The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis
Abstract
Objective To study the contribution of the symptomatic lesion in establishing multiple sclerosis (MS) diagnosis and prognosis. Methods We performed an observational study based on a prospective clinically isolated syndrome (CIS) cohort of 1,107 patients recruited for clinical and brain MRI follow-up from 1995 to 2014. Eligible patients (n = 954) were divided into 4 groups according to baseline MRI: patients with a normal MRI (n = 290); patients with a single asymptomatic lesion (n = 18); patients with a single cord/brainstem symptomatic lesion (n = 35); and patients with more than 1 lesion (n = 611). For each group, we studied the risk of second attack, with 2005 McDonald MS and Expanded Disability Status Scale 3.0, using univariable and multivariable regression models adjusted by age, sex, oligoclonal bands, and disease-modifying treatments. We tested the diagnostic performance of a modified dissemination in space (DIS) criterion that includes symptomatic lesions in the total count and compared it to the DIS criteria (at least 1 asymptomatic lesion in at least 2 of the 4 MS characteristic MS locations) for all patients and for the subgroup of patients with brainstem or spinal cord topography. Results Patients with a cord/brainstem single symptomatic lesion have a higher risk of second attack and disability accumulation than patients with 0 lesions but have a similar risk compared to patients with 1 asymptomatic lesion. Diagnostic properties are reasonably maintained when the…
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“Based on histopathological studies, cortical lesions and juxtacortical lesions extending into the cortex are known to be typical of MS. 74,75”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [75]
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Cites
MRI criteria for MS in patients with clinically isolated syndromes
Montalban, X., Tintoré, M., Swanton, J., Barkhof, F., Fazekas, F., Filippi, M., Frederiksen, J., Kappos, L., Palace, J., Polman, C., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cec45c · Cited by 252
Kang, H., Metz, L., Traboulsee, A., Eliasziw, M., Zhao, G., Cheng, Y., Zhao, Y., Li, D., the Minocycline in CIS Study Group, Traboulsee, A., et al. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458513501230 · Cited by 25
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Research works printed but not linked: 11
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- 10.1093/brain/awv105 · DOI · Paper page
- 10.1002/ana.410130302 · DOI · Paper page
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- 10.1212/WNL.33.11.1444 · DOI · Paper page
- 10.1136/jnnp.2005.073247 · DOI
- 10.1016/S1474-4422(07)70176-X · DOI
- 10.1007/s00415-015-7668-9 · DOI
- Brownlee WJ, Swanton JK, Miszkiel KA, Miller DH, Ciccarelli O. Should we include lesions in the symptomatic region in dissemination in space in patients with clinically isolated syndromes? Mult Scler 2015;21:S11.
- 10.1212/WNL.0b013e3181feb26f · DOI
- 10.1212/01.wnl.0000341935.41852.82 · DOI · Paper page
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167
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Metadata
- Authors
- Tintore, M., Otero-Romero, S., Río, J., Arrambide, G., Pujal, B., Tur, C., Galán, I., Comabella, M., Nos, C., Arévalo, M. J., Vidal-Jordana, A., Castilló, J., Rodríguez-Acevedo, B., Midaglia, L., Mitjana, R., Auger, C., Sastre-Garriga, J., Rovira, À., & Montalban, X.
- Affiliations
- From Centre d'Esclerosi Múltiple de Catalunya (CEMCAT), Department of Neurology/Neuroimmunology (M.T., S.O.-R., J.R., G.A., B.P., C.T., I.G., M.C., C.N., M.J.A., A.V.-J., J.C., B.R.-A., L.M., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (R.M., C.A., À.R.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.
- Universitat Autònoma de Barcelona (ES)
- ORCID
- Venue
- Neurology
- Published
- 2016-09-27
- Volume
- 87
- Issue
- 13
- Pages
- 1368-1374
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2510596572
- Cited by
- 54
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 18 · 2017: 10
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- multiple sclerosis, clinically isolated syndrome, dissemination in space, diagnostic criteria, prognosis, relapse risk, disability progression, brainstem lesions, spinal cord lesions, asymptomatic lesions, MRI lesions
- MeSH terms
- Adult, Brain Stem, Demyelinating Diseases, Diagnosis, Differential, Disability Evaluation, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Prognosis, Prospective Studies, Risk Factors, Spinal Cord, Biomarkers, Multivariate Analysis
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