The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mixed pathology is more likely in black than white decedents with Alzheimer dementia
Open accessAbstract
OBJECTIVE: To compare the burden of neuropathology in black and white participants with clinical Alzheimer disease (AD). METHODS: Participants included 122 persons enrolled in the Rush Alzheimer's Disease Clinical Core, a prospective cohort study of AD. Forty-one black decedents were matched two-to-one to 81 white decedents according to age at death, sex, years of education, and cognition proximate to death. We examined common brain pathologies related to dementia (AD, Lewy body, and macroscopic and microinfarct pathology) and arteriolar sclerosis and atherosclerosis. We calculated the frequency of each dementia pathology both alone and in combination (mixed pathologies). Racial differences in the odds of a single pathology vs mixed pathologies, and in the odds of vessel disease and its severity, were examined using logistic regression analyses. RESULTS: AD pathology was confirmed in >93% of both black and white decedents with AD dementia. However, black decedents were less likely to have Alzheimer pathology as a single dementia pathology than white decedents (19.5% vs 42.0%), and were more likely to have AD mixed with an additional pathology (70.7% vs 50.6%), particularly Alzheimer pathology and Lewy bodies, and Alzheimer pathology, Lewy bodies, and infarcts. Black decedents also had more severe arteriolar sclerosis and atherosclerosis. CONCLUSION: Black decedents with AD dementia are more likely to have mixed brain pathologies compared with age-, sex-, education-, and cognition-matched white decedents with AD dementia.
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“It is now well established that the prototypical multidomain amnestic dementia phenotype historically used to define probable AD [1] does not “rule in” AD pathologic change (which implies change from normal) at autopsy [50–52]”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
In the citing paper
“and the absence of the syndrome does not “rule out” AD pathologic change.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
In the citing paper
“AD neuropathologic change is documented in approximately 80% of cases with a traditional clinical diagnosis of “AD dementia” (see Fig. 5 for an example of clinical misdiagnosis of “AD dementia”) [50–52,162,185,209–211].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992
Self-citationNeuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336
Self-citationThe Neuropathology of Older Persons with and Without Dementia from Community versus Clinic Cohorts
Schneider, J. A., Aggarwal, N. T., Barnes, L., Boyle, P., & Bennett, D. A. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1227 · Cited by 372
Self-citationMatthews, F. E., Brayne, C., Lowe, J., McKeith, I., Wharton, S. B., & Ince, P. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000180 · Cited by 279
Vascular burden and Alzheimer disease pathologic progression
Lo, R. Y., Jagust, W. J., Weiner, M., Aisen, P., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31826c1b9d · Cited by 156
Self-citationRacial Disparities in Diabetes Mortality in the 50 Most Populous US Cities
Rosenstock, S., Whitman, S., West, J. F., & Balkin, M. (2014) · Journal of Urban Health · doi:10.1007/s11524-013-9861-4 · Cited by 83
A DESCRIPTIVE STUDY OF NEURITIC PLAQUES AND NEUROFIBRILLARY TANGLES IN AN AUTOPSY POPULATION
DeWOLFE MILLER, F., HICKS, S. P., D'AMATO, C. J., & LANDIS, J. R. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113897 · Cited by 70
Sandberg, G., Stewart, W., Smialek, J., & Troncoso, J. C. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00236-0 · Cited by 68
Research works printed but not linked: 24
- 10.1111/j.1532-5415.2006.00747.x · DOI
- 10.1212/WNL.56.1.49 · DOI
- 10.1056/NEJM199307083290201 · DOI
- 10.1161/01.CIR.83.4.1463 · DOI
- 10.1159/000096129 · DOI
- 10.1212/WNL.34.7.939 · DOI · Paper page
- 10.1212/WNL.41.4.479 · DOI · Paper page
- 10.1002/ana.24388 · DOI · Paper page
- de la Monte SM, Hutchins GM, Moore GW. Racial differences in the etiology of dementia and frequency of Alzheimer lesions in the brain. J Natl Med Assoc 1989;81:644–652.
- 10.1097/01.jnen.0000248548.20799.a3 · DOI
- 10.1001/archneur.63.1.87 · DOI
- 10.1177/0891988705281872 · DOI · Paper page
- 10.1212/01.wnl.0000196472.93744.57 · DOI
- 10.1038/mp.2011.136 · DOI
- 10.1097/JGP.0b013e3181d5745d · DOI
- 10.1017/S1041610213000768 · DOI
- 10.1377/hlthaff.2013.1353 · DOI
- 10.1097/01.wad.0000190802.03717.20 · DOI
- 10.1097/MAJ.0000000000000308 · DOI
- 10.1016/S0277-9536(99)00077-5 · DOI
- 10.1002/1097-0142(20010101)91:1 <233::AID-CNCR10>3.0.CO;2-8 · DOI
- 10.1016/S1047-2797(01)00265-4 · DOI
- 10.1097/MOT.0b013e3283447b1c · DOI
- 10.1001/jamaneurol.2013.3961 · DOI
Cited by
Sorted by citations
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
Self-citation2023 Alzheimer's disease facts and figures
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2020 Alzheimer's disease facts and figures
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Impact of multiple pathologies on the threshold for clinically overt dementia
Kapasi, A., DeCarli, C., & Schneider, J. A. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1717-7 · Cited by 739
Self-citation
Metadata
- Authors
- Barnes, L. L., Leurgans, S., Aggarwal, N. T., Shah, R. C., Arvanitakis, Z., James, B. D., Buchman, A. S., Bennett, D. A., & Schneider, J. A.
- Affiliations
- Rush University Medical Center (US)
- ORCID
- Venue
- Neurology
- Published
- 2015-08-11
- Volume
- 85
- Issue
- 6
- Pages
- 528-534
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4540250
- OpenAlex
- W2115821900
- Cited by
- 236
- References
- 10
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 30 · 2023: 22 · 2022: 37 · 2021: 25 · 2020: 20 · 2019: 17 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 1
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P30-AG 10161, P30AG010161)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, racial disparities, Lewy bodies, cerebral microinfarcts, arteriolosclerosis, atherosclerosis, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Black or African American, Brain, Diagnosis, Female, Humans, Male, Psychiatric Status Rating Scales, Cohort Studies, Case-Control Studies, Lewy Bodies, White People
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- CoChat. (2026). Citation check: Mixed pathology is more likely in black than white decedents with Alzheimer dementia. https://app.cochat.ai/papers/10.1212/wnl.0000000000001834
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- Barnes, L. L., Leurgans, S., Aggarwal, N. T., Shah, R. C., Arvanitakis, Z., James, B. D., Buchman, A. S., Bennett, D. A., & Schneider, J. A. (2015). Mixed pathology is more likely in black than white decedents with Alzheimer dementia. Neurology. https://doi.org/10.1212/wnl.0000000000001834
