Neurodegenerative basis of age-related cognitive decline
Open accessAbstract
OBJECTIVE: To assess the contribution of dementia-related neuropathologic lesions to age-related and disease-related change in cognitive function. METHODS: A total of 354 Catholic nuns, priests, and brothers had annual clinical evaluations for up to 13 years, died, and underwent brain autopsy. The clinical evaluations included detailed testing of cognitive function from which previously established composite measures of global cognition and specific cognitive functions were derived. As part of a uniform neuropathologic evaluation, the density of neurofibrillary tangles was summarized in a composite measure and the presence of Lewy bodies and gross and microscopic cerebral infarction was noted. RESULTS: During follow-up, rate of global cognitive decline was gradual at first and then more than quadrupled in the last 4 to 5 years of life consistent with the onset of progressive dementia. Neurofibrillary tangles, cerebral infarction, and neocortical Lewy bodies all contributed to gradual age-related cognitive decline and little age-related decline was evident in the absence of these lesions. Neurofibrillary tangles and neocortical Lewy bodies contributed to precipitous disease-related cognitive decline, but substantial disease-related decline was evident even in the absence of these lesions. CONCLUSION: Mild age-related decline in cognitive function is mainly due to the neuropathologic lesions traditionally associated with dementia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Since the publication of the 2011 NIA-AA guidelines, data have accumulated indicating that cognitive decline in Alzheimer's disease occurs continuously over a long period.
“Since the publication of the 2011 guidelines, data have continued to accumulate indicating that the cognitive decline in AD occurs continuously over a long period [6–8]”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [7]
The Discussion (Neuropathologic lesions and decline in cognitive systems; page unavailable) links gradual decline before dementia to lesions associated with AD and related disorders. Global cognitive decline reports decline over years that accelerated in the last 52 months of life. The study does not establish that decline occurs continuously in AD specifically: it examined a selected older cohort with multiple kinds of pathology. (LLM, conf=0.82)
Experimental — accuracy not yet measuredEven in extreme old age, the presence of many neocortical NFTs correlates with antemortem cognitive decline.
“Even in extreme old age, the presence of many neocortical NFTs correlates with antemortem cognitive decline (105, 188-191).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
Self-citationBrookmeyer, R., Gray, S. G., & Kawas, C. H. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.9.1337 · Cited by 1,774 · see citing works
Neuropathology of older persons without cognitive impairment from two community-based studies
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Kelly, J. F., Aggarwal, N. T., Shah, R. C., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000219668.47116.e6 · Cited by 1,336 · see citing works
Self-citationThe neuropathology of probable Alzheimer disease and mild cognitive impairment
Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935 · see citing works
Self-citationTDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Amador‐Ortiz, C., Lin, W., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff‐Radford, N. R., Hutton, M. L., & Dickson, D. W. (2007) · Annals of Neurology · doi:10.1002/ana.21154 · Cited by 916 · see citing works
Individual differences in rates of change in cognitive abilities of older persons.
Wilson, R. S., Beckett, L. A., Barnes, L. L., Schneider, J. A., Bach, J., Evans, D. A., & Bennett, D. A. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.2.179 · Cited by 842 · see citing works
Self-citationSynaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Neuropathologic Features of Amnestic Mild Cognitive Impairment
Petersen, R. C., Parisi, J. E., Dickson, D. W., Johnson, K. A., Knopman, D. S., Boeve, B. F., Jicha, G. A., Ivnik, R. J., Smith, G. E., Tangalos, E. G., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.665 · Cited by 616 · see citing works
Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
Guillozet-Bongaarts, A. L., Weıntraub, S., Mash, D. C., & Mesulam, M. M. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.729 · Cited by 572 · see citing works
