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Reversion from mild cognitive impairment to normal or near-normal cognition: Risk factors and prognosis
Open accessAbstract
OBJECTIVES: We sought to identify characteristics of individuals with mild cognitive impairment (MCI) that are associated with a relatively high probability of reverting back to normal cognition, and to estimate the risk of future cognitive decline among those who revert. METHODS: We first studied 3,020 individuals diagnosed with MCI on at least 1 visit to an Alzheimer's Disease Center in the United States. All underwent standardized Uniform Data Set evaluations at their first visit with an MCI diagnosis and on a subsequent visit, about 1 year later, at which cognitive status was reassessed. Multiple logistic regression was used to identify predictors of reverting from MCI back to normal cognition. We then estimated the risk of developing MCI or dementia over the next 3 years among those who had reverted, compared with individuals who had not had a study visit with MCI. RESULTS: About 16% of subjects diagnosed with MCI reverted back to normal or near-normal cognition approximately 1 year later. Five characteristics assessed at the first MCI visit contributed significantly to a model predicting a return to normal cognition: Mini-Mental State Examination (MMSE) score, Clinical Dementia Rating (CDR) score, MCI type, Functional Activities Questionnaire (FAQ) score, and APOE ε4 status. Survival analysis showed that the risk of retransitioning to MCI or dementia over the next 3 years was sharply elevated among those who had MCI and then improved, compared with individuals with no history of MCI. CONCLUSIONS: Even in a cohort of patients seen at dementia research centers, reversion from MCI was fairly common. Nonetheless, those who reverted remained at increased risk for future cognitive decline.
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Model selection and multimodel inference: a practical information-theoretic approach.
Guthery, F. S., Burnham, K. P., & Anderson, D. R. (2003) · The Journal of Wildlife Management · doi:10.2307/3802723 · Cited by 41,495
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
Statistical Analysis With Missing Data
Lahiff, M., Little, R. J. A., & Rubin, D. B. (1989) · Journal of the American Statistical Association · doi:10.2307/2289883 · Cited by 17,385
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Sheikh (1986) · doi:10.1300/j018v05n01_09 · Cited by 7,236
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978
Multiple imputation of discrete and continuous data by fully conditional specification
van Buuren, S. (2007) · Statistical Methods in Medical Research · doi:10.1177/0962280206074463 · Cited by 2,827
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,871
Multiple imputation in health‐are databases: An overview and some applications
Rubin, D. B., & Nathaniel Schenker, A. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100410 · Cited by 1,553
SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders
Litvan, I., Bhatia, K. P., Burn, D. J., Goetz, C. G., Lang, A. E., McKeith, I. G., Quinn, N. P., Sethi, K. D., Shults, C. W., & Wenning, G. K. (2003) · Movement Disorders · doi:10.1002/mds.10459 · Cited by 1,011
Mild Cognitive Impairment as a Clinical Entity and Treatment Target
Petersen, R. C., & Morris, J. C. (2005) · Archives of Neurology · doi:10.1001/archneur.62.7.1160 · Cited by 935
The National Alzheimer's Coordinating Center (NACC) Database: The Uniform Data Set
Beekly, D. L., Ramos, E. M., Lee, W. W., Deitrich, W. D., Jacka, M. E., Wu, J., Hubbard, J. L., Koepsell, T. D., Morris, J. C., & Kukull, W. A. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318142774e · Cited by 907
Self-citationMild cognitive impairment, amnestic type
Ganguli, M., Dodge, H. H., Shen, C., & DeKosky, S. T. (2004) · Neurology · doi:10.1212/01.wnl.0000132523.27540.81 · Cited by 674
Incidence and outcome of mild cognitive impairment in a population-based prospective cohort
Larrieu, S., Letenneur, L., Orgogozo, J., Fabrigoule, C., Amieva, H., Carret, N. L., Barberger‐Gateau, P., & Dartigues, J. (2002) · Neurology · doi:10.1212/01.wnl.0000034176.07159.f8 · Cited by 663
Outcomes of Mild Cognitive Impairment by Definition
Ganguli, M., Snitz, B. E., Saxton, J. A., Chang, C.-C. H., Lee, C.-W., Bilt, J. V., Hughes, T. F., Loewenstein, D., Unverzagt, F. W., & Petersen, R. C. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.101 · Cited by 303
Variations in case definition affect prevalence but not outcomes of mild cognitive impairment
Fisk, J. D., Merry, H. R., & Rockwood, K. J. (2003) · Neurology · doi:10.1212/01.wnl.0000089238.07771.c7 · Cited by 258
Transitions to mild cognitive impairments, dementia, and death: findings from the Nun Study
Tyas, S. L., Salazar, J. C., Snowdon, D. A., Desrosiers, M. F., Riley, K. P., Mendiondo, M. S., & Kryscio, R. J. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm085 · Cited by 163
Two-year outcome of MCI subtypes and aetiologies in the Goteborg MCI study
Nordlund, A., Rolstad, S., KLANG, O., Edman, Å., Hansen, S., & Wallin, A. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.171066 · Cited by 126
de Jager, C. A., & Budge, M. M. (2005) · Neurocase · doi:10.1080/13554790490896820 · Cited by 99
Are subjective cognitive complaints a risk factor for dementia?
Gallassi, R., Oppi, F., Poda, R., Scortichini, S., Maserati, M. S., Marano, G., & Sambati, L. (2010) · Neurological Sciences · doi:10.1007/s10072-010-0224-6 · Cited by 75
Estrogen Receptor-Beta Regulates Epithelial Cell Differentiation in the Mouse Ventral Prostate
Imamov, O., Morani, A., Shim, G. J., Omoto, Y., Warner, M. N., & Gustafsson, J. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080510 · Cited by 49
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Arévalo-Rodríguez, I., Smailagic, N., Figuls, M. R. I., Ciapponi, A., Sanchez-Perez, E., Giannakou, A., Pedraza, O. L., Bonfill, X., & Cullum, S. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010783.pub2 · Cited by 947
Classification and Epidemiology of MCI
Roberts, R. O., & Knopman, D. S. (2013) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2013.07.003 · Cited by 908
Hill, N. T. M., Mowszowski, L., Naismith, S. L., Chadwick, V. L., Valenzuela, M., & Lampit, A. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030360 · Cited by 782
López, J. A., González, H. M., & Léger, G. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00013-3 · Cited by 887
Metadata
- Authors
- Koepsell, T. D., & Monsell, S. E.
- Affiliations
- University of Washington (US)
- ORCID
- Monsell, Sarah E.
- Venue
- Neurology
- Published
- 2012-10-09
- Volume
- 79
- Issue
- 15
- Pages
- 1591-1598
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3475624
- OpenAlex
- W2002159622
- Cited by
- 369
- References
- 28
- Citations by year
- 2026: 24 · 2025: 37 · 2024: 29 · 2023: 27 · 2022: 45 · 2021: 31 · 2020: 33 · 2019: 27 · 2018: 23 · 2017: 15 · 2016: 24 · 2015: 22 · 2014: 17 · 2013: 14
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 016976, U01AG016976, UO1 AG016976)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- mild cognitive impairment, cognitive decline, dementia risk, Mini-Mental State Examination, Clinical Dementia Rating, APOE ε4, MCI subtypes, Functional Activities Questionnaire, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Neuropsychological Tests, Prognosis, Remission, Spontaneous, Risk Factors, Disease Progression, Cognitive Dysfunction
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