The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mixed pathology is more likely in black than white decedents with Alzheimer dementia
Open accessAbstract
OBJECTIVE: To compare the burden of neuropathology in black and white participants with clinical Alzheimer disease (AD). METHODS: Participants included 122 persons enrolled in the Rush Alzheimer's Disease Clinical Core, a prospective cohort study of AD. Forty-one black decedents were matched two-to-one to 81 white decedents according to age at death, sex, years of education, and cognition proximate to death. We examined common brain pathologies related to dementia (AD, Lewy body, and macroscopic and microinfarct pathology) and arteriolar sclerosis and atherosclerosis. We calculated the frequency of each dementia pathology both alone and in combination (mixed pathologies). Racial differences in the odds of a single pathology vs mixed pathologies, and in the odds of vessel disease and its severity, were examined using logistic regression analyses. RESULTS: AD pathology was confirmed in >93% of both black and white decedents with AD dementia. However, black decedents were less likely to have Alzheimer pathology as a single dementia pathology than white decedents (19.5% vs 42.0%), and were more likely to have AD mixed with an additional pathology (70.7% vs 50.6%), particularly Alzheimer pathology and Lewy bodies, and Alzheimer pathology, Lewy bodies, and infarcts. Black decedents also had more severe arteriolar sclerosis and atherosclerosis. CONCLUSION: Black decedents with AD dementia are more likely to have mixed brain pathologies compared with age-, sex-, education-, and cognition-matched white decedents with AD dementia.
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“It is now well established that the prototypical multidomain amnestic dementia phenotype historically used to define probable AD [1] does not “rule in” AD pathologic change (which implies change from normal) at autopsy [50–52]”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
In the citing paper
“and the absence of the syndrome does not “rule out” AD pathologic change.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
In the citing paper
“AD neuropathologic change is documented in approximately 80% of cases with a traditional clinical diagnosis of “AD dementia” (see Fig. 5 for an example of clinical misdiagnosis of “AD dementia”) [50–52,162,185,209–211].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [52]
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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
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Metadata
- Authors
- Barnes, L. L., Leurgans, S., Aggarwal, N. T., Shah, R. C., Arvanitakis, Z., James, B. D., Buchman, A. S., Bennett, D. A., & Schneider, J. A.
- Affiliations
- Rush University Medical Center (US)
- ORCID
- Venue
- Neurology
- Published
- 2015-08-11
- Volume
- 85
- Issue
- 6
- Pages
- 528-534
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4540250
- OpenAlex
- W2115821900
- Cited by
- 236
- References
- 10
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 30 · 2023: 22 · 2022: 37 · 2021: 25 · 2020: 20 · 2019: 17 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 1
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P30-AG 10161, P30AG010161)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, racial disparities, Lewy bodies, cerebral microinfarcts, arteriolosclerosis, atherosclerosis, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Black or African American, Brain, Diagnosis, Female, Humans, Male, Psychiatric Status Rating Scales, Cohort Studies, Case-Control Studies, Lewy Bodies, White People
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