Anterior cerebral artery infarction: Stroke mechanism and clinical-imaging study in 100 patients
Abstract
Background Stroke mechanisms and clinical features of anterior cerebral artery (ACA) territory infarction have rarely been investigated using MRI. Objectives To verify stroke mechanisms and to make clinical imaging correlation. Methods Clinical, MRI, and angiographic findings of 100 consecutive patients with ACA infarction were studied. Results Motor dysfunction (n = 91) was the most common symptom, and severe motor dysfunction was related to supplementary motor area/paracentral lobule involvement (p = 0.016). Hypobulia/apathy (n = 43) was related to involvement of frontal pole (p = 0.002), corpus callosum/cingulate gyrus (p = 0.003), and superior frontal gyrus (p Conclusion Anterior cerebral artery (ACA) atherosclerosis is the most important stroke etiology in our population, causing infarction with various mechanisms. Topographic lesion patterns and consequent clinical features of ACA infarction are determined by diverse pathogenic mechanisms and the status of collateral circulation.
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Apathy is a well-recognized feature of strokes affecting the medial frontal cortex and the medial and anterior thalamus.
“In addition, apathy is a well-recognized feature of strokes affecting similar portions of the medial frontal cortex (Kang & Kim, 2008; Le Heron et al., 2018) and the medial and anterior thalamus (Carrera & Bogousslavsky, 2006; Krause et al., 2012; Serra et al., 2013) respectively.”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kang & Kim, 2008
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Capsular Infarcts: The Underlying Vascular Lesions
Fisher, C. M. (1979) · Archives of Neurology · doi:10.1001/archneur.1979.00500380035003 · Cited by 439 · see citing works
Wong, K. S., Gao, S., Chan, Y. L., Hansberg, T., Lam, W. W. M., Droste, D. W., Kay, R., & Ringelstein, E. B. (2002) · Annals of Neurology · doi:10.1002/ana.10250 · Cited by 268 · see citing works
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The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
The anatomy of apathy: a neurocognitive framework for amotivated behaviour
Le Heron, C., Apps., M. A. J., & Husain, M. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.07.003 · Cited by 380 · see citing works
Neuropsychiatric sequelae of stroke
Ferro, J. M., Caeiro, L., & Figueira, M. L. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.46 · Cited by 237 · see citing works
Hahn, C., Lim, H.-K., Won, W. Y., Ahn, K. J., Jung, W.-S., & Lee, C. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053493 · Cited by 76 · see citing works
Hird, E. J., Slanina-Davies, A., Lewis, G., Hamer, M., & Roiser, J. P. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02922-y · Cited by 79 · see citing works
- Authors
- Kang, S. Y., & Kim, J. S.
- Affiliations
- Asan Medical Center (KR)
- Venue
- Neurology
- Published
- 2008-06-10
- Volume
- 70
- Issue
- 24_part_2
- Pages
- 2386-2393
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1968888795
- Cited by
- 177
- References
- 2
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 17 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 15 · 2014: 10 · 2013: 11 · 2012: 9
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- anterior cerebral artery infarction, stroke mechanisms, motor impairment, aphasia, grasp reflex, corpus callosum involvement, supplementary motor area, collateral circulation, embolism, MRI lesion localization, clinical-radiological correlation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cerebral Angiography, Intracranial Arteriosclerosis, Cerebrovascular Circulation, Corpus Callosum, Female, Gyrus Cinguli, Humans, Korea, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed, Comorbidity, Causality, Infarction, Anterior Cerebral Artery
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