CoChat
Sign Up
Cited by 316

Inflammation in ALS/FTD pathogenesis

McCauley, Madelyn E., Baloh, Robert H.·2019·Acta Neuropathologica
DOI 10.1007/s00401-018-1933-9PMC PMC6482122
Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s00401-018-1933-9

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Recent evidence from GWAS and follow-up analyses suggests that a proportion of genetic risk for neurological and psychiatric diseases acts through myeloid cells.

    “However, recent evidence from genome-wide association studies (GWAS) and other follow-up analyses has suggested that a proportion of the genetic risk of neurological and psychiatric diseases acts through myeloid cells22–25.”

    From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [24]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 137

  1. [1]Ajami B Bennett JL Krieger C McNagny KM Rossi FM Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool Nat Neurosci 2011 14 1142 1149 10.1038/nn.2887 21804537 · DOI · Paper page
  2. [2]Ajami B Bennett JL Krieger C Tetzlaff W Rossi FM Local self-renewal can sustain CNS microglia maintenance and function throughout adult life Nat Neurosci 2007 10 1538 1543 10.1038/nn2014 18026097 · DOI · Paper page
  3. [4]Alexianu ME Kozovska M Appel SH Immune reactivity in a mouse model of familial ALS correlates with disease progression Neurology 2001 57 1282 1289 10.1212/WNL.57.7.1282 11591849 · DOI
  4. [5]Alshikho MJ, Zurcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O et al (2018) Integrated MRI and [(11) C]-PBR28 PET imaging in amyotrophic lateral sclerosis. Ann Neurol. https://doi.org/10.1002/ana.25251 PMC6105567 29740862 · DOI
  5. [6]Amick J Roczniak-Ferguson A Ferguson SM C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling Mol Biol Cell 2016 27 3040 3051 10.1091/mbc.e16-01-0003 27559131 PMC5063613 · DOI
  6. [7]Appel SH Smith RG Alexianu M Siklos L Engelhardt J Colom LV Increased intracellular calcium triggered by immune mechanisms in amyotrophic lateral sclerosis Clin Neurosci 1995 3 368 374 9021258
  7. [8]Appel SH Stewart SS Appel V Harati Y Mietlowski W Weiss W A double-blind study of the effectiveness of cyclosporine in amyotrophic lateral sclerosis Arch Neurol 1988 45 381 386 10.1001/archneur.1988.00520280027011 3281637 · DOI
  8. [9]Ash PE Bieniek KF Gendron TF Caulfield T Lin WL Dejesus-Hernandez M Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS Neuron 2013 77 639 646 10.1016/j.neuron.2013.02.004 23415312 PMC3593233 · DOI
  9. [10]Atanasio A Decman V White D Ramos M Ikiz B Lee HC C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice Sci Rep 2016 6 23204 10.1038/srep23204 26979938 PMC4793236 · DOI · Paper page
  10. [11]Baumann J Results of treatment of certain diseases of the central nervous system with ACTH and corticosteroids Acta Neurol Scand Suppl 1965 13 Pt 2 453 461 4284452
  11. [12]Beers DR Henkel JS Xiao Q Zhao W Wang J Yen AA Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis Proc Natl Acad Sci USA 2006 103 16021 16026 10.1073/pnas.0607423103 17043238 PMC1613228 · DOI · Paper page
  12. [13]Beers DR Zhao W Appel SH The role of regulatory T lymphocytes in amyotrophic lateral sclerosis JAMA Neurol 2018 75 656 658 10.1001/jamaneurol.2018.0043 29507936 · DOI
  13. [14]Beers DR Zhao W Wang J Zhang X Wen S Neal D ALS patients’ regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity JCI Insight 2017 2 e89530 10.1172/jci.insight.89530 28289705 PMC5333967 · DOI
  14. [15]Ben Younes-Chennoufi A Rozier A Dib M Bouche P Lacomblez L Mombo N Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis J Neuroimmunol 1995 57 111 115 10.1016/0165-5728(94)00169-O 7706428 · DOI
