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Cited by 266Dementia and Cognitive Impairment ResearchHealth disparities and outcomesAging, Health, and Disability

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Associations of Social Isolation and Loneliness With Later Dementia

Shen, Chun, Rolls, Edmund T., Cheng, Wei, Kang, Jujiao, Dong, Guiying, Xie, Chao, Zhao, Xing-Ming, Sahakian, Barbara J., Feng, Jianfeng·2022·Neurology
DOI 10.1212/wnl.0000000000200583
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Abstract

Background and objectives To investigate the independent associations of social isolation and loneliness with incident dementia and to explore the potential neurobiological mechanisms. Methods We utilized the UK Biobank cohort to establish Cox proportional hazard models with social isolation and loneliness as separate exposures. Demographic (sex, age, and ethnicity), socioeconomic (education level, household income, and Townsend deprivation index), biological (body mass index, APOE genotype, diabetes, cancer, cardiovascular disease, and other), cognitive (speed of processing and visual memory), behavioral (current smoker, alcohol intake, and physical activity), and psychological (social isolation or loneliness, depressive symptoms, and neuroticism) factors measured at baseline were adjusted. Then, voxel-wise brainwide association analyses were used to identify gray matter volumes (GMVs) associated with social isolation and with loneliness. Partial least squares regression was performed to test the spatial correlation of GMV differences and gene expression using the Allen Human Brain Atlas. Results We included 462,619 participants (mean age at baseline 57.0 years [SD 8.1]). With a mean follow-up of 11.7 years (SD 1.7), 4,998 developed all-cause dementia. Social isolation was associated with a 1.26-fold increased risk of dementia (95% CI, 1.15-1.37) independently of various risk factors including loneliness and depression (i.e., full adjustment). However, the fully adjusted haz…

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Research works printed but not linked: 34

  1. National Academies of Sciences, Engineering, and Medicine. Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System. The National Academies Press; 2020.
  2. Prince MJ, Wimo A, Guerchet MM, Ali GC, Wu Y-T, Prina M. World Alzheimer Report 2015: The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. Alzheimer's Disease International; 2015.
  3. 10.3233/JAD-180439 · DOI · Paper page
  4. 10.1017/S0033291720001014 · DOI
  5. 10.1136/jnnp-2012-302755 · DOI · Paper page
  6. 10.1126/science.1145463 · DOI
  7. 10.1038/nn.2724 · DOI · Paper page
  8. 10.1093/scan/nsu009 · DOI
  9. 10.1017/S2045796021000135 · DOI
  10. 10.1038/s41398-017-0086-2 · DOI
  11. 10.1038/mp.2016.186 · DOI
  12. 10.1016/j.tics.2018.10.005 · DOI
  13. 10.1038/s42003-020-01622-9 · DOI
  14. 10.1093/geronb/gby037 · DOI
  15. 10.1038/s41467-020-18201-5 · DOI
  16. 10.1016/j.jalz.2019.07.014 · DOI
  17. 10.1371/journal.pone.0154222 · DOI
  18. 10.1016/j.biopsych.2020.03.010 · DOI
  19. 10.1016/0191-8869(85)90026-1 · DOI · Paper page
  20. 10.1002/(SICI)1097-0258(19970715)16:13<1515::AID-SIM572>3.0.CO;2-1 · DOI
  21. 10.1016/j.neuroimage.2003.08.003 · DOI · Paper page
  22. 10.1016/j.jalz.2017.08.012 · DOI
  23. 10.1177/0898264312460275 · DOI · Paper page
  24. 10.1016/j.neubiorev.2004.05.005 · DOI
  25. 10.1038/nrn3918 · DOI
  26. 10.1126/science.1210027 · DOI · Paper page
  27. 10.1007/s11064-020-03102-2 · DOI
  28. 10.1523/JNEUROSCI.0747-14.2014 · DOI · Paper page
  29. 10.1093/brain/awq203 · DOI · Paper page
  30. 10.1002/ana.20624 · DOI · Paper page
  31. 10.1073/pnas.0903563106 · DOI · Paper page
  32. 10.1093/aje/kwx246 · DOI · Paper page
  33. 10.1016/S0140-6736(13)61570-6 · DOI · Paper page
  34. 10.1007/s10654-019-00499-1 · DOI · Paper page

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Metadata

Authors
Shen, C., Rolls, E. T., Cheng, W., Kang, J., Dong, G., Xie, C., Zhao, X.-M., Sahakian, B. J., & Feng, J.
Affiliations
University of Cambridge (GB)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2022-07-12
Volume
99
Issue
2
Pages
e164-e175
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000200583
OpenAlex
W4281763070
Cited by
266
References
16
Citations by year
2026: 52 · 2025: 90 · 2024: 63 · 2023: 45 · 2022: 16
FWCI
34.08
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Warwick Research Archive Portal (University of Warwick) (submittedVersion)
Funders
  • Wellcome Trust (200181/Z/15/Z)
  • Medical Research Council (MC_PC_17228)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
social isolation, loneliness, dementia risk, gray matter volume, structural brain differences, depressive symptoms, mitochondrial dysfunction, oxidative phosphorylation, gene expression, dementia risk factors
MeSH terms
Dementia, Humans, Loneliness, Longitudinal Studies, Middle Aged, Risk Factors, Social Isolation

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