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
Bennett, D. A., Schneider, J. A., Bienias, J. L., Evans, D. A., & Wilson, R. S. (2005) · Neurology · doi:10.1212/01.wnl.0000152982.47274.9e · Cited by 537 · see citing works
Self-citationBennett, D. A., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Arnold, S. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.378 · Cited by 526 · see citing works
Self-citationSloane, P. D., Zimmerman, S. I., Suchindran, C., Reed, P. S., Wang, L., Boustani, M. A., & Sudha, S. (2002) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.23.100901.140525 · Cited by 461 · see citing works
Neuropathologic Substrate of Mild Cognitive Impairment
Markesbery, W. R., Schmitt, F. A., Kryscio, R. J., Davis, D. G., Smith, C. D., & Wekstein, D. R. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.38 · Cited by 460 · see citing works
Amieva, H., Jacqmin‐Gadda, H., Orgogozo, J., Carret, N. L., Helmer, C., Letenneur, L., Barberger‐Gateau, P., Fabrigoule, C., & Dartigues, J. (2005) · Brain · doi:10.1093/brain/awh451 · Cited by 437 · see citing works
Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
Schneider, J. A., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Neurology · doi:10.1212/01.wnl.0000118211.78503.f5 · Cited by 436 · see citing works
Self-citationGrober, E. H., Hall, C. B., Lipton, R. B., Zonderman, A. B., Resnick, S. M., & Kawas, C. H. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708080302 · Cited by 424 · see citing works
(1979) · MPG.PuRe (Max Planck Society) · Cited by 313 · see citing works
Relation of cerebral infarctions to dementia and cognitive function in older persons
Schneider, J. A., Wilson, R. S., Cochran, E. J., Bienias, J. L., Arnold, S. E., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000055863.87435.b2 · Cited by 305 · see citing works
Self-citationAbnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype
Josephs, K. A., Whitwell, J. L., Knopman, D. S., Hu, W. T., Stroh, D. A., Baker, M., Rademakers, R., Boeve, B. F., Parisi, J. E., Smith, G. E., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000304041.09418.b1 · Cited by 254 · see citing works
Trajectory of mild cognitive impairment onset
Howieson, D. B., Carlson, N. E., Moore, M. M., Wasserman, D. K., ABENDROTH, C. D., Payne-Murphy, J. C., & Kaye, J. A. (2008) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617708080375 · Cited by 162 · see citing works
Terminal decline in cognitive function
Wilson, R. S., Beckett, L. A., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000068019.60901.c1 · Cited by 157 · see citing works
Self-citationGreen, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O'Brien, R., & Zonderman, A. B. (2006) · Annals of Neurology · doi:10.1002/ana.21031 · Cited by 132 · see citing works
Terminal Cognitive Decline: Accelerated Loss of Cognition in the Last Years of Life
Wilson, R. S., Beck, T. L., Bienias, J. L., & Bennett, D. A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31803130ae · Cited by 117 · see citing works
Self-citationDistinguishing Preterminal and Terminal Cognitive Decline
Sliwinski, M. J., Stawski, R. S., Hall, C. B., Katz, M. J., Verghese, J., & Lipton, R. B. (2006) · European Psychologist · doi:10.1027/1016-9040.11.3.172 · Cited by 99 · see citing works
Religious Orders Study: Overview and Change in Cognitive and Motor Speed
Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Aging Neuropsychology and Cognition · doi:10.1080/13825580490511125 · Cited by 87 · see citing works
Self-citationOnset of terminal decline in cognitive abilities in individuals without dementia
Thorvaldsson, V., Hofer, S. M., Berg, S., Skoog, I. G., Sacuiu, S. F., & Johansson, B. E. A. (2008) · Neurology · doi:10.1212/01.wnl.0000312379.02302.ba · Cited by 81 · see citing works
Predictors of Preclinical Alzheimer Disease and Dementia: A Clinicopathologic Study
Galvin, J. E., Powlishta, K. K., Wilkins, K., McKeel, D. W., Xiong, C., Grant, E., Storandt, M., & Morris, J. C. (2005) · Archives of Neurology · doi:10.1001/archneur.62.5.758 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- DISCLOSURE Dr. Wilson serves as a Consulting Editor for Aging, Neuropsychology, and Cognition and Psychology and Aging; and receives research support from the NIH/NIA (R01AG024871 [principal investigator], P30AG10161 [coin- vestigator], R01AG11101 [coinvestigator], R01AG15819 [coinvesti- gator], R01AG021972 [coinvestigator], U24AG026395 [coinvestigator], R01AG017917 [coinvestigator], R01AG009966 [coinvestigator], and U01AG016979 [coinvestigator]) and the