basic ADLs (Mioshi et al., 2007; Pocnet et al., 2013).”
BackgroundSo, M., Foxe, D., Kumfor, F., Murray, C., Hsieh, S., Savage, G. R., Ahmed, R. M., Burrell, J. R., Hodges, J. R., Irish, M., et al. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617718000541 · Cited by 127
“This is an important variable to consider, given the diversity of clinical dementia presentations, and their likely variability across daily functioning and cognitive deficits (Hodges, Bozeat, Ralph, Patterson, & Spatt, 2000; Mioshi et al., 2007).”
BackgroundKishita, N., Backhouse, T., & Mioshi, E. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988719856690 · Cited by 103
“Cognitive impairments and functional abilities differ between typical Alzheimer disease and other types of dementia such as frontotemporal dementia.(52,53) Future research needs to explore whether interventions that found to be most effective are equally beneficial to those who do not fall into the typical population…”
BackgroundSensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia
Piguet, O., Hornberger, M., Shelley, B. P., Kipps, C., & Hodges, J. R. (2009) · Neurology · doi:10.1212/01.wnl.0000343004.98599.45 · Cited by 102
Eating Behavior in Aging and Dementia: The Need for a Comprehensive Assessment
Fostinelli, S., Amicis, R. S. D., Leone, A., Giustizieri, V., Binetti, G. G., Bertoli, S., Battezzati, A., & Cappa, S. F. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.604488 · Cited by 108
Liu, S., Liu, J., Wang, X., Shi, Z., Zhou, Y., Li, J., Yu, T., & Ji, Y. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217002630 · Cited by 101
“In bv-FTD, the cardinal clinical features include early disinhibition, early emotional blunting, and early stereotypic behavior, ultimately leading to severe disability in daily living (Neary et al., 1998; Mioshi et al., 2007).”
BackgroundEmotion, social functioning and activities of daily living in frontotemporal dementia
Kipps, C., Mioshi, E., & Hodges, J. R. (2009) · Neurocase · doi:10.1080/13554790802632892 · Cited by 98
“…scale, the Disability Assessment for Dementia (DAD) (Gelinas, Gauthier, McIntyre, & Gauthier, 1999), we recently established that bvFTD patients were more affected in their ADLs than those with Alzheimer’s disease, or FTD patients with predominantly language dysfunction (Mioshi et al., 2007).”
Trajectory of Mobility Decline by Type of Dementia
Tolea, M. I., Morris, J. C., & Galvin, J. E. (2015) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000091 · Cited by 93
Musa, G., Slachevsky, A., Muñoz‐Neira, C., Méndez‐Orellana, C., Villagra, R., González-Billault, C. E., Ibáñez, A. M., Hornberger, M., & Lillo, P. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190924 · Cited by 102
“In both AD and bvFTD, there is no simple relationship between the degree of cognitive and functional impairment, suggesting that functional impairment could be also associated with another dimension of the dementia syndrome, such as social and behavioral disturbance [112].”
InfluentialNef, T., Urwyler, P., Büchler, M., Tarnanas, I., Stucki, R., Cazzoli, D., Müri, R. M., & Mosimann, U. P. (2015) · Sensors · doi:10.3390/s150511725 · Cited by 96
“Although IADLs are found to decline from the early and pre-diagnostic stages onward [2,5], the focus of research on common self-care or domestic activities disregards many other activities that may have gained more”
BackgroundDifferentiating the frontal variant of Alzheimer's disease
Woodward, M., Jacova, C., Black, S. E., Kertesz, A., Mackenzie, I. R., Feldman, H., & the ACCORD investigator group (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2415 · Cited by 90
“The diagnosis of AD was made applying the NINCDSADRDA criteria and the diagnosis of FTD made on the basis of the Neary 1988 criteria (Neary et al., 1998).”
MethodHornberger, M., Shelley, B. P., Kipps, C. M., Piguet, O., & Hodges, J. R. (2009) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.163873 · Cited by 84
Crawford, S., Whitnall, L., Robertson, J. S., & Evans, J. J. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2771 · Cited by 84
“In another study by Mioshi et al. (2007), the relationship between the ability to perform activities of daily living and cognitive dysfunction was investigated across three variants of fronto-temporal dementia.”
