Subjective cognitive impairment: Fickle but fateful
Abstract
Memory is a fragile, fickle thing. Almost every adult experiences a memory lapse occasionally. In younger people, shrugging it off or ignoring it may be the norm. As people hit their 40s, resignation that memory loss is a consequence of aging creeps into the apologies. In the 21st century, the possibility that memory lapses represent Alzheimer disease (AD) dementia has fostered a new anxiety. The specter of “Alzheimer's” lurking in everyday memory lapses tends to make a name forgotten or a set of keys misplaced all the more memorable. Almost like the famous Catch-22, conventional wisdom about memory complaints, without objective evidence of impairment, had been that if someone had enough insight to …
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Healthy middle-aged subjects typically have no significant atrophy or vascular pathology that might otherwise interfere with WM-related neural plasticity.
“Yet, different to older adults, healthy middle-aged subjects typically have no significant atrophy or vascular pathology that might otherwise interfere with WM-related neural plasticity [39].”
From Adaptive working memory training does not produce transfer effects in cognition and neuroimaging (2022) · cites this paper as [39]
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Snitz, B. E., Weissfeld, L. A., Cohen, A. D., Lopez, O. L., Nebes, R. D., Aizenstein, H. J., McDade, E., Price, J. C., Mathis, C. A., & Klunk, W. E. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.01.008 · Cited by 140 · see citing works
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Adaptive working memory training does not produce transfer effects in cognition and neuroimaging
Ripp, I., Emch, M., Wu, Q., Lizarraga, A., Udale, R., von Bastian, C. C., Koch, K., & Yakushev, I. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02272-7 · Cited by 31 · see citing works
- Authors
- Knopman, D. S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Knopman, David S.
- ORCID
- Knopman, David S.
- Venue
- Neurology
- Published
- 2012-09-25
- Volume
- 79
- Issue
- 13
- Pages
- 1308-1309
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2082091943
- Cited by
- 17
- References
- 10
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 1
- Type
- journal article
- Language
- en
- Update notices
- correction (2013-01-22)
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- subjective cognitive impairment, memory impairment, memory lapses, Alzheimer's disease, dementia, aging, subjective memory complaints
- MeSH terms
- Brain, Female, Glucose, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Positron-Emission Tomography
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