NIH/NIEHS (ES10902 [coinvesti- gator]). Dr. Leurgans receives/has received research support from the NIH (NINDS R01NS28127 [biostatistician], NINDS R01NS40902 [biostat- istician], NIA P01AG009466 [statistics core leader], P30AG010161 [data leader], NIA R01AG024480 [], NIA P01AG014449 [statistics core leader], R01AG033678 [], NIA R01AG017917 [biostatistician]), NIA R01AG024871 [], NIA R01AG22018 [biostatistician], and NIA R01 AG15819 [biostatisti- cian]) and the Michael J. Fox Foundation. Dr. Boyle receives research support from the NIH (R01AG034374 [principal investigator] and R01AG033678 [principal investigator]). Dr. Schneider serves as an Asso- ciate Editor of the Journal of Alzheimer's Disease; serves as a consultant for Avid Radiopharmaceuticals, Inc.; and receives research support from the NIH (R01AG024480 [neuropathologist], P01AG009466 [neuropatholo- gist], P01AG014449 [], R01AG015819 [], R01AG017917 [], R01AG031553 [neuropatholo- gist], R21AG030346 [], R01AG034374 [neuropatholo- gist], R01AG033678 [], R01AG036042 [], RC2AG036547 [], R01HL096944 [neuropathologist], and P30AG010161 [pathology core leader]). Dr. Bennett serves on the editorial board of Neurology ® ; has served as a consultant to Schering-Plough Corp., Medivation, Inc., and the Gerson Lehrman Group; and receives research sup- port from Danone Inc., the NIH (R01AG017917 [principal investigator], R01AG015819 [principal investigator], R01AG036042 [principal investiga- tor], RC2AG036547 [principal investigator], U01AG032984 [co-principal investigator, leader of epidemiologic cohort studies], R01AG024480 [coin- vestigator], R01AG024871 [-Investigator], P01AG009466 [coinvestigator], U24AG026395 [coinvestigator], R01AG030142 [coinvestigator], P01AG01449
- Neurology® Launches Subspecialty Alerts by E-mail! Customize your online journal experience by signing up for e-mail alerts related to your subspecialty or area of interest. Access this free service by visiting http://www.neurology.org/cgi/alerts/etoc or click on the "E-mail Alerts" link on the home page. An extensive list of subspecialties, methods, and study design choices will be available for you to choose from-allowing you priority alerts to cutting-edge research in your field!
Cited by
Sorted by citations
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537 · see citing works
Self-citationHyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationNelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Self-citationReligious Orders Study and Rush Memory and Aging Project
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260 · see citing works
Self-citationMemory aging and brain maintenance
Nyberg, L. H., Lövdén, M., Riklund, K., Lindenberger, U., & Bäckman, L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.04.005 · Cited by 1,220 · see citing works
The neuropathology of probable Alzheimer disease and mild cognitive impairment
Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935 · see citing works
Self-citationOverview and Findings from the Rush Memory and Aging Project
Bennett, D. A., Schneider, J. A., Buchman, A. S., Barnes, L. L., Boyle, P. A., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322663 · Cited by 837 · see citing works
Self-citationTiming of onset of cognitive decline: results from Whitehall II prospective cohort study
Singh-Manoux, A., Kivimaki, M., Glymour, M. M., Elbaz, A., Berr, C., Ebmeier, K. P., Ferrie, J. E., & Dugravot, A. (2012) · BMJ · doi:10.1136/bmj.d7622 · Cited by 836 · see citing works
Overview and Findings from the Religious Orders Study
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322573 · Cited by 647 · see citing works
Self-citationBiessels, G. J., Strachan, M. W. J., Visseren, F. L. J., Kappelle, L. J., & Whitmer, R. A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70088-3 · Cited by 555 · see citing works
Cerebral microinfarcts: the invisible lesions
Smith, E. E., Schneider, J. A., Wardlaw, J. M., & Greenberg, S. M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70307-6 · Cited by 456 · see citing works
Self-citationWhat is the association between sedentary behaviour and cognitive function? A systematic review
Falck, R. S., Davis, J. C., & Liu-Ambrose, T. Y. L. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095551 · Cited by 454 · see citing works
Sabia, S., Dugravot, A., Dartigues, J., Abell, J. G., Elbaz, A., Mika Kivimaki, B., & Singh‐Manoux, A. (2017) · BMJ · doi:10.1136/bmj.j2709 · Cited by 446 · see citing works
The natural history of cognitive decline in Alzheimer's disease.