Background“All is not lost”—Rethinking the nature of memory and the self in dementia
Strikwerda‐Brown, C., Grilli, M. D., Andrews‐Hanna, J. R., & Irish, M. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100932 · Cited by 85
“It is interesting therefore that this syndrome displays lower rates of disability (Mioshi et al., 2007), and improved survival rates (Hodges et al.”
BackgroundResultda Silva, T. B. L., Bahia, V. S., Carvalho, V. A., Guimarães, H. C., Caramelli, P., Balthazar, M. L. F., Damasceno, B. P., Bottino, C. M. D. C., Brucki, S. M. D., Nitríni, R., et al. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000437351 · Cited by 84
Addenbrooke’s Cognitive Examinations: ACE, ACE-R, ACE-III, ACEapp, and M-ACE
Hodges, J. R., & Larner, A. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-44775-9_6 · Cited by 83
Bringing words back to mind – Improving word production in semantic dementia
Savage, S. A., Ballard, K. J., Piguet, O., & Hodges, J. R. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.014 · Cited by 83
Self-citationRate of Change of Functional Abilities in Frontotemporal Dementia
Mioshi, E., & Hodges, J. R. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000255652 · Cited by 79
“Recent studies have established that FTD impacts considerably on everyday activities even at the early stages, which cannot be attributed to language deficits only in those with SemDem and PNFA [”
BackgroundCarvalho, V. A., Barbosa, M. T., & Caramelli, P. (2010) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0b013e3181c5e2e5 · Cited by 77
“Only 3 years have passed since the publication of the ACE-R(20) and a fairly reduced number of studies with the application of this new version in patients with AD are already available.(20,29,30) The authors have proposed some improvements in the revised version, especially the redistribution of subdomain scores and…”
BackgroundProgress and Challenges in Frontotemporal Dementia Research: A 20-Year Review
Hodges, J. R., & Piguet, O. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171087 · Cited by 79
“to the clinic [127] and carers, particularly those car-”
BackgroundGiving Words New Life: Generalization of Word Retraining Outcomes in Semantic Dementia
Savage, S. A., Piguet, O., & Hodges, J. R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131826 · Cited by 78
“Word finding difficulty, or anomia, is a common and frustrating experience for many dementia sufferers, resulting in communication difficulties which impact upon activities of daily living [1] and well-being [2, 3].”
Longitudinal change in everyday function and behavioral symptoms in frontotemporal dementia
O'Connor, C. M., Clemson, L., Hornberger, M., Leyton, C. E., Hodges, J. R., Piguet, O., & Mioshi, E. (2016) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000264 · Cited by 73
“Specifically, a gradient of functional disability exists across the 3 primary clinical FTD subtypes: patients with behavioral variant FTD (bvFTD) are severely impaired, followed by nonfluent variant primary progressive aphasia (nfvPPA) and semantic variant primary progressive aphasia (svPPA).(1,4) Despite functional d…”
BackgroundSelf-citationOsher, J. E., Wicklund, A. H., RADEMAKER, A. W., Johnson, N., & Weıntraub, S. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507307173 · Cited by 69
“The MMSE registered a higher degree of severity and greater change over time than the ADLQ in patients with PPA.”
ResultInfluentialBorroni, B., Agosti, C., Premi, E., Cerini, C., Cosseddu, M., Paghera, B., Bellelli, G., & Padovani, A. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02911.x · Cited by 65
“outcome measures needs to be further evaluated, but these instruments do not cover all aspects of the disease [9].”
BackgroundA Qualitative Review of Instrumental Activities of Daily Living in Dementia: what’s cooking?
Sikkes, S. A. M., & de Rotrou, J. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.24 · Cited by 63
Differences in Functional Impairment Across Subtypes of Dementia
Gure, T. R., Kabeto, M. U., Plassman, B. L., Piette, J. D., & Langa, K. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp197 · Cited by 58
O’Connor, C. M. C., Clemson, L. M., Brodaty, H., Low, L., Jeon, Y., Gitlin, L. N., Piguet, O., & Mioshi, E. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1387614 · Cited by 60
“A separate model was constructed for each of the dependent variables analyzed: NPI-C behavioral domains present/absent, NPI-C apathy composite, NPI-C agitation composite, NPI-C disinhibition composite, NPI-C motor disturbance composite, DAD total, DAD basic ADLs, DAD instrumental ADLs, EuroQol 5-”
BackgroundInfluentialBoxer, A. L., Gold, M., Huey, E. D., Hu, W. T., Rosen, H. J., Kramer, J. H., Gao, F., Burton, E. A., Chow, T. W., Kao, A. W., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.03.003 · Cited by 55
“[49] Mioshi E, Kipps CM, Dawson K, Mitchell J, Graham A, Hodges JR.”
