The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study
Open accessAbstract
OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease. RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.
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“Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”
From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]
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“Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”
From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]
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“Moreover, patients with autoimmune diseases showed a slightly increased frequency of developing ALS.86”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [86]
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Kiernan, M. C., Vucic, S., Cheah, B. C., Turner, M. R., Eisen, A., Hardiman, O., Burrell, J. R., & Zoing, M. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61156-7 · Cited by 2,603
Self-citationHaverkamp, L. J., Appel, V., & Appel, S. H. (1995) · Brain · doi:10.1093/brain/118.3.707 · Cited by 697
Energy metabolism in amyotrophic lateral sclerosis
Dupuis, L., Pradat, P., Ludolph, A. C., & Loeffler, J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70224-6 · Cited by 575
Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players
Chio, A. (2005) · Brain · doi:10.1093/brain/awh373 · Cited by 484
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
Philips, T., Bento‐Abreu, A., Nonneman, A., Haeck, W., Staats, K. A., Geelen, V., Hersmus, N., Küsters, B., Bosch, L. V. D., Damme, P. V., et al. (2013) · Brain · doi:10.1093/brain/aws339 · Cited by 282
Premorbid weight, body mass, and varsity athletics in ALS
Scarmeas, N., Shih, T., Stern, Y., Ottman, R., & Rowland, L. P. (2002) · Neurology · doi:10.1212/wnl.59.5.773 · Cited by 246
Seminog, O. O., & Goldacre, M. J. (2012) · Thorax · doi:10.1136/thoraxjnl-2012-202480 · Cited by 182
Self-citationTDP-43 frontotemporal lobar degeneration and autoimmune disease
Miller, Z. A., Rankin, K. P., Graff-Radford, N. R., Takada, L. T., Sturm, V. E., Cleveland, C. M., Criswell, L. A., Jaeger, P. A., Stan, T., Heggeli, K. A., et al. (2013) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304644 · Cited by 170
Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis
Gallo, V., Wark, P. A., Jenab, M., Pearce, N. E., Brayne, C., Vermeulen, R. C. H., Andersen, P. M., Hallmans, G., Kyrozis, A., Vanacore, N., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182840689 · Cited by 167
Lifetime physical activity and the risk of amyotrophic lateral sclerosis
Huisman, M. H. B., Seelen, M., de Jong, S. W., Dorresteijn, K. R. I. S., van Doormaal, P. T. C., van der Kooi, A. J., de Visser, M., Schelhaas, H. J., van den Berg, L. H., & Veldink, J. H. (2013) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304724 · Cited by 156
Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis
Sutedja, N. A., van der Schouw, Y. T., Fischer, K., Sizoo, E. M., Huisman, M. H. B., Veldink, J. H., & van den Berg, L. H. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.236752 · Cited by 144
Fois, A. F., Wotton, C. J., Yeates, D., Turner, M. R., & Goldacre, M. J. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.175463 · Cited by 143
Self-citationHematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
Appel, S. H., Engelhardt, J. I., Henkel-Tigges, J., Siklós, L., Beers, D. R., Yen, A. A., Simpson, E. P., Luo, Y., Carrum, G., Heslop, H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000327668.43541.22 · Cited by 140
Epidemiology of amyotrophic lateral sclerosis: 1. A case‐control comparison based on ALS deaths
Kurtzke, J. F., & Beebe, G. W. (1980) · Neurology · doi:10.1212/wnl.30.5.453 · Cited by 135
Gunnarsson, L., Bodin, L., Söderfeldt, B. A., & Axelson, O. (1992) · Occupational and Environmental Medicine · doi:10.1136/oem.49.11.791 · Cited by 126
Evidence for autoimmunity in amyotrophic lateral sclerosis
Appel, S. H., Smith, R. G., Engelhardt, J. I., & Stefani, E. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90106-9 · Cited by 121
Appel, S. H. (1986) · Archives of Neurology · doi:10.1001/archneur.1986.00520030026007 · Cited by 105
Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis
Körner, S., Kollewe, K., Ilsemann, J., Müller-Heine, A., Dengler, R., Krampfl, K., & Petri, S. (2012) · European Journal of Neurology · doi:10.1111/ene.12015 · Cited by 101
Turner, M. R., Wotton, C. J., Talbot, K., & Goldacre, M. J. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301161 · Cited by 73
Self-citationIsmail, A., Cooper-Knock, J., Highley, J. R., Milano, A., Kirby, J., Goodall, E., Lowe, J., Scott, I., Constantinescu, C. S., Walters, S. J., et al. (2013) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303326 · Cited by 65
Familial risks for amyotrophic lateral sclerosis and autoimmune diseases
Hemminki, K., Li, X., Sundquist, J., & Sundquist, K. (2008) · Neurogenetics · doi:10.1007/s10048-008-0164-y · Cited by 33
Antecedent Medical Diseases in Patients With Amyotrophic Lateral Sclerosis
Armon, C. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530150051017 · Cited by 32
A case of celiac disease mimicking amyotrophic lateral sclerosis
Turner, M. R., Chohan, G., Quaghebeur, G., Greenhall, R., Hadjivassiliou, M., & Talbot, K. (2007) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0631 · Cited by 32
Self-citationTurner, M. R. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-304935 · Cited by 30
Self-citationMultiple sclerosis and amyotrophic lateral sclerosis: is there a link?
Etemadifar, M., Abtahi, S.-H., Akbari, M., & Maghzi, A. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511427719 · Cited by 30
Associated autoimmune diseases in patients with multifocal motor neuropathy and their family members
Cats, E. A., Bertens, A. S., Veldink, J. H., van den Berg, L. H., & van der Pol, W. L. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6315-3 · Cited by 27
HLA Frequencies in Amyotrophic Lateral Sclerosis
Bartfeld, H., Pollack, M. S., Cunningham-Rundles, S., & Donnenfeld, H. (1982) · Archives of Neurology · doi:10.1001/archneur.1982.00510170012003 · Cited by 15
Amyotrophic lateral sclerosis is not linked to multiple sclerosis in a population based study
van Doormaal, P. T. C., Gallo, A., van Rheenen, W., Veldink, J. H., van Es, M. A., & van den Berg, L. H. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304864 · Cited by 11
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Fang, F., Ingre, C., Roos, P. M., Kamel, F., & Piehl, F. (2015) · Clinical Epidemiology · doi:10.2147/clep.s37505 · Cited by 503
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Metadata
- Authors
- Turner, M. R., Goldacre, R., Ramagopalan, S., Talbot, K., & Goldacre, M. J.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Neurology
- Published
- 2013-10
- Volume
- 81
- Issue
- 14
- Pages
- 1222-1225
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3795611
- OpenAlex
- W2167295920
- Cited by
- 185
- References
- 28
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 12 · 2023: 13 · 2022: 22 · 2021: 19 · 2020: 19 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 11 · 2013: 2
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Motor Neurone Disease Association (TURNER/JAN13/944-795)
- Medical Research Council (MR/K01014X/1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- amyotrophic lateral sclerosis, autoimmune disease, asthma, celiac disease, multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren's syndrome, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes, ALS incidence, genetic risk factors, environmental risk factors
- MeSH terms
- Amyotrophic Lateral Sclerosis, Autoimmune Diseases, England, Female, Hospital Records, Humans, Male, Risk, Cohort Studies, Comorbidity, Incidence
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