The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Systemic metabolism in frontotemporal dementia
Abstract
Objective To document the metabolic changes in frontotemporal dementia, including serum cholesterol and insulin levels, and compare and contrast these changes to motor neuron disease, where metabolism is proposed to affect disease progression. Methods A cohort of 90 patients with dementia (31 behavioral-variant frontotemporal dementia [bvFTD], 30 semantic dementia [SD], and 29 Alzheimer disease [AD]) underwent fasting blood cholesterol, glucose, and peripheral insulin level analysis. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). These results were compared with a cohort of 19 control subjects. Results The bvFTD cohort had lower high-density lipoprotein (HDL) cholesterol levels compared with control and AD groups, and increased total cholesterol/HDL ratio and triglyceride levels compared with the control group. The SD cohort had increased triglyceride levels compared with control subjects. Both FTD groups had increased fasting insulin levels and HOMA-IR index compared with the control group, and this remained increased in the subjects with bvFTD compared to subjects with AD. Conclusion Both patients with bvFTD and those with SD have increased triglyceride and insulin levels and lower HDL cholesterol levels compared with controls, suggesting a state of peripheral insulin resistance. These factors have been found to affect prognosis in motor neuron disease favorably, although insulin resistance has been proposed as a me…
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Cholesterol dysregulation and lipid dyshomeostasis have been identified in several neurodegenerative diseases.
“Importantly, cholesterol dysregulation6–9 and lipid dyshomeostasis8,10–15 have been identified in several neurodegenerative diseases.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [14]
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Assessment of Eating Behavior Disturbance and Associated Neural Networks in Frontotemporal Dementia
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Self-citationLipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders
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Self-citationGRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
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Fuller, O. K., McLennan, E. D., Egan, C. L., Burrows, E. L., & Febbraio, M. A. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114810 · Cited by 6
Metadata
- Authors
- Ahmed, R. M., MacMillan, M., Bartley, L., Halliday, G. M., Kiernan, M. C., Hodges, J. R., & Piguet, O.
- Affiliations
- From Neuroscience Research Australia (R.M.A., M.M., L.B., G.M.H., M.C.K., J.R.H., O.P.), Sydney; Prince of Wales Clinical School (R.M.A., J.R.H.), School of Medical Sciences (G.M.H., O.P.), and ARC Centre of Excellence in Cognition and its Disorders (R.M.A., G.M.H., J.R.H., O.P.), the University of New South Wales, Sydney; and Sydney Medical School (M.C.K.), Brain and Mind Research Institute, University of Sydney, Australia.
- Venue
- Neurology
- Published
- 2014-11-11
- Volume
- 83
- Issue
- 20
- Pages
- 1812-1818
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 70
- References
- 7
- Language
- en
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