  15. [16]Bennett ML Bennett FC Liddelow SA Ajami B Zamanian JL Fernhoff NB New tools for studying microglia in the mouse and human CNS Proc Natl Acad Sci USA 2016 113 E1738 E1746 10.1073/pnas.1525528113 26884166 PMC4812770 · DOI · Paper page
  16. [17]Bettencourt C Houlden H Exome sequencing uncovers hidden pathways in familial and sporadic ALS Nat Neurosci 2015 18 611 613 10.1038/nn.4012 25919956 · DOI
  17. [20]Bossu P Salani F Alberici A Archetti S Bellelli G Galimberti D Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients J Neuroinflamm 2011 8 65 10.1186/1742-2094-8-65 PMC3141503 21645364 · DOI
  18. [22]Brown RH Jr Al-Chalabi A Amyotrophic lateral sclerosis N Engl J Med 2017 377 1602 10.1056/NEJMra1603471 29045202 · DOI
  19. [23]Brown RH Jr Hauser SL Harrington H Weiner HL Failure of immunosuppression with a ten- to 14-day course of high-dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis Arch Neurol 1986 43 383 384 10.1001/archneur.1986.00520040063021 3954622 · DOI
  20. [25]Burberry A Suzuki N Wang JY Moccia R Mordes DA Stewart MH Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease Sci Transl Med 2016 8 347ra393 10.1126/scitranslmed.aaf6038 PMC5024536 27412785 · DOI · Paper page
  21. [27]Cheng F Wang HW Cuenca A Huang M Ghansah T Brayer J A critical role for Stat3 signaling in immune tolerance Immunity 2003 19 425 436 10.1016/S1074-7613(03)00232-2 14499117 · DOI · Paper page
  22. [28]Chew TS O’Shea NR Sewell GW Oehlers SH Mulvey CM Crosier PS Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis Dis Models Mech 2015 8 817 829 10.1242/dmm.020362 PMC4527293 26044960 · DOI
  23. [29]Cirulli ET Lasseigne BN Petrovski S Sapp PC Dion PA Leblond CS Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways Science 2015 347 1436 1441 10.1126/science.aaa3650 25700176 PMC4437632 · DOI · Paper page
  24. [31]Clement AM Nguyen MD Roberts EA Garcia ML Boillee S Rule M Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 2003 302 113 117 10.1126/science.1086071 14526083 · DOI
  25. [32]Coffelt SB de Visser KE Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor Immunity 2016 44 722 724 10.1016/j.immuni.2016.03.014 27096314 · DOI
  26. [36]Drachman DB Chaudhry V Cornblath D Kuncl RW Pestronk A Clawson L Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation Ann Neurol 1994 35 142 150 10.1002/ana.410350205 8109895 · DOI
  27. [37]Duarte F Binet S Lacomblez L Bouche P Preud’homme JL Meininger V Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis J Neurol Sci 1991 104 88 91 10.1016/0022-510X(91)90220-2 1919600 · DOI
  28. [39]Fang F Al-Chalabi A Ronnevi LO Turner MR Wirdefeldt K Kamel F Amyotrophic lateral sclerosis and cancer: a register-based study in Sweden Amyotroph Lateral Scler Motor Neuron Disord 2013 14 362 368 10.3109/21678421.2013.775309 PMC5451142 23527497 · DOI
  29. [40]Faraco G Park L Anrather J Iadecola C Brain perivascular macrophages: characterization and functional roles in health and disease J Mol Med 2017 95 1143 1152 10.1007/s00109-017-1573-x 28782084 PMC5812456 · DOI · Paper page
  30. [43]Fitzgerald KA McWhirter SM Faia KL Rowe DC Latz E Golenbock DT IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Nat Immunol 2003 4 491 496 10.1038/ni921 12692549 · DOI
  31. [44]Frakes AE Ferraiuolo L Haidet-Phillips AM Schmelzer L Braun L Miranda CJ Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis Neuron 2014 81 1009 1023 10.1016/j.neuron.2014.01.013 24607225 PMC3978641 · DOI · Paper page
  32. [45]Freedman DM Wu J Daugherty SE Kuncl RW Enewold LR Pfeiffer RM The risk of amyotrophic lateral sclerosis after cancer in US elderly adults: a population-based prospective study Int J Cancer 2014 135 1745 1750 10.1002/ijc.28795 24550098 PMC4107108 · DOI