Wilson, R. S., Segawa, E., Boyle, P. A., Anagnos, S. E., Hizel, L. P., & Bennett, D. A. (2012) · Psychology and Aging · doi:10.1037/a0029857 · Cited by 386 · see citing works
Self-citationHamer, M., Lavoie, K., & Bacon, S. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092993 · Cited by 374 · see citing works
Nelson, P. T., Head, E., Schmitt, F. A., Davis, P. R., Neltner, J. H., Jicha, G. A., Abner, E. L., Smith, C. D., Van Eldik, L. J., Kryscio, R. J., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0826-y · Cited by 365 · see citing works
Jack, C. R., Wiste, H. J., Weigand, S. D., Rocca, W. A., Knopman, D. S., Mielke, M. M., Lowe, V. J., Senjem, M. L., Gunter, J. L., Preboske, G. M., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70194-2 · Cited by 358 · see citing works
Elliott, M. L., Caspi, A., Houts, R., Ambler, A. P., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R. J., Knodt, A. R., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00044-4 · Cited by 330 · see citing works
Much of late life cognitive decline is not due to common neurodegenerative pathologies
Boyle, P. A., Wilson, R. S., Yu, L., Barr, A. M., Honer, W. G., Schneider, J. A., & Bennett, D. A. (2013) · Annals of Neurology · doi:10.1002/ana.23964 · Cited by 323 · see citing works
Self-citationBarnes, L. L., Shah, R. C., Aggarwal, N. T., Bennett, D. A., & Schneider, J. A. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322627 · Cited by 301 · see citing works
Self-citationProspective Study of Sedentary Behavior, Risk of Depression, and Cognitive Impairment
Hamer, M., & Stamatakis, E. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000156 · Cited by 254 · see citing works
TDP-43 Pathology, Cognitive Decline, and Dementia in Old Age
Wilson, R. S., Yu, L., Trojanowski, J. Q., Chen, E., Boyle, P. A., Bennett, D. A., & Schneider, J. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3961 · Cited by 248 · see citing works
Self-citationImpact of Smoking on Cognitive Decline in Early Old Age: The Whitehall II Cohort Study
Sabia, S., Elbaz, A., Dugravot, A., Head, J., Shipley, M., Hagger-Johnson, G., Kivimaki, M., & Singh-Manoux, A. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2016 · Cited by 235 · see citing works
Emerging Concepts in Alzheimer's Disease
Vinters, H. V. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163927 · Cited by 232 · see citing works
Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Tuligenga, R. H., Dugravot, A., Tabák, Á. G., Elbaz, A., Brunner, E. J., Mika Kivimaki, B., & Singh‐Manoux, A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70192-x · Cited by 213 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Brain Pathology Contributes to Simultaneous Change in Physical Frailty and Cognition in Old Age
Buchman, A. S., Yu, L., Wilson, R. S., Boyle, P. A., Schneider, J. A., Bennett, D. A., & Kritchevsky, S. B. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu117 · Cited by 203 · see citing works
Self-citationA genome-wide scan for common variants affecting the rate of age-related cognitive decline
Jager, P. L. D., Shulman, J. M., Chibnik, L. B., Keenan, B. T., Raj, T., Wilson, R. S., Yu, L., Leurgans, S. E., Tran, D., Aubin, C., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.033 · Cited by 192 · see citing works
Self-citationRegional Multiple Pathology Scores Are Associated with Cognitive Decline in L ewy Body Dementias
Howlett, D. R., Whitfield, D., Johnson, M. A., Attems, J., O'Brien, J. T., Aarsland, D., Lai, M. K. P., Lee, J. H., Chen, C., Ballard, C. G., et al. (2014) · Brain Pathology · doi:10.1111/bpa.12182 · Cited by 196 · see citing works
Temporal course and pathologic basis of unawareness of memory loss in dementia
Wilson, R. S., Boyle, P. A., Yu, L., Barnes, L. L., Sytsma, J., Buchman, A. S., Bennett, D. A., & Schneider, J. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001935 · Cited by 188 · see citing works
Self-citationAlcohol consumption and cognitive decline in early old age
Sabia, S., Elbaz, A., Britton, A. R., Bell, S., Dugravot, A., Shipley, M. J., Mika Kivimaki, B., & Singh‐Manoux, A. (2014) · Neurology · doi:10.1212/wnl.0000000000000063 · Cited by 182 · see citing works
Genome-wide association study of the rate of cognitive decline in Alzheimer’s disease
Sherva, R., Tripodis, Y., Bennett, D. A., Chibnik, L. B., Crane, P. K., de Jager, P. L., Farrer, L. A., Saykin, A. J., Shulman, J. M., Naj, A., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.01.008 · Cited by 180 · see citing works
Self-citationGharbi‐Meliani, A., Dugravot, A., Sabia, S., Régy, M., Fayossé, A., Schnitzler, A., Mika Kivimaki, B., Singh‐Manoux, A., & Dumurgier, J. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00740-0 · Cited by 179 · see citing works
Does cognitive reserve shape cognitive decline?