BackgroundUnderstanding the cognitive underpinnings of functional impairments in early dementia: a review
Giebel, C. M., Challis, D., & Montaldi, D. (2015) · Aging & Mental Health · doi:10.1080/13607863.2014.1003282 · Cited by 50
“One indicator of the influential role of prospective memory in performing everyday tasks comes from deficits reported in the planning and initiation of IADLs across dementia types (AD, FTD and SD) (Mioshi et al., 2007).”
BackgroundInfluentialBehavioural-variant frontotemporal dementia: An update
Piguet, O., & Hodges, J. R. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn70100003 · Cited by 50
Cooking “Shrimp à la Créole”: A pilot study of an ecological rehabilitation in semantic dementia
Bier, N., Macoir, J., Joubert, S., Bottari, C. L., Chayer, C., Pigot, H., Giroux, S., & SemAssist Team (2011) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2011.580614 · Cited by 51
“Since BADL and IADL are compromised in SD (Mioshi & Hodges, 2009; Mioshi et al., 2007), this approach seems relevant to improve everyday function in this population.”
BackgroundGiebel, C. M., & Challis, D. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4570 · Cited by 48
“The maximum score is 30, and a cut off of 21 and above is indicative of mild dementia (Perneczky et al., 2006), although reports vary on the cut off for mild dementia (Mioshi et al., 2007; Nagaratnam et al., 2014; Perry et al., 2000).”
BackgroundInfluentialActivities of Daily Living in Behavioral Variant Frontotemporal Dementia
Mioshi, E., Kipps, C., & Hodges, J. R. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318182d293 · Cited by 44
“Eight patients were not included in the study because of either (1) a physical impairment that could potentially confound assessment of ADLs; (2) evidence of major depression; or ( 3 ) evidence of significant cerebrovascular disease (infarcts or confluent white matter changes).”
BackgroundMethodShifting Patterns of Everyday Activity in Early Dementia
Phinney, A., Dahlke, S., & Purves, B. (2013) · Journal of Family Nursing · doi:10.1177/1074840713486727 · Cited by 43
“Families and friends are often uncertain how to interact with someone whose memory and language is failing and as a result, people may find themselves increasingly isolated from intimate family relationships and significant social interactions (Adler & Kuskowski, 2003; Burgener & Dickerson-Putman, 1999; Burgener, Shim…”
BackgroundLeyton, C. E., Hornberger, M., Mioshi, E., & Hodges, J. R. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000313980 · Cited by 42
“showed that SD patients were significantly younger than PNFA patients. This difference, however, was small, no more than 5 years, and the mean age did not exceed 70 in either group. Moreover, there was no significant correlation between age and either baseline ACE scores or annualised rate of change of ACE scores. Age…”
ResultBier, N., Brambati, S., Macoir, J., Paquette, G., Schmitz, X., Belleville, S., Faucher, C., & Joubert, S. (2015) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2014.997745 · Cited by 35
“These difficulties can have a huge impact on independence in everyday life, such as problems with recognising food and preparing a meal correctly (Bier et al., 2011, 2013) or choosing appropriate clothes for the weather or occasion (Mioshi et al., 2007).”