  33. [48]Galli SJ Borregaard N Wynn TA Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils Nat Immunol 2011 12 1035 1044 10.1038/ni.2109 22012443 PMC3412172 · DOI · Paper page
  34. [49]Gardner A Ruffell B Dendritic cells and cancer immunity Trends Immunol 2016 37 855 865 10.1016/j.it.2016.09.006 27793569 PMC5135568 · DOI
  35. [50]Gendron TF Bieniek KF Zhang YJ Jansen-West K Ash PE Caulfield T Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS Acta Neuropathol 2013 126 829 844 10.1007/s00401-013-1192-8 24129584 PMC3830741 · DOI
  36. [51]Ghoshal N Dearborn JT Wozniak DF Cairns NJ Core features of frontotemporal dementia recapitulated in progranulin knockout mice Neurobiol Dis 2012 45 395 408 10.1016/j.nbd.2011.08.029 21933710 PMC3225509 · DOI · Paper page
  37. [52]Gibbons L Rollinson S Thompson JC Robinson A Davidson YS Richardson A Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration Neurobiol Aging 2015 36 1603 e1601 e1604 10.1016/j.neurobiolaging.2014.10.023 PMC4504979 25435337 · DOI
  38. [53]Gibson SB Abbott D Farnham JM Thai KK McLean H Figueroa KP Population-based risks for cancer in patients with ALS Neurology 2016 87 289 294 10.1212/WNL.0000000000002757 27170569 PMC4955272 · DOI
  39. [54]Gijselinck I Van Langenhove T van der Zee J Sleegers K Philtjens S Kleinberger G A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study Lancet Neurol 2012 11 54 65 10.1016/S1474-4422(11)70261-7 22154785 · DOI
  40. [56]Gleason CE Ordureau A Gourlay R Arthur JS Cohen P Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon beta J Biol Chem 2011 286 35663 35674 10.1074/jbc.M111.267567 21862579 PMC3195586 · DOI
  41. [57]Goldknopf IL Sheta EA Bryson J Folsom B Wilson C Duty J Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson’s disease Biochem Biophys Res Commun 2006 342 1034 1039 10.1016/j.bbrc.2006.02.051 16516157 · DOI
  42. [58]Goldmann T Wieghofer P Jordao MJ Prutek F Hagemeyer N Frenzel K Origin, fate and dynamics of macrophages at central nervous system interfaces Nat Immunol 2016 17 797 805 10.1038/ni.3423 27135602 PMC4968048 · DOI · Paper page
  43. [59]Graves MC Fiala M Dinglasan LA Liu NQ Sayre J Chiappelli F Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells Amyotroph Lateral Scler Motor Neuron Disord 2004 5 213 219 10.1080/14660820410020286 15799549 · DOI
  44. [60]Gurney ME Pu H Chiu AY Dal Canto MC Polchow CY Alexander DD Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 1994 264 1772 1775 10.1126/science.8209258 8209258 · DOI · Paper page
  45. [61]Hall ED Oostveen JA Gurney ME Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS Glia 1998 23 249 256 10.1002/(SICI)1098-1136(199807)23:3<249::AID-GLIA7>3.0.CO;2-# 9633809 · DOI
  46. [62]Hanisch UK Kettenmann H Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat Neurosci 2007 10 1387 1394 10.1038/nn1997 17965659 · DOI · Paper page
  47. [63]Harms MB Cady J Zaidman C Cooper P Bali T Allred P Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis Neurobiol Aging 2013 34 2234 e2213 e2239 10.1016/j.neurobiolaging.2013.03.006 PMC3679344 23597494 · DOI
  48. [65]Haverkamp LJ Appel V Appel SH Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction Brain 1995 118 (Pt 3) 707 719 10.1093/brain/118.3.707 7600088 · DOI
  49. [67]Heng TS Painter MW Immunological Genome Project C The Immunological Genome Project: networks of gene expression in immune cells Nat Immunol 2008 9 1091 1094 10.1038/ni1008-1091 18800157 · DOI · Paper page
  50. [68]Henkel JS Beers DR Wen S Rivera AL Toennis KM Appel JE Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival EMBO Mol Med 2013 5 64 79 10.1002/emmm.201201544 23143995 PMC3569654 · DOI
