The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Course in Parkinson disease subtypes: A 39-year clinicopathologic study
Abstract
BACKGROUND: Individual variations in the course of Lewy body Parkinson disease (PD) are well known. Patients have been classified into different clinical subtypes to identify differences in the course among the subgroups. Several studies indicate that the outcome is more favorable in tremor dominant (TD) cases but others report no difference. A majority of progression studies are based on cross-sectional single point data or short-term clinical observations. The lack of longitudinally followed autopsy-confirmed PD cohort remains a major weakness in the literature. Biochemical studies of brain indicate most pronounced abnormalities in akinetic/rigid (AR) and the least in TD cases. We postulate that PD course in these subtypes is concordant with the biochemical findings. OBJECTIVE: To compare the course in TD, mixed (MX), and AR subtypes of PD. METHODS: Longitudinal clinical follow-up and autopsy studies were performed on 166 patients with PD over 39 years (1968-2006). Patients were classified into TD, AR, and MX based on the entire clinical course. Only the pathologically confirmed PD cases were included. RESULTS: Sixty-six percent of cases had MX, 26% AR, and 8% TD profile. The age at onset was younger (p < 0.001) and progression to Hoehn & Yahr stage 4 was slower (p = 0.016) in the TD cases. Dementia was most common in AR (p = 0.039) and the least common in TD. In general, the course was most favorable in TD, followed by MX and AR subgroups. CONCLUSION: The three subtypes of Parkinson disease have different courses which are concordant with the differences in brain biochemical abnormalities.
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Cites
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Self-citationThe Neuropathologic Basis of Different Clinical Subgroups of Parkinson's Disease
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Cited by
Pharmacological Treatment of Parkinson Disease: A Review
Connolly, B. S., & Lang, A. E. (2014) · JAMA · doi:10.1001/jama.2014.3654 · Cited by 1,498
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
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The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study)
Pont‐Sunyer, C., Hotter, A., Gaig, C., Seppi, K., Compta, Y., Katzenschlager, R., Mas, N., Hofeneder, D., Brücke, T., Bayés, A., et al. (2015) · Movement Disorders · doi:10.1002/mds.26077 · Cited by 511
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Motor symptoms in Parkinson’s disease: A unified framework
Moustafa, A. A., Chakravarthy, S., Phillips, J. R., Gupta, A., Keri, S., Polner, B., Frank, M. J., & Jahanshahi, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.010 · Cited by 481
Metadata
- Authors
- Rajput, A. H., Voll, A., Rajput, M. L., Robinson, C. A., & Rajput, A.
- Venue
- Neurology
- Published
- 2009-07-21
- Volume
- 73
- Issue
- 3
- Pages
- 206-212
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057135238
- Cited by
- 270
- References
- 35
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
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