The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke
Open accessAbstract
OBJECTIVES: The usefulness of the implantable loop recorder (ILR) with improved atrial fibrillation (AF) detection capability (Reveal XT) and the factors associated with AF in the setting of unexplained stroke were investigated. METHODS: A cohort study is reported of 51 patients in whom ILRs were implanted for the investigation of ischemic stroke for which no cause had been found (cryptogenic) following appropriate vascular and cardiac imaging and at least 24 hours of cardiac rhythm monitoring. RESULTS: The patients were aged from 17 to 73 (median 52) years. Of the 30 patients with a shunt investigation, 22 had a patent foramen ovale (73.3%; 95% confidence interval [CI] 56.5%-90.1%). AF was identified in 13 (25.5%; 95% CI 13.1%-37.9%) cases. AF was associated with increasing age (p = 0.018), interatrial conduction block (p = 0.02), left atrial volume (p = 0.025), and the occurrence of atrial premature contractions on preceding external monitoring (p = 0.004). The median (range) of monitoring prior to AF detection was 48 (0-154) days. CONCLUSION: In patients with unexplained stroke, AF was detected by ILR in 25.5%. Predictors of AF were identified, which may help to target investigations. ILRs may have a central role in the future in the investigation of patients with unexplained stroke.
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“Much longer monitoring using ILRs can further improve the diagnostic yield for syncope, as high as 85% in some studies (Cotter et al., 2013).”
From 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (2017) · cites this paper as Cotter et al., 2013
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Cites
Adams, H. P., Bendixen, B. H., Kappelle, L. J., Biller, J., Love, B. B., Gordon, D., & Marsh, E. E. (1993) · Stroke · doi:10.1161/01.str.24.1.35 · Cited by 12,350
Subclinical atrial fibrillation and the risk of stroke
Healey, J. S., Connolly, S. J., Gold, M. R., Israel, C. W., Van Gelder, I. C., Capucci, A., Lau, C. P., Fain, E., Yang, S., Bailleul, C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105575 · Cited by 2,100
Marini, C., De Santis, F., Sacco, S., Russo, T., Olivieri, L., Totaro, R., & Carolei, A. (2005) · Stroke · doi:10.1161/01.str.0000166053.83476.4a · Cited by 949
Hindricks, G., Pokushalov, E., Urban, L., Taborsky, M., Kuck, K.-H., Lebedev, D., Rieger, G., & Pürerfellner, H. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.877852 · Cited by 422
Jabaudon, D., Sztajzel, J. M., Sievert, K., Landis, T., & Sztajzel, R. F. (2004) · Stroke · doi:10.1161/01.str.0000131269.69502.d9 · Cited by 414
Capucci, A., Santini, M., Padeletti, L., Gulizia, M. M., Botto, G., Boriani, G., Ricci, R. P., Favale, S., Zolezzi, F., Belardino, N. D., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.044 · Cited by 400
BOTTO, G. L., PADELETTI, L., SANTINI, M., CAPUCCI, A., GULIZIA, M., ZOLEZZI, F., FAVALE, S., MOLON, G., RICCI, R., BIFFI, M., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01320.x · Cited by 380
New Approach to Stroke Subtyping: The A-S-C-O (Phenotypic) Classification of Stroke
Amarenco, P., Bogousslavsky, J., Caplan, L. R., Donnan, G. A., & Hennerici, M. G. (2009) · Cerebrovascular Diseases · doi:10.1159/000210433 · Cited by 333
Liao, J., Khalid, Z., Scallan, C., Morillo, C., & O’Donnell, M. (2007) · Stroke · doi:10.1161/strokeaha.106.478685 · Cited by 331
Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke
Tayal, A. H., Tian, M., Kelly, K., Jones, S. C., Wright, D. G., Singh, D., Jarouse, J., Brillman, J. S., Murali, S., & Gupta, R. (2008) · Neurology · doi:10.1212/01.wnl.0000325059.86313.31 · Cited by 316
Cited by
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Cryptogenic stroke and underlying atrial fibrillation
Sanna, T., Diener, H.-C., Passman, R. S., Di Lazzaro, V., Bernstein, R. A., Morillo, C. A., Rymer, M. M., Thijs, V., Rogers, T., Beckers, F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313600 · Cited by 2,161
The Clinical Profile and Pathophysiology of Atrial Fibrillation
Andrade, J. G., Khairy, P., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.303211 · Cited by 1,232
Sposato, L. A., Cipriano, L. E., Saposnik, G., Vargas, E. R., Riccio, P. M., & Hachinski, V. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70027-x · Cited by 694
Andrade, J. G., Aguilar, M., Atzema, C. L., Bell, A., Cairns, J. A., Cheung, C. C., Cox, J. L., Dorian, P., Gladstone, D. J., Healey, J. S., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.09.001 · Cited by 593
Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P., Balsam, P., Baranchuk, A., Cantillon, D. J., Dilaveris, P., Dubner, S. J., El-Sherif, N., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.038 · Cited by 303
Metadata
- Authors
- Cotter, P. E., Martin, P. J., Ring, L., Warburton, E. A., Belham, M., & Pugh, P. J.
- Affiliations
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Venue
- Neurology
- Published
- 2013-04-23
- Volume
- 80
- Issue
- 17
- Pages
- 1546-1550
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3662328
- OpenAlex
- W2021263194
- Cited by
- 254
- References
- 19
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 25 · 2020: 11 · 2019: 21 · 2018: 18 · 2017: 21 · 2016: 26 · 2015: 29 · 2014: 44 · 2013: 9
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- atrial fibrillation, implantable loop recorder, cryptogenic stroke, patent foramen ovale, left atrial volume, premature atrial contractions, atrial fibrillation risk factors, cardiac rhythm monitoring
- MeSH terms
- Adolescent, Adult, Aged, Atrial Fibrillation, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Cohort Studies, Incidence, Stroke, Young Adult
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