  51. [69]Henkel JS Beers DR Zhao W Appel SH Microglia in ALS: the good, the bad, and the resting J Neuroimmune Pharmacol 2009 4 389 398 10.1007/s11481-009-9171-5 19731042 · DOI · Paper page
  52. [70]Henkel JS Engelhardt JI Siklos L Simpson EP Kim SH Pan T Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann Neurol 2004 55 221 235 10.1002/ana.10805 14755726 · DOI
  53. [71]Herman M Ciancanelli M Ou YH Lorenzo L Klaudel-Dreszler M Pauwels E Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood J Exp Med 2012 209 1567 1582 10.1084/jem.20111316 22851595 PMC3428952 · DOI
  54. [73]Ismail A Cooper-Knock J Highley JR Milano A Kirby J Goodall E Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72 J Neurol Neurosurg Psychiatry 2013 84 79 87 10.1136/jnnp-2012-303326 23085936 · DOI · Paper page
  55. [75]Ivashkiv LB Donlin LT Regulation of type I interferon responses Nat Rev Immunol 2014 14 36 49 10.1038/nri3581 24362405 PMC4084561 · DOI
  56. [76]Jara JH Genc B Stanford MJ Pytel P Roos RP Weintraub S Evidence for an early innate immune response in the motor cortex of ALS J Neuroinflam 2017 14 129 10.1186/s12974-017-0896-4 PMC5485686 28651542 · DOI
  57. [77]Johnson JO Mandrioli J Benatar M Abramzon Y Van Deerlin VM Trojanowski JQ Exome sequencing reveals VCP mutations as a cause of familial ALS Neuron 2010 68 857 864 10.1016/j.neuron.2010.11.036 21145000 PMC3032425 · DOI · Paper page
  58. [78]Kabashi E Valdmanis PN Dion P Spiegelman D McConkey BJ Vande Velde C TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis Nat Genet 2008 40 572 574 10.1038/ng.132 18372902 · DOI · Paper page
  59. [79]Kawamata T Akiyama H Yamada T McGeer PL Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue Am J Pathol 1992 140 691 707 1347673 PMC1886170
  60. [80]Kelemen J Hedlund W Orlin JB Berkman EM Munsat TL Plasmapheresis with immunosuppression in amyotrophic lateral sclerosis Arch Neurol 1983 40 752 753 10.1001/archneur.1983.04050110070012 6625990 · DOI
  61. [82]Kim WK Alvarez X Fisher J Bronfin B Westmoreland S McLaurin J CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood Am J Pathol 2006 168 822 834 10.2353/ajpath.2006.050215 16507898 PMC1606539 · DOI · Paper page
  62. [83]Kreutzberg GW Microglia: a sensor for pathological events in the CNS Trends Neurosci 1996 19 312 318 10.1016/0166-2236(96)10049-7 8843599 · DOI · Paper page
  63. [84]Kwiatkowski TJ Jr Bosco DA Leclerc AL Tamrazian E Vanderburg CR Russ C Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 2009 323 1205 1208 10.1126/science.1166066 19251627 · DOI
  64. [85]La Spada AR Taylor JP Repeat expansion disease: progress and puzzles in disease pathogenesis Nat Rev Genet 2010 11 247 258 10.1038/nrg2748 20177426 PMC4704680 · DOI
  65. [86]Leigh PN Whitwell H Garofalo O Buller J Swash M Martin JE Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity Brain 1991 114 (Pt 2) 775 788 10.1093/brain/114.2.775 1646064 · DOI
  66. [87]Liao B Zhao W Beers DR Henkel JS Appel SH Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS Exp Neurol 2012 237 147 152 10.1016/j.expneurol.2012.06.011 22735487 PMC4126417 · DOI
  67. [88]Lomen-Hoerth C Anderson T Miller B The overlap of amyotrophic lateral sclerosis and frontotemporal dementia Neurology 2002 59 1077 1079 10.1212/WNL.59.7.1077 12370467 · DOI
  68. [89]London A Cohen M Schwartz M Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair Front Cell Neurosci 2013 7 34 10.3389/fncel.2013.00034 23596391 PMC3625831 · DOI · Paper page
  69. [90]Lu CH Allen K Oei F Leoni E Kuhle J Tree T Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis Neurol Neuroimmunol Neuroinflam 2016 3 e244 10.1212/NXI.0000000000000244 PMC4897985 27308305 · DOI
