Estimating Epilepsy Incidence and Prevalence in the US Pediatric Population Using Nationwide Health Insurance Claims Data
Abstract
This study aims to determine prevalence and incidence of epilepsy in the US pediatric population. We analyzed commercial claims and Medicaid insurance claims data between 2008 and 2012. Over 8 million continuously enrolled lives aged 0 to 19 years were included. Our definition of a prevalent case of epilepsy was based on I nternational Classification of Diseases–coded diagnoses of epilepsy or seizures and evidence of prescribed antiepileptic drugs. Incident cases were identified in subjects continuously enrolled for ≥2 years of which the first 2 years had no indication of epilepsy or seizures. The overall prevalence estimate for 2012 was 6.8 per 1,000 children. The overall incidence estimate for 2012 was 104 per 100,000 pediatric population. This study provides estimates of the prevalence and incidence of epilepsy in the US pediatric population, using large claims datasets from multiple US population sectors. The findings appear reasonably representative of the US-insured pediatric population.
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The estimated frequency of epilepsy in 15q11.2 deletion carriers is 3.5% or 2.1% depending on control group.
“Based on the prevalence of epilepsy in the paediatric population of 6.8 per 1000 children,39 we estimate the frequency of epilepsy in deletion carriers at 3.5% or 2.1% (table 4).”
From Estimating the effect size of the 15Q11.2 BP1–BP2 deletion and its contribution to neurodevelopmental symptoms: recommendations for practice (2019) · cites this paper as [39]
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- Authors
- Kim, H., Thurman, D. J., Durgin, T., Faught, E., & Helmers, S.
- Affiliations
- Emory University (US)
- UCB Pharma (United States) (US)
- Corresponding author
- Kim, Hyunmi
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2015-12-29
- Volume
- 31
- Issue
- 6
- Pages
- 743-749
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2340909582
- Cited by
- 45
- References
- 37
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 1
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GlaxoSmithKline
- SK Life Science
- Eisai
- UCB Pharma
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Healthcare Policy and Management
- Keywords
- pediatric epilepsy, epilepsy prevalence, epilepsy incidence, health insurance claims data, Medicaid, private insurance, antiepileptic drugs, seizures, ICD-10 diagnoses, United States
- MeSH terms
- Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Female, Humans, Infant, Infant, Newborn, Insurance, Health, Male, Retrospective Studies, United States, Incidence, Prevalence, Databases, Factual, Age Distribution, International Classification of Diseases, Young Adult
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