BackgroundVallejo, V., Wyss, P., Chesham, A., Mitache, A. V., Müri, R. M., Mosimann, U. P., & Nef, T. (2017) · Computers in Human Behavior · doi:10.1016/j.chb.2017.01.021 · Cited by 49
Moheb, N., Mendez, M. F., Kremen, S. A., & Teng, E. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000455119 · Cited by 41
Magnetic Resonance Imaging in Frontotemporal Dementia Shows Subcortical Atrophy
Chow, T. W., Izenberg, A., Binns, M. A., Freedman, M., Stuss, D. T., Scott, C. J. M., Ramirez, J., & Black, S. E. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000144028 · Cited by 40
“have made similar reports of atrophy in these brain regions of living patients with FTD, using different methodology (voxel-based morphometry). The PPA group, as might be expected for individuals with left-hemisphere dominance with aphasia, showed much more asymmetry, whereas the bvFTD group’s left/right atrophy score…”
Bier, N., Paquette, G., & Macoir, J. (2018) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2015.1094395 · Cited by 32
“Although it has not been extensively studied, the loss of knowledge about the world in SemD has a significant impact on everyday life (Bier et al., 2013; Mioshi et al., 2007).”
BackgroundKishita, N., Contreras, M. L., West, J., & Mioshi, E. (2020) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2020.07.005 · Cited by 37
“Moreover, ADL deficits do not always show association with cognitive scores in various dementia subtypes (Mioshi et al., 2007; O'Connor, Clemson, Flanagan, et al., 2016; O'Connor, Clemson, Hornberger, et al., 2016), highlighting the importance of including ADL scores in studies investigating wellbeing of carers of peo…”
BackgroundO’Connor, C. M. C., Smith, R., Nott, M. T., Lorang, C. E. B., & Mathews, R. M. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511410558 · Cited by 38
“Cognitive and functional decline in dementia generally impairs performance of basic care activities of daily living (ADLs).(1,2) Participation in personal care ADLs, such as eating or showering,(3) is a fundamental contributor to quality of life (QOL) in residents with dementia, where participation is defined as activ…”
BackgroundQuantitating Severity and Progression in Primary Progressive Aphasia
Dickerson, B. C. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9534-2 · Cited by 35
“Questionnaire-based instruments can be helpful for this purpose, particularly those that aim to ascertain the type and degree of impairments in instrumental and basic activities of daily living (Johnson et al. 2004; Mioshi et al. 2007; Wicklund et al. 2007; Mioshi and Hodges 2009).”
Giebel, C. M., Sutcliffe, C., & Challis, D. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988716686835 · Cited by 35
“Although both complex instrumental activities of daily living (IADLs) and basic ADLs deteriorate in the early stages of dementia, people with dementia (PwD) experience greater levels of deficits with IADLs early on.(5,6) The majority of research focuses on global impairment in performing IADLs or ADLs,(7-10) though ex…”
BackgroundFunctional Disability in Alzheimer Disease
Bahia, V. S., Carthery‐Goulart, M. T., Novelli, M. M. P. C., Kato-Narita, E. M., Areza‐Fegyveres, R., Caramelli, P., & Nitríni, R. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181cfc878 · Cited by 33
Transition of Distinctive Symptoms of Semantic Dementia during Longitudinal Clinical Observation
Kashibayashi, T., Ikeda, M., Komori, K., Shinagawa, S., Shimizu, H., Toyota, Y., Mori, T., Ishikawa, T., Fukuhara, R., Ueno, S., et al. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000269972 · Cited by 35
Emotion Recognition in the Dementias: Brain Correlates and Patient Implications
Kumfor, F., & Piguet, O. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.16 · Cited by 34
Monitoring Progression of Primary Progressive Aphasia: Current Approaches and Future Directions
Sapolsky, D., Domoto‐Reilly, K., Negreira, A. M., Brickhouse, M. J., McGinnis, S. M., & Dickerson, B. C. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.2 · Cited by 31
Lussier, M., Adam, S., Chikhaoui, B., Consel, C., Gagnon, M., Gilbert, B., Giroux, S., Guay, M., Hudon, C., Imbeault, H., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180652 · Cited by 34
Memory Impairment at Initial Clinical Presentation in Posterior Cortical Atrophy
Ahmed, S., Baker, I., Husain, M., Thompson, S., Kipps, C., Hornberger, M., Hodges, J., & Butler, C. R. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-160018 · Cited by 31
“, in restricting activities of daily living [20].”
Activities of daily living in motor neuron disease: role of behavioural and motor changes
Mioshi, E., Lillo, P., Kiernan, M., & Hodges, J. (2012) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2011.07.042 · Cited by 30
“In FTD without MND, recent studies have suggested that frontal dysfunction (apathy, disinhibition and executive dysfunction) explain ADL performance.(5) In the present study, the best model to explain ADL disability included not only fine and gross motor skills, but also motivation and abnormal behaviour.”
