Cited by 293Phytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents StudiesPomegranate: compositions and health benefits

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

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Salehi, Bahare, Sharifi-Rad, Javad, Cappellini, Francesca, Reiner, Željko, Zorzan, Debora, Imran, Muhammad, Sener, Bilge, Kilic, Mehtap +9 more·2020·Frontiers in Pharmacology

Abstract

Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and anti-inflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, anti-obesity as well as their antidiabetes and anticancer effects.

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  1. Walton M. C. Mcghie T. K. Reynolds G. W. Hendriks W. H. (2006b). The Flavonol Quercetin-3-Glucoside Inhibits Cyanidin-3-Glucoside Absorption in Vitro. J. Agric. Food Chem. 54, 4913– 4920. 10.1021/jf0607922 16787048 · DOI

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Authors
Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., Al-Sayed, E., Martorell, M., Tonelli, C., Petroni, K., Docea, A. O., Calina, D., & Maroyi, A.
Affiliations
  • Bam University of Medical Sciences (IR)
  • University of Milan (IT)
  • University Hospital Centre Zagreb (HR)
  • University of Lahore (PK)
  • Ain Shams University (EG)
  • University of Concepción (CL)
  • University of Medicine and Pharmacy of Craiova (RO)
  • University of Fort Hare (ZA)
Corresponding author
  • Martorell, Miquel
  • Petroni, Katia
  • Maroyi, Alfred
Venue
Frontiers in Pharmacology
Published
2020-08-26
Volume
11
Pages
1300-1300
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3081210209
Cited by
293
References
248
Citations by year
2026: 27 · 2025: 50 · 2024: 59 · 2023: 52 · 2022: 76 · 2021: 26 · 2020: 3
FWCI
3.43
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, PIA/APOYO CCTE AFB170007, CONICYT PIA/APOYO CCTE AFB170007., AFB170007)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
anthocyanins, phenolic pigments, antioxidant activity, anti-inflammatory activity, bioavailability, cardioprotection, neuroprotection, anti-obesity, antidiabetic effect, anticancer effects, molecular mechanisms of action

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