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Cued memory decline in biomarker-defined preclinical Alzheimer disease
Open accessAbstract
Objective: To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging. Methods: Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ+/− status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education. Results: A total of 276 older adults (Clinical Dementia Rating = 0, mean Mini-Mental State Examination score = 29 ± 1.06) were followed up for a mean of 3.6 ± 1.2 years. Despite the infrequency of cued memory decline (only 19% of participants scored ≤46/48 in total recall by year 3), Aβ+ participants were 3.55 times (95% confidence interval = 1.77–7.12) more likely to exhibit decline in total recall (≤46/48) compared with their Aβ− peers. Furthermore, Aβ+ participants who scored ≤46/48 had smaller hippocampal volumes (t = 3.37, p = 0.001) and evidence of early functional decline, i.e., greater risk of progression to global Clinical Dementia Rating of 0.5 (χ2 = 14.30, p < 0.001), compared with their Aβ+ peers with intact total recall. Conclusions: Cued memory decline in healthy older adults may be particularly indicative of Aβ-related decline during the preclinical stage of AD and useful for identifying Aβ+ clinically normal individuals at greatest risk of short-term clinical progression.
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“Numerous studies have shown that CU individuals with abnormal amyloid biomarkers have more rapid progression of atrophy, hypometabolism, and clinical/cognitive decline than individuals without biomarker evidence of Aβ deposition [13,33,80,93–99]”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [99]
Citations
Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Self-citationImaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411
Population-Based Norms for the Mini-Mental State Examination by Age and Educational Level
Crum, R. M. (1993) · JAMA · doi:10.1001/jama.1993.03500180078038 · Cited by 2,958
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
Revising the definition of Alzheimer's disease: a new lexicon
Dubois, B., Feldman, H. H., Jacova, C., Cummings, J. L., DeKosky, S. T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N. C., Galasko, D., et al. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70223-4 · Cited by 1,869
Genuine memory deficits in dementia
Grober, E. H., & Herman Buschke, L. (1987) · Developmental Neuropsychology · doi:10.1080/87565648709540361 · Cited by 1,045
Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027
Self-citationSynthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents
Mathis, C. A., Wang, Y., Holt, D. P., Huang, G.-F., Debnath, M. L., & Klunk, W. E. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030026b · Cited by 976
Screening for dementia by memory testing
Grober, E. H., Herman Buschke, L., Crystal, H., Bang, S., & Dresner, R. (1988) · Neurology · doi:10.1212/wnl.38.6.900 · Cited by 956
The Preclinical Alzheimer Cognitive Composite: Measuring Amyloid-Related Decline
Donohue, M. C., Sperling, R. A., Salmon, D. P., Rentz, D. M., Raman, R., Thomas, R. G., Weiner, M., & Aisen, P. S. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.803 · Cited by 860
Self-citationThe A4 Study: Stopping AD Before Symptoms Begin?
Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 778
Self-citationAmyloid deposition, hypometabolism, and longitudinal cognitive decline
Landau, S. M., Mintun, M. A., Joshi, A. D., Koeppe, R. A., Petersen, R. C., Aisen, P. S. S., Weiner, M. W., Jagust, W. J., & Initiative, A. D. N. (2012) · Annals of Neurology · doi:10.1002/ana.23650 · Cited by 742
Jack, C. R., Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.22628 · Cited by 602
Berendsen, A. A. M., Kang, J. H., van de Rest, O., Jankovic, N., Kampman, E., Jong, J. C. K., Franco, O. H., Ikram, M. A., Pikhart, H., Nilsson, L. M., et al. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000464269 · Cited by 566
Herman Buschke, L. (1984) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638408401233 · Cited by 556
Subjective cognitive complaints and amyloid burden in cognitively normal older individuals
Amariglio, R. E., Becker, J. A., Carmasin, J., Wadsworth, L. P., Lorius, N., Sullivan, C., Maye, J. E., Gidicsin, C., Pepin, L. C., Sperling, R. A., et al. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.011 · Cited by 472
Self-citationFrontal lobe damage produces episodic memory impairment
Wheeler, M. A., Stuss, D. T., & Tulving, E. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700000655 · Cited by 400
Memory impairment on free and cued selective reminding predicts dementia
Grober, E. H., Lipton, R. B., Hall, C. B., & Crystal, H. (2000) · Neurology · doi:10.1212/wnl.54.4.827 · Cited by 393
Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
Lam, B., Masellis, M., Freedman, M., Stuss, D. T., & Black, S. E. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt155 · Cited by 386
Mungas, D., Marshall, S. C., Weldon, M., Haan, M. N., & Reed, B. R. (1996) · Neurology · doi:10.1212/wnl.46.3.700 · Cited by 343
Advances in the prevention of Alzheimer's disease and dementia
Solomon, A., Mangialasche, F., Richard, E., Andrieu, S., Bennett, D., Breteler, M. M. B., Fratiglioni, L., Hooshmand, B., Khachaturian, A. S., Schneider, L. S. S., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12178 · Cited by 330
Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Amariglio, R. E., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2031 · Cited by 328
Self-citationStiff‐man syndrome treated with intrathecal baclofen
Penn, R. D., & Mangieri, E. A. (1993) · Neurology · doi:10.1212/wnl.43.11.2412 · Cited by 235
Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease
Lim, Y. Y., Maruff, P. T., Pietrzak, R. H., Ames, D. J., Ellis, K. A., Harrington, K., Lautenschlager, N. T., Szoeke, C. E. I., Martins, R. N., Masters, C. L., et al. (2013) · Brain · doi:10.1093/brain/awt286 · Cited by 219
Free and Cued Selective Reminding Identifies Very Mild Dementia in Primary Care
Grober, E. H., Sanders, A. E., Hall, C. B., & Lipton, R. B. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181cfc78b · Cited by 218
Rentz, D. M., Parra, M. A., Amariglio, R. E., Stern, Y., Sperling, R. A., & Ferris, S. H. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt222 · Cited by 212
Self-citationThe Amnestic Syndrome of Hippocampal type in Alzheimer's Disease: An MRI Study
Sarazin, M., Chauviré, V., Gérardin, E., Olivier Colliot, A., Kinkingnéhun, S., de Souza, L. C., Hugonot-Diener, L., Garnero, L., Lehéricy, S., Marie Chupin, A., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091150 · Cited by 203
Learning and retention in preclinical and early Alzheimer's disease.