  70. [91]Lyck L Santamaria ID Pakkenberg B Chemnitz J Schroder HD Finsen B An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling J Neurosci Methods 2009 182 143 156 10.1016/j.jneumeth.2009.06.003 19520115 · DOI
  71. [93]Mantovani S Garbelli S Pasini A Alimonti D Perotti C Melazzini M Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process J Neuroimmunol 2009 210 73 79 10.1016/j.jneuroim.2009.02.012 19307024 · DOI
  72. [94]Marchlik E Thakker P Carlson T Jiang Z Ryan M Marusic S Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality J Leukoc Biol 2010 88 1171 1180 10.1189/jlb.0210071 20651301 · DOI
  73. [95]Markovinovic A Cimbro R Ljutic T Kriz J Rogelj B Munitic I Optineurin in amyotrophic lateral sclerosis: multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms Prog Neurobiol 2017 154 1 20 10.1016/j.pneurobio.2017.04.005 28456633 · DOI
  74. [97]Mathys H Adaikkan C Gao F Young JZ Manet E Hemberg M Temporal tracking of microglia activation in neurodegeneration at single-cell resolution Cell reports 2017 21 366 380 10.1016/j.celrep.2017.09.039 29020624 PMC5642107 · DOI · Paper page
  75. [98]May C Nordhoff E Casjens S Turewicz M Eisenacher M Gold R Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array PLoS One 2014 9 e89596 10.1371/journal.pone.0089596 24586901 PMC3935926 · DOI
  76. [99]McCombe PA Henderson RD The Role of immune and inflammatory mechanisms in ALS Curr Mol Med 2011 11 246 254 10.2174/156652411795243450 21375489 PMC3182412 · DOI
  77. [100]McGoldrick P Zhang M van Blitterswijk M Sato C Moreno D Xiao S Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression Neurology 2018 90 e323 e331 10.1212/WNL.0000000000004865 29282338 PMC5798652 · DOI
  78. [101]Mehta P Kaye W Raymond J Wu R Larson T Punjani R Prevalence of amyotrophic lateral sclerosis—United States, 2014 MMWR Morb Mortal Wkly Rep 2018 67 216 218 10.15585/mmwr.mm6707a3 29470458 PMC5858037 · DOI
  79. [102]Meissner F Molawi K Zychlinsky A Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis Proc Natl Acad Sci USA 2010 107 13046 13050 10.1073/pnas.1002396107 20616033 PMC2919927 · DOI
  80. [103]Miller ZA Rankin KP Graff-Radford NR Takada LT Sturm VE Cleveland CM TDP-43 frontotemporal lobar degeneration and autoimmune disease J Neurol Neurosurg Psychiatry 2013 84 956 962 10.1136/jnnp-2012-304644 23543794 PMC3840954 · DOI · Paper page
  81. [104]Miller ZA Sturm VE Camsari GB Karydas A Yokoyama JS Grinberg LT Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: completing the picture Neurol (R) Neuroimmunol Neuroinflam 2016 3 e301 10.1212/NXI.0000000000000301 PMC5087253 27844039 · DOI · Paper page
  82. [105]Monstad I Dale I Petlund CF Sjaastad O Plasma exchange in motor neuron disease. A controlled study J Neurol 1979 221 59 66 10.1007/BF00313170 92537 · DOI
  83. [106]Munitic I Giardino Torchia ML Meena NP Zhu G Li CC Ashwell JD Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells J Immunol 2013 191 6231 6240 10.4049/jimmunol.1301696 24244017 PMC3886234 · DOI
  84. [107]Murdock BJ Zhou T Kashlan SR Little RJ Goutman SA Feldman EL Correlation of peripheral immunity with rapid amyotrophic lateral sclerosis progression JAMA Neurol 2017 74 1446 1454 10.1001/jamaneurol.2017.2255 28973548 PMC5822195 · DOI
  85. [108]Nataf S Pays L Gene co-expression analysis unravels a link between C9orf72 and RNA metabolism in myeloid cells Acta Neuropathol Commun 2015 3 64 10.1186/s40478-015-0242-y 26472214 PMC4608290 · DOI
  86. [109]Neumann H Kotter MR Franklin RJ Debris clearance by microglia: an essential link between degeneration and regeneration Brain 2009 132 288 295 10.1093/brain/awn109 18567623 PMC2640215 · DOI · Paper page
  87. [110]Neumann M Sampathu DM Kwong LK Truax AC Micsenyi MC Chou TT Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science 2006 314 130 133 10.1126/science.1134108 17023659 · DOI · Paper page
