Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease
Abstract
Depression is a frequent finding in patients with Parkinson's disease (PD). Regional cerebral glucose metabolism was measured in depressed and nondepressed patients with PD and in age‐comparable normal control subjects using 2‐[18 F]‐fluoro‐2‐deoxy‐D‐glucose and positron emission tomography (PET). Relative metabolic activity in the caudate and orbital‐inferior region of the frontal lobe was significantly lower in the depressed patients with PD as compared to both nondepressed patients and control subjects. There was a significant inverse correlation between relative glucose metabolism in the orbital‐inferior area of the frontal lobe and depression scores. This study suggests that depression in PD is associated with dysfunction in the caudate and orbital‐inferior area of the frontal lobe. This metabolic pattern is unlike that seen in patients with PD who have other behavioral deficits such as dementia, and suggests that disruption of basal ganglia circuits involving the inferior region of the frontal lobe may affect the regulation of mood.
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Parkinson's disease patients with depression show altered metabolism or blood flow in orbital and medial frontal cortex compared with non-depressed Parkinson's patients or healthy controls.
“Patients with Parkinson’s disease who manifest depression show altered metabolism or blood flow in the orbital and medial frontal cortex compared to non-depressed Parkinson’s patients or healthy controls (42, 43).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [42]
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- Authors
- Mayberg, H. S., Starkstein, S. E., Sadzot, B., Preziosi, T., Andrezejewski, P. L., Dannals, R. F., Wagner, H. N., & Robinson, R. G.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Mayberg, Helen S.
- ORCID
- Mayberg, Helen S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1990-07
- Volume
- 28
- Issue
- 1
- Pages
- 57-64
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2110498558
- Cited by
- 412
- References
- 59
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 10 · 2013: 18 · 2012: 6
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ns015080-15)
- National Institute of Neurological Disorders and Stroke (NS 15080)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, depression, regional cerebral glucose metabolism, inferior frontal lobe, caudate nucleus, orbitofrontal cortex, basal ganglia circuitry, mood regulation, neuroimaging of depression
- MeSH terms
- Aged, Depression, Female, Frontal Lobe, Glucose, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Tomography, Emission-Computed
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