Grober, E. H., & Kawas, C. H. (1997) · Psychology and Aging · doi:10.1037//0882-7974.12.1.183 · Cited by 203
Petersen, R. C., Wiste, H. J., Weigand, S. D., Rocca, W. A., Roberts, R. O., Mielke, M. M., Lowe, V. J., Knopman, D. S., Pankratz, V. S., Machulda, M. M., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.3098 · Cited by 196
Hedden, T., Mormino, E. C., Amariglio, R. E., Younger, A. P., Schultz, A. P., Becker, J. A., Buckner, R. L., Johnson, K. A., Sperling, R. A., & Rentz, D. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2462-12.2012 · Cited by 182
Self-citationBiomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
Wagner, M., Wolf, S., Reischies, F. M., Daerr, M., Wolfsgruber, S., Jessen, F., Popp, J., Maier, W., Hüll, M., Frölich, L., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318245f447 · Cited by 179
Derby, C. A., Burns, L. C., Wang, C., Katz, M. J., Zimmerman, M. E., L’Italien, G., Guo, Z., Berman, R., & Lipton, R. B. (2013) · Neurology · doi:10.1212/wnl.0b013e31828ab2c9 · Cited by 118
Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults
Huijbers, W., Mormino, E. C., Wigman, S. E., Ward, A. M., Vannini, P., McLaren, D. G., Becker, J. A., Schultz, A. P., Hedden, T., Johnson, K. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3579-13.2014 · Cited by 91
Self-citationFamiliarity-based memory as an early cognitive marker of preclinical and prodromal AD
Wolk, D. A., Mancuso, L., Kliot, D., Arnold, S. E., & Dickerson, B. C. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.02.014 · Cited by 84
The Free and Cued Selective Reminding Test: evidence of psychometric adequacy
Grober, E. H., Ocepek‐Welikson, K., & Teresi, J. A. (2009) · Cited by 75
Trajectories of Alzheimer disease‐related cognitive measures in a longitudinal sample
Bilgel, M., An, Y., Lang, A., Prince, J., Ferrucci, L., Jedynak, B., & Resnick, S. M. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.520 · Cited by 65
Semantic knowledge for famous names in mild cognitive impairment
Seidenberg, M., Guidotti, L. M., Nielson, K. A., Woodard, J. L., Durgerian, S., Zhang, Q., Gander, A., Antuono, P., & Rao, S. M. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708090103 · Cited by 45
Aschenbrenner, A. J., Balota, D. A., Tse, C., Fagan, A. M., Holtzman, D. M., Benzinger, T. L. S., & Morris, J. C. (2014) · Neuropsychology · doi:10.1037/neu0000133 · Cited by 32
Research works printed but not linked: 2
- Cox PR. Life Tables. New York: John Wiley & Sons; 1972.
- 10.1037/0882-7974.12.1.183 · DOI
Cited by
Sorted by citations
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Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
Self-citationAssociation of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging
Winer, J. R., Deters, K., Kennedy, G., Jin, M., Goldstein‐Piekarski, A. N., Poston, K. L., & Mormino, E. C. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.2876 · Cited by 249
Self-citationCurrent advances in digital cognitive assessment for preclinical Alzheimer's disease
Öhman, F., Hassenstab, J., Berron, D., Schöll, M., & Papp, K. V. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12217 · Cited by 214
Self-citationMormino, E. C., & Papp, K. V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179928 · Cited by 124
Self-citationEffects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults
Bilgel, M., An, Y., Helphrey, J. H., Elkins, W., Gómez, G., Wong, D. F., Davatzikos, C. A., Ferrucci, L., & Resnick, S. M. (2018) · Brain · doi:10.1093/brain/awy150 · Cited by 95
Metadata
- Authors
- Papp, K. V., Rentz, D. M., Mormino, E. C., Schultz, A. P., Amariglio, R. E., Quiroz, Y., Johnson, K. A., & Sperling, R. A.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Neurology
- Published
- 2017-04-11
- Volume
- 88
- Issue
- 15
- Pages
- 1431-1438
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC5386436
- OpenAlex
- W2592328671
- Cited by
- 52
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 1
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Eisai
- H. Lundbeck A/S
- National Institutes of Health (5u01ag024904-10)
- Genentech
- National Institute on Aging (U01-AG-024904, R01AG026484, R21AG038994, K24AG035007, R01AG027435, R01AG037497, P50AG005134, U19AG010483, U01AG032438, K23AG053422, R01AG034556, P01AG036694)
- National Institute of Mental Health (R01MH090291)
- National Institute of Biomedical Imaging and Bioengineering (R01EB014894)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- preclinical Alzheimer's disease, cued recall, memory decline, amyloid PET, amyloid burden, hippocampal volume, Free and Cued Selective Reminding Test, Clinical Dementia Rating, functional decline
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Aniline Compounds, Cues, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Mental Status Schedule, Neuropsychological Tests, Mental Recall, Thiazoles, Biomarkers, Disease Progression, Positron-Emission Tomography
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