  88. [111]Ng AS Rademakers R Miller BL Frontotemporal dementia: a bridge between dementia and neuromuscular disease Ann N Y Acad Sci 2015 1338 71 93 10.1111/nyas.12638 25557955 PMC4399703 · DOI
  89. [113]Oakes JA Davies MC Collins MO TBK1: a new player in ALS linking autophagy and neuroinflammation Mol Brain 2017 10 5 10.1186/s13041-017-0287-x 28148298 PMC5288885 · DOI · Paper page
  90. [114]Obaid R Wani SE Azfer A Hurd T Jones R Cohen P Optineurin negatively regulates osteoclast differentiation by modulating NF-kappaB and interferon signaling: implications for paget’s disease Cell Rep 2015 13 1096 1102 10.1016/j.celrep.2015.09.071 26527009 PMC4646838 · DOI
  91. [115]Olarte MR Schoenfeldt RS McKiernan G Rowland LP Plasmapheresis in amyotrophic lateral sclerosis Ann Neurol 1980 8 644 645 10.1002/ana.410080625 7212658 · DOI
  92. [116]Pagani MR Gonzalez LE Uchitel OD Autoimmunity in amyotrophic lateral sclerosis: past and present Neurol Res Int 2011 2011 497080 10.1155/2011/497080 21826267 PMC3150148 · DOI
  93. [117]Paolicelli RC Jawaid A Henstridge CM Valeri A Merlini M Robinson JL TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss Neuron 2017 95 297–308 e296 10.1016/j.neuron.2017.05.037 PMC5519492 28669544 · DOI · Paper page
  94. [119]Pelvig DP Pakkenberg H Stark AK Pakkenberg B Neocortical glial cell numbers in human brains Neurobiol Aging 2008 29 1754 1762 10.1016/j.neurobiolaging.2007.04.013 17544173 · DOI · Paper page
  95. [120]Pestronk A Adams RN Cornblath D Kuncl RW Drachman DB Clawson L Patterns of serum IgM antibodies to GM1 and GD1a gangliosides in amyotrophic lateral sclerosis Ann Neurol 1989 25 98 102 10.1002/ana.410250118 2913936 · DOI
  96. [121]Petkau TL Kosior N de Asis K Connolly C Leavitt BR Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation J Neuroinflam 2017 14 225 10.1186/s12974-017-1000-9 PMC5693502 29149899 · DOI
  97. [122]Polfliet MM van de Veerdonk F Dopp EA van Kesteren-Hendrikx EM van Rooijen N Dijkstra CD The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis J Neuroimmunol 2002 122 1 8 10.1016/S0165-5728(01)00445-3 11777538 · DOI
  98. [123]Popovich PG Hickey WF Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord J Neuropathol Exp Neurol 2001 60 676 685 10.1093/jnen/60.7.676 11444796 · DOI
  99. [125]Pramatarova A Laganiere J Roussel J Brisebois K Rouleau GA Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J Neurosci 2001 21 3369 3374 10.1523/JNEUROSCI.21-10-03369.2001 11331366 PMC6762496 · DOI · Paper page
  100. [126]Prinz M Priller J The role of peripheral immune cells in the CNS in steady state and disease Nat Neurosci 2017 20 136 144 10.1038/nn.4475 28092660 · DOI · Paper page
  101. [127]Ransohoff RM A polarizing question: do M1 and M2 microglia exist? Nat Neurosci 2016 19 987 991 10.1038/nn.4338 27459405 · DOI · Paper page
  102. [129]Rizzu P Blauwendraat C Heetveld S Lynes EM Castillo-Lizardo M Dhingra A C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers Acta Neuropathol Commun 2016 4 37 10.1186/s40478-016-0306-7 27079381 PMC4832459 · DOI
  103. [130]Sakaguchi S Miyara M Costantino CM Hafler DA FOXP3 + regulatory T cells in the human immune system Nat Rev Immunol 2010 10 490 500 10.1038/nri2785 20559327 · DOI
  104. [132]Sanagi T Yuasa S Nakamura Y Suzuki E Aoki M Warita H Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis J Neurosci Res 2010 88 2736 2746 10.1002/jnr.22424 20648658 · DOI
  105. [133]Sareen D O’Rourke JG Meera P Muhammad AK Grant S Simpkinson M Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion Sci Transl Med 2013 5 208ra149 10.1126/scitranslmed.3007529 24154603 PMC4090945 · DOI · Paper page
