The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Life-span cognitive activity, neuropathologic burden, and cognitive aging
Open accessAbstract
OBJECTIVE: To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders. METHODS: On enrollment, older participants in a longitudinal clinical-pathologic cohort study rated late-life (i.e., current) and early-life participation in cognitively stimulating activities. After a mean of 5.8 years of annual cognitive function testing, 294 individuals had died and undergone neuropathologic examination. Chronic gross infarcts, chronic microscopic infarcts, and neocortical Lewy bodies were identified, and measures of β-amyloid burden and tau-positive tangle density in multiple brain regions were derived. RESULTS: In a mixed-effects model adjusted for age at death, sex, education, gross and microscopic infarction, neocortical Lewy bodies, amyloid burden, and tangle density, more frequent late-life cognitive activity (estimate = 0.028, standard error [SE] = 0.008, p < 0.001) and early-life cognitive activity (estimate = 0.034, SE = 0.013, p = 0.008) were each associated with slower cognitive decline. The 2 measures together accounted for 14% of the residual variability in cognitive decline not related to neuropathologic burden. The early-life-activity association was attributable to cognitive activity in childhood (estimate = 0.027, SE = 0.012, p = 0.026) and middle age (estimate = 0.029, SE = 0.013, p = 0.025) but not young adulthood (estimate = -0.020, SE = 0.014, p = 0.163). CONCLUSIONS: More frequent cognitive activity across the life span has an association with slower late-life cognitive decline that is independent of common neuropathologic conditions, consistent with the cognitive reserve hypothesis.
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Self-citationNeuropathology of older persons without cognitive impairment from two community-based studies
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Self-citationUse it or lose it: Engaged lifestyle as a buffer of cognitive decline in aging?
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Training of Working Memory Impacts Structural Connectivity
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Bennett, D. A., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Arnold, S. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.378 · Cited by 526
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Relation of cognitive activity to risk of developing Alzheimer disease
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Self-citationEarly and late life cognitive activity and cognitive systems in old age
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Self-citationA life course approach to cognitive reserve: a model for cognitive aging and development?
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Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260
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Person-specific contribution of neuropathologies to cognitive loss in old age
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Self-citationAttributable risk of Alzheimer's dementia attributed to age-related neuropathologies
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Metadata
- Authors
- Wilson, R. S., Boyle, P. A., Yu, L., Barnes, L. L., Schneider, J. A., & Bennett, D. A.
- Venue
- Neurology
- Published
- 2013-07-23
- Volume
- 81
- Issue
- 4
- Pages
- 314-321
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2048147200
- Cited by
- 296
- References
- 15
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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