The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
Open accessAbstract
Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and anti-inflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, anti-obesity as well as their antidiabetes and anticancer effects.
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Blood-brain barrier permeability is one of the significant challenges for pharmacological reach in the central nervous system.
“One of the significant challenges for the pharmacological reach in the central nervous system (CNS) is the blood-brain barrier permeability [207].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [207]
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Calina, D., Buga, A. M., Mitroi, M., Buha, A., Caruntu, C., Scheau, C., Bouyahya, A., El Omari, N., El Menyiy, N., & Docea, A. O. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082395 · Cited by 65 · see citing works
Self-citationBlueberry Anthocyanins-Enriched Extracts Attenuate Cyclophosphamide-Induced Cardiac Injury
Liu, Y., Tan, D., Shi, L., Liu, X., Zhang, Y., Tong, C., Song, D., & Hou, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127813 · Cited by 64 · see citing works
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Research works printed but not linked: 1
- Walton M. C. Mcghie T. K. Reynolds G. W. Hendriks W. H. (2006b). The Flavonol Quercetin-3-Glucoside Inhibits Cyanidin-3-Glucoside Absorption in Vitro. J. Agric. Food Chem. 54, 4913– 4920. 10.1021/jf0607922 16787048 · DOI
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Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T. A., Ahmad, B., Atif, M., Mubarak, M. S., Sytar, O., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3268136 · Cited by 389 · see citing works
Self-citationSharifi-Rad, J., Dey, A., Koirala, N., Shaheen, S., El Omari, N., Salehi, B., Goloshvili, T., Cirone Silva, N. C., Bouyahya, A., Vitalini, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.600139 · Cited by 183 · see citing works
Self-citationNeuropharmacological Effects of Quercetin: A Literature-Based Review
Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665031 · Cited by 165 · see citing works
Self-citationSharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Self-citationTherapeutic Applications of Curcumin in Diabetes: A Review and Perspective
Quispe, C., Herrera-Bravo, J., Javed, Z., Khan, K., Raza, S., Gulsunoglu-Konuskan, Z., Daştan, S. D., Sytar, O., Martorell, M., Sharifi-Rad, J., et al. (2022) · BioMed Research International · doi:10.1155/2022/1375892 · Cited by 92 · see citing works
Self-citationAmin, R., Quispe, C., Docea, A. O., Ydyrys, A., Kulbayeva, M., Durna Daştan, S., Calina, D., & Sharifi-Rad, J. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105376 · Cited by 74 · see citing works
Self-citationA Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy
Sharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., Kurt, B., Lankatillake, C., Docea, A. O., Moreira, A. C., et al. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03376-0 · Cited by 60 · see citing works
Self-citationSharifi-Rad, J., Bahukhandi, A., Dhyani, P., Sati, P., Capanoglu, E., Docea, A. O., Al-Harrasi, A., Dey, A., & Calina, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.664197 · Cited by 43 · see citing works
“Nuclear factor-kappa B (NF-κB) along with its inhibitory protein, IκB controls the transcription of pro-inflammatory mediators and cytokines such as NO (nitric oxide), iNOS (inducible isoform NO), COX-2 (ciclooxigenase 2), TNF-α (Tumour necrosis alfa), PGE2 (prostaglandin E2), and IL-1β (interleukin 1β) (30, 31) Besid…”
BackgroundReversal of brain aging by targeting telomerase: A nutraceutical approach
Tsoukalas, D., Buga, A., Docea, A., Sarandi, E., Mitrut, R., Renieri, E., Spandidos, D., Rogoveanu, I., Cercelaru, L., Niculescu, M., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5032 · Cited by 40 · see citing works
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Self-citation
- Authors
- Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., Al-Sayed, E., Martorell, M., Tonelli, C., Petroni, K., Docea, A. O., Calina, D., & Maroyi, A.
- Affiliations
- Bam University of Medical Sciences (IR)
- University of Milan (IT)
- University Hospital Centre Zagreb (HR)
- University of Lahore (PK)
- Ain Shams University (EG)
- University of Concepción (CL)
- University of Medicine and Pharmacy of Craiova (RO)
- University of Fort Hare (ZA)
- Corresponding author
- Martorell, Miquel
- Petroni, Katia
- Maroyi, Alfred
- ORCID
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2020-08-26
- Volume
- 11
- Pages
- 1300-1300
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC7479177
- OpenAlex
- W3081210209
- Cited by
- 293
- References
- 248
- Citations by year
- 2026: 27 · 2025: 50 · 2024: 59 · 2023: 52 · 2022: 76 · 2021: 26 · 2020: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Comisión Nacional de Investigación Científica y Tecnológica (CCTE AFB170007, PIA/APOYO CCTE AFB170007, CONICYT PIA/APOYO CCTE AFB170007., AFB170007)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- anthocyanins, phenolic pigments, antioxidant activity, anti-inflammatory activity, bioavailability, cardioprotection, neuroprotection, anti-obesity, antidiabetic effect, anticancer effects, molecular mechanisms of action
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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