  106. [134]Schafer DP Stevens B Microglia function in central nervous system development and plasticity Cold Spring Harbor Perspect Biol 2015 7 a020545 10.1101/cshperspect.a020545 PMC4588063 26187728 · DOI · Paper page
  107. [135]Sellier C Campanari ML Julie Corbier C Gaucherot A Kolb-Cheynel I Oulad-Abdelghani M Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death EMBO J 2016 35 1276 1297 10.15252/embj.201593350 27103069 PMC4910533 · DOI · Paper page
  108. [136]Sheean RK McKay FC Cretney E Bye CR Perera ND Tomas D Association of regulatory T-Cell expansion with progression of amyotrophic lateral sclerosis: a study of humans and a transgenic mouse model JAMA Neurol 2018 75 681 689 10.1001/jamaneurol.2018.0035 29507931 PMC5885208 · DOI
  109. [137]Shi Y Lin S Staats KA Li Y Chang WH Hung ST Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med 2018 24 313 325 10.1038/nm.4490 29400714 PMC6112156 · DOI · Paper page
  110. [138]Shy ME Rowland LP Smith T Trojaborg W Latov N Sherman W Motor neuron disease and plasma cell dyscrasia Neurology 1986 36 1429 1436 10.1212/WNL.36.11.1429 3762961 · DOI
  111. [139]Sjogren M Folkesson S Blennow K Tarkowski E Increased intrathecal inflammatory activity in frontotemporal dementia: pathophysiological implications J Neurol Neurosurg Psychiatry 2004 75 1107 1111 10.1136/jnnp.2003.019422 15258209 PMC1739153 · DOI · Paper page
  112. [140]Slowicka K Vereecke L Mc Guire C Sze M Maelfait J Kolpe A Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-kappaB signaling Eur J Immunol 2016 46 971 980 10.1002/eji.201545863 26677802 · DOI
  113. [141]Spiller KJ Restrepo CR Khan T Dominique MA Fang TC Canter RG Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy Nat Neurosci 2018 21 329 340 10.1038/s41593-018-0083-7 29463850 PMC5857237 · DOI · Paper page
  114. [142]Sreedharan J Blair IP Tripathi VB Hu X Vance C Rogelj B TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis Science 2008 319 1668 1672 10.1126/science.1154584 18309045 PMC7116650 · DOI · Paper page
  115. [143]Sudria-Lopez E Koppers M de Wit M van der Meer C Westeneng HJ Zundel CA Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects Acta Neuropathol 2016 132 145 147 10.1007/s00401-016-1581-x 27206760 PMC4911370 · DOI · Paper page
  116. [144]Sullivan PM Zhou X Robins AM Paushter DH Kim D Smolka MB The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway Acta Neuropathol Commun 2016 4 51 10.1186/s40478-016-0324-5 27193190 PMC4870812 · DOI · Paper page
  117. [145]Tanishima M Takashima S Honda A Yasuda D Tanikawa T Ishii S Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling J Biol Chem 2017 292 17250 17257 10.1074/jbc.M117.813899 28882891 PMC5655504 · DOI
  118. [146]Therrien M Rouleau GA Dion PA Parker JA Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans PLoS One 2013 8 e83450 10.1371/journal.pone.0083450 24349511 PMC3861484 · DOI · Paper page
  119. [147]Thonhoff JR Beers DR Zhao W Pleitez M Simpson EP Berry JD Expanded autologous regulatory T-lymphocyte infusions in ALS: a phase I, first-in-human study Neurol (R) Neuroimmunol Neuroinflam 2018 5 e465 10.1212/NXI.0000000000000465 PMC5961523 29845093 · DOI
  120. [148]Tocut M Brenner R Zandman-Goddard G Autoimmune phenomena and disease in cancer patients treated with immune checkpoint inhibitors Autoimmun Rev 2018 17 610 616 10.1016/j.autrev.2018.01.010 29631064 · DOI
  121. [149]Town T Nikolic V Tan J The microglial “activation” continuum: from innate to adaptive responses Journal of neuroinflammation 2005 2 24 10.1186/1742-2094-2-24 16259628 PMC1298325 · DOI
