The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Neural control of the heart: Recent concepts and clinical correlations
Abstract
Areas distributed throughout the neuraxis, including the anterior insula, anterior cingulate cortex (ACC), amygdala, hypothalamus, periaqueductal gray matter, parabrachial nucleus, and several regions of the medulla, exert a beat-to-beat control on cardiac function. These areas are critically involved in emotional behavior, stress responses, and homeostatic reflexes and exert their influence on heart rate (HR) and cardiac contractility via the sympathetic and parasympathetic nervous systems. Over the past several years, advances in neuroanatomical, neurophysiologic, and functional imaging studies have provided insight into the central and peripheral mechanisms of neural control of cardiac function in humans. Whereas some issues, such as lateralization of this central control, remain unresolved, the adverse cardiac consequences of a wide variety of neurologic disorders emphasize the need to better understand the functional anatomy and neurochemical mechanisms of the neural control of the heart. Important examples are severe arrhythmias and myocardial injury in the setting of neurologic catastrophes and sudden unexplained death in epilepsy. This review will focus on some of the current experimental and clinical information related to these relevant issues for the neurologist.
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“Additionally, the c-ICNs have also been associated with autonomic nervous system (ANS) modulation [45–50] possibly helping to explain the ANS dysfunction consistently reported across psychopathologies [51, 52].”
In the citing paper
“Autonomic influences modulate the intrinsic rate and sympathetic activation or parasympathetic inhibition39 can cause sinus tachycardia.”
From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [39]
Citations
Cites
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Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
The sympathetic control of blood pressure
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Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury
Sposato, L. A., Hilz, M. J., Aspberg, S., Murthy, S. B., Bahit, M. C., Hsieh, C., Sheppard, M. N., & Scheitz, J. F. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.009 · Cited by 333
Stroke-heart syndrome: clinical presentation and underlying mechanisms
Scheitz, J. F., Nolte, C. H., Doehner, W., Hachinski, V., & Endres, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30336-3 · Cited by 319
Advances in Photopletysmography Signal Analysis for Biomedical Applications
Moraes, J. L., Rocha, M. X., Vasconcelos, G. G., Vasconcelos Filho, J. E., De Albuquerque, V. H. C., & Alexandria, A. R. (2018) · Sensors · doi:10.3390/s18061894 · Cited by 292
Heart–Brain Axis: Effects of Neurologic Injury on Cardiovascular Function
Tahsili-Fahadan, P., & Geocadin, R. G. (2017) · Circulation Research · doi:10.1161/circresaha.116.308446 · Cited by 291
Quigley, K. S., Gianaros, P. J., Norman, G. J., Jennings, J. R., Berntson, G. G., & de Geus, E. J. C. (2024) · Psychophysiology · doi:10.1111/psyp.14604 · Cited by 281
Metadata
- Authors
- Palma, J.-A., & Benarroch, E. E.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 2014-07-15
- Volume
- 83
- Issue
- 3
- Pages
- 261-271
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2074959430
- Cited by
- 237
- References
- 130
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 35 · 2023: 29 · 2022: 20 · 2021: 26 · 2020: 18 · 2019: 20 · 2018: 16 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- cardiac autonomic regulation, heart rate, cardiac contractility, sympathetic nervous system, parasympathetic nervous system, anterior insula, anterior cingulate cortex, amygdala, hypothalamus, periaqueductal gray, parabrachial nucleus, medulla, emotional behavior, stress response, cardiac arrhythmias, myocardial injury, neurological disorders
- MeSH terms
- Autonomic Nervous System, Brain, Heart, Heart Diseases, Humans, Nervous System Diseases
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