Apathy and white matter integrity in Alzheimer's disease: a whole brain analysis with tract-based spatial statistics
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The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (p(corrected)<0.05) in the genu of the corpus callosum compared to the nonapathy group. The severity of apathy was negatively correlated with FA values of the left anterior and posterior cingulum, right superior longitudinal fasciculus, splenium, body and genu of the corpus callosum and bilateral uncinate fasciculusin the apathy group (p(corrected)<0.05). This study was the first to explore FA values in whole brain WM in AD patients with apathy. The findings of these microstructural alterations of WM may be the key to the understanding of underlying neurobiological mechanism and clinical significances of apathy in AD.
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Apathy in Alzheimer's disease is associated with decreased anterior cingulate cortex white matter integrity by diffusion tensor imaging.
“Similarly apathy is associated with decreased perfusion in ACC (Benoit et al., 2004; Lanctôt et al., 2007; Robert et al., 2006), decreased ACC white matter integrity by DTI (Hahn et al., 2013; Kim et al., 2011; Ota et al., 2012) and increased amyloid burden in right ACC (Mori et al., 2014).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Hahn et al., 2013
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- Authors
- Hahn, C., Lim, H.-K., Won, W. Y., Ahn, K. J., Jung, W.-S., & Lee, C. U.
- Affiliations
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- St. Paul's Hospital (KR)
- Corresponding author
- Lee, Chang Uk
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-03
- Volume
- 8
- Issue
- 1
- Pages
- e53493
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3536751
- OpenAlex
- W2014288707
- Cited by
- 76
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 4 · 2013: 2
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation
- Rural Development Administration
- National Research Foundation of Korea
- Ministry of Education, Science and Technology (2012R1A1A2042339)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, apathy, white matter integrity, fractional anisotropy, corpus callosum, cingulum, uncinate fasciculus, superior longitudinal fasciculus, white matter microstructure, disease severity
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Brain Mapping, Corpus Callosum, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Reproducibility of Results, Models, Statistical, Anisotropy, Diffusion Tensor Imaging, Apathy
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