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Autoimmune disease preceding amyotrophic lateral sclerosis: An epidemiologic study
Open accessAbstract
OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease. RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors.
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“Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”
From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]
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“Considering that diabetes mellitus type 1 has been shown to have a positive association with the risk of ALS, we expect that the misclassification of some cases of diabetes mellitus type 1 as type 2 would most likely have underestimated the real inverse association between diabetes type 2 and risk of ALS [38, 41].”
From Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study (2024) · cites this paper as [41]
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“Moreover, patients with autoimmune diseases showed a slightly increased frequency of developing ALS.86”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [86]
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Metadata
- Authors
- Turner, M. R., Goldacre, R., Ramagopalan, S., Talbot, K., & Goldacre, M. J.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Neurology
- Published
- 2013-10
- Volume
- 81
- Issue
- 14
- Pages
- 1222-1225
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3795611
- OpenAlex
- W2167295920
- Cited by
- 185
- References
- 28
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 12 · 2023: 13 · 2022: 22 · 2021: 19 · 2020: 19 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 11 · 2013: 2
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Motor Neurone Disease Association (TURNER/JAN13/944-795)
- Medical Research Council (MR/K01014X/1)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- amyotrophic lateral sclerosis, autoimmune disease, asthma, celiac disease, multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren's syndrome, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes, ALS incidence, genetic risk factors, environmental risk factors
- MeSH terms
- Amyotrophic Lateral Sclerosis, Autoimmune Diseases, England, Female, Hospital Records, Humans, Male, Risk, Cohort Studies, Comorbidity, Incidence
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