Self-citationMusa, G., Lillo, P., van der Hiele, K., Méndez‐Orellana, C., Ibáñez, A. M., & Slachevsky, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.734251 · Cited by 31
“This is also congruent with the findings of Mioshi, Kipps (28), who described marked impairment of both BADLs and IADLs in patients with bvFTD.”
ResultInfluentialYaddaden, A., Couture, M., Gagnon‐Roy, M., Belchior, P. D. C., Lussier, M., Bottari, C. L., Giroux, S., Pigot, H., & Bier, N. (2020) · Journal of Rehabilitation and Assistive Technologies Engineering · doi:10.1177/2055668320909074 · Cited by 30
“eating, dressing, grooming).(8,9) Among IADL, maintaining the ability to prepare meals independently is of paramount importance to individuals with cognitive deficits and for their caregivers.”
BackgroundResultJang, J., Cushing, N., Clemson, L. M., Hodges, J. R., & Mioshi, E. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000339670 · Cited by 30
Clinical comparison of progressive aphasia associated with Alzheimer versus FTD-spectrum pathology
Xiong, L., Xuereb, J., Spillantini, M., Patterson, K., Hodges, J., & Nestor, P. (2010) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.209916 · Cited by 31
“A recent study of ADLs that divided FTLD into its three clinical subtypes and also included a clinical AD group matched for disease duration, reported that the bvFTD group was most affected, whereas clinical PA and clinical AD were less severely impaired.(30) Taken together these studies suggest that bvFTD may be the…”
ResultSpreadbury, J. H., & Kipps, C. (2016) · Dementia · doi:10.1177/1471301216661427 · Cited by 33
“Research by Mioshi et al. (2007) using the Disability Assessment for Dementia scale (Gélinas, Gauthier, McIntyre, & Gauthier, 1999) found that dysfunction in ADL ability was most pronounced in bvFTD followed by AD and then FTD language variants.”
MethodLin, N., Gao, J., Mao, C., Sun, H., Lü, Q., & Cui, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.687053 · Cited by 29
Neural Correlates of Activities of Daily Living in Frontotemporal Dementia
Mioshi, E., Hodges, J. R., & Hornberger, M. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713477474 · Cited by 29
“FTD is known to cause major disability, affecting everyday life activities such as basic (showering, changing clothes, eating) and instrumental (managing finances, preparing meals, doing housechores) activities of daily living (ADLs).(1,2) Recent studies have shown that patients with FTD show marked ADL impairment in…”
Candela, F., Zucchetti, G., Ortega, E., Rabaglietti, E., & Magistro, D. (2015) · Holistic Nursing Practice · doi:10.1097/hnp.0000000000000106 · Cited by 28
Borroni, B., Grassi, M., Agosti, C., Premi, E., Archetti, S., Alberici, A., Bellelli, G., Caimi, L., Luca, M. D., & Padovani, A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.004 · Cited by 27
O'Connor, C. M., Clemson, L., Flanagan, E., Kaizik, C., Brodaty, H., Hodges, J. R., Piguet, O., & Mioshi, E. (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000449283 · Cited by 27
Self-citationO’Connor, C. M. C., Clemson, L. M., Brodaty, H., Gitlin, L. N., Piguet, O., & Mioshi, E. (2015) · Disability and Rehabilitation · doi:10.3109/09638288.2015.1055375 · Cited by 27
“with previously reported data that people with bvFTD are typically more impaired in ADLs than people with svPPA [9,10].”
MethodResultAmanzio, M., D’Agata, F., Palermo, S., Rubino, E., Zucca, M., Galati, A., Pinessi, L., Castellano, G., & Rainero, I. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.008 · Cited by 25
The Impact of Semantic Dementia on Everyday Actions: Evidence from an Ecological Study
Bier, N., Bottari, C. L., Hudon, C., Joubert, S., Paquette, G., & Macoir, J. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712001105 · Cited by 25
“(Mioshi & Hodges, 2009; Mioshi et al., 2007) showed that patients with SemD present with deficits in everyday activities when measured with an informant-based questionnaire.”
