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Cited by 237Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementDementia and Cognitive Impairment Research

Neuropsychiatric sequelae of stroke

Ferro, José M., Caeiro, Lara, Figueira, Maria Luísa·2016·Nature Reviews Neurology
DOI 10.1038/nrneurol.2016.46
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Abstract

Stroke survivors are often affected by psychological distress and neuropsychiatric disturbances. About one-third of stroke survivors experience depression, anxiety or apathy, which are the most common neuropsychiatric sequelae of stroke. Neuropsychiatric sequelae are disabling, and can have a negative influence on recovery, reduce quality of life and lead to exhaustion of the caregiver. Despite the availability of screening instruments and effective treatments, neuropsychiatric disturbances attributed to stroke are currently underdiagnosed and undertreated. Stroke severity, stroke-related disabilities, cerebral small vessel disease, previous psychiatric disease, poor coping strategies and unfavourable psychosocial environment influence the presence and severity of the psychiatric sequelae of stroke. Although consistent associations between psychiatric disturbances and specific stroke locations have yet to be confirmed, functional MRI studies are beginning to unveil the anatomical networks that are disrupted in stroke-associated psychiatric disorders. Evidence regarding biochemical and genetic biomarkers for stroke-associated psychiatric disorders is still limited, and better understanding of the biological determinants and pathophysiology of these disorders is needed. Investigation into the management of these conditions must be continued, and should include pilot studies to assess the benefits of innovative behavioural interventions and large-scale cooperative randomized controlled pharmacological trials of drugs that are safe to use in patients with stroke.

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  • These brain pathologies are described as both etiological factors and consequences of psychiatric disorders and neurodegenerative diseases.

    “These brain pathologies are described as both etiological factors and consequences of psychiatric disorders and neurodegenerative diseases [15].”

    From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [15]

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Authors
Ferro, J. M., Caeiro, L., & Figueira, M. L.
Affiliations
University of Lisbon (PT)
Corresponding author
Ferro, José M.
ORCID
Venue
Nature Reviews Neurology
Publisher
Springer Science and Business Media LLC
Published
2016-04-11
Volume
12
Issue
5
Pages
269-280
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
DOI
10.1038/nrneurol.2016.46
OpenAlex
W2318998344
Cited by
237
References
168
Citations by year
2026: 18 · 2025: 21 · 2024: 23 · 2023: 31 · 2022: 33 · 2021: 31 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 11 · 2016: 2
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundação para a Ciência e a Tecnologia
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
stroke, neuropsychiatric sequelae, depression, anxiety, apathy, stroke survivors, psychological distress, cerebral small vessel disease, stroke location, functional MRI, biomarkers, pathophysiology, screening, quality of life, caregiver burden
MeSH terms
Anxiety Disorders, Depressive Disorder, Humans, Personality Disorders, Stress Disorders, Post-Traumatic, Survivors, Stroke, Apathy

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