Singh‐Manoux, A., Marmot, M. G., Glymour, M. M., Sabia, S., Mika Kivimaki, B., & Dugravot, A. (2011) · Annals of Neurology · doi:10.1002/ana.22391 · Cited by 170 · see citing works
Cognitive decline in the elderly: an analysis of population heterogeneity
Hayden, K. M., Reed, B., Manly, J. J., Tommet, D., Pietrzak, R. H., Chelune, G. J., Yang, F. M., Revell, A. J., Bennett, D. A., & Jones, R. N. (2011) · Age and Ageing · doi:10.1093/ageing/afr101 · Cited by 169 · see citing works
Self-citationDietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study
Ozawa, M., Shipley, M. J., Mika Kivimaki, B., Singh‐Manoux, A., & Brunner, E. J. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.013 · Cited by 165 · see citing works
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Karr, J. E., Graham, R., Hofer, S. M., & Terrera, G. M. (2018) · Psychology and Aging · doi:10.1037/pag0000236 · Cited by 147 · see citing works
Boyle, P. A., Yu, L., Wilson, R. S., Segawa, E., Buchman, A. S., & Bennett, D. A. (2013) · Psychology and Aging · doi:10.1037/a0033103 · Cited by 146 · see citing works
Self-citationMansens, D., Deeg, D. J. H., & Comijs, H. C. (2017) · Aging & Mental Health · doi:10.1080/13607863.2017.1328481 · Cited by 140 · see citing works
Desai Bradaric, B., Patel, A., Schneider, J. A., Carvey, P. M., & Hendey, B. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0684-8 · Cited by 139 · see citing works
Self-citationTrajectories of End of Life: A Systematic Review
Cohen‐Mansfield, J., Skornick-Bouchbinder, M., & Brill, S. (2017) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbx093 · Cited by 135 · see citing works
Opwonya, J., Doan, D. N. T., Kim, S. G., Kim, J. I., Ku, B. U., Kim, S., Park, S., & Kim, J. U. (2021) · Neuropsychology Review · doi:10.1007/s11065-021-09495-3 · Cited by 141 · see citing works
Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline
Boyle, P. A., Yang, J., Yu, L., Leurgans, S. E., Capuano, A. W., Schneider, J. A., Wilson, R. S., & Bennett, D. A. (2016) · Brain · doi:10.1093/brain/aww341 · Cited by 129 · see citing works
Self-citationAssociation of midlife diet with subsequent risk for dementia
Akbaraly, T. N., Singh-Manoux, A., Dugravot, A., Brunner, E. J., Kivimäki, M., & Sabia, S. (2019) · JAMA · doi:10.1001/jama.2019.1432 · Cited by 121 · see citing works
Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain
Zhao, W., Zhao, L., Chang, X., Lu, X., & Tu, Y. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215192120 · Cited by 121 · see citing works
Neuropathologic Basis of Age-Associated Brain Atrophy
Erten‐Lyons, D., Dodge, H. H., Woltjer, R. L., Silbert, L. C., Howieson, D. B., Kramer, P., & Kaye, J. A. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1957 · Cited by 121 · see citing works
Falck, R. S., Landry, G. J., Best, J. R., Davis, J. C., Chiu, B. K., & Liu-Ambrose, T. Y. L. (2017) · Physical Therapy · doi:10.1093/ptj/pzx074 · Cited by 120 · see citing works
Xiong, J., Ye, M., Wang, L., & Zheng, G. (2020) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2020.103810 · Cited by 123 · see citing works
McAleese, K. E., Colloby, S. J., Thomas, A. J., Al‐Sarraj, S., Ansorge, O., Neal, J., Roncaroli, F., Love, S., Francis, P. T., & Attems, J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12291 · Cited by 110 · see citing works
Lim, A. S. P., Yu, L., Costa, M. D., Leurgans, S. E., Buchman, A. S., Bennett, D. A., & Saper, C. B. (2012) · SLEEP · doi:10.5665/sleep.1820 · Cited by 108 · see citing works
Self-citationObesity phenotypes in midlife and cognition in early old age
Singh‐Manoux, A., Czernichow, S., Elbaz, A., Dugravot, A., Sabia, S., Hagger‐Johnson, G., Kaffashian, S., Zins, M., Brunner, E. J., Nabi, H., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182661f63 · Cited by 106 · see citing works
Alzheimer's disease pathophysiology in the Retina