BackgroundMethodResultInfluentialAssociation between cognition and daily life functioning in dementia subtypes
Bouwens, S., Heugten, C. M. V., & Verhey, F. R. J. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2193 · Cited by 24
Brega, A. G., Reynolds, A., Bennett, R. E., Leehey, M. A., Bounds, L. S., Cogswell, J. B., Hagerman, R. J., Hagerman, P. J., & Grigsby, J. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2231 · Cited by 23
“Our data are consistent with those of Mioshi et al. (2007), who studied ADLs in persons with frontotemporal dementia (FTD) and Alzheimer disease.”
Neuroimaging correlates of everyday action in dementia
Seidel, G. A., Giovannetti, T., Price, C. C., Tanner, J. J., Mitchell, S. M., Eppig, J. S., & Libon, D. J. (2013) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2013.844773 · Cited by 23
“Recent evidence using such measures has suggested that distinct patterns of everyday action impairment are associated with deficits in different cognitive processes (Bangen et al., 2010; Forde & Humphreys, 2002; Mioshi et al., 2007).”
BackgroundGiovannetti, T., Seligman, S. C., Britnell, P., Brennan, L., & Libon, D. J. (2014) · Neuropsychology · doi:10.1037/neu0000167 · Cited by 23
Frontotemporal dementias: Recent advances and current controversies
Hodges, J., & Leyton, C. E. (2010) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.74249 · Cited by 23
“[26] Patients may perform normally on standard neuropsychological tests of memory, language, attention, and visual spatial ability, but more recent tests designed to assess emotion processing, [27] social cognition, [28] theory of mind, [29] and complex decision making [30] are more sensitive and…”
Giebel, C. M., & Challis, D. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4170 · Cited by 22
Functional Status in Behavioral Variant Frontotemporal Dementia: A Systematic Review
da Silva, T. B. L., Bahia, V. S., Nitríni, R., & Yassuda, M. S. (2013) · BioMed Research International · doi:10.1155/2013/837120 · Cited by 24
“With the revised criteria, a diagnosis of “possible” bvFTD requires three of the six clinically discriminated characteristics (loss of inhibition, apathy/inertia, loss of empathy, perseveration/compulsive behaviors, hyperorality, and dysexecutive neuropsychological profile).”
BackgroundMethodDemencia frontotemporal variante conductual: aproximación clínica y terapéutica
Fernández‐Matarrubia, M., Matías‐Guiu, J. A., Moreno‐Ramos, T., & Matías‐Guiu, J. (2013) · Neurología · doi:10.1016/j.nrl.2013.03.001 · Cited by 24
“…DFT vc. En fases tempranas, a pesar de existir alteraciones conductuales y de personalidad acusadas, los test neuro-psicológicos pueden ser normales 30 , dado que reflejan más la disfunción frontal dorsolateral que la ventromedial. ello, puede ser útil completar la valoración con escalas…”
Looi, J. C., Walterfang, M., Styner, M. A., Niethammer, M., Svensson, L. A., Lindberg, O. E., Östberg, P., Botes, L., Örndahl, E., Chua, P. M.-L., et al. (2011) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.09.014 · Cited by 21
“Lesser frontostriatal dysfunction, manifest as preserved executive function, is consistent with relative preservation of functional activities of daily living (ADLs) in SD, whereas in FTD, greater frontostriatal dysfunction is associated with impaired ADLs (Mioshi et al., 2007).”
Gregory, C. A., Halliday, G., Hodges, J. R., & Snowdon, J. A. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210002103 · Cited by 21
“It was included in the current battery as prior studies in patients with behavioral variant FTD, who present with decline in self-care and show early impairment in activities of daily living (Mioshi et al., 2007), show consistent impairment on the Faux Pas test (Gregory et al.”
ResultPronounced Impairment of Activities of Daily Living in Posterior Cortical Atrophy
Ahmed, S., Culley, S., Blanco‐Duque, C., Hodges, J. R., Butler, C., & Mioshi, E. (2020) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000506125 · Cited by 20
“frontotemporal dementia, Alzheimer’s disease (4), primary 85 progressive aphasia (6)) and atypical parkinsonian syndromes (15).”
