A DESCRIPTIVE STUDY OF NEURITIC PLAQUES AND NEUROFIBRILLARY TANGLES IN AN AUTOPSY POPULATION
Abstract
From July 1, 1980 to December 2, 1982, all individuals at autopsy at the University of Michigan Medical Center greater than or equal to 65 years of age and selected individuals less than 65 years of age were examined for neuritic plaques and neurofibrillary tangles. Sections of the hippocampal, parahippocampal temporal gyrus, and fusiform gyrus were examined. In a total population of 199, each individual was classified as having none, few, or many of each lesion. The frequency of the joint presence of many plaques and tangles increased monotonically after age 71 years. There was no significant difference in the joint distribution of these lesions with sex or race. There was a strong correlation between the presence of one lesion and the other; the correlation for the two lesions was similar for males and females, but for blacks, it was significantly higher than for non-blacks. The distribution of these lesions in autopsy populations may be useful in identifying other related hypothetical risk factors for dementia of Alzheimer's type.
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Only a few studies have directly investigated the association between sex and AD and other common neuropathologies, and these had small sample sizes (less than 200 brain autopsies) or did not examine pathologies other than AD.
“Yet, to date, only a few studies have directly investigated the association between sex and AD and other common neuropathologies. Further, these included only a small sample size (less than 200 brain autopsies) [41,53], or did not examine pathologies other than AD [41,43,53].”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [41]
Few if any previous studies that investigated the association of sex with AD pathologies have examined menopausal factors.
“Few if any of the previous studies which investigated the association of sex with AD pathologies have examined menopausal factors [25,41,43,53].”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [41]
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Medical Student Journal of Australia: Volume Five, Issue 1
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- Authors
- DeWOLFE MILLER, F., HICKS, S. P., D'AMATO, C. J., & LANDIS, J. R.
- Affiliations
- University of Michigan (US)
- ORCID
- LANDIS, J. RICHARD
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-09
- Volume
- 120
- Issue
- 3
- Pages
- 331-341
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2144810614
- Cited by
- 70
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuritic plaques, neurofibrillary tangles, Alzheimer's disease, dementia, hippocampus, fusiform gyrus, sex differences, racial differences, risk factors, autopsy findings
- MeSH terms
- Age Factors, Alzheimer Disease, Autopsy, Black or African American, Brain, Cross-Sectional Studies, Female, Humans, Male, Michigan, Middle Aged, Neurofibrils, Sex Factors, Black People, White People
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