Gaire, B. P., Koronyo, Y., Fuchs, D.-T. S., Shi, H., Rentsendorj, A., Danziger, R., Vit, J., Mirzaei, N., Doustar, J., Sheyn, J., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101273 · Cited by 102 · see citing works
Silverberg, N. B., Elliott, C. L., Ryan, L. M., Masliah, E., & Hodes, R. J. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.03.004 · Cited by 102 · see citing works
Wu, Z., Phyo, A. Z. Z., Alharbi, T., Woods, R. L., & Ryan, J. L. (2020) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200232 · Cited by 100 · see citing works
Balasubramanian, A. B., Kawas, C. H., Peltz, C. B., Brookmeyer, R., & Corrada, M. M. (2012) · Neurology · doi:10.1212/wnl.0b013e318266fc77 · Cited by 99 · see citing works
PROOF study group, Martin, M. S., Sforza, E. A., Roche, F., Barthélemy, J., & Thomas-Antérion, C. (2015) · SLEEP · doi:10.5665/sleep.4392 · Cited by 99 · see citing works
Hagger‐Johnson, G., Sabia, S., Brunner, E. J., Shipley, M. J., Bobák, M., Marmot, M. G., Mika Kivimaki, B., & Singh‐Manoux, A. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.122960 · Cited by 96 · see citing works
Castro-Hernández, R., Berulava, T., Metelova, M., Epple, R., Centeno, T. P., Richter, J., Kaurani, L., Pradhan, R., Sakib, M. S., Burkhardt, S., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204933120 · Cited by 88 · see citing works
Amyloid-beta and depression in healthy older adults: A systematic review
Harrington, K., Lim, Y. Y., Gould, E., & Maruff, P. T. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414557161 · Cited by 88 · see citing works
Pietrzak, R. H., Lim, Y. Y., Ames, D. J., Harrington, K., Restrepo, C., Martins, R. N., Rembach, A., Laws, S. M., Masters, C. L., Villemagne, V. L., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.015 · Cited by 84 · see citing works
Moberly, A. C., Harris, M. S., Boyce, L., & Nittrouer, S. (2017) · Journal of Speech Language and Hearing Research · doi:10.1044/2016_jslhr-h-16-0119 · Cited by 83 · see citing works
Terminal dedifferentiation of cognitive abilities
Wilson, R. S., Segawa, E., Hizel, L. P., Boyle, P. A., & Bennett, D. A. (2012) · Neurology · doi:10.1212/wnl.0b013e31824f7ff2 · Cited by 81 · see citing works
Self-citationConscientiousness, dementia related pathology, and trajectories of cognitive aging.
Wilson, R. S., Boyle, P. A., Yu, L., Segawa, E., Sytsma, J., & Bennett, D. A. (2015) · Psychology and Aging · doi:10.1037/pag0000013 · Cited by 81 · see citing works
Self-citationTOMM40 ′523 variant and cognitive decline in older persons with APOE ε3/3 genotype
Yu, L., Lutz, M. W., Wilson, R. S., Burns, D. K., Roses, A. D., Saunders, A. M., Gaiteri, C., Jager, P. L. D., Barnes, L. L., & Bennett, D. A. (2017) · Neurology · doi:10.1212/wnl.0000000000003614 · Cited by 78 · see citing works
Self-citationLewy Bodies and Olfactory Dysfunction in Old Age
Wilson, R. S., Yu, L., Schneider, J. A., Arnold, S. E., Buchman, A. S., & Bennett, D. A. (2011) · Chemical Senses · doi:10.1093/chemse/bjq139 · Cited by 78 · see citing works
Self-citationGold, B. T., Shao, X., Sudduth, T. L., Jicha, G. A., Wilcock, D. M., Seago, E. R., & Wang, D. J. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12357 · Cited by 76 · see citing works
Kremen, W. S., Lachman, M. E., Pruessner, J. C., Sliwinski, M. J., & Wilson, R. S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls125 · Cited by 77 · see citing works
Self-citationChandramowlishwaran, P., Vijay, A., Abraham, D., Li, G., Mwangi, S. M., & Srinivasan, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614331 · Cited by 74 · see citing works
Disentangling the effects of age and APOE on neuropathology and late life cognitive decline
Yu, L., Boyle, P. A., Leurgans, S., Schneider, J. A., & Bennett, D. A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.074 · Cited by 71 · see citing works
Self-citationResidual decline in cognition after adjustment for common neuropathologic conditions.