BackgroundMethodInfluentialFunctional decline in the aphasic variant of Alzheimer's disease
Moeller, S., Sridhar, J., Martersteck, A., Coventry, C., Kuang, A., Zhang, H., Weıntraub, S., Mesulam, M. M., & Rogalski, E. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12331 · Cited by 19
Can IQCODE differentiate Alzheimer's disease and frontotemporal dementia?
Larner, A. J. (2010) · Age and Ageing · doi:10.1093/ageing/afq014 · Cited by 20
Functional disability in primary progressive aphasia
O’Connor, C. M. C., Ahmed, S., & Mioshi, E. (2014) · Aphasiology · doi:10.1080/02687038.2014.910588 · Cited by 22
“While patients with nfvPPA have relatively preserved basic ADLs, impairments in instrumental ADLs are common, ranging from mild to severe impairment by around 2 years into disease progression (Jang et al., 2012; Mioshi et al., 2007).”
BackgroundInfluentialLima-Silva, T. B., Bahia, V. S., Carvalho, V. A., Guimarães, H. C., Caramelli, P., Balthazar, M., Damasceno, B., Bottino, C. M. D. C., Brucki, S. M. D., Mioshi, E., et al. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn74000006 · Cited by 19
Self-citationJicha, G. A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9558-7 · Cited by 20
“…al. 2010; Boxer and Boeve 2007; Chow 2005; Galariotis et al. 2005a; GraffRadford and Woodruff 2007; Kaye et al. 2010; Mendez 2009; Chow et al. 2009; Kertesz et al. 2000; Lindau et al. 2003; Mathuranath et al. 2000a; Mioshi et al. 2007; Perry and Hodges 2000; Robles et al. 1999; Salmon et al. 2008).”
BackgroundHernandez, R., Jin, H., Lee, P.-J., Schneider, S., Junghaenel, D. U., Stone, A. A., Meijer, E., Gao, H., Maupin, D. J., & Zelinski, E. M. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-079241 · Cited by 18
Cederfeldt, M., Gosman‐Hedström, G., Sävborg, M., & Tarkowski, E. (2008) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2008.05.009 · Cited by 17
“Dementia has an impact on activities of daily living (Nygård, 2004; Mioshi et al., 2007) but, to the best of our knowledge, no study, has examined the influence of prestroke dementia on P-ADL in the acute phase after stroke.”
BackgroundRodríguez-Bailón, M., Montoro-Membila, N., Morán, T. G., Arnedo-Montoro, M. L., & Funes, M. J. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1013022 · Cited by 17
“A moderate dependence in simple or basic activities of daily living (BADL) and more complex or instrumental activities of daily living (IADL) has become a critical diagnostic criterion for dementia (Mioshi et al., 2007; Reisberg et al., 2001; Zanetti, Frisoni, Rozzini, Bianchetti, & Trabucchi, 1998).”
BackgroundResultInfluentialBier, N., & Macoir, J. (2009) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390902927885 · Cited by 17
“From a general perspective, Mioshi and collaborators (Mioshi et al., 2007) showed that patients with SD present deficits in”
BackgroundMethodInfluentialGiebel, C. M., Knopman, D. S., Mioshi, E., & Khondoker, M. R. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720901791 · Cited by 15
Jarry, C., Osiurak, F., Baumard, J., Lesourd, M., Coiffard, C., Lucas, C., Merck, C., Etcharry‐Bouyx, F., Chauviré, V., Belliard, S., et al. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107714 · Cited by 20
Metadata
- Authors
- Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- Venue
- Neurology
- Published
- 2007-06-12
- Volume
- 68
- Issue
- 24
- Pages
- 2077-2084
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2079397002
- Cited by
- 188
- References
- 52
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 15 · 2013: 13 · 2012: 7
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Wellcome Trust (073580)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- activities of daily living, frontotemporal dementia, Alzheimer's disease, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, instrumental activities of daily living, basic activities of daily living, cognitive impairment, caregiver burden, Disability Assessment for Dementia, Clinical Dementia Rating, Addenbrooke's Cognitive Examination-Revised
- MeSH terms
- Activities of Daily Living, Aged, Alzheimer Disease, Cognition Disorders, Cross-Sectional Studies, Dementia, Disability Evaluation, Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Age Distribution, Sex Distribution
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