The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Habitual intake of dietary flavonoids and risk of Parkinson disease
Open accessAbstract
OBJECTIVE: To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD). METHODS: In the current analysis, we included 49,281 men in the Health Professional Follow-up Study and 80,336 women from the Nurses' Health Study. Five major sources of flavonoid-rich foods (tea, berry fruits, apples, red wine, and orange/orange juice) were also examined. Flavonoid intake was assessed using an updated food composition database and a validated food frequency questionnaire. RESULTS: We identified 805 participants (438 men and 367 women) who developed PD during 20-22 years of follow-up. In men, after adjusting for multiple confounders, participants in the highest quintile of total flavonoids had a 40%lower PD risk than those in the lowest quintile (hazard ratio [HR] = 0.60; 95% confidence interval 0.43, 0.83; p trend = 0.001). No significant relationship was observed in women (p trend = 0.62) or in pooled analyses (p trend = 0.23). In the pooled analyses for the subclasses, intakes of anthocyanins and a rich dietary source, berries, were significantly associated with a lower PD risk (HR comparing 2 extreme intake quintiles were 0.76 for anthocyanins and 0.77 for berries, respectively; p trend < 0.02 for both). CONCLUSIONS: Our findings suggest that intake of some flavonoids may reduce PD risk, particularly in men, but a protective effect of other constituents of plant foods cannot be excluded.
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Prospective Study of Caffeine Consumption and Risk of Parkinson’s Disease in Men and Women
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Self-citationFlavonoid permeability across an in situ model of the blood–brain barrier
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Habitual intake of flavonoid subclasses and incident hypertension in adults
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Self-citationHow should we assess the effects of exposure to dietary polyphenols in vitro?
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The Flavonoid Baicalein Inhibits Fibrillation of α-Synuclein and Disaggregates Existing Fibrils
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Important Flavonoids and Their Role as a Therapeutic Agent
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M. (2020) · Molecules · doi:10.3390/molecules25225243 · Cited by 1,696
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Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
Kalt, W., Cassidy, A., Howard, L. R., Krikorian, R., Stull, A. J., Tremblay, F., & Zamora-Ros, R. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz065 · Cited by 659
Self-citationThe microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic
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Metadata
- Authors
- Gao, X., Cassidy, A., Schwarzschild, M. A., Rimm, E. B., & Ascherio, A.
- Venue
- Neurology
- Published
- 2012-04-10
- Volume
- 78
- Issue
- 15
- Pages
- 1138-1145
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1964373857
- Cited by
- 332
- References
- 39
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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