Yu, L., Boyle, P. A., Segawa, E., Leurgans, S. E., Schneider, J. A., Wilson, R. S., & Bennett, D. A. (2014) · Neuropsychology · doi:10.1037/neu0000159 · Cited by 71 · see citing works
Self-citationLindbohm, J. V., Mars, N., Walker, K. A., Singh‐Manoux, A., Livingston, G., Brunner, E. J., Sipilä, P. N., Saksela, K., Ferrie, J. E., Lovering, R. C., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12419 · Cited by 70 · see citing works
Barnes, J., Carmichael, O. T., Leung, K. K., Schwarz, C. G., Ridgway, G. R., Bartlett, J. W., Malone, I. B., Schott, J. M., Rossor, M. N., Biessels, G. J., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.003 · Cited by 70 · see citing works
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Bell, J. A., Mika Kivimaki, B., Bullmore, E. T., Steptoe, A., Bullmore, E. T., Vértes, P. E., Cardinal, R. N., Richardson, S. T., Leday, G., Freeman, T., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.155 · Cited by 67 · see citing works
Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice
Ren, B., Yuan, T., Zhang, X., Wang, L., Pan, J., Liu, Y., Zhao, B., Zhao, W., Liu, Z., & Liu, X. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07598 · Cited by 68 · see citing works
Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study
Li, G., Larson, E. B., Shofer, J. B., Crane, P. K., Gibbons, L. E., McCormick, W. C., Bowen, J. D., & Thompson, M. L. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15077 · Cited by 67 · see citing works
Terminal decline and practice effects in older adults without dementia
Dodge, H. H., Wang, C.-N., Chang, C.-C. H., & Ganguli, M. (2011) · Neurology · doi:10.1212/wnl.0b013e31822b0068 · Cited by 64 · see citing works
Brainstem Aminergic Nuclei and Late-Life Depressive Symptoms
Wilson, R. S., Nag, S., Boyle, P. A., Hizel, L. P., Yu, L., Buchman, A. S., Shah, R. C., Schneider, J. A., Arnold, S. E., & Bennett, D. A. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2224 · Cited by 58 · see citing works
Self-citationAssociation of financial and health literacy with cognitive health in old age
Wilson, R. S., Yu, L., James, B. D., Bennett, D. A., & Boyle, P. A. (2016) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2016.1178210 · Cited by 59 · see citing works
Self-citationAssociation Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults
Zhou, Z., Ryan, J. L., Tonkin, A. M., Zoungas, S., Lacaze, P. A., Wolfe, R. S., Orchard, S. G., Murray, A. M., McNeil, J. J., Yu, C., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207923 · Cited by 58 · see citing works
Terminal decline in motor function.
Wilson, R. S., Segawa, E., Buchman, A. S., Boyle, P. A., Hizel, L. P., & Bennett, D. A. (2012) · Psychology and Aging · doi:10.1037/a0028182 · Cited by 58 · see citing works
Self-citationBennett, D. A., Yu, L., & Jager, P. L. D. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.037 · Cited by 53 · see citing works
Self-citationCertified normal: Alzheimer's disease biomarkers and normative estimates of cognitive functioning
Hassenstab, J. J., Chasse, R., Grabow, P., Benzinger, T. L. S., Fagan, A. M., Xiong, C., Jasielec, M. S., Grant, E., & Morris, J. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.014 · Cited by 57 · see citing works
Márquez, D. X., Wilson, R. S., Aguiñaga, S., Vásquez, P. M., Fogg, L., Yang, Z. G., Wilbur, J., Hughes, S. L., & Spanbauer, C. (2017) · Journal of Aging and Physical Activity · doi:10.1123/japa.2016-0049 · Cited by 56 · see citing works
Self-citationMcFall, G. P., McDermott, K. L., & Dixon, R. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180571 · Cited by 52 · see citing works
Vongthip, W., Nilkhet, S., Boonruang, K., Sukprasansap, M., Tencomnao, T., & Baek, S. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-57824-2 · Cited by 51 · see citing works
Cognitive aging in older Black and White persons.
