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Cited by 343

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Altered serotonin metabolism in depressed patients with Parkinson's disease

Mayeux, Richard, Stern, Yaakov, Cote, Lucien, Williams, Janet B.W.·1984·Neurology
DOI 10.1212/wnl.34.5.642
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Abstract

Depression is a common symptom in patients with Parkinson's disease. It is not related to the severity of the motor symptoms or changes in dopamine metabolism and does not improve on treatment with dopamine agonists. Alterations in serotonin metabolism are found in primary (endogenous) depression. The brain content of serotonin in Parkinson's disease is also reduced, but this has not been related to any manifestation of the disorder. We found that the CSF content of the major metabolite of serotonin, 5-hydroxyindoleacetic acid, was lower in depressed than in nondepressed parkinsonians. The data suggest that the alterations in serotonin metabolism in Parkinson's disease identify a subgroup of patients who are prone to depression.

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Metadata

Authors
Mayeux, R., Stern, Y., Cote, L., & Williams, J. B. W.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1984-05
Volume
34
Issue
5
Pages
642-642
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.34.5.642
OpenAlex
W1980409090
Cited by
343
References
0
FWCI
7.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Altered serotonin metabolism in depressed patients with Parkinson's disease. https://app.cochat.ai/papers/10.1212/wnl.34.5.642
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Mayeux, R., Stern, Y., Cote, L., & Williams, J. B. W. (1984). Altered serotonin metabolism in depressed patients with Parkinson's disease. Neurology. https://doi.org/10.1212/wnl.34.5.642

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.