  122. [152]Uchitel OD Appel SH Crawford F Sczcupak L Immunoglobulins from amyotrophic lateral sclerosis patients enhance spontaneous transmitter release from motor-nerve terminals Proc Natl Acad Sci USA 1988 85 7371 7374 10.1073/pnas.85.19.7371 2902629 PMC282188 · DOI
  123. [154]Vance C Rogelj B Hortobagyi T De Vos KJ Nishimura AL Sreedharan J Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 2009 323 1208 1211 10.1126/science.1165942 19251628 PMC4516382 · DOI
  124. [155]Wang WB Levy DE Lee CK STAT3 negatively regulates type I IFN-mediated antiviral response J Immunol 2011 187 2578 2585 10.4049/jimmunol.1004128 21810606 · DOI
  125. [156]Weydt P Yuen EC Ransom BR Moller T Increased cytotoxic potential of microglia from ALS-transgenic mice Glia 2004 48 179 182 10.1002/glia.20062 15378658 · DOI
  126. [157]Wong PC Pardo CA Borchelt DR Lee MK Copeland NG Jenkins NA An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 1995 14 1105 1116 10.1016/0896-6273(95)90259-7 7605627 · DOI
  127. [158]Wood H A hexanucleotide repeat expansion in C9ORF72 links amyotrophic lateral sclerosis and frontotemporal dementia Nature Rev Neurol 2011 7 595 10.1038/nrneurol.2011.162 22009283 · DOI
  128. [159]Worbs T Hammerschmidt SI Forster R Dendritic cell migration in health and disease Nat Rev Immunol 2017 17 30 48 10.1038/nri.2016.116 27890914 · DOI
  129. [161]Xiao Y Zou Q Xie X Liu T Li HS Jie Z The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity J Exp Med 2017 214 1493 1507 10.1084/jem.20161524 28356390 PMC5413337 · DOI · Paper page
  130. [162]Yamanaka K Boillee S Roberts EA Garcia ML McAlonis-Downes M Mikse OR Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice Proc Natl Acad Sci USA 2008 105 7594 7599 10.1073/pnas.0802556105 18492803 PMC2396671 · DOI · Paper page
  131. [163]Yi FH Lautrette C Vermot-Desroches C Bordessoule D Couratier P Wijdenes J In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients J Neuroimmunol 2000 109 211 220 10.1016/S0165-5728(00)00288-5 10996223 · DOI
  132. [164]Yin F Banerjee R Thomas B Zhou P Qian L Jia T Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice J Exp Med 2010 207 117 128 10.1084/jem.20091568 20026663 PMC2812536 · DOI · Paper page
  133. [166]Zhang R Gascon R Miller RG Gelinas DF Mass J Hadlock K Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS) J Neuroimmunol 2005 159 215 224 10.1016/j.jneuroim.2004.10.009 15652422 · DOI
  134. [167]Zhang R Hadlock KG Do H Yu S Honrada R Champion S Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS) J Neuroimmunol 2011 230 114 123 10.1016/j.jneuroim.2010.08.012 20884065 PMC3448551 · DOI
  135. [169]Zhao W Beers DR Liao B Henkel JS Appel SH Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms Neurobiol Dis 2012 48 418 428 10.1016/j.nbd.2012.07.008 22820142 PMC3897268 · DOI
  136. [170]Zhao W Xie W Le W Beers DR He Y Henkel JS Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism J Neuropathol Exp Neurol 2004 63 964 977 10.1093/jnen/63.9.964 15453095 · DOI
  137. [171]Zondler L Muller K Khalaji S Bliederhauser C Ruf WP Grozdanov V Peripheral monocytes are functionally altered and invade the CNS in ALS patients Acta Neuropathol 2016 132 391 411 10.1007/s00401-016-1548-y 26910103 · DOI · Paper page

Cited by

Sorted by citations

Authors
McCauley, M. E., & Baloh, R. H.
ORCID
Baloh, Robert H.
Venue
Acta Neuropathologica
Publisher
Springer Science and Business Media LLC
Published
2018-11-21
Volume
137
Issue
5
Pages
715-730
ISSN
  • 0001-6322
  • 1432-0533
DOI
10.1007/s00401-018-1933-9
PMC
PMC6482122
Cited by
316
References
33
Language
en
Licence
Funders
  • National Institute of Neurological Disorders and Stroke (NS097545)
  • Muscular Dystrophy Association (352536)
  • National Institute of General Medical Sciences (T32 GM118288)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review