Wilson, R. S., Capuano, A. W., Sytsma, J., Bennett, D. A., & Barnes, L. L. (2015) · Psychology and Aging · doi:10.1037/pag0000024 · Cited by 50 · see citing works
Self-citation“End-Stage” Neurofibrillary Tangle Pathology in Preclinical Alzheimer's Disease: Fact or Fiction?
Abner, E. L., Kryscio, R. J., Schmitt, F. A., SantaCruz, K. S., Jicha, G. A., Lin, Y., Neltner, J. M., Smith, C. D., Van Eldik, L. J., & Nelson, P. T. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101980 · Cited by 49 · see citing works
Social networks and cognitive function in older adults: findings from the HAPIEE study
Nie, Y., Richards, M., Kubínová, R., Titarenko, A. V., Malyutina, S. K., Kozela, M., Pająk, A., Bobák, M., & Ruiz, M. A. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02531-0 · Cited by 53 · see citing works
Buchman, A. S., & Bennett, D. A. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0397-9 · Cited by 51 · see citing works
Self-citationBooth, S. L., Shea, M. K., Barger, K., Leurgans, S. E., James, B. D., Holland, T. M., Agarwal, P., Fu, X., Wang, J., Matuszek, G., et al. (2022) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12255 · Cited by 47 · see citing works
Self-citationYu, L., Boyle, P. A., Schneider, J. A., Segawa, E., Wilson, R. S., Leurgans, S. E., & Bennett, D. A. (2013) · Psychology and Aging · doi:10.1037/a0031642 · Cited by 47 · see citing works
Self-citationPlasticity in Early Alzheimer Disease
Hill, N. L., Kolanowski, A. M., & Gill, D. J. (2011) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0b013e31821e588e · Cited by 45 · see citing works
Corley, J., Conte, F. P., Harris, S. E., Taylor, A. M., Redmond, P. H., Russ, T. C., Deary, I. J., & Cox, S. R. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01900-4 · Cited by 40 · see citing works
Skinner, J. S., Abel, W. M., McCoy, K., & Wilkins, C. H. (2017) · Ethnicity & Disease · doi:10.18865/ed.27.4.387 · Cited by 43 · see citing works
Resistance Exercise-Induced Responses in Physiological Factors Linked with Cognitive Health
Marston, K. J., Brown, B. M., Rainey‐Smith, S. R., & Peiffer, J. J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181079 · Cited by 42 · see citing works
Age and the association of dementia-related pathology with trajectories of cognitive decline
Jansen, W. J., Wilson, R. S., Visser, P. J., Nag, S., Schneider, J. A., James, B. D., Leurgans, S. E., Capuano, A. W., Bennett, D. A., & Boyle, P. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.029 · Cited by 43 · see citing works
Self-citationFunctional Connectome Analyses Reveal the Human Olfactory Network Organization
Arnold, T. C., You, Y., Ding, M., Zuo, X., de Araújo, I., & Li, W. (2020) · eNeuro · doi:10.1523/eneuro.0551-19.2020 · Cited by 42 · see citing works
Optimal anti-amyloid-beta therapy for Alzheimer’s disease via a personalized mathematical model
Hao, W., Lenhart, S., & Petrella, J. R. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010481 · Cited by 40 · see citing works
- Authors
- Wilson, R. S., Leurgans, S. E., Boyle, P. A., Schneider, J. A., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Neurology
- Published
- 2010-09-21
- Volume
- 75
- Issue
- 12
- Pages
- 1070-1078
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC2942064
- OpenAlex
- W2057852669
- Cited by
- 234
- References
- 30
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 32 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 12 · 2014: 13 · 2013: 20 · 2012: 26
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG015819, P30AG010161, R01AG034374)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- age-related cognitive decline, dementia, neurofibrillary tangles, Lewy bodies, cerebral infarction, neuropathology, cognitive function, progressive dementia, brain autopsy
- MeSH terms
- Age Factors, Aging, Brain, Cognition, Cognition Disorders, Dementia, Female, Humans, Longitudinal Studies, Male, Nerve Degeneration, Neuropsychological Tests, Lewy Bodies, Neurofibrillary Tangles, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
