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Cited by 190Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis ResearchHistorical and Modern Theater Studies

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Activities of daily living in frontotemporal dementia and Alzheimer disease

Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., Hodges, J. R.·2007·Neurology
DOI 10.1212/01.wnl.0000264897.13722.53
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Abstract

OBJECTIVE: To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction. METHODS: Fifty-nine patients and caregivers participated in this cross-sectional study: behavioral variant frontotemporal dementia (bv-FTD, n = 15), progressive nonfluent aphasia (PNFA, n = 10), semantic dementia (n = 15), and Alzheimer disease (AD, n = 19). Caregivers were interviewed with the Disability Assessment for Dementia (DAD) to provide two outcome measures about ADLs: basic and instrumental ADLs (BADLs, IADL). In addition, patients were rated on the Clinical Dementia Rating Scale (CDR), and performance on cognitive measures (Addenbrooke's Cognitive Examination Revised [ACE-R]) was assessed. RESULTS: On the DAD, the bv-FTD group was most affected (56% of normal), whereas PNFA and semantic dementia patients were least impaired (83% and 85%); AD was intermediate (76%). The opposite pattern was seen on the ACE-R, where PNFA and semantic dementia groups were most affected, and bv-FTD showed least impairment; AD was again intermediate. Scores on the DAD did not correlate with cognitive measures, CDR, or disease duration. We further analyzed which aspect of ADLs was most affected, and a unique pattern of deficits emerged for the bv-FTD group (initiation affected > planning > execution for BADLs). CONCLUSION: Frontotemporal dementia has a devastating effect on activities of daily living, which is of considerable importance to caregivers and not captured by bedside cognitive tests.

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Metadata

Authors
Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R.
Affiliations
MRC Cognition and Brain Sciences Unit (GB)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-06-12
Volume
68
Issue
24
Pages
2077-2084
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000264897.13722.53
OpenAlex
W2079397002
Cited by
188
References
52
Citations by year
2026: 6 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 15 · 2013: 13 · 2012: 7
FWCI
8.46
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders
Wellcome Trust (073580)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
activities of daily living, frontotemporal dementia, Alzheimer's disease, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, instrumental activities of daily living, basic activities of daily living, cognitive impairment, caregiver burden, Disability Assessment for Dementia, Clinical Dementia Rating, Addenbrooke's Cognitive Examination-Revised
MeSH terms
Activities of Daily Living, Aged, Alzheimer Disease, Cognition Disorders, Cross-Sectional Studies, Dementia, Disability Evaluation, Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Age